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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RBPJ

Z-value: 0.88

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Transcription factors associated with RBPJ

Gene Symbol Gene ID Gene Info
RBPJ
ENSG00000168214.16 recombination signal binding protein for immunoglobulin kappa J region

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RBPJhg19_v2_chr4_+_26321284_26321377,
hg19_v2_chr4_+_26322409_26322479		0.711.1e-05Click!

Activity profile of RBPJ motif

Sorted Z-values of RBPJ motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_45957088 9.61 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr3_-_45957534 8.38 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr3_-_100712352 6.08 ENST00000471714.1
ENST00000284322.5
ABI3BP
ABI family, member 3 (NESH) binding protein
chr3_-_19975665 4.99 ENST00000295824.9
ENST00000389256.4
EFHB
EF-hand domain family, member B
chr1_-_223536679 3.39 ENST00000608996.1
SUSD4
sushi domain containing 4
chr1_-_223537401 3.31 ENST00000343846.3
ENST00000454695.2
ENST00000484758.2
SUSD4
sushi domain containing 4
chr19_+_50706866 3.22 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
MYH14
myosin, heavy chain 14, non-muscle
chr20_+_43211149 3.02 ENST00000372886.1
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr7_-_120498357 2.48 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12
tetraspanin 12
chr6_+_126070726 2.45 ENST00000368364.3
HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr8_-_80680078 2.40 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr16_-_53737795 2.28 ENST00000262135.4
ENST00000564374.1
ENST00000566096.1
RPGRIP1L
RPGRIP1-like
chr16_-_53737722 2.24 ENST00000569716.1
ENST00000562588.1
ENST00000562230.1
ENST00000379925.3
ENST00000563746.1
ENST00000568653.3
RPGRIP1L
RPGRIP1-like
chr1_+_61869748 2.22 ENST00000357977.5
NFIA
nuclear factor I/A
chr11_+_111789580 2.13 ENST00000278601.5
C11orf52
chromosome 11 open reading frame 52
chr5_-_124080203 2.02 ENST00000504926.1
ZNF608
zinc finger protein 608
chr6_-_76203454 1.92 ENST00000237172.7
FILIP1
filamin A interacting protein 1
chrX_+_37865804 1.89 ENST00000297875.2
ENST00000357972.5
SYTL5
synaptotagmin-like 5
chr15_+_40697988 1.89 ENST00000487418.2
ENST00000479013.2
IVD
isovaleryl-CoA dehydrogenase
chr6_-_76203345 1.87 ENST00000393004.2
FILIP1
filamin A interacting protein 1
chr1_+_61547405 1.68 ENST00000371189.4
NFIA
nuclear factor I/A
chr5_+_42423872 1.63 ENST00000230882.4
ENST00000357703.3
GHR
growth hormone receptor
chr3_+_69812877 1.62 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr2_+_38177575 1.45 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2
regulator of microtubule dynamics 2
chr3_+_32726620 1.43 ENST00000331889.6
ENST00000328834.5
CNOT10
CCR4-NOT transcription complex, subunit 10
chr10_+_118305435 1.33 ENST00000369221.2
PNLIP
pancreatic lipase
chr5_-_139943830 1.31 ENST00000412920.3
ENST00000511201.2
ENST00000356738.2
ENST00000354402.5
ENST00000358580.5
ENST00000508496.2
APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr7_+_90338712 1.28 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr3_+_171561127 1.22 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr1_+_61547894 1.18 ENST00000403491.3
NFIA
nuclear factor I/A
chr19_-_50529193 1.16 ENST00000596445.1
ENST00000599538.1
VRK3
vaccinia related kinase 3
chr1_+_210406121 1.16 ENST00000367012.3
SERTAD4
SERTA domain containing 4
chr9_-_130712995 1.08 ENST00000373084.4
FAM102A
family with sequence similarity 102, member A
chr7_+_128784712 1.08 ENST00000289407.4
TSPAN33
tetraspanin 33
chrX_-_46187069 1.08 ENST00000446884.1
RP1-30G7.2
RP1-30G7.2
chr17_-_56606639 1.06 ENST00000579371.1
SEPT4
septin 4
chr17_-_56606664 1.05 ENST00000580844.1
SEPT4
septin 4
chr17_-_56606705 1.03 ENST00000317268.3
SEPT4
septin 4
chr18_-_52989217 1.02 ENST00000570287.2
TCF4
transcription factor 4
chr12_-_90049878 1.00 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr12_-_90049828 0.99 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_-_2461684 0.98 ENST00000378453.3
HES5
hes family bHLH transcription factor 5
chr15_+_59730348 0.91 ENST00000288228.5
ENST00000559628.1
ENST00000557914.1
ENST00000560474.1
FAM81A
family with sequence similarity 81, member A
chr1_+_15272271 0.89 ENST00000400797.3
KAZN
kazrin, periplakin interacting protein
chr2_+_219135115 0.89 ENST00000248451.3
ENST00000273077.4
PNKD
paroxysmal nonkinesigenic dyskinesia
chr16_-_70719925 0.88 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr7_+_30811004 0.87 ENST00000265299.6
FAM188B
family with sequence similarity 188, member B
chr10_-_44144292 0.86 ENST00000374433.2
ZNF32
zinc finger protein 32
chr9_-_98269481 0.85 ENST00000418258.1
ENST00000553011.1
ENST00000551845.1
PTCH1
patched 1
chr3_-_183735651 0.84 ENST00000427120.2
ENST00000392579.2
ENST00000382494.2
ENST00000446941.2
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr15_+_74218787 0.84 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr1_+_113933371 0.81 ENST00000369617.4
MAGI3
membrane associated guanylate kinase, WW and PDZ domain containing 3
chr10_-_44144152 0.81 ENST00000395797.1
ZNF32
zinc finger protein 32
chr19_-_39694894 0.81 ENST00000318438.6
SYCN
syncollin
chr3_+_69812701 0.77 ENST00000472437.1
MITF
microphthalmia-associated transcription factor
chr7_+_90339169 0.77 ENST00000436577.2
CDK14
cyclin-dependent kinase 14
chr16_+_23313591 0.74 ENST00000343070.2
SCNN1B
sodium channel, non-voltage-gated 1, beta subunit
chr10_+_115439630 0.64 ENST00000369318.3
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr6_-_134373732 0.62 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr11_+_64052944 0.62 ENST00000535675.1
ENST00000543383.1
GPR137
G protein-coupled receptor 137
chr7_-_16505440 0.61 ENST00000307068.4
SOSTDC1
sclerostin domain containing 1
chr10_-_27530997 0.61 ENST00000375901.1
ENST00000412279.1
ENST00000375905.4
ACBD5
acyl-CoA binding domain containing 5
chr1_+_43855560 0.59 ENST00000562955.1
SZT2
seizure threshold 2 homolog (mouse)
chr8_-_101348408 0.58 ENST00000519527.1
ENST00000522369.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr11_+_64052692 0.58 ENST00000377702.4
GPR137
G protein-coupled receptor 137
chr17_+_73452545 0.57 ENST00000314256.7
KIAA0195
KIAA0195
chr4_+_184826418 0.56 ENST00000308497.4
ENST00000438269.1
STOX2
storkhead box 2
chr17_-_16118835 0.55 ENST00000582357.1
ENST00000436828.1
ENST00000411510.1
ENST00000268712.3
NCOR1
nuclear receptor corepressor 1
chr19_+_56652686 0.54 ENST00000592949.1
ZNF444
zinc finger protein 444
chr1_+_174769006 0.54 ENST00000489615.1
RABGAP1L
RAB GTPase activating protein 1-like
chr5_+_63461642 0.53 ENST00000296615.6
ENST00000381081.2
ENST00000389100.4
RNF180
ring finger protein 180
chr19_-_40724246 0.51 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr2_+_109271481 0.49 ENST00000542845.1
ENST00000393314.2
LIMS1
LIM and senescent cell antigen-like domains 1
chr13_-_20357057 0.49 ENST00000338910.4
PSPC1
paraspeckle component 1
chr10_-_49459800 0.48 ENST00000305531.3
FRMPD2
FERM and PDZ domain containing 2
chr2_-_219134822 0.47 ENST00000444053.1
ENST00000248450.4
AAMP
angio-associated, migratory cell protein
chr10_+_115439699 0.47 ENST00000369315.1
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr9_+_102584128 0.44 ENST00000338488.4
ENST00000395097.2
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr12_+_175930 0.43 ENST00000538872.1
ENST00000326261.4
IQSEC3
IQ motif and Sec7 domain 3
chr3_+_142442841 0.43 ENST00000476941.1
ENST00000273482.6
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr10_+_60144782 0.43 ENST00000487519.1
TFAM
transcription factor A, mitochondrial
chr1_+_6511651 0.42 ENST00000434576.1
ESPN
espin
chr19_-_46088068 0.41 ENST00000263275.4
ENST00000323060.3
OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr11_-_8290263 0.41 ENST00000428101.2
LMO1
LIM domain only 1 (rhombotin 1)
chr5_-_137071689 0.39 ENST00000505853.1
KLHL3
kelch-like family member 3
chr7_+_150026938 0.39 ENST00000343855.4
ZBED6CL
ZBED6 C-terminal like
chr1_-_85870177 0.39 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr12_+_4758264 0.38 ENST00000266544.5
NDUFA9
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr2_+_106361333 0.38 ENST00000233154.4
ENST00000451463.2
NCK2
NCK adaptor protein 2
chr13_-_20357110 0.37 ENST00000427943.1
PSPC1
paraspeckle component 1
chr5_+_38445641 0.37 ENST00000397210.3
ENST00000506135.1
ENST00000508131.1
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr2_+_3642545 0.36 ENST00000382062.2
ENST00000236693.7
ENST00000349077.4
COLEC11
collectin sub-family member 11
chr11_+_64053005 0.35 ENST00000538032.1
GPR137
G protein-coupled receptor 137
chr1_+_156737292 0.35 ENST00000271526.4
ENST00000353233.3
PRCC
papillary renal cell carcinoma (translocation-associated)
chr19_+_44100632 0.33 ENST00000533118.1
ZNF576
zinc finger protein 576
chr5_+_175815732 0.32 ENST00000274787.2
HIGD2A
HIG1 hypoxia inducible domain family, member 2A
chr6_-_26056695 0.30 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr1_-_43855479 0.30 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chrX_+_19362011 0.30 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr7_-_27169801 0.30 ENST00000511914.1
HOXA4
homeobox A4
chr1_-_40105617 0.29 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr19_+_37178482 0.29 ENST00000536254.2
ZNF567
zinc finger protein 567
chr19_+_50529212 0.28 ENST00000270617.3
ENST00000445728.3
ENST00000601364.1
ZNF473
zinc finger protein 473
chrX_-_153236620 0.28 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr5_-_137514333 0.28 ENST00000411594.2
ENST00000430331.1
BRD8
bromodomain containing 8
chr6_+_50061315 0.27 ENST00000415106.1
RP11-397G17.1
RP11-397G17.1
chrX_-_153236819 0.27 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr19_+_50528971 0.27 ENST00000598809.1
ENST00000595661.1
ENST00000391821.2
ZNF473
zinc finger protein 473
chr14_+_73603126 0.26 ENST00000557356.1
ENST00000556864.1
ENST00000556533.1
ENST00000556951.1
ENST00000557293.1
ENST00000553719.1
ENST00000553599.1
ENST00000556011.1
ENST00000394157.3
ENST00000357710.4
ENST00000324501.5
ENST00000560005.2
ENST00000555254.1
ENST00000261970.3
ENST00000344094.3
ENST00000554131.1
ENST00000557037.1
PSEN1
presenilin 1
chr7_+_102553430 0.26 ENST00000339431.4
ENST00000249377.4
LRRC17
leucine rich repeat containing 17
chr5_-_39074479 0.26 ENST00000514735.1
ENST00000296782.5
ENST00000357387.3
RICTOR
RPTOR independent companion of MTOR, complex 2
chr2_-_79315112 0.25 ENST00000305089.3
REG1B
regenerating islet-derived 1 beta
chr1_-_8000872 0.25 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chrX_+_122993827 0.25 ENST00000371199.3
XIAP
X-linked inhibitor of apoptosis
chr5_-_137514288 0.24 ENST00000454473.1
ENST00000418329.1
ENST00000455658.2
ENST00000230901.5
ENST00000402931.1
BRD8
bromodomain containing 8
chr3_+_155860751 0.23 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr12_-_14133053 0.23 ENST00000609686.1
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr16_+_53738053 0.22 ENST00000394647.3
FTO
fat mass and obesity associated
chr1_+_43855545 0.22 ENST00000372450.4
ENST00000310739.4
SZT2
seizure threshold 2 homolog (mouse)
chr14_-_53258180 0.22 ENST00000554230.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr2_-_40657397 0.21 ENST00000408028.2
ENST00000332839.4
ENST00000406391.2
ENST00000542024.1
ENST00000542756.1
ENST00000405901.3
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr10_-_38146510 0.21 ENST00000395867.3
ZNF248
zinc finger protein 248
chr19_+_44100544 0.20 ENST00000391965.2
ENST00000525771.1
ZNF576
zinc finger protein 576
chr11_+_66384053 0.20 ENST00000310137.4
ENST00000393979.3
ENST00000409372.1
ENST00000443702.1
ENST00000409738.4
ENST00000514361.3
ENST00000503028.2
ENST00000412278.2
ENST00000500635.2
RBM14
RBM4
RBM14-RBM4
RNA binding motif protein 14
RNA binding motif protein 4
RBM14-RBM4 readthrough
chr8_+_107738240 0.19 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr1_-_112531777 0.19 ENST00000315987.2
ENST00000302127.4
KCND3
potassium voltage-gated channel, Shal-related subfamily, member 3
chr19_+_44100727 0.19 ENST00000528387.1
ENST00000529930.1
ENST00000336564.4
ENST00000607544.1
ENST00000526798.1
ZNF576
SRRM5
zinc finger protein 576
serine/arginine repetitive matrix 5
chr12_-_31945172 0.18 ENST00000340398.3
H3F3C
H3 histone, family 3C
chr1_-_211752073 0.18 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr12_-_4758159 0.17 ENST00000545990.2
AKAP3
A kinase (PRKA) anchor protein 3
chr4_+_26321284 0.17 ENST00000506956.1
ENST00000512671.1
ENST00000345843.3
ENST00000342295.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr16_+_85645007 0.15 ENST00000405402.2
GSE1
Gse1 coiled-coil protein
chrX_+_36065053 0.15 ENST00000313548.4
CHDC2
calponin homology domain containing 2
chr1_+_36690011 0.15 ENST00000354618.5
ENST00000469141.2
ENST00000478853.1
THRAP3
thyroid hormone receptor associated protein 3
chr2_+_44001172 0.15 ENST00000260605.8
ENST00000406852.3
ENST00000443170.3
ENST00000398823.2
ENST00000605786.1
DYNC2LI1
dynein, cytoplasmic 2, light intermediate chain 1
chr16_+_21964662 0.15 ENST00000561553.1
ENST00000565331.1
UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr10_+_124320156 0.15 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1
deleted in malignant brain tumors 1
chr3_+_107241783 0.14 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
BBX
bobby sox homolog (Drosophila)
chr6_+_30297306 0.12 ENST00000420746.1
ENST00000513556.1
TRIM39
TRIM39-RPP21
tripartite motif containing 39
TRIM39-RPP21 readthrough
chr1_-_197744390 0.12 ENST00000367396.3
DENND1B
DENN/MADD domain containing 1B
chr1_+_185126291 0.12 ENST00000367500.4
SWT1
SWT1 RNA endoribonuclease homolog (S. cerevisiae)
chr21_+_38792602 0.12 ENST00000398960.2
ENST00000398956.2
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr17_-_7991021 0.11 ENST00000319144.4
ALOX12B
arachidonate 12-lipoxygenase, 12R type
chr9_-_104357277 0.11 ENST00000374806.1
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr17_+_29421900 0.11 ENST00000358273.4
ENST00000356175.3
NF1
neurofibromin 1
chr22_-_31885727 0.11 ENST00000330125.5
ENST00000344710.5
ENST00000397518.1
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr10_-_97200772 0.10 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr5_+_178322893 0.09 ENST00000361362.2
ENST00000520660.1
ENST00000520805.1
ZFP2
ZFP2 zinc finger protein
chr12_-_16759711 0.09 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chrX_-_73834449 0.09 ENST00000332687.6
ENST00000349225.2
RLIM
ring finger protein, LIM domain interacting
chr4_-_176733897 0.08 ENST00000393658.2
GPM6A
glycoprotein M6A
chrX_-_118925600 0.07 ENST00000361575.3
RPL39
ribosomal protein L39
chr8_+_107738343 0.06 ENST00000521592.1
OXR1
oxidation resistance 1
chr6_-_31510181 0.06 ENST00000458640.1
ENST00000396172.1
ENST00000417556.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr15_-_77988485 0.06 ENST00000561030.1
LINGO1
leucine rich repeat and Ig domain containing 1
chr19_-_55690758 0.06 ENST00000590851.1
SYT5
synaptotagmin V
chr10_+_74927875 0.04 ENST00000242505.6
FAM149B1
family with sequence similarity 149, member B1
chr20_+_32250079 0.04 ENST00000375222.3
C20orf144
chromosome 20 open reading frame 144
chr10_-_51371321 0.04 ENST00000602930.1
AGAP8
ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
chr6_+_42531798 0.04 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr11_-_107436443 0.04 ENST00000429370.1
ENST00000417449.2
ENST00000428149.2
ALKBH8
alkB, alkylation repair homolog 8 (E. coli)
chr3_+_107241882 0.04 ENST00000416476.2
BBX
bobby sox homolog (Drosophila)
chr12_+_6309963 0.04 ENST00000382515.2
CD9
CD9 molecule
chr10_+_124320195 0.03 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr11_-_32452357 0.03 ENST00000379079.2
ENST00000530998.1
WT1
Wilms tumor 1
chr1_+_110026544 0.03 ENST00000369870.3
ATXN7L2
ataxin 7-like 2
chr2_+_171571827 0.02 ENST00000375281.3
SP5
Sp5 transcription factor
chr3_-_49967292 0.02 ENST00000455683.2
MON1A
MON1 secretory trafficking family member A
chr5_+_132009675 0.02 ENST00000231449.2
ENST00000350025.2
IL4
interleukin 4
chr7_-_150924121 0.02 ENST00000441774.1
ENST00000222388.2
ENST00000287844.2
ABCF2
ATP-binding cassette, sub-family F (GCN20), member 2
chr22_+_40297079 0.01 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr11_-_67290867 0.01 ENST00000353903.5
ENST00000294288.4
CABP2
calcium binding protein 2
chr1_+_93297582 0.01 ENST00000370321.3
RPL5
ribosomal protein L5
chr2_+_159825143 0.01 ENST00000454300.1
ENST00000263635.6
TANC1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr12_-_7848364 0.01 ENST00000329913.3
GDF3
growth differentiation factor 3
chrX_+_123094369 0.00 ENST00000455404.1
ENST00000218089.9
STAG2
stromal antigen 2
chr11_+_112832202 0.00 ENST00000534015.1
NCAM1
neural cell adhesion molecule 1

Network of associatons between targets according to the STRING database.

First level regulatory network of RBPJ

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 18.0 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
1.2 4.8 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.6 3.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.4 1.6 GO:0000255 allantoin metabolic process(GO:0000255)
0.3 0.9 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.3 0.8 GO:2000974 auditory receptor cell fate determination(GO:0042668) negative regulation of pro-B cell differentiation(GO:2000974)
0.2 2.0 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.2 4.5 GO:0021670 lateral ventricle development(GO:0021670)
0.2 0.8 GO:0010157 response to chlorate(GO:0010157)
0.2 1.9 GO:0006552 leucine catabolic process(GO:0006552)
0.2 5.1 GO:0072189 ureter development(GO:0072189)
0.2 3.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.4 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.1 1.1 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1 0.5 GO:0019046 release from viral latency(GO:0019046)
0.1 0.6 GO:0060648 mammary gland bud morphogenesis(GO:0060648) regulation of determination of dorsal identity(GO:2000015)
0.1 0.8 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 3.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 0.4 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 0.4 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.4 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.1 0.3 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.1 0.6 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.1 0.6 GO:0030242 pexophagy(GO:0030242)
0.1 0.2 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.1 0.2 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.1 0.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 1.3 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.1 0.4 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.1 0.5 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 1.2 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.1 0.2 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 1.8 GO:0010842 retina layer formation(GO:0010842)
0.0 2.4 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.2 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 6.7 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.3 GO:1904796 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) regulation of core promoter binding(GO:1904796)
0.0 0.3 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.7 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.3 GO:0048539 bone marrow development(GO:0048539)
0.0 0.4 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.0 0.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 1.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 5.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.4 GO:1900038 negative regulation of vascular permeability(GO:0043116) negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.1 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 1.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.6 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.0 0.4 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.3 GO:0060539 diaphragm development(GO:0060539)
0.0 0.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.8 GO:0035904 aorta development(GO:0035904)
0.0 0.6 GO:0001893 maternal placenta development(GO:0001893)
0.0 0.5 GO:0046710 GDP metabolic process(GO:0046710)
0.0 0.7 GO:0055078 sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.4 GO:0042438 melanin biosynthetic process(GO:0042438)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.5 GO:0005879 axonemal microtubule(GO:0005879)
0.6 3.2 GO:0097513 myosin II filament(GO:0097513)
0.5 1.6 GO:0070195 growth hormone receptor complex(GO:0070195)
0.4 2.0 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.3 6.3 GO:0005614 interstitial matrix(GO:0005614)
0.2 3.1 GO:0097227 sperm annulus(GO:0097227)
0.1 0.8 GO:1990130 Iml1 complex(GO:1990130)
0.1 0.8 GO:0044294 dendritic growth cone(GO:0044294)
0.1 1.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 3.0 GO:0016580 Sin3 complex(GO:0016580)
0.1 2.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.9 GO:0042382 paraspeckles(GO:0042382)
0.1 1.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.7 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.9 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.4 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0031862 prostanoid receptor binding(GO:0031862)
1.3 5.1 GO:0035939 microsatellite binding(GO:0035939)
0.3 0.9 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.8 GO:0005119 smoothened binding(GO:0005119)
0.1 3.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.0 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 1.9 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 2.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.6 GO:0098821 BMP receptor activity(GO:0098821)
0.1 0.4 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.1 1.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.3 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.2 GO:0035514 DNA demethylase activity(GO:0035514)
0.1 0.2 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.1 2.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.4 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.7 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 1.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.7 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 2.0 GO:0030332 cyclin binding(GO:0030332)
0.0 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 2.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.6 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.8 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 4.5 GO:0005518 collagen binding(GO:0005518)
0.0 0.5 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 1.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 1.6 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.1 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0016594 glycine binding(GO:0016594)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 5.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 6.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 3.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.7 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.6 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.3 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.0 0.3 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis