ISMARA results: RFX3

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RFX3_RFX2

Z-value: 16.04

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Transcription factors associated with RFX3_RFX2

Gene Symbol	Gene ID	Gene Info
RFX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000080298.11	regulatory factor X3
RFX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000087903.8	regulatory factor X2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RFX2	hg19_v2_chr19_-_6110474_6110551	0.99	3.7e-24	Click!
RFX3	hg19_v2_chr9_-_3525968_3526016	0.97	6.3e-19	Click!

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_-_43916433 Show fit	273.94	ENST00000291536.3	RSPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	radial spoke head 1 homolog (Chlamydomonas)
chr21_-_43916296 Show fit	261.08	ENST00000398352.3	RSPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	radial spoke head 1 homolog (Chlamydomonas)
chr1_-_109656439 Show fit	229.02	ENST00000369949.4	C1orf194 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 194
chr1_-_159869912 Show fit	167.66	ENST00000368099.4	CCDC19 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 19
chr16_-_67427389 Show fit	155.73	ENST00000562206.1 ENST00000290942.5 ENST00000393957.2	TPPP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulin polymerization-promoting protein family member 3
chr1_+_151682909 Show fit	148.99	ENST00000326413.3 ENST00000442233.2	RIIAD1 Ensembl NCBI GeneCards UniProt NextProt Show fit AL589765.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 Uncharacterized protein; cDNA FLJ36032 fis, clone TESTI2017069
chr22_+_23487513 Show fit	139.51	ENST00000263116.2 ENST00000341989.4	RAB36 Ensembl NCBI GeneCards UniProt NextProt Show fit	RAB36, member RAS oncogene family
chr17_-_6735035 Show fit	138.16	ENST00000338694.2	TEKT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	tektin 1
chr17_-_6735012 Show fit	137.77	ENST00000535086.1	TEKT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	tektin 1
chr17_-_74137374 Show fit	133.39	ENST00000322957.6	FOXJ1 Ensembl NCBI GeneCards UniProt NextProt Show fit	forkhead box J1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
19.1	938.2	GO:0035082	axoneme assembly(GO:0035082)
26.7	855.1	GO:0044458	motile cilium assembly(GO:0044458)
7.1	352.6	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
1.5	352.3	GO:0060271	cilium morphogenesis(GO:0060271)
2.9	309.2	GO:0007368	determination of left/right symmetry(GO:0007368)
27.8	305.4	GO:0060294	cilium movement involved in cell motility(GO:0060294)
10.9	240.6	GO:0003341	cilium movement(GO:0003341)
1.6	194.7	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
4.4	167.3	GO:0071801	regulation of podosome assembly(GO:0071801)
3.3	156.9	GO:0048741	skeletal muscle fiber development(GO:0048741)

Showing 1 to 10 of 187 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.9	1002.2	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)
44.6	535.0	GO:0072687	meiotic spindle(GO:0072687)
1.3	430.8	GO:0005929	cilium(GO:0005929)
13.6	395.7	GO:0030992	intraciliary transport particle B(GO:0030992)
54.5	381.3	GO:0002177	manchette(GO:0002177)
0.6	285.7	GO:0005874	microtubule(GO:0005874)
8.5	245.7	GO:0034451	centriolar satellite(GO:0034451)
2.8	238.3	GO:0036126	sperm flagellum(GO:0036126)
11.9	226.5	GO:0036038	MKS complex(GO:0036038)
3.8	206.8	GO:0009925	basal plasma membrane(GO:0009925)

Showing 1 to 10 of 99 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	704.2	GO:0003674	molecular_function(GO:0003674)
0.5	457.5	GO:0005509	calcium ion binding(GO:0005509)
1.6	406.9	GO:0008017	microtubule binding(GO:0008017)
16.1	354.9	GO:0045504	dynein heavy chain binding(GO:0045504)
5.5	227.1	GO:0043015	gamma-tubulin binding(GO:0043015)
6.2	173.6	GO:0017160	Ral GTPase binding(GO:0017160)
0.3	172.3	GO:0005525	GTP binding(GO:0005525)
2.1	160.9	GO:0003777	microtubule motor activity(GO:0003777)
0.1	160.2	GO:0003677	DNA binding(GO:0003677)
2.0	118.7	GO:0030544	Hsp70 protein binding(GO:0030544)

Showing 1 to 10 of 132 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	66.6	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5	53.6	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.7	46.3	PID PLK1 PATHWAY	PLK1 signaling events
0.6	45.4	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.2	39.7	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.7	36.6	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.8	32.9	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3	29.5	PID TNF PATHWAY	TNF receptor signaling pathway
0.4	21.3	PID EPHA FWDPATHWAY	EPHA forward signaling
0.2	19.7	PID NOTCH PATHWAY	Notch signaling pathway

Showing 1 to 10 of 34 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	88.3	REACTOME KINESINS	Genes involved in Kinesins
2.8	74.6	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.5	51.4	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.7	43.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.7	42.0	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
2.1	38.6	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
1.3	35.8	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
1.6	32.9	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
1.6	31.7	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
1.5	25.7	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Showing 1 to 10 of 47 entries

Results for RFX3_RFX2

Z-value: 16.04

Motif logo

Transcription factors associated with RFX3_RFX2

Activity-expression correlation:

Activity profile of RFX3_RFX2 motif

Sorted Z-values of RFX3_RFX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: