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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RREB1
Z-value: 1.29
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Transcription factors associated with RREB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RREB1 | hg19_v2_chr6_+_7107830_7107993 | 0.27 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51471362 Show fit | 8.62 |
ENST00000376853.4
ENST00000424910.2 |
kallikrein-related peptidase 6 |
|
| chr19_-_51471381 Show fit | 8.47 |
ENST00000594641.1
|
kallikrein-related peptidase 6 |
|
| chr19_-_51456198 Show fit | 6.39 |
ENST00000594846.1
|
kallikrein-related peptidase 5 |
|
| chr19_-_51456344 Show fit | 6.34 |
ENST00000336334.3
ENST00000593428.1 |
kallikrein-related peptidase 5 |
|
| chr19_-_51456321 Show fit | 6.34 |
ENST00000391809.2
|
kallikrein-related peptidase 5 |
|
| chr6_+_151646800 Show fit | 4.67 |
ENST00000354675.6
|
A kinase (PRKA) anchor protein 12 |
|
| chr18_-_21242774 Show fit | 4.45 |
ENST00000322980.9
|
ankyrin repeat domain 29 |
|
| chr4_+_75230853 Show fit | 3.90 |
ENST00000244869.2
|
epiregulin |
|
| chr12_+_96588279 Show fit | 3.81 |
ENST00000552142.1
|
ELK3, ETS-domain protein (SRF accessory protein 2) |
|
| chr2_+_234104079 Show fit | 3.37 |
ENST00000417661.1
|
inositol polyphosphate-5-phosphatase, 145kDa |
Network of associatons between targets according to the STRING database.
First level regulatory network of RREB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 19.1 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.8 | 17.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.1 | 7.4 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.2 | 6.3 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.4 | 6.1 | GO:0006183 | GTP biosynthetic process(GO:0006183) |
| 0.3 | 4.7 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.0 | 4.7 | GO:0031424 | keratinization(GO:0031424) |
| 1.3 | 3.9 | GO:0042700 | luteinizing hormone signaling pathway(GO:0042700) |
| 0.4 | 3.9 | GO:0070141 | response to UV-A(GO:0070141) |
| 1.1 | 3.4 | GO:0045659 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 19.1 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 15.5 | GO:0030141 | secretory granule(GO:0030141) |
| 0.1 | 8.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 1.0 | 7.8 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.1 | 6.3 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.0 | 4.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 3.4 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 3.3 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.6 | 3.2 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 2.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 6.3 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.0 | 5.4 | GO:0005525 | GTP binding(GO:0005525) |
| 0.5 | 4.7 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.3 | 4.7 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 1.5 | 4.5 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.1 | 4.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.6 | 3.4 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.3 | 3.2 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.0 | 2.9 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 7.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 5.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.2 | 4.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.9 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 2.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 2.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 2.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.6 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.1 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 4.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 3.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 2.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 2.3 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.1 | 1.9 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 1.7 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 1.7 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 1.4 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |