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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PRRX1_ALX4_PHOX2A

Z-value: 0.79

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Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol Gene ID Gene Info
PRRX1
ENSG00000116132.7 paired related homeobox 1
ALX4
ENSG00000052850.5 ALX homeobox 4
PHOX2A
ENSG00000165462.5 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PHOX2Ahg19_v2_chr11_-_71952236_71952319,
hg19_v2_chr11_-_71955210_71955227		0.667.6e-05Click!
ALX4hg19_v2_chr11_-_44331679_443317160.271.5e-01Click!
PRRX1hg19_v2_chr1_+_170633047_1706330840.135.0e-01Click!

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_69313145 6.51 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr6_-_66417107 4.04 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr2_-_31440377 3.57 ENST00000444918.2
ENST00000403897.3
CAPN14
calpain 14
chr2_+_102413726 3.06 ENST00000350878.4
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr6_+_34204642 2.74 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr1_+_50569575 2.63 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr18_+_616672 2.49 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr17_-_38859996 2.39 ENST00000264651.2
KRT24
keratin 24
chr2_+_54683419 1.72 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr8_+_7397150 1.68 ENST00000533250.1
RP11-1118M6.1
proline rich 23 domain containing 1
chr8_-_7638935 1.67 ENST00000528972.1
AC084121.16
proline rich 23 domain containing 2
chr2_+_228678550 1.66 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr1_-_94147385 1.60 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr7_+_107224364 1.59 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chrX_+_107288239 1.58 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr1_+_62439037 1.57 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr11_-_7847519 1.57 ENST00000328375.1
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr1_+_84630645 1.56 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_8975061 1.55 ENST00000299698.7
A2ML1
alpha-2-macroglobulin-like 1
chr4_-_143227088 1.54 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr4_-_89951028 1.50 ENST00000506913.1
FAM13A
family with sequence similarity 13, member A
chrX_+_107288197 1.47 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr15_+_42066632 1.44 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr10_-_75226166 1.43 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr9_+_124329336 1.40 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr18_+_616711 1.37 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr7_-_111032971 1.34 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr10_-_29923893 1.30 ENST00000355867.4
SVIL
supervillin
chr12_-_118797475 1.26 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr14_+_24099318 1.23 ENST00000432832.2
DHRS2
dehydrogenase/reductase (SDR family) member 2
chr12_-_89746173 1.20 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr7_-_93520259 1.13 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr5_-_39270725 1.10 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr5_-_11588907 1.08 ENST00000513598.1
ENST00000503622.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr11_+_55578854 1.01 ENST00000333973.2
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr9_+_75229616 1.00 ENST00000340019.3
TMC1
transmembrane channel-like 1
chr17_-_60885659 1.00 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr17_-_60885700 0.98 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr7_-_93520191 0.98 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr1_+_109756523 0.93 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr5_-_11589131 0.92 ENST00000511377.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr10_+_18689637 0.92 ENST00000377315.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr17_-_9694614 0.91 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chr19_+_7030589 0.91 ENST00000329753.5
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr8_-_91095099 0.89 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr15_-_34331243 0.88 ENST00000306730.3
AVEN
apoptosis, caspase activation inhibitor
chr12_+_122688090 0.87 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr1_+_206557366 0.84 ENST00000414007.1
ENST00000419187.2
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr2_+_101437487 0.84 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr6_-_107235287 0.82 ENST00000436659.1
ENST00000428750.1
ENST00000427903.1
RP1-60O19.1
RP1-60O19.1
chr19_-_7040190 0.82 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chr2_-_208994548 0.78 ENST00000282141.3
CRYGC
crystallin, gamma C
chr19_+_7049332 0.76 ENST00000381393.3
MBD3L2
methyl-CpG binding domain protein 3-like 2
chr12_+_1099675 0.75 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr9_-_123639304 0.73 ENST00000436309.1
PHF19
PHD finger protein 19
chr6_-_107235331 0.72 ENST00000433965.1
ENST00000430094.1
RP1-60O19.1
RP1-60O19.1
chr10_-_90611566 0.71 ENST00000371930.4
ANKRD22
ankyrin repeat domain 22
chr3_-_164914640 0.69 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr8_+_11961898 0.68 ENST00000400085.3
ZNF705D
zinc finger protein 705D
chr1_-_234667504 0.66 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr11_-_71955210 0.65 ENST00000298231.5
PHOX2A
paired-like homeobox 2a
chr1_+_243419306 0.65 ENST00000355875.4
ENST00000391846.1
ENST00000366541.3
ENST00000343783.6
SDCCAG8
serologically defined colon cancer antigen 8
chr17_+_74463650 0.65 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr1_+_87012753 0.63 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr19_-_11456935 0.62 ENST00000590788.1
ENST00000586590.1
ENST00000589555.1
ENST00000586956.1
ENST00000593256.2
ENST00000447337.1
ENST00000591677.1
ENST00000586701.1
ENST00000589655.1
TMEM205
RAB3D
transmembrane protein 205
RAB3D, member RAS oncogene family
chr6_-_27835357 0.62 ENST00000331442.3
HIST1H1B
histone cluster 1, H1b
chr5_+_147691979 0.61 ENST00000274565.4
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr18_-_44181442 0.60 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr12_+_59989918 0.60 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr4_-_103940791 0.60 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
SLC9B1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr3_-_124774802 0.59 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr22_-_27456361 0.58 ENST00000453934.1
CTA-992D9.6
CTA-992D9.6
chr12_-_7656357 0.58 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163
CD163 molecule
chr17_-_39150385 0.58 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr4_-_143226979 0.58 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr14_-_81893734 0.58 ENST00000555447.1
STON2
stonin 2
chr17_-_39254391 0.57 ENST00000333822.4
KRTAP4-8
keratin associated protein 4-8
chr10_+_69865866 0.57 ENST00000354393.2
MYPN
myopalladin
chr2_+_196313239 0.57 ENST00000413290.1
AC064834.1
AC064834.1
chr2_+_234600253 0.56 ENST00000373424.1
ENST00000441351.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_+_92632542 0.56 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr14_-_81425828 0.56 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128
centrosomal protein 128kDa
chr1_+_154401791 0.56 ENST00000476006.1
IL6R
interleukin 6 receptor
chr13_+_57715052 0.55 ENST00000377931.1
PRR20A
proline rich 20A
chr9_-_123639445 0.55 ENST00000312189.6
PHF19
PHD finger protein 19
chr8_-_122653630 0.54 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr9_-_123639600 0.54 ENST00000373896.3
PHF19
PHD finger protein 19
chr6_+_26087646 0.53 ENST00000309234.6
HFE
hemochromatosis
chr6_-_40555176 0.52 ENST00000338305.6
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr12_-_91546926 0.51 ENST00000550758.1
DCN
decorin
chr11_-_63439013 0.51 ENST00000398868.3
ATL3
atlastin GTPase 3
chr12_-_43833515 0.50 ENST00000549670.1
ENST00000395541.2
ADAMTS20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr12_-_10978957 0.50 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr9_+_136501478 0.50 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr19_-_44174330 0.49 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr13_-_88463487 0.48 ENST00000606221.1
RP11-471M2.3
RP11-471M2.3
chr6_+_53883790 0.47 ENST00000509997.1
MLIP
muscular LMNA-interacting protein
chr7_+_93535817 0.47 ENST00000248572.5
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr3_-_195310802 0.47 ENST00000421243.1
ENST00000453131.1
APOD
apolipoprotein D
chr19_-_6393216 0.47 ENST00000595047.1
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chr3_-_194188956 0.46 ENST00000256031.4
ENST00000446356.1
ATP13A3
ATPase type 13A3
chr9_-_95244781 0.45 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
ASPN
asporin
chr7_+_143701022 0.44 ENST00000408922.2
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr14_-_36988882 0.44 ENST00000498187.2
NKX2-1
NK2 homeobox 1
chr17_-_39274606 0.44 ENST00000391413.2
KRTAP4-11
keratin associated protein 4-11
chr11_-_89653576 0.43 ENST00000420869.1
TRIM49D1
tripartite motif containing 49D1
chr3_-_87325612 0.43 ENST00000561167.1
ENST00000560656.1
ENST00000344265.3
POU1F1
POU class 1 homeobox 1
chr15_+_52155001 0.43 ENST00000544199.1
TMOD3
tropomodulin 3 (ubiquitous)
chr19_-_6393465 0.42 ENST00000394456.5
GTF2F1
general transcription factor IIF, polypeptide 1, 74kDa
chrX_+_119737806 0.42 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr1_+_52682052 0.41 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr4_+_74606223 0.41 ENST00000307407.3
ENST00000401931.1
IL8
interleukin 8
chr8_-_57472154 0.41 ENST00000499425.1
ENST00000523664.1
ENST00000518943.1
ENST00000524338.1
LINC00968
long intergenic non-protein coding RNA 968
chr10_+_71075552 0.41 ENST00000298649.3
HK1
hexokinase 1
chr14_+_96722539 0.41 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr4_+_155484103 0.40 ENST00000302068.4
FGB
fibrinogen beta chain
chr7_+_93535866 0.40 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr17_-_5321549 0.39 ENST00000572809.1
NUP88
nucleoporin 88kDa
chr19_-_44174305 0.39 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chr4_+_109571740 0.38 ENST00000361564.4
OSTC
oligosaccharyltransferase complex subunit (non-catalytic)
chr12_+_120105558 0.38 ENST00000229328.5
ENST00000541640.1
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chrX_-_124097620 0.38 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr12_+_72080253 0.38 ENST00000549735.1
TMEM19
transmembrane protein 19
chr2_+_223725652 0.38 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr9_-_21305312 0.37 ENST00000259555.4
IFNA5
interferon, alpha 5
chr3_-_151034734 0.37 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr9_-_21351377 0.37 ENST00000380210.1
IFNA6
interferon, alpha 6
chr10_-_105110890 0.37 ENST00000369847.3
PCGF6
polycomb group ring finger 6
chr17_-_39023462 0.36 ENST00000251643.4
KRT12
keratin 12
chrX_-_11284095 0.36 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr12_-_8088871 0.36 ENST00000075120.7
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr3_-_87325728 0.36 ENST00000350375.2
POU1F1
POU class 1 homeobox 1
chr9_+_34652164 0.34 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr4_+_142558078 0.34 ENST00000529613.1
IL15
interleukin 15
chr10_+_77056134 0.34 ENST00000528121.1
ENST00000416398.1
ZNF503-AS1
ZNF503 antisense RNA 1
chr10_-_105110831 0.34 ENST00000337211.4
PCGF6
polycomb group ring finger 6
chr5_-_9630463 0.34 ENST00000382492.2
TAS2R1
taste receptor, type 2, member 1
chr3_+_12329397 0.34 ENST00000397015.2
PPARG
peroxisome proliferator-activated receptor gamma
chr8_-_93107443 0.34 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_+_109571800 0.34 ENST00000512478.2
OSTC
oligosaccharyltransferase complex subunit (non-catalytic)
chr3_+_39371191 0.34 ENST00000326306.4
CCR8
chemokine (C-C motif) receptor 8
chr6_+_42896865 0.34 ENST00000372836.4
ENST00000394142.3
CNPY3
canopy FGF signaling regulator 3
chr12_+_18414446 0.33 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr6_+_53883708 0.33 ENST00000514921.1
ENST00000274897.5
ENST00000370877.2
MLIP
muscular LMNA-interacting protein
chr10_+_5454505 0.33 ENST00000355029.4
NET1
neuroepithelial cell transforming 1
chr12_-_118628350 0.33 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr11_-_11374904 0.32 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr1_-_110933611 0.32 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr2_-_55496174 0.32 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
MTIF2
mitochondrial translational initiation factor 2
chr1_+_115572415 0.32 ENST00000256592.1
TSHB
thyroid stimulating hormone, beta
chr21_-_35899113 0.32 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr16_-_67517716 0.32 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr14_+_65453432 0.32 ENST00000246166.2
FNTB
farnesyltransferase, CAAX box, beta
chr2_-_80531399 0.31 ENST00000409148.1
ENST00000415098.1
ENST00000452811.1
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr18_-_64271316 0.31 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr21_-_27423339 0.31 ENST00000415997.1
APP
amyloid beta (A4) precursor protein
chr1_+_224544552 0.30 ENST00000465271.1
ENST00000366858.3
CNIH4
cornichon family AMPA receptor auxiliary protein 4
chr17_-_37009882 0.30 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
RPL23
ribosomal protein L23
chr15_+_80733570 0.30 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr1_-_68698197 0.30 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr1_-_200379129 0.30 ENST00000367353.1
ZNF281
zinc finger protein 281
chr1_-_68698222 0.30 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr4_-_119759795 0.30 ENST00000419654.2
SEC24D
SEC24 family member D
chr2_-_166930131 0.30 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr3_+_159943362 0.29 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr1_-_209957882 0.29 ENST00000294811.1
C1orf74
chromosome 1 open reading frame 74
chr4_+_155484155 0.29 ENST00000509493.1
FGB
fibrinogen beta chain
chr8_-_93107696 0.29 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr20_+_16729003 0.29 ENST00000246081.2
OTOR
otoraplin
chr10_-_10836865 0.29 ENST00000446372.2
SFTA1P
surfactant associated 1, pseudogene
chr1_-_198509804 0.29 ENST00000489986.1
ENST00000367382.1
ATP6V1G3
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
chr19_+_13842559 0.28 ENST00000586600.1
CCDC130
coiled-coil domain containing 130
chr8_+_38677850 0.28 ENST00000518809.1
ENST00000520611.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr1_+_224544572 0.28 ENST00000366857.5
ENST00000366856.3
CNIH4
cornichon family AMPA receptor auxiliary protein 4
chr14_-_36989336 0.28 ENST00000522719.2
NKX2-1
NK2 homeobox 1
chr12_-_110937351 0.28 ENST00000552130.2
VPS29
vacuolar protein sorting 29 homolog (S. cerevisiae)
chr9_+_27524283 0.28 ENST00000276943.2
IFNK
interferon, kappa
chr17_-_10276319 0.27 ENST00000252172.4
ENST00000418404.3
MYH13
myosin, heavy chain 13, skeletal muscle
chr12_+_8666126 0.27 ENST00000299665.2
CLEC4D
C-type lectin domain family 4, member D
chr1_+_180199393 0.27 ENST00000263726.2
LHX4
LIM homeobox 4
chr6_+_121756809 0.26 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr5_+_137203465 0.26 ENST00000239926.4
MYOT
myotilin
chr7_+_129015484 0.26 ENST00000490911.1
AHCYL2
adenosylhomocysteinase-like 2
chr12_-_10324716 0.26 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr14_+_52164820 0.26 ENST00000554167.1
FRMD6
FERM domain containing 6
chr13_-_52980263 0.26 ENST00000258613.4
ENST00000544466.1
THSD1
thrombospondin, type I, domain containing 1
chr11_-_8964580 0.25 ENST00000325884.1
ASCL3
achaete-scute family bHLH transcription factor 3
chr5_-_119740532 0.25 ENST00000569928.1
RP11-574H6.1
RP11-574H6.1
chr8_+_7801144 0.25 ENST00000443676.1
ZNF705B
zinc finger protein 705B
chr17_+_71228793 0.25 ENST00000426147.2
C17orf80
chromosome 17 open reading frame 80
chr1_+_12916941 0.25 ENST00000240189.2
PRAMEF2
PRAME family member 2
chr11_+_113779704 0.24 ENST00000537778.1
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
chr12_-_28125638 0.24 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chr8_-_62602327 0.24 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr1_-_178840157 0.24 ENST00000367629.1
ENST00000234816.2
ANGPTL1
angiopoietin-like 1
chr2_-_183291741 0.24 ENST00000351439.5
ENST00000409365.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr19_+_34855874 0.24 ENST00000588991.2
GPI
glucose-6-phosphate isomerase
chr19_+_34855925 0.23 ENST00000590375.1
ENST00000356487.5
GPI
glucose-6-phosphate isomerase
chr8_-_16035454 0.23 ENST00000355282.2
MSR1
macrophage scavenger receptor 1
chr5_+_36152179 0.22 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.5 2.7 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.4 1.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.4 1.7 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.4 1.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.3 0.9 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.3 0.8 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.3 1.4 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 1.6 GO:0097338 response to clozapine(GO:0097338)
0.2 0.9 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.2 0.9 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.2 0.6 GO:0021558 trochlear nerve development(GO:0021558)
0.2 0.6 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.2 1.4 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.2 0.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 0.8 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.2 0.6 GO:0002384 hepatic immune response(GO:0002384)
0.2 0.5 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 0.5 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.2 4.0 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 1.0 GO:0060005 vestibular reflex(GO:0060005)
0.2 1.6 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 0.5 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.2 0.5 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.2 0.9 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.2 1.8 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 0.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.4 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.4 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.1 0.6 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.4 GO:0060178 regulation of exocyst assembly(GO:0001928) regulation of exocyst localization(GO:0060178)
0.1 1.4 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 3.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.3 GO:0045062 extrathymic T cell selection(GO:0045062)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.5 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.1 2.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 2.5 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 0.9 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.1 0.3 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.4 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 0.3 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.1 0.3 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.3 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.6 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.6 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.5 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.1 0.7 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.1 0.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.6 GO:1902572 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.1 0.3 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.1 0.7 GO:0021759 globus pallidus development(GO:0021759)
0.1 2.1 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.1 0.3 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.1 0.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.3 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.1 0.2 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.1 0.9 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.1 0.3 GO:0018343 protein farnesylation(GO:0018343)
0.1 0.6 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.8 GO:0051775 response to redox state(GO:0051775)
0.0 0.2 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.7 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.6 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.4 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.4 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.9 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.2 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.3 GO:0003383 apical constriction(GO:0003383)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 2.6 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.3 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.0 1.0 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.8 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 1.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.4 GO:0035878 nail development(GO:0035878)
0.0 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 2.0 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 1.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.6 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.1 GO:1903978 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) regulation of microglial cell activation(GO:1903978)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.3 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.2 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.4 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.1 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.6 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 0.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 2.2 GO:0070268 cornification(GO:0070268)
0.0 0.4 GO:0048821 erythrocyte development(GO:0048821)
0.0 0.6 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.0 GO:0002282 microglial cell activation involved in immune response(GO:0002282) negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.0 1.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.0 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.0 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.1 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.6 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.2 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.3 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.1 GO:0072364 regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter(GO:0072364)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.4 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.0 0.3 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.5 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 0.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.2 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.1 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.7 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0 3.8 GO:0050890 cognition(GO:0050890)
0.0 0.6 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:0051489 regulation of filopodium assembly(GO:0051489)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1990032 parallel fiber(GO:1990032)
0.4 1.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.3 0.9 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.2 1.7 GO:0032437 cuticular plate(GO:0032437)
0.2 2.7 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 1.4 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.3 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 1.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.5 GO:1990357 terminal web(GO:1990357)
0.1 0.9 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.3 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 1.0 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.3 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.1 0.8 GO:0044327 dendritic spine head(GO:0044327)
0.1 2.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.7 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.5 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.1 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.7 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.6 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.7 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.3 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0 1.0 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.2 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.6 GO:0042588 zymogen granule(GO:0042588)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.7 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.6 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 2.8 GO:0005882 intermediate filament(GO:0005882)
0.0 0.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.6 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.4 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.4 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.4 3.1 GO:0004111 creatine kinase activity(GO:0004111)
0.4 2.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.3 0.9 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.3 0.9 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.2 1.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.2 0.9 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.2 1.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 2.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 0.6 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.2 0.9 GO:0005499 vitamin D binding(GO:0005499)
0.2 0.6 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.2 0.5 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.1 0.6 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 1.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.4 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 2.2 GO:0005549 odorant binding(GO:0005549)
0.1 0.9 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.4 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 0.9 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 1.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 3.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.2 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.3 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.2 GO:0046848 hydroxyapatite binding(GO:0046848)
0.1 0.5 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.0 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 2.6 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 0.9 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.2 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 0.9 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.7 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.4 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 1.7 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.7 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.5 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.2 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.3 GO:0050544 arachidonic acid binding(GO:0050544) DBD domain binding(GO:0050692)
0.0 0.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.6 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.3 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 3.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 1.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 7.5 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.0 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.6 ST STAT3 PATHWAY STAT3 Pathway
0.0 3.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 2.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 4.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.5 PID MYC PATHWAY C-MYC pathway
0.0 1.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 1.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 1.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.8 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 2.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 1.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.9 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.9 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 1.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis