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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RFX5
Z-value: 1.60
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Transcription factors associated with RFX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX5 | hg19_v2_chr1_-_151319710_151319833 | 0.40 | 3.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 44.1 | GO:0031295 | T cell costimulation(GO:0031295) |
| 8.4 | 42.1 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 1.4 | 20.1 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 3.8 | 18.8 | GO:0002905 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.2 | 18.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.2 | 15.0 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.2 | 10.8 | GO:0048741 | skeletal muscle fiber development(GO:0048741) |
| 0.0 | 7.6 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 0.3 | 5.9 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
| 0.4 | 5.5 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 103.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 1.0 | 20.1 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 2.1 | 19.0 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.8 | 15.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 7.6 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 5.5 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 5.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 5.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 3.1 | GO:1902911 | protein kinase complex(GO:1902911) |
| 0.0 | 3.1 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 59.7 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.8 | 20.1 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.7 | 19.0 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.6 | 19.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 3.8 | 18.8 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 1.7 | 15.0 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.3 | 7.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 5.9 | GO:0005525 | GTP binding(GO:0005525) |
| 1.1 | 5.5 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 5.4 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 2.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 0.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 53.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.2 | 35.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 18.4 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 2.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 1.9 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 1.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 0.7 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |