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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RELA
Z-value: 1.30
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Transcription factors associated with RELA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg19_v2_chr11_-_65430554_65430579 | 0.59 | 5.5e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_228678550 Show fit | 6.28 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr4_-_74864386 Show fit | 5.18 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr19_-_51471362 Show fit | 5.16 |
ENST00000376853.4
ENST00000424910.2 |
kallikrein-related peptidase 6 |
|
| chr19_-_51471381 Show fit | 5.10 |
ENST00000594641.1
|
kallikrein-related peptidase 6 |
|
| chr1_-_186649543 Show fit | 4.96 |
ENST00000367468.5
|
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
|
| chr4_-_74964904 Show fit | 4.50 |
ENST00000508487.2
|
chemokine (C-X-C motif) ligand 2 |
|
| chr4_-_74904398 Show fit | 4.05 |
ENST00000296026.4
|
chemokine (C-X-C motif) ligand 3 |
|
| chr19_-_51472031 Show fit | 3.34 |
ENST00000391808.1
|
kallikrein-related peptidase 6 |
|
| chrX_-_73072534 Show fit | 3.23 |
ENST00000429829.1
|
X inactive specific transcript (non-protein coding) |
|
| chr9_-_136344197 Show fit | 2.77 |
ENST00000414172.1
ENST00000371897.4 |
solute carrier family 2 (facilitated glucose transporter), member 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.4 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 2.1 | 6.3 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.6 | 5.1 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 1.7 | 5.0 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.1 | 4.9 | GO:0071498 | cellular response to fluid shear stress(GO:0071498) |
| 0.4 | 4.6 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.2 | 4.5 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 1.0 | 3.8 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.1 | 3.6 | GO:0060334 | regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.2 | 3.2 | GO:1904259 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 7.4 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 6.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 4.6 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 4.4 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 4.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 3.9 | GO:0002102 | podosome(GO:0002102) |
| 1.0 | 3.8 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.2 | 3.2 | GO:0045180 | basal cortex(GO:0045180) |
| 0.2 | 3.1 | GO:0030478 | actin cap(GO:0030478) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 16.4 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 14.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.1 | 6.3 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.0 | 5.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.2 | 5.0 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 3.7 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 3.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 3.5 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 0.7 | 3.3 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.0 | 3.1 | GO:0031490 | chromatin DNA binding(GO:0031490) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 14.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 13.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 5.0 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 4.4 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.1 | 4.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 4.3 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 4.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 3.8 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 2.7 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 11.0 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 6.2 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 5.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 5.0 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.2 | 3.8 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 3.0 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 3.0 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.8 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 2.8 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |