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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RFX5

Z-value: 1.60

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.13 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319710_1513198330.403.0e-02Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_32557610 23.03 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_-_32498046 19.62 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr5_-_149792295 18.80 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_32920794 12.17 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr6_+_33043703 11.13 ENST00000418931.2
ENST00000535465.1
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr11_+_111385497 10.76 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
C11orf88
chromosome 11 open reading frame 88
chr6_+_32821924 10.01 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr10_+_82116529 8.58 ENST00000411538.1
ENST00000256039.2
DYDC2
DPY30 domain containing 2
chr1_+_85527987 7.62 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chr6_-_32634425 6.58 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr6_+_32812568 6.34 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr17_-_19266045 6.33 ENST00000395616.3
B9D1
B9 protein domain 1
chr8_+_101170257 5.90 ENST00000251809.3
SPAG1
sperm associated antigen 1
chr6_-_32908792 5.86 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_-_32731299 5.84 ENST00000435145.2
ENST00000437316.2
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chrX_+_125953746 5.70 ENST00000371125.3
CXorf64
chromosome X open reading frame 64
chr1_+_36549676 5.50 ENST00000207457.3
TEKT2
tektin 2 (testicular)
chr17_-_19265855 4.50 ENST00000440841.1
ENST00000395615.1
ENST00000461069.2
B9D1
B9 protein domain 1
chr10_-_82116497 4.32 ENST00000372204.3
DYDC1
DPY30 domain containing 1
chr17_-_19265982 4.18 ENST00000268841.6
ENST00000261499.4
ENST00000575478.1
B9D1
B9 protein domain 1
chr10_-_82116505 4.09 ENST00000372202.1
ENST00000421924.2
ENST00000453477.1
DYDC1
DPY30 domain containing 1
chr1_-_27339317 3.45 ENST00000289166.5
FAM46B
family with sequence similarity 46, member B
chr3_-_27410847 3.42 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr19_+_10527449 3.23 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr10_-_82116467 3.09 ENST00000454362.1
DYDC1
DPY30 domain containing 1
chr11_+_45868957 2.73 ENST00000443527.2
CRY2
cryptochrome 2 (photolyase-like)
chr11_-_118436606 2.70 ENST00000530872.1
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr6_-_32812420 2.62 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr11_-_118436707 2.47 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr19_+_10563567 2.17 ENST00000344979.3
PDE4A
phosphodiesterase 4A, cAMP-specific
chr1_+_46049706 2.06 ENST00000527470.1
ENST00000525515.1
ENST00000537798.1
ENST00000402363.3
ENST00000528238.1
ENST00000350030.3
ENST00000470768.1
ENST00000372052.4
ENST00000351223.3
NASP
nuclear autoantigenic sperm protein (histone-binding)
chr6_+_26440700 2.05 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr12_-_110841462 1.89 ENST00000455511.3
ENST00000450008.2
ANAPC7
anaphase promoting complex subunit 7
chr11_-_6640585 1.72 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
TPP1
tripeptidyl peptidase I
chr13_-_30424821 1.68 ENST00000380680.4
UBL3
ubiquitin-like 3
chr16_+_67381263 1.63 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
LRRC36
leucine rich repeat containing 36
chr22_+_31518938 1.59 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr6_+_26365443 1.58 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr6_-_32731243 1.56 ENST00000427449.1
ENST00000411527.1
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr16_+_67381289 1.45 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr11_-_85430088 1.33 ENST00000533057.1
ENST00000533892.1
SYTL2
synaptotagmin-like 2
chr4_-_83719884 1.23 ENST00000282709.4
ENST00000273908.4
SCD5
stearoyl-CoA desaturase 5
chr6_+_26458152 1.12 ENST00000312541.5
BTN2A1
butyrophilin, subfamily 2, member A1
chr1_+_150254936 1.08 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
C1orf51
chromosome 1 open reading frame 51
chr6_-_32908765 1.02 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr11_-_72433346 0.95 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_+_26383318 0.85 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr6_-_24667180 0.80 ENST00000545995.1
TDP2
tyrosyl-DNA phosphodiesterase 2
chr6_+_26383404 0.77 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr15_+_45003675 0.71 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr8_-_99306564 0.69 ENST00000430223.2
NIPAL2
NIPA-like domain containing 2
chr6_-_30181133 0.64 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chr1_+_249132462 0.61 ENST00000306562.3
ZNF672
zinc finger protein 672
chr6_-_24666819 0.61 ENST00000341060.3
TDP2
tyrosyl-DNA phosphodiesterase 2
chr2_-_242088850 0.61 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
PASK
PAS domain containing serine/threonine kinase
chr6_-_30181156 0.60 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr5_-_55412774 0.53 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr8_-_99306611 0.51 ENST00000341166.3
NIPAL2
NIPA-like domain containing 2
chr3_+_43328004 0.49 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK
SNF related kinase
chrX_+_19362011 0.46 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr17_+_38137073 0.37 ENST00000541736.1
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr10_+_14880287 0.32 ENST00000437161.2
HSPA14
heat shock 70kDa protein 14
chr10_+_14880157 0.27 ENST00000378372.3
HSPA14
heat shock 70kDa protein 14
chr16_-_74808710 0.26 ENST00000219368.3
ENST00000544337.1
FA2H
fatty acid 2-hydroxylase
chr20_+_42875887 0.16 ENST00000342560.5
GDAP1L1
ganglioside induced differentiation associated protein 1-like 1
chr6_+_26458171 0.08 ENST00000493173.1
ENST00000541522.1
ENST00000429381.1
ENST00000469185.1
BTN2A1
butyrophilin, subfamily 2, member A1
chr20_+_42875935 0.07 ENST00000438466.1
ENST00000372952.3
ENST00000537864.1
ENST00000445952.1
GDAP1L1
ganglioside induced differentiation associated protein 1-like 1
chr17_+_30348024 0.06 ENST00000327564.7
ENST00000584368.1
ENST00000394713.3
ENST00000341671.7
LRRC37B
leucine rich repeat containing 37B
chr5_+_79615790 0.03 ENST00000296739.4
SPZ1
spermatogenic leucine zipper 1

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 42.1 GO:0002399 MHC class II protein complex assembly(GO:0002399)
3.8 18.8 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.4 20.1 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.9 2.7 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.4 1.2 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.4 5.5 GO:0036159 inner dynein arm assembly(GO:0036159)
0.3 44.1 GO:0031295 T cell costimulation(GO:0031295)
0.3 5.9 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.2 1.0 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.2 0.7 GO:1904438 positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.2 10.8 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.2 2.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.2 15.0 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.2 18.4 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 5.4 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.1 0.6 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 1.6 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 5.2 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 1.3 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 3.4 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.6 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 1.2 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.6 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 1.6 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 1.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 0.5 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 1.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.3 GO:0048733 sebaceous gland development(GO:0048733)
0.0 7.6 GO:0007018 microtubule-based movement(GO:0007018)
0.0 2.0 GO:0002456 T cell mediated immunity(GO:0002456)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 103.7 GO:0042613 MHC class II protein complex(GO:0042613)
2.1 19.0 GO:1990111 spermatoproteasome complex(GO:1990111)
1.0 20.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.8 15.0 GO:0036038 MKS complex(GO:0036038)
0.2 5.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.7 GO:0031905 early endosome lumen(GO:0031905)
0.1 7.6 GO:0030286 dynein complex(GO:0030286)
0.0 1.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.5 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 5.5 GO:0036126 sperm flagellum(GO:0036126)
0.0 5.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 1.4 GO:0016235 aggresome(GO:0016235)
0.0 1.6 GO:0043198 dendritic shaft(GO:0043198)
0.0 3.1 GO:1902911 protein kinase complex(GO:1902911)
0.0 3.1 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 18.8 GO:0042289 MHC class II protein binding(GO:0042289)
1.7 15.0 GO:0008158 hedgehog receptor activity(GO:0008158)
1.5 59.7 GO:0042605 peptide antigen binding(GO:0042605)
1.1 5.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.8 20.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.7 19.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.6 19.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5 1.4 GO:0036317 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
0.3 7.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.3 1.7 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.2 1.2 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.2 1.6 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.2 2.7 GO:0009881 photoreceptor activity(GO:0009881)
0.1 5.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.5 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 1.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.0 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 2.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 5.2 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 1.9 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 5.9 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 23.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.4 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.7 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 53.8 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 35.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.2 18.4 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 0.7 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.9 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 2.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)