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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RHOXF1
Z-value: 0.89
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Transcription factors associated with RHOXF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RHOXF1 | hg19_v2_chrX_-_119249819_119249847 | -0.03 | 8.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_54764346 Show fit | 5.81 |
ENST00000297313.3
ENST00000344277.6 |
regulator of G-protein signaling 20 |
|
| chr12_+_8975061 Show fit | 4.11 |
ENST00000299698.7
|
alpha-2-macroglobulin-like 1 |
|
| chr6_+_151646800 Show fit | 3.53 |
ENST00000354675.6
|
A kinase (PRKA) anchor protein 12 |
|
| chr22_+_31488433 Show fit | 3.40 |
ENST00000455608.1
|
smoothelin |
|
| chr5_+_7654057 Show fit | 3.34 |
ENST00000537121.1
|
adenylate cyclase 2 (brain) |
|
| chrX_+_135251783 Show fit | 3.28 |
ENST00000394153.2
|
four and a half LIM domains 1 |
|
| chr15_-_90039805 Show fit | 2.95 |
ENST00000544600.1
ENST00000268122.4 |
Rh family, C glycoprotein |
|
| chr17_-_38859996 Show fit | 2.88 |
ENST00000264651.2
|
keratin 24 |
|
| chrX_+_135251835 Show fit | 2.75 |
ENST00000456445.1
|
four and a half LIM domains 1 |
|
| chr6_+_151561506 Show fit | 2.74 |
ENST00000253332.1
|
A kinase (PRKA) anchor protein 12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RHOXF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.3 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 8.1 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.4 | 6.6 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.6 | 4.8 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.0 | 3.7 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.6 | 3.4 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.1 | 3.4 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 3.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 3.3 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.2 | 3.2 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 24.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 13.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 7.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.3 | 5.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.7 | 4.8 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 4.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 3.8 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 3.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 3.3 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.1 | 2.8 | GO:0042627 | chylomicron(GO:0042627) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 12.1 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 8.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 7.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 5.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 5.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 5.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 4.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 4.0 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 3.6 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.6 | 3.4 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 7.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.9 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 6.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 5.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 4.1 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.2 | 3.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 3.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 3.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 7.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 7.0 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 5.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 3.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 3.2 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 3.1 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 3.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 3.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 3.0 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |