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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RARG
Z-value: 1.47
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Transcription factors associated with RARG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RARG | hg19_v2_chr12_-_53625958_53626036 | 0.89 | 3.1e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RARG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 26.3 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 1.9 | 11.2 | GO:0002760 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 2.7 | 11.0 | GO:0006218 | uridine catabolic process(GO:0006218) |
| 0.1 | 9.5 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.9 | 9.4 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 8.9 | GO:0070268 | cornification(GO:0070268) |
| 2.2 | 8.8 | GO:0036118 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 1.2 | 8.4 | GO:0051121 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.8 | 7.8 | GO:1900004 | negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572) |
| 1.9 | 7.7 | GO:0046110 | xanthine metabolic process(GO:0046110) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.7 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.2 | 13.2 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.0 | 12.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 12.5 | GO:0030141 | secretory granule(GO:0030141) |
| 0.1 | 11.4 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 1.6 | 11.2 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 11.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 9.8 | GO:0005604 | basement membrane(GO:0005604) |
| 0.3 | 9.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 9.5 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 57.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 14.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 11.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 11.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 2.2 | 11.0 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 2.5 | 9.9 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.9 | 9.4 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.1 | 9.1 | GO:0005178 | integrin binding(GO:0005178) |
| 2.8 | 8.4 | GO:0016165 | linoleate 13S-lipoxygenase activity(GO:0016165) |
| 0.1 | 8.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 27.9 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 20.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 12.2 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 11.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 10.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.4 | 10.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 9.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.7 | 9.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 7.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 14.8 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 14.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.4 | 14.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.6 | 10.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.2 | 9.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 9.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 9.4 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.2 | 8.4 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 8.3 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 7.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |