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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RORC

Z-value: 0.40

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RAR related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151798546_1517985900.319.4e-02Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_4671352 0.75 ENST00000542744.1
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr12_+_7167980 0.62 ENST00000360817.5
ENST00000402681.3
C1S
complement component 1, s subcomponent
chr1_+_104198377 0.50 ENST00000370083.4
AMY1A
amylase, alpha 1A (salivary)
chr8_+_71485681 0.46 ENST00000391684.1
AC120194.1
AC120194.1
chr3_-_45957088 0.42 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr17_-_46623441 0.40 ENST00000330070.4
HOXB2
homeobox B2
chr3_-_45957534 0.35 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chrX_-_102531717 0.34 ENST00000372680.1
TCEAL5
transcription elongation factor A (SII)-like 5
chr6_-_46922659 0.29 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chr7_-_128415844 0.29 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr19_+_38924316 0.29 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chr3_+_160559931 0.29 ENST00000464260.1
ENST00000295839.9
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr10_-_21435488 0.27 ENST00000534331.1
ENST00000529198.1
ENST00000377118.4
C10orf113
chromosome 10 open reading frame 113
chr19_-_10450287 0.24 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chr16_-_1821496 0.23 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr19_-_49140609 0.22 ENST00000601104.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chrX_-_43832711 0.21 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr12_+_56414795 0.20 ENST00000431367.2
IKZF4
IKAROS family zinc finger 4 (Eos)
chr12_+_93963590 0.20 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr9_-_110251836 0.18 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr19_-_49140692 0.18 ENST00000222122.5
DBP
D site of albumin promoter (albumin D-box) binding protein
chr12_+_93964158 0.17 ENST00000549206.1
SOCS2
suppressor of cytokine signaling 2
chr3_-_65583561 0.17 ENST00000460329.2
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr1_-_240906911 0.17 ENST00000431139.2
RP11-80B9.4
RP11-80B9.4
chr19_+_1269324 0.15 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr14_-_23451845 0.15 ENST00000262713.2
AJUBA
ajuba LIM protein
chr20_-_23433494 0.14 ENST00000377007.3
CST11
cystatin 11
chr16_-_69385681 0.13 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr4_+_85504075 0.12 ENST00000295887.5
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr20_+_37209820 0.10 ENST00000537425.1
ENST00000373348.3
ENST00000416116.1
ADIG
adipogenin
chr12_-_39734783 0.10 ENST00000552961.1
KIF21A
kinesin family member 21A
chr12_-_54652060 0.10 ENST00000552562.1
CBX5
chromobox homolog 5
chr7_-_43965937 0.09 ENST00000455877.1
ENST00000223341.7
ENST00000447717.3
ENST00000426198.1
URGCP
upregulator of cell proliferation
chr2_+_148778570 0.09 ENST00000407073.1
MBD5
methyl-CpG binding domain protein 5
chr12_-_82152420 0.09 ENST00000552948.1
ENST00000548586.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr1_-_217311090 0.08 ENST00000493603.1
ENST00000366940.2
ESRRG
estrogen-related receptor gamma
chr7_+_20687017 0.08 ENST00000258738.6
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr1_+_26869597 0.08 ENST00000530003.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr14_+_21785693 0.08 ENST00000382933.4
ENST00000557351.1
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr1_-_185286461 0.07 ENST00000367498.3
IVNS1ABP
influenza virus NS1A binding protein
chr20_-_33732952 0.07 ENST00000541621.1
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr16_+_1832902 0.07 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2
nucleotide binding protein 2
chr7_-_141541221 0.07 ENST00000350549.3
ENST00000438520.1
PRSS37
protease, serine, 37
chr19_+_12780512 0.06 ENST00000242796.4
WDR83
WD repeat domain 83
chr4_+_140586922 0.06 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr2_-_148778323 0.06 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
ORC4
origin recognition complex, subunit 4
chr10_-_121296045 0.06 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr17_-_48785216 0.06 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr11_+_65292884 0.06 ENST00000527009.1
SCYL1
SCY1-like 1 (S. cerevisiae)
chr1_-_153522562 0.06 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr1_+_114447763 0.06 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chr7_+_112063192 0.06 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr14_-_23451467 0.05 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
AJUBA
RP11-298I3.5
ajuba LIM protein
chr17_-_37764128 0.05 ENST00000302584.4
NEUROD2
neuronal differentiation 2
chr2_+_160590469 0.05 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr16_+_24266874 0.05 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr1_-_145826450 0.04 ENST00000462900.2
GPR89A
G protein-coupled receptor 89A
chr19_-_8567478 0.04 ENST00000255612.3
PRAM1
PML-RARA regulated adaptor molecule 1
chr3_+_185303962 0.04 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr3_-_42452050 0.03 ENST00000441172.1
ENST00000287748.3
LYZL4
lysozyme-like 4
chr18_-_23671139 0.03 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr2_+_119699864 0.03 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr1_-_62190793 0.03 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr6_+_43738444 0.03 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
VEGFA
vascular endothelial growth factor A
chr10_-_103578162 0.02 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr19_-_39735646 0.02 ENST00000413851.2
IFNL3
interferon, lambda 3
chr6_+_44094627 0.02 ENST00000259746.9
TMEM63B
transmembrane protein 63B
chr8_-_95449155 0.01 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr12_+_56624436 0.01 ENST00000266980.4
ENST00000437277.1
SLC39A5
solute carrier family 39 (zinc transporter), member 5
chr7_+_20686946 0.01 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr2_+_119699742 0.01 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr5_+_177557997 0.00 ENST00000313386.4
ENST00000515098.1
ENST00000542098.1
ENST00000502814.1
ENST00000507457.1
ENST00000508647.1
RMND5B
required for meiotic nuclear division 5 homolog B (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.4 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.2 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.0 0.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.3 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.1 GO:0007518 myoblast fate determination(GO:0007518)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.0 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.1 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.1 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990425 ryanodine receptor complex(GO:1990425)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016160 amylase activity(GO:0016160)
0.1 0.3 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME OPSINS Genes involved in Opsins