ISMARA results: PRRX1_ALX4

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for PRRX1_ALX4_PHOX2A

Z-value: 0.79

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Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol	Gene ID	Gene Info
PRRX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000116132.7	paired related homeobox 1
ALX4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000052850.5	ALX homeobox 4
PHOX2A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000165462.5	paired like homeobox 2A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PHOX2A	hg19_v2_chr11_-_71952236_71952319, hg19_v2_chr11_-_71955210_71955227	0.66	7.6e-05	Click!
ALX4	hg19_v2_chr11_-_44331679_44331716	0.27	1.5e-01	Click!
PRRX1	hg19_v2_chr1_+_170633047_170633084	0.13	5.0e-01	Click!

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_69313145 Show fit	6.51	ENST00000305363.4	TMPRSS11E Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protease, serine 11E
chr6_-_66417107 Show fit	4.04	ENST00000370621.3 ENST00000370618.3 ENST00000503581.1 ENST00000393380.2	EYS Ensembl NCBI GeneCards UniProt NextProt Show fit	eyes shut homolog (Drosophila)
chr2_-_31440377 Show fit	3.57	ENST00000444918.2 ENST00000403897.3	CAPN14 Ensembl NCBI GeneCards UniProt NextProt Show fit	calpain 14
chr2_+_102413726 Show fit	3.06	ENST00000350878.4	MAP4K4 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitogen-activated protein kinase kinase kinase kinase 4
chr6_+_34204642 Show fit	2.74	ENST00000347617.6 ENST00000401473.3 ENST00000311487.5 ENST00000447654.1 ENST00000395004.3	HMGA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	high mobility group AT-hook 1
chr1_+_50569575 Show fit	2.63	ENST00000371827.1	ELAVL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr18_+_616672 Show fit	2.49	ENST00000338387.7	CLUL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin-like 1 (retinal)
chr17_-_38859996 Show fit	2.39	ENST00000264651.2	KRT24 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 24
chr2_+_54683419 Show fit	1.72	ENST00000356805.4	SPTBN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	spectrin, beta, non-erythrocytic 1
chr8_+_7397150 Show fit	1.68	ENST00000533250.1	RP11-1118M6.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline rich 23 domain containing 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.0	GO:0050908	detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0	3.8	GO:0050890	cognition(GO:0050890)
0.1	3.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.5	2.7	GO:0090402	oncogene-induced cell senescence(GO:0090402)
0.0	2.6	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1	2.5	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.1	2.3	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	2.2	GO:0070268	cornification(GO:0070268)
0.1	2.1	GO:0071498	cellular response to fluid shear stress(GO:0071498)
0.0	2.0	GO:0060997	dendritic spine morphogenesis(GO:0060997)

Showing 1 to 10 of 140 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0005882	intermediate filament(GO:0005882)
0.2	2.7	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	2.0	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.2	1.7	GO:0032437	cuticular plate(GO:0032437)
0.1	1.6	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.5	1.4	GO:1990032	parallel fiber(GO:1990032)
0.2	1.4	GO:0005955	calcineurin complex(GO:0005955)
0.1	1.4	GO:0097431	mitotic spindle pole(GO:0097431)
0.4	1.3	GO:0042720	mitochondrial inner membrane peptidase complex(GO:0042720)
0.1	1.3	GO:0036449	microtubule minus-end(GO:0036449)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.5	GO:0008236	serine-type peptidase activity(GO:0008236)
0.1	3.6	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	3.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.4	3.1	GO:0004111	creatine kinase activity(GO:0004111)
0.2	2.8	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.1	2.6	GO:0017091	AU-rich element binding(GO:0017091)
0.1	2.5	GO:0008327	methyl-CpG binding(GO:0008327)
0.1	2.2	GO:0005549	odorant binding(GO:0005549)
0.4	2.1	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0	1.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)

Showing 1 to 10 of 98 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
4.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
3.1	PID EPHB FWD PATHWAY	EPHB forward signaling
2.7	PID IL4 2PATHWAY	IL4-mediated signaling events
1.7	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
1.6	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
1.6	PID IL3 PATHWAY	IL3-mediated signaling events
1.4	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
1.4	PID RAS PATHWAY	Regulation of Ras family activation
1.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
1.3	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.7	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	2.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	2.3	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	1.9	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	1.8	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1	1.7	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	1.6	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	1.5	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	1.5	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	1.3	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport

Showing 1 to 10 of 42 entries

Results for PRRX1_ALX4_PHOX2A

Z-value: 0.79

Motif logo

Transcription factors associated with PRRX1_ALX4_PHOX2A

Activity-expression correlation:

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: