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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RAD21_SMC3
Z-value: 1.53
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Transcription factors associated with RAD21_SMC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMC3 | hg19_v2_chr10_+_112327425_112327516 | -0.57 | 8.9e-04 | Click! |
| RAD21 | hg19_v2_chr8_-_117886955_117887105 | 0.00 | 9.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_114737472 Show fit | 15.24 |
ENST00000420161.1
|
AC110769.3 |
|
| chr15_+_45722727 Show fit | 9.17 |
ENST00000396650.2
ENST00000558435.1 ENST00000344300.3 |
chromosome 15 open reading frame 48 |
|
| chr5_+_148521381 Show fit | 8.05 |
ENST00000504238.1
|
actin binding LIM protein family, member 3 |
|
| chr5_-_136834982 Show fit | 7.44 |
ENST00000510689.1
ENST00000394945.1 |
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 |
|
| chr5_+_148521046 Show fit | 7.39 |
ENST00000326685.7
ENST00000356541.3 ENST00000309868.7 |
actin binding LIM protein family, member 3 |
|
| chr5_+_148521136 Show fit | 7.28 |
ENST00000506113.1
|
actin binding LIM protein family, member 3 |
|
| chr2_+_114737146 Show fit | 6.20 |
ENST00000412690.1
|
AC010982.1 |
|
| chr19_-_19051927 Show fit | 4.88 |
ENST00000600077.1
|
homer homolog 3 (Drosophila) |
|
| chr5_-_139726181 Show fit | 4.75 |
ENST00000507104.1
ENST00000230990.6 |
heparin-binding EGF-like growth factor |
|
| chr14_-_75079026 Show fit | 4.69 |
ENST00000261978.4
|
latent transforming growth factor beta binding protein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RAD21_SMC3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.4 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 1.5 | 11.8 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.4 | 9.4 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 7.9 | GO:0010506 | regulation of autophagy(GO:0010506) |
| 0.1 | 7.6 | GO:0010812 | negative regulation of cell-substrate adhesion(GO:0010812) |
| 0.4 | 7.1 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
| 0.8 | 6.9 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.8 | 6.1 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.4 | 5.6 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
| 0.0 | 5.3 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 12.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.6 | 11.8 | GO:0032059 | muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059) |
| 0.1 | 9.9 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.2 | 7.7 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 7.4 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.6 | 7.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.3 | 6.9 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 5.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 5.2 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.5 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 13.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 12.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 12.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.6 | 8.9 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.1 | 8.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.3 | 7.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 7.2 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.5 | 6.9 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.7 | 6.2 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 8.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 7.5 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 7.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 7.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 6.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 5.5 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 5.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 4.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 22.7 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.3 | 21.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 5.6 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 5.4 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 5.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 4.7 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 4.6 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 3.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |