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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RFX7_RFX4_RFX1
Z-value: 11.26
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Transcription factors associated with RFX7_RFX4_RFX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX7 | hg19_v2_chr15_-_56535464_56535521 | -0.49 | 5.6e-03 | Click! |
| RFX4 | hg19_v2_chr12_+_106976678_106976708, hg19_v2_chr12_+_107078474_107078533 | -0.30 | 1.1e-01 | Click! |
| RFX1 | hg19_v2_chr19_-_14117074_14117141 | -0.25 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_55888186 Show fit | 256.66 |
ENST00000291934.3
|
transmembrane protein 190 |
|
| chr1_-_109655355 Show fit | 139.37 |
ENST00000369945.3
|
chromosome 1 open reading frame 194 |
|
| chr1_-_109655377 Show fit | 138.59 |
ENST00000369948.3
|
chromosome 1 open reading frame 194 |
|
| chr1_-_161337662 Show fit | 134.54 |
ENST00000367974.1
|
chromosome 1 open reading frame 192 |
|
| chr9_-_138391692 Show fit | 108.68 |
ENST00000429260.2
|
chromosome 9 open reading frame 116 |
|
| chr10_+_23216944 Show fit | 107.90 |
ENST00000298032.5
ENST00000409983.3 ENST00000409049.3 |
armadillo repeat containing 3 |
|
| chr10_+_23217006 Show fit | 105.22 |
ENST00000376528.4
ENST00000447081.1 |
armadillo repeat containing 3 |
|
| chr16_+_80574854 Show fit | 98.84 |
ENST00000305904.6
ENST00000568035.1 |
dynein, light chain, roadblock-type 2 |
|
| chr10_-_25305011 Show fit | 96.31 |
ENST00000331161.4
ENST00000376363.1 |
enkurin, TRPC channel interacting protein |
|
| chr6_+_163148973 Show fit | 94.58 |
ENST00000366888.2
|
PARK2 co-regulated |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX7_RFX4_RFX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.3 | 383.2 | GO:0035082 | axoneme assembly(GO:0035082) |
| 5.5 | 364.0 | GO:0042073 | intraciliary transport(GO:0042073) |
| 14.7 | 308.3 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.7 | 243.6 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 1.6 | 207.4 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.9 | 197.1 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 42.4 | 169.5 | GO:0090299 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 10.9 | 153.2 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 10.1 | 141.2 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 6.6 | 132.1 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 377.3 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 15.6 | 296.5 | GO:0036038 | MKS complex(GO:0036038) |
| 25.5 | 280.1 | GO:0036157 | outer dynein arm(GO:0036157) |
| 51.3 | 256.7 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.7 | 186.9 | GO:0005929 | cilium(GO:0005929) |
| 6.3 | 182.0 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 14.2 | 170.0 | GO:0072687 | meiotic spindle(GO:0072687) |
| 3.0 | 168.3 | GO:0036126 | sperm flagellum(GO:0036126) |
| 7.7 | 161.4 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 2.6 | 139.9 | GO:0009925 | basal plasma membrane(GO:0009925) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.2 | 289.9 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 3.2 | 258.9 | GO:0043621 | protein self-association(GO:0043621) |
| 0.4 | 201.2 | GO:0005525 | GTP binding(GO:0005525) |
| 3.7 | 190.0 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 6.7 | 188.5 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 6.7 | 161.4 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 14.7 | 132.1 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 4.6 | 113.8 | GO:0031005 | filamin binding(GO:0031005) |
| 7.5 | 104.5 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 4.0 | 95.1 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 116.5 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 1.4 | 69.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.6 | 38.9 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.2 | 38.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 25.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 18.1 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.2 | 8.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 8.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.8 | 7.9 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.1 | 7.1 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 52.9 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.4 | 41.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 1.4 | 38.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.5 | 33.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.3 | 29.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 24.5 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.3 | 12.6 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.7 | 12.1 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.4 | 9.2 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.1 | 6.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |