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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for REST

Z-value: 0.95

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.096.5e-01Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_33936491 2.10 ENST00000330120.3
RXFP3
relaxin/insulin-like family peptide receptor 3
chr20_+_62327996 2.07 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr8_-_91095099 1.98 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr19_-_51845378 1.76 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr4_+_8582287 1.71 ENST00000382487.4
GPR78
G protein-coupled receptor 78
chr9_+_135457530 1.55 ENST00000263610.2
BARHL1
BarH-like homeobox 1
chr7_+_154862028 1.55 ENST00000287907.2
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
chr12_+_71833756 1.55 ENST00000536515.1
ENST00000540815.2
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr20_+_30555805 1.53 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr6_+_35773070 1.53 ENST00000373853.1
ENST00000360215.1
LHFPL5
lipoma HMGIC fusion partner-like 5
chr10_+_99609996 1.35 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr12_-_29936731 1.06 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr5_-_151304337 1.00 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
GLRA1
glycine receptor, alpha 1
chr2_+_115199876 0.96 ENST00000436732.1
ENST00000410059.1
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr7_+_145813453 0.95 ENST00000361727.3
CNTNAP2
contactin associated protein-like 2
chr17_+_30813576 0.93 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr15_-_72612470 0.90 ENST00000287202.5
CELF6
CUGBP, Elav-like family member 6
chr10_-_79398250 0.90 ENST00000286627.5
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr3_-_42743006 0.87 ENST00000310417.5
HHATL
hedgehog acyltransferase-like
chr3_+_9745510 0.84 ENST00000383831.3
CPNE9
copine family member IX
chr5_+_167956121 0.78 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr19_+_4769117 0.75 ENST00000540211.1
ENST00000317292.3
ENST00000586721.1
ENST00000592709.1
ENST00000588711.1
ENST00000589639.1
ENST00000591008.1
ENST00000592663.1
ENST00000588758.1
MIR7-3HG
MIR7-3 host gene (non-protein coding)
chr2_-_30143525 0.72 ENST00000431873.1
ALK
anaplastic lymphoma receptor tyrosine kinase
chr9_-_74061751 0.70 ENST00000357533.2
ENST00000423814.3
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr14_+_93389425 0.68 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr3_+_9745487 0.68 ENST00000383832.3
CPNE9
copine family member IX
chr19_-_3971050 0.67 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chr4_+_158141843 0.66 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr20_+_44657845 0.64 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr3_-_48700310 0.63 ENST00000164024.4
ENST00000544264.1
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3
chr2_-_51259641 0.62 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr2_-_51259528 0.61 ENST00000404971.1
NRXN1
neurexin 1
chr4_+_158141899 0.61 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr15_-_22473353 0.60 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr6_+_110299501 0.58 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr11_+_22359562 0.56 ENST00000263160.3
SLC17A6
solute carrier family 17 (vesicular glutamate transporter), member 6
chr10_-_79398127 0.55 ENST00000372443.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr7_+_63361201 0.54 ENST00000450544.1
RP11-340I6.8
RP11-340I6.8
chr12_+_119419294 0.53 ENST00000267260.4
SRRM4
serine/arginine repetitive matrix 4
chr14_+_93897199 0.53 ENST00000553484.1
UNC79
unc-79 homolog (C. elegans)
chr11_-_75141206 0.52 ENST00000376292.4
KLHL35
kelch-like family member 35
chr15_-_83378638 0.51 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr6_+_153071925 0.51 ENST00000367244.3
ENST00000367243.3
VIP
vasoactive intestinal peptide
chr17_-_3301704 0.50 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr4_+_158141806 0.49 ENST00000393815.2
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr1_-_102462565 0.48 ENST00000370103.4
OLFM3
olfactomedin 3
chr7_-_100808394 0.48 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr5_-_176037105 0.47 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr15_-_83378526 0.47 ENST00000535348.1
ENST00000535359.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr15_-_83378611 0.47 ENST00000542200.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr6_+_25652501 0.46 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr4_-_175750364 0.46 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr12_+_113796347 0.45 ENST00000545182.2
ENST00000280800.3
PLBD2
phospholipase B domain containing 2
chr10_-_50970322 0.45 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr12_+_113229452 0.44 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr10_-_44880491 0.44 ENST00000374426.2
ENST00000395795.4
ENST00000395794.2
ENST00000374429.2
ENST00000395793.3
ENST00000343575.6
CXCL12
chemokine (C-X-C motif) ligand 12
chr9_-_104357277 0.42 ENST00000374806.1
PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr1_-_241520385 0.40 ENST00000366564.1
RGS7
regulator of G-protein signaling 7
chr7_-_100808843 0.40 ENST00000249330.2
VGF
VGF nerve growth factor inducible
chr10_-_50970382 0.39 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr9_+_140033862 0.39 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr5_+_175298487 0.37 ENST00000393745.3
CPLX2
complexin 2
chr7_+_150748288 0.37 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr12_+_113229543 0.36 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr9_-_139096955 0.36 ENST00000371748.5
LHX3
LIM homeobox 3
chr10_-_102790852 0.34 ENST00000470414.1
ENST00000370215.3
PDZD7
PDZ domain containing 7
chr14_-_106478603 0.33 ENST00000390596.2
IGHV4-4
immunoglobulin heavy variable 4-4
chr8_-_57358432 0.33 ENST00000517415.1
ENST00000314922.3
PENK
proenkephalin
chr3_-_113897899 0.33 ENST00000383673.2
ENST00000295881.7
DRD3
dopamine receptor D3
chrX_-_47479246 0.32 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr1_-_40105617 0.32 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr17_-_3337135 0.32 ENST00000248384.1
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr22_+_23054174 0.31 ENST00000390308.2
IGLV3-21
immunoglobulin lambda variable 3-21
chr20_+_36012051 0.31 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr20_-_60795296 0.29 ENST00000340177.5
HRH3
histamine receptor H3
chr5_+_63802109 0.29 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr15_-_27018884 0.27 ENST00000299267.4
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr20_-_62284766 0.26 ENST00000370053.1
STMN3
stathmin-like 3
chr12_-_99288536 0.26 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr1_+_154540246 0.26 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr12_+_113229737 0.25 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr17_-_27332931 0.25 ENST00000442608.3
ENST00000335960.6
SEZ6
seizure related 6 homolog (mouse)
chrX_-_153141302 0.22 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chrX_-_49056635 0.22 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr17_-_27333163 0.21 ENST00000360295.9
SEZ6
seizure related 6 homolog (mouse)
chr12_-_12837423 0.21 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr1_+_212606219 0.21 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr1_+_65775204 0.20 ENST00000371069.4
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr14_-_94759408 0.19 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_131513864 0.19 ENST00000458606.1
ENST00000423981.1
AMER3
APC membrane recruitment protein 3
chr17_-_27333311 0.18 ENST00000317338.12
ENST00000585644.1
SEZ6
seizure related 6 homolog (mouse)
chr14_-_94759595 0.18 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_-_151689259 0.17 ENST00000420342.1
ENST00000290583.4
CELF3
CUGBP, Elav-like family member 3
chr14_-_51561784 0.16 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr6_+_25652432 0.16 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr8_+_6565854 0.16 ENST00000285518.6
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5
chrX_-_153237258 0.16 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr14_-_94759361 0.16 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr19_+_41036371 0.16 ENST00000392023.1
SPTBN4
spectrin, beta, non-erythrocytic 4
chr3_+_75955817 0.15 ENST00000487694.3
ENST00000602589.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr22_+_22749343 0.15 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43
chr1_+_210111534 0.14 ENST00000422431.1
ENST00000534859.1
ENST00000399639.2
ENST00000537238.1
SYT14
synaptotagmin XIV
chr14_-_106781017 0.13 ENST00000390612.2
IGHV4-28
immunoglobulin heavy variable 4-28
chr2_-_27531313 0.13 ENST00000296099.2
UCN
urocortin
chr12_-_24737089 0.13 ENST00000483544.1
LINC00477
long intergenic non-protein coding RNA 477
chr2_+_226265364 0.13 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr3_+_120626919 0.12 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr11_-_6677018 0.12 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr12_+_71833550 0.12 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr10_+_60936921 0.11 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr18_-_40857493 0.11 ENST00000255224.3
SYT4
synaptotagmin IV
chr20_-_44144249 0.10 ENST00000217428.6
SPINT3
serine peptidase inhibitor, Kunitz type, 3
chr14_+_96039882 0.10 ENST00000556346.1
ENST00000553785.1
RP11-1070N10.4
RP11-1070N10.4
chr11_-_66115032 0.10 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr2_-_51259292 0.09 ENST00000401669.2
NRXN1
neurexin 1
chr11_+_64808675 0.08 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chrX_+_153237740 0.08 ENST00000369982.4
TMEM187
transmembrane protein 187
chr2_-_51259229 0.06 ENST00000405472.3
NRXN1
neurexin 1
chr11_-_125773085 0.06 ENST00000227474.3
ENST00000534158.1
ENST00000529801.1
PUS3
pseudouridylate synthase 3
chr3_-_131753830 0.05 ENST00000429747.1
CPNE4
copine IV
chr5_-_135701164 0.04 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr19_-_45926739 0.04 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr1_+_33352036 0.03 ENST00000373467.3
HPCA
hippocalcin
chr6_+_154360616 0.03 ENST00000229768.5
ENST00000419506.2
ENST00000524163.1
ENST00000414028.2
ENST00000435918.2
ENST00000337049.4
OPRM1
opioid receptor, mu 1
chr12_-_57871853 0.03 ENST00000549602.1
ENST00000430041.2
ARHGAP9
Rho GTPase activating protein 9
chr14_-_74892805 0.02 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr20_-_60795316 0.02 ENST00000317393.6
HRH3
histamine receptor H3
chr3_+_193853927 0.01 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr3_-_113897545 0.01 ENST00000467632.1
DRD3
dopamine receptor D3

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.3 1.0 GO:0071109 superior temporal gyrus development(GO:0071109)
0.3 0.9 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.3 0.9 GO:0006500 N-terminal protein palmitoylation(GO:0006500)
0.3 0.8 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.2 0.7 GO:1901899 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.2 2.0 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.2 0.4 GO:0021586 pons maturation(GO:0021586)
0.2 0.7 GO:0036269 swimming behavior(GO:0036269)
0.2 1.0 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 0.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 1.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.2 1.7 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 1.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.4 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 0.6 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.1 1.9 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.1 0.4 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.3 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.1 0.5 GO:1903367 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 0.5 GO:0008218 bioluminescence(GO:0008218)
0.1 0.3 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.1 0.3 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.7 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.1 0.4 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.1 0.5 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 0.5 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.6 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 1.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.2 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.1 0.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 0.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 2.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.3 GO:0014050 negative regulation of glutamate secretion(GO:0014050) regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063)
0.0 1.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.2 GO:0019046 release from viral latency(GO:0019046)
0.0 0.4 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.3 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.7 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 1.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.7 GO:0016048 detection of temperature stimulus(GO:0016048)
0.0 0.9 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.0 0.3 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.0 1.0 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.5 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.0 0.1 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 2.1 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.2 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 1.6 GO:0030901 midbrain development(GO:0030901)
0.0 0.5 GO:0042462 eye photoreceptor cell development(GO:0042462)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.2 0.9 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.2 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 0.5 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.1 1.5 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.3 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 1.5 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 1.0 GO:0033010 paranodal junction(GO:0033010)
0.1 0.3 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.7 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.1 GO:0032127 dense core granule membrane(GO:0032127)
0.0 0.2 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 2.5 GO:0043195 terminal bouton(GO:0043195)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0043196 varicosity(GO:0043196)
0.0 0.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.8 GO:0005901 caveola(GO:0005901)
0.0 1.4 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.1 GO:0004966 galanin receptor activity(GO:0004966)
0.4 2.0 GO:0005499 vitamin D binding(GO:0005499)
0.3 0.9 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.3 1.5 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 0.8 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.2 1.4 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 1.6 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 1.1 GO:0008430 selenium binding(GO:0008430)
0.1 1.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.4 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.7 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.6 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.3 GO:0001515 opioid peptide activity(GO:0001515)
0.1 2.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.3 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 1.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.3 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.6 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.2 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 ST STAT3 PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 2.1 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 3.0 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins