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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RELA

Z-value: 1.30

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Transcription factors associated with RELA

Gene Symbol Gene ID Gene Info
RELA
ENSG00000173039.14 RELA proto-oncogene, NF-kB subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RELAhg19_v2_chr11_-_65430554_654305790.595.5e-04Click!

Activity profile of RELA motif

Sorted Z-values of RELA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_228678550 6.28 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr4_-_74864386 5.18 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr19_-_51471362 5.16 ENST00000376853.4
ENST00000424910.2
KLK6
kallikrein-related peptidase 6
chr19_-_51471381 5.10 ENST00000594641.1
KLK6
kallikrein-related peptidase 6
chr1_-_186649543 4.96 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr4_-_74964904 4.50 ENST00000508487.2
CXCL2
chemokine (C-X-C motif) ligand 2
chr4_-_74904398 4.05 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr19_-_51472031 3.34 ENST00000391808.1
KLK6
kallikrein-related peptidase 6
chrX_-_73072534 3.23 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr9_-_136344197 2.77 ENST00000414172.1
ENST00000371897.4
SLC2A6
solute carrier family 2 (facilitated glucose transporter), member 6
chr10_+_104154229 2.69 ENST00000428099.1
ENST00000369966.3
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr7_-_93520259 2.67 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr9_+_75263565 2.63 ENST00000396237.3
TMC1
transmembrane channel-like 1
chr11_+_102188224 2.54 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr11_+_102188272 2.51 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr12_-_76425368 2.38 ENST00000602540.1
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr22_-_37640277 2.32 ENST00000401529.3
ENST00000249071.6
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr19_+_41725088 2.31 ENST00000301178.4
AXL
AXL receptor tyrosine kinase
chr3_+_101546827 2.30 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr1_-_38100539 2.30 ENST00000401069.1
RSPO1
R-spondin 1
chr22_-_37640456 2.28 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr7_-_93520191 2.25 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr6_+_138188551 2.22 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr2_+_233925064 2.20 ENST00000359570.5
ENST00000538935.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr12_-_49259643 2.20 ENST00000309739.5
RND1
Rho family GTPase 1
chr14_-_35873856 2.17 ENST00000553342.1
ENST00000216797.5
ENST00000557140.1
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr11_-_58345569 2.14 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr14_+_103589789 2.12 ENST00000558056.1
ENST00000560869.1
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr18_-_31802056 2.07 ENST00000538587.1
NOL4
nucleolar protein 4
chr19_+_10381769 2.06 ENST00000423829.2
ENST00000588645.1
ICAM1
intercellular adhesion molecule 1
chr5_+_150591678 2.05 ENST00000523466.1
GM2A
GM2 ganglioside activator
chr1_-_209825674 1.86 ENST00000367030.3
ENST00000356082.4
LAMB3
laminin, beta 3
chr11_+_94501497 1.79 ENST00000317829.8
ENST00000317837.9
ENST00000433060.2
AMOTL1
angiomotin like 1
chr9_-_125667618 1.78 ENST00000423239.2
RC3H2
ring finger and CCCH-type domains 2
chr7_-_24797032 1.72 ENST00000409970.1
ENST00000409775.3
DFNA5
deafness, autosomal dominant 5
chr15_+_57884117 1.70 ENST00000267853.5
MYZAP
myocardial zonula adherens protein
chr1_-_38100491 1.67 ENST00000356545.2
RSPO1
R-spondin 1
chr6_+_106534192 1.65 ENST00000369091.2
ENST00000369096.4
PRDM1
PR domain containing 1, with ZNF domain
chr16_+_29823427 1.62 ENST00000358758.7
ENST00000567659.1
ENST00000572820.1
PRRT2
proline-rich transmembrane protein 2
chr19_-_50143452 1.60 ENST00000246792.3
RRAS
related RAS viral (r-ras) oncogene homolog
chr10_-_29923893 1.60 ENST00000355867.4
SVIL
supervillin
chr7_-_24797546 1.55 ENST00000414428.1
ENST00000419307.1
ENST00000342947.3
DFNA5
deafness, autosomal dominant 5
chr12_-_28124903 1.52 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr19_-_11688447 1.44 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chr7_+_134464414 1.43 ENST00000361901.2
CALD1
caldesmon 1
chr4_-_76944621 1.38 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr7_+_143013198 1.36 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr15_+_57884086 1.36 ENST00000380569.2
ENST00000380561.2
ENST00000574161.1
ENST00000572390.1
ENST00000396180.1
ENST00000380560.2
GCOM1
GRINL1A complex locus 1
chr7_+_134464376 1.36 ENST00000454108.1
ENST00000361675.2
CALD1
caldesmon 1
chr14_-_53417732 1.34 ENST00000399304.3
ENST00000395631.2
ENST00000341590.3
ENST00000343279.4
FERMT2
fermitin family member 2
chr11_-_128392085 1.33 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr1_-_203274418 1.31 ENST00000457348.1
RP11-134P9.1
long intergenic non-protein coding RNA 1136
chr18_-_31802282 1.30 ENST00000535475.1
NOL4
nucleolar protein 4
chr10_+_30722866 1.29 ENST00000263056.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr2_-_177502659 1.29 ENST00000295549.4
AC017048.3
long intergenic non-protein coding RNA 1116
chr19_-_4831701 1.28 ENST00000248244.5
TICAM1
toll-like receptor adaptor molecule 1
chr7_+_143078652 1.27 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr5_-_150460914 1.24 ENST00000389378.2
TNIP1
TNFAIP3 interacting protein 1
chr19_-_11688500 1.21 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr2_+_219745020 1.17 ENST00000258411.3
WNT10A
wingless-type MMTV integration site family, member 10A
chr3_+_111578027 1.17 ENST00000431670.2
ENST00000412622.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr2_-_89442621 1.17 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr1_-_94079648 1.16 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr21_+_34775181 1.13 ENST00000290219.6
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr11_+_18287721 1.12 ENST00000356524.4
SAA1
serum amyloid A1
chr2_+_64681641 1.11 ENST00000409537.2
LGALSL
lectin, galactoside-binding-like
chr11_+_18287801 1.11 ENST00000532858.1
ENST00000405158.2
SAA1
serum amyloid A1
chr21_+_34775772 1.11 ENST00000405436.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr21_+_34775698 1.10 ENST00000381995.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr1_+_211432700 1.10 ENST00000452621.2
RCOR3
REST corepressor 3
chr11_+_118478313 1.09 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr1_+_24645807 1.09 ENST00000361548.4
GRHL3
grainyhead-like 3 (Drosophila)
chr2_-_74669009 1.04 ENST00000272430.5
RTKN
rhotekin
chr7_+_150811705 1.03 ENST00000335367.3
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr5_-_150460539 1.01 ENST00000520931.1
ENST00000520695.1
ENST00000521591.1
ENST00000518977.1
TNIP1
TNFAIP3 interacting protein 1
chr6_-_131384373 0.99 ENST00000392427.3
ENST00000525271.1
ENST00000527411.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr19_-_9879293 0.99 ENST00000397902.2
ENST00000592859.1
ENST00000588267.1
ZNF846
zinc finger protein 846
chr1_+_24646002 0.98 ENST00000356046.2
GRHL3
grainyhead-like 3 (Drosophila)
chr1_+_24645865 0.97 ENST00000342072.4
GRHL3
grainyhead-like 3 (Drosophila)
chr17_+_7905912 0.96 ENST00000254854.4
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr10_+_102756800 0.95 ENST00000370223.3
LZTS2
leucine zipper, putative tumor suppressor 2
chr15_+_57884199 0.95 ENST00000587652.1
ENST00000380568.3
ENST00000380565.4
ENST00000380563.2
GCOM1
MYZAP
POLR2M
GRINL1A complex locus 1
myocardial zonula adherens protein
polymerase (RNA) II (DNA directed) polypeptide M
chr5_-_132112907 0.94 ENST00000458488.2
SEPT8
septin 8
chr1_-_54303949 0.94 ENST00000234725.8
NDC1
NDC1 transmembrane nucleoporin
chr6_+_32605195 0.94 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr19_+_39390320 0.92 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr3_+_111578131 0.92 ENST00000498699.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr14_+_22984601 0.90 ENST00000390509.1
TRAJ28
T cell receptor alpha joining 28
chr1_-_205744205 0.90 ENST00000446390.2
RAB7L1
RAB7, member RAS oncogene family-like 1
chr2_-_100987007 0.89 ENST00000595083.1
AC012493.2
Uncharacterized protein
chr1_-_205744574 0.85 ENST00000367139.3
ENST00000235932.4
ENST00000437324.2
ENST00000414729.1
RAB7L1
RAB7, member RAS oncogene family-like 1
chr1_-_54303934 0.84 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr12_-_127256772 0.83 ENST00000536517.1
LINC00944
long intergenic non-protein coding RNA 944
chr19_+_2476116 0.82 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr5_-_132112921 0.81 ENST00000378721.4
ENST00000378701.1
SEPT8
septin 8
chr1_-_155959853 0.81 ENST00000462460.2
ENST00000368316.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr19_+_37342547 0.80 ENST00000331800.4
ENST00000586646.1
ZNF345
zinc finger protein 345
chr10_+_104155450 0.79 ENST00000471698.1
ENST00000189444.6
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr6_+_32121908 0.79 ENST00000375143.2
ENST00000424499.1
PPT2
palmitoyl-protein thioesterase 2
chr5_-_150466692 0.79 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1
TNFAIP3 interacting protein 1
chr1_-_209824643 0.78 ENST00000391911.1
ENST00000415782.1
LAMB3
laminin, beta 3
chr3_-_156878540 0.78 ENST00000461804.1
CCNL1
cyclin L1
chr6_+_32121789 0.77 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr19_+_41222998 0.75 ENST00000263370.2
ITPKC
inositol-trisphosphate 3-kinase C
chr9_-_32526184 0.74 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr7_-_98741714 0.74 ENST00000361125.1
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr1_-_41950342 0.74 ENST00000372587.4
EDN2
endothelin 2
chr19_-_14217672 0.74 ENST00000587372.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr2_+_161993465 0.74 ENST00000457476.1
TANK
TRAF family member-associated NFKB activator
chr9_-_139927462 0.74 ENST00000314412.6
FUT7
fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
chr7_-_98741642 0.73 ENST00000361368.2
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr4_-_76928641 0.72 ENST00000264888.5
CXCL9
chemokine (C-X-C motif) ligand 9
chrX_-_131352152 0.72 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr9_+_36572851 0.71 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
MELK
maternal embryonic leucine zipper kinase
chr5_-_127418573 0.70 ENST00000508353.1
ENST00000508878.1
ENST00000501652.1
ENST00000514409.1
CTC-228N24.3
CTC-228N24.3
chr7_+_22766766 0.69 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6
interleukin 6 (interferon, beta 2)
chr19_+_39390587 0.69 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr6_-_29324054 0.69 ENST00000543825.1
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr12_+_110011571 0.69 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
MVK
mevalonate kinase
chr1_+_151171012 0.66 ENST00000349792.5
ENST00000409426.1
ENST00000441902.2
ENST00000368890.4
ENST00000424999.1
ENST00000368888.4
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
chr22_-_28315115 0.65 ENST00000455418.3
ENST00000436663.1
ENST00000320996.10
ENST00000335272.5
PITPNB
phosphatidylinositol transfer protein, beta
chr14_+_32798462 0.65 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_30712313 0.65 ENST00000376377.2
ENST00000259874.5
IER3
immediate early response 3
chr5_-_178054014 0.64 ENST00000520957.1
CLK4
CDC-like kinase 4
chr1_+_107683644 0.64 ENST00000370067.1
NTNG1
netrin G1
chr10_+_13141585 0.64 ENST00000378764.2
OPTN
optineurin
chr14_+_61789382 0.63 ENST00000555082.1
PRKCH
protein kinase C, eta
chr14_+_73704201 0.63 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr10_+_18948311 0.61 ENST00000377275.3
ARL5B
ADP-ribosylation factor-like 5B
chr17_+_38474489 0.61 ENST00000394089.2
ENST00000425707.3
RARA
retinoic acid receptor, alpha
chr19_-_54984354 0.60 ENST00000301200.2
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr5_+_82767284 0.59 ENST00000265077.3
VCAN
versican
chr1_+_107683436 0.58 ENST00000370068.1
NTNG1
netrin G1
chrX_-_119709637 0.58 ENST00000404115.3
CUL4B
cullin 4B
chr7_+_44663908 0.58 ENST00000543843.1
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr14_+_32798547 0.57 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr17_-_34207295 0.57 ENST00000463941.1
ENST00000293272.3
CCL5
chemokine (C-C motif) ligand 5
chr12_+_49761147 0.57 ENST00000549298.1
SPATS2
spermatogenesis associated, serine-rich 2
chr5_+_159895275 0.57 ENST00000517927.1
MIR146A
microRNA 146a
chr14_-_22005062 0.57 ENST00000317492.5
SALL2
spalt-like transcription factor 2
chr14_-_69446034 0.57 ENST00000193403.6
ACTN1
actinin, alpha 1
chrX_-_139015153 0.54 ENST00000370557.1
ATP11C
ATPase, class VI, type 11C
chr2_+_161993412 0.54 ENST00000259075.2
ENST00000432002.1
TANK
TRAF family member-associated NFKB activator
chr4_-_103749205 0.54 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr13_-_52027134 0.53 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr11_-_7961141 0.53 ENST00000360759.3
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr11_+_1860832 0.52 ENST00000252898.7
TNNI2
troponin I type 2 (skeletal, fast)
chr5_+_14143728 0.52 ENST00000344204.4
ENST00000537187.1
TRIO
trio Rho guanine nucleotide exchange factor
chr3_+_5163905 0.52 ENST00000256496.3
ENST00000419534.2
ARL8B
ADP-ribosylation factor-like 8B
chr10_-_100174900 0.52 ENST00000370575.4
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr3_-_134369853 0.52 ENST00000508956.1
ENST00000503669.1
ENST00000423778.2
KY
kyphoscoliosis peptidase
chr16_-_28223166 0.52 ENST00000304658.5
XPO6
exportin 6
chr22_+_20748405 0.50 ENST00000400451.2
ENST00000403682.3
ENST00000357502.5
ZNF74
zinc finger protein 74
chr6_-_31550192 0.50 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr11_+_1860682 0.48 ENST00000381906.1
TNNI2
troponin I type 2 (skeletal, fast)
chr10_+_13142075 0.48 ENST00000378757.2
ENST00000430081.1
ENST00000378752.3
ENST00000378748.3
OPTN
optineurin
chr4_-_103749179 0.47 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr11_-_64570706 0.47 ENST00000294066.2
ENST00000377350.3
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr2_-_43453734 0.47 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr19_-_4182530 0.46 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chr10_+_89419370 0.46 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr4_-_122085469 0.44 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr9_-_32526299 0.43 ENST00000379882.1
ENST00000379883.2
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_-_155947951 0.43 ENST00000313695.7
ENST00000497907.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr2_+_234602305 0.43 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr19_+_42363917 0.42 ENST00000598742.1
RPS19
ribosomal protein S19
chr4_+_41614720 0.42 ENST00000509277.1
LIMCH1
LIM and calponin homology domains 1
chr1_+_111770278 0.40 ENST00000369748.4
CHI3L2
chitinase 3-like 2
chr21_+_35552978 0.40 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310
long intergenic non-protein coding RNA 310
chr5_-_132113036 0.40 ENST00000378706.1
SEPT8
septin 8
chr1_+_101185290 0.39 ENST00000370119.4
ENST00000347652.2
ENST00000294728.2
ENST00000370115.1
VCAM1
vascular cell adhesion molecule 1
chr12_+_49761224 0.39 ENST00000553127.1
ENST00000321898.6
SPATS2
spermatogenesis associated, serine-rich 2
chr2_+_17721920 0.39 ENST00000295156.4
VSNL1
visinin-like 1
chr1_-_39395165 0.39 ENST00000372985.3
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr1_+_111770232 0.39 ENST00000369744.2
CHI3L2
chitinase 3-like 2
chr4_-_103749313 0.39 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr10_+_99609996 0.38 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr19_-_17958771 0.38 ENST00000534444.1
JAK3
Janus kinase 3
chr1_-_1822495 0.37 ENST00000378609.4
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr1_-_233431458 0.37 ENST00000258229.9
ENST00000430153.1
PCNXL2
pecanex-like 2 (Drosophila)
chr4_+_169418255 0.37 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr10_+_13142225 0.37 ENST00000378747.3
OPTN
optineurin
chr19_-_39390440 0.36 ENST00000249396.7
ENST00000414941.1
ENST00000392081.2
SIRT2
sirtuin 2
chr9_+_82187487 0.35 ENST00000435650.1
ENST00000414465.1
ENST00000376537.4
ENST00000376534.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_-_153935938 0.35 ENST00000368621.1
ENST00000368623.3
SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr1_+_247579451 0.35 ENST00000391828.3
ENST00000366497.2
NLRP3
NLR family, pyrin domain containing 3
chr11_-_62446527 0.35 ENST00000294119.2
ENST00000529640.1
ENST00000534176.1
ENST00000301935.5
UBXN1
UBX domain protein 1
chr7_-_123389104 0.35 ENST00000223023.4
WASL
Wiskott-Aldrich syndrome-like
chr10_-_43904235 0.34 ENST00000356053.3
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr11_-_790060 0.34 ENST00000330106.4
CEND1
cell cycle exit and neuronal differentiation 1
chr2_+_61108771 0.34 ENST00000394479.3
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr19_-_39390350 0.33 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr5_+_177019159 0.33 ENST00000332598.6
TMED9
transmembrane emp24 protein transport domain containing 9
chr1_-_153935983 0.33 ENST00000537590.1
ENST00000356205.4
SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr1_-_27216729 0.33 ENST00000431781.2
ENST00000374135.4
GPN2
GPN-loop GTPase 2
chr16_+_3096638 0.33 ENST00000336577.4
MMP25
matrix metallopeptidase 25
chr3_-_111852128 0.33 ENST00000308910.4
GCSAM
germinal center-associated, signaling and motility
chr8_+_38758737 0.32 ENST00000521746.1
ENST00000420274.1
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr4_-_103749105 0.32 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr12_+_49761273 0.32 ENST00000551540.1
ENST00000552918.1
ENST00000548777.1
ENST00000547865.1
ENST00000552171.1
SPATS2
spermatogenesis associated, serine-rich 2

Network of associatons between targets according to the STRING database.

First level regulatory network of RELA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
1.7 5.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
1.0 3.8 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.8 2.5 GO:0045210 FasL biosynthetic process(GO:0045210)
0.8 3.0 GO:0052250 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.7 2.2 GO:0071947 B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.7 2.2 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.7 2.2 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.7 2.0 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.6 13.4 GO:0016540 protein autoprocessing(GO:0016540)
0.6 5.1 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.5 2.7 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.5 2.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.5 1.5 GO:1902534 single-organism membrane invagination(GO:1902534)
0.4 2.6 GO:0060005 vestibular reflex(GO:0060005)
0.4 4.6 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.3 2.4 GO:2000669 positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669)
0.3 1.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.3 1.6 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.3 0.9 GO:0051685 maintenance of ER location(GO:0051685)
0.3 0.5 GO:1901983 regulation of protein acetylation(GO:1901983)
0.3 2.4 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.3 1.3 GO:0045359 positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.2 0.7 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.2 1.2 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.2 0.7 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
0.2 1.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 0.7 GO:2000777 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.2 0.7 GO:0002384 hepatic immune response(GO:0002384) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.2 0.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 2.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.2 0.9 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.2 1.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.2 1.5 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 1.6 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.2 3.2 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.2 4.5 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.2 1.0 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.2 1.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2 1.3 GO:0030578 PML body organization(GO:0030578)
0.2 3.0 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.2 1.6 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.2 0.5 GO:0031938 regulation of chromatin silencing at telomere(GO:0031938)
0.2 0.6 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 1.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.6 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 2.2 GO:0016322 neuron remodeling(GO:0016322)
0.1 4.9 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.1 1.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 2.1 GO:0051601 exocyst localization(GO:0051601)
0.1 1.2 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.5 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.6 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.1 0.3 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.1 0.3 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.4 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.1 0.5 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 3.6 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 1.6 GO:0050884 neuromuscular process controlling posture(GO:0050884)
0.1 2.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.5 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.3 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.1 0.3 GO:0035509 negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 2.8 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 0.4 GO:0031296 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.1 0.4 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.6 GO:2000321 positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.1 0.4 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 0.7 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.1 0.3 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.1 1.0 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 0.8 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 2.0 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.1 0.8 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.5 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 1.3 GO:0033622 integrin activation(GO:0033622)
0.1 0.2 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 0.3 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.1 0.2 GO:2000157 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.1 0.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.5 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.2 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.2 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 0.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 1.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.6 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.1 GO:1904529 regulation of actin filament binding(GO:1904529) negative regulation of actin filament binding(GO:1904530) regulation of actin binding(GO:1904616) negative regulation of actin binding(GO:1904617)
0.0 1.5 GO:0002076 osteoblast development(GO:0002076)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.3 GO:0060022 hard palate development(GO:0060022)
0.0 0.6 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 2.0 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 0.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 1.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 1.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 1.2 GO:0003094 glomerular filtration(GO:0003094)
0.0 2.5 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.0 0.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.2 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.4 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.6 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 1.5 GO:0035329 hippo signaling(GO:0035329)
0.0 0.2 GO:0061744 psychomotor behavior(GO:0036343) motor behavior(GO:0061744)
0.0 0.5 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.3 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.3 GO:0030091 protein repair(GO:0030091)
0.0 0.6 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141) positive regulation of cell adhesion molecule production(GO:0060355)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 1.1 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0072553 terminal button organization(GO:0072553)
0.0 1.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.0 3.2 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.1 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0002725 negative regulation of T cell cytokine production(GO:0002725) MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.6 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.2 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.0 0.4 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 1.0 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 1.2 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 1.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0032415 regulation of sodium:proton antiporter activity(GO:0032415) positive regulation of sodium:proton antiporter activity(GO:0032417)
0.0 0.1 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.8 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.7 2.0 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.5 2.0 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.4 1.2 GO:0071749 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.3 2.6 GO:0005610 laminin-5 complex(GO:0005610)
0.3 2.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 3.1 GO:0030478 actin cap(GO:0030478)
0.2 3.2 GO:0045180 basal cortex(GO:0045180)
0.2 1.6 GO:0036449 microtubule minus-end(GO:0036449)
0.2 0.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 1.9 GO:0032426 stereocilium tip(GO:0032426)
0.1 2.4 GO:0033643 host cell part(GO:0033643)
0.1 0.4 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.1 1.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.3 GO:0016938 kinesin I complex(GO:0016938)
0.1 1.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.6 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 2.2 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 3.9 GO:0002102 podosome(GO:0002102)
0.1 1.4 GO:0097342 ripoptosome(GO:0097342)
0.1 1.0 GO:0008091 spectrin(GO:0008091)
0.1 2.1 GO:0000145 exocyst(GO:0000145)
0.1 0.6 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 4.6 GO:0005901 caveola(GO:0005901)
0.0 1.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 6.5 GO:0005884 actin filament(GO:0005884)
0.0 1.0 GO:0005861 troponin complex(GO:0005861)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 3.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 2.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0071204 U7 snRNP(GO:0005683) histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 7.4 GO:0045121 membrane raft(GO:0045121)
0.0 1.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 29.5 GO:0005615 extracellular space(GO:0005615)
0.0 0.7 GO:0044291 cell-cell contact zone(GO:0044291)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)
0.0 0.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.4 GO:0005776 autophagosome(GO:0005776)
0.0 2.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 4.4 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 2.0 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
1.2 5.0 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.0 16.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.7 3.3 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.4 2.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.3 0.3 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.2 1.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 0.7 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.2 2.0 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.2 0.7 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.2 2.7 GO:0008199 ferric iron binding(GO:0008199)
0.2 2.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.2 2.6 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.2 1.6 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 0.5 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 0.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.6 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 2.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 3.7 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.0 GO:0031014 troponin T binding(GO:0031014)
0.1 0.3 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 3.5 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.0 GO:0042731 PH domain binding(GO:0042731)
0.1 0.4 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 2.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.8 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.6 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 1.5 GO:0048185 activin binding(GO:0048185)
0.1 0.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.7 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 1.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.3 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 0.8 GO:0004568 chitinase activity(GO:0004568)
0.1 0.5 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 1.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.3 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.1 2.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.1 GO:0035877 death effector domain binding(GO:0035877) cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 0.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.7 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.6 GO:0010851 cyclase regulator activity(GO:0010851)
0.1 0.3 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 2.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 1.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.0 0.3 GO:0045159 myosin II binding(GO:0045159)
0.0 0.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 1.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 5.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.0 GO:0042056 chemoattractant activity(GO:0042056)
0.0 14.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.3 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.3 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 1.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 2.8 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 2.1 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.3 GO:0001164 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 2.9 GO:0008201 heparin binding(GO:0008201)
0.0 3.5 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 1.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 2.3 GO:0000149 SNARE binding(GO:0000149)
0.0 0.4 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 1.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.2 13.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 5.0 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 4.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 2.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 4.3 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.1 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 0.8 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 0.7 ST STAT3 PATHWAY STAT3 Pathway
0.1 1.9 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 1.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 4.4 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 1.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 2.1 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 2.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 3.8 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.1 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 14.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 2.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.7 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.3 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 23.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 11.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.2 3.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.3 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 6.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 2.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 5.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.8 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 0.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 2.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 5.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 2.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 1.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 2.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.1 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.9 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 3.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 2.2 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 2.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.2 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex