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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for RUNX3_BCL11A

Z-value: 0.82

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Transcription factors associated with RUNX3_BCL11A

Gene Symbol Gene ID Gene Info
RUNX3
ENSG00000020633.14 RUNX family transcription factor 3
BCL11A
ENSG00000119866.16 BAF chromatin remodeling complex subunit BCL11A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BCL11Ahg19_v2_chr2_-_60780607_60780634-0.461.1e-02Click!
RUNX3hg19_v2_chr1_-_25256368_252564760.431.6e-02Click!

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_17272608 3.45 ENST00000421459.2
VIM
vimentin
chr10_+_17270214 2.83 ENST00000544301.1
VIM
vimentin
chr11_-_58345569 2.58 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr22_+_31488433 2.40 ENST00000455608.1
SMTN
smoothelin
chr5_-_39270725 2.28 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chrX_-_106960285 2.02 ENST00000503515.1
ENST00000372397.2
TSC22D3
TSC22 domain family, member 3
chr1_+_152486950 1.64 ENST00000368790.3
CRCT1
cysteine-rich C-terminal 1
chr1_+_45205498 1.52 ENST00000372218.4
KIF2C
kinesin family member 2C
chr1_+_45205478 1.47 ENST00000452259.1
ENST00000372224.4
KIF2C
kinesin family member 2C
chr2_+_33359687 1.45 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
LTBP1
latent transforming growth factor beta binding protein 1
chr2_+_33359646 1.40 ENST00000390003.4
ENST00000418533.2
LTBP1
latent transforming growth factor beta binding protein 1
chr5_-_39203093 1.40 ENST00000515010.1
FYB
FYN binding protein
chr14_+_85996471 1.34 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr4_+_88896819 1.28 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
SPP1
secreted phosphoprotein 1
chr6_+_86159821 1.28 ENST00000369651.3
NT5E
5'-nucleotidase, ecto (CD73)
chr1_-_94147385 1.27 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr3_-_33686925 1.20 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr10_+_5566916 1.17 ENST00000315238.1
CALML3
calmodulin-like 3
chr1_+_23695680 1.14 ENST00000454117.1
ENST00000335648.3
ENST00000518821.1
ENST00000437367.2
C1orf213
chromosome 1 open reading frame 213
chr11_-_66725837 1.06 ENST00000393958.2
ENST00000393960.1
ENST00000524491.1
ENST00000355677.3
PC
pyruvate carboxylase
chr1_+_209859510 1.01 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr2_-_55646957 1.01 ENST00000263630.8
CCDC88A
coiled-coil domain containing 88A
chr22_+_40297079 1.00 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr6_+_45296048 0.97 ENST00000465038.2
ENST00000352853.5
ENST00000541979.1
ENST00000371438.1
RUNX2
runt-related transcription factor 2
chr22_+_40297105 0.96 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr13_-_103053946 0.94 ENST00000376131.4
FGF14
fibroblast growth factor 14
chr2_-_55647057 0.90 ENST00000436346.1
CCDC88A
coiled-coil domain containing 88A
chr1_-_179112173 0.90 ENST00000408940.3
ENST00000504405.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr11_-_128457446 0.88 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr6_+_45296391 0.87 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr12_-_4754339 0.86 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr10_+_112404132 0.86 ENST00000369519.3
RBM20
RNA binding motif protein 20
chr2_-_119605253 0.85 ENST00000295206.6
EN1
engrailed homeobox 1
chr14_-_35183755 0.85 ENST00000555765.1
CFL2
cofilin 2 (muscle)
chr5_+_131409476 0.84 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr7_+_18535346 0.84 ENST00000405010.3
ENST00000406451.4
ENST00000428307.2
HDAC9
histone deacetylase 9
chr12_-_71031185 0.81 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr17_-_74533963 0.81 ENST00000293230.5
CYGB
cytoglobin
chr15_-_64665911 0.80 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr6_+_74405501 0.79 ENST00000437994.2
ENST00000422508.2
CD109
CD109 molecule
chr20_-_54967187 0.79 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
AURKA
aurora kinase A
chr4_-_152147579 0.79 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3D19
SH3 domain containing 19
chr8_+_31497271 0.78 ENST00000520407.1
NRG1
neuregulin 1
chr19_-_44285401 0.78 ENST00000262888.3
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr11_-_102826434 0.77 ENST00000340273.4
ENST00000260302.3
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr20_+_30028322 0.76 ENST00000376309.3
DEFB123
defensin, beta 123
chr1_+_39546988 0.73 ENST00000484793.1
MACF1
microtubule-actin crosslinking factor 1
chr13_-_46756351 0.72 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_+_68048803 0.69 ENST00000204961.4
EFNB1
ephrin-B1
chr3_-_189840223 0.69 ENST00000427335.2
LEPREL1
leprecan-like 1
chr12_-_53012343 0.69 ENST00000305748.3
KRT73
keratin 73
chr4_+_71091786 0.69 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr1_-_24469602 0.68 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr11_+_35198243 0.67 ENST00000528455.1
CD44
CD44 molecule (Indian blood group)
chr1_-_149889382 0.66 ENST00000369145.1
ENST00000369146.3
SV2A
synaptic vesicle glycoprotein 2A
chr11_+_124735282 0.65 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr10_-_14372870 0.65 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr6_+_30029008 0.64 ENST00000332435.5
ENST00000376782.2
ENST00000359374.4
ENST00000376785.2
ZNRD1
zinc ribbon domain containing 1
chr9_-_93925369 0.63 ENST00000457976.1
RP11-305L7.3
RP11-305L7.3
chr14_-_35183886 0.63 ENST00000298159.6
CFL2
cofilin 2 (muscle)
chr1_+_110453462 0.62 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr10_-_13276329 0.61 ENST00000378681.3
ENST00000463405.2
UCMA
upper zone of growth plate and cartilage matrix associated
chr15_+_67418047 0.61 ENST00000540846.2
SMAD3
SMAD family member 3
chr2_-_50574856 0.61 ENST00000342183.5
NRXN1
neurexin 1
chr11_-_19262486 0.61 ENST00000250024.4
E2F8
E2F transcription factor 8
chr12_-_51717948 0.60 ENST00000267012.4
BIN2
bridging integrator 2
chr12_-_51717875 0.60 ENST00000604560.1
BIN2
bridging integrator 2
chr12_-_51717922 0.60 ENST00000452142.2
BIN2
bridging integrator 2
chr11_+_35198118 0.59 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44
CD44 molecule (Indian blood group)
chr3_-_99569821 0.59 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chrX_+_37639302 0.58 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr8_+_27168988 0.58 ENST00000397501.1
ENST00000338238.4
ENST00000544172.1
PTK2B
protein tyrosine kinase 2 beta
chr9_-_95166841 0.58 ENST00000262551.4
OGN
osteoglycin
chr10_+_101419187 0.58 ENST00000370489.4
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr9_-_95166884 0.57 ENST00000375561.5
OGN
osteoglycin
chr4_-_57976544 0.56 ENST00000295666.4
ENST00000537922.1
IGFBP7
insulin-like growth factor binding protein 7
chr2_-_105030466 0.55 ENST00000449772.1
AC068535.3
AC068535.3
chr4_-_57524061 0.55 ENST00000508121.1
HOPX
HOP homeobox
chr19_+_41257084 0.55 ENST00000601393.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr15_+_63335899 0.54 ENST00000561266.1
TPM1
tropomyosin 1 (alpha)
chr1_+_66999799 0.54 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr3_+_141105235 0.53 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr7_-_148580563 0.53 ENST00000476773.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr1_+_110453608 0.52 ENST00000369801.1
CSF1
colony stimulating factor 1 (macrophage)
chr8_+_27182862 0.51 ENST00000521164.1
ENST00000346049.5
PTK2B
protein tyrosine kinase 2 beta
chr7_+_45067265 0.51 ENST00000474617.1
CCM2
cerebral cavernous malformation 2
chr21_-_40033618 0.50 ENST00000417133.2
ENST00000398910.1
ENST00000442448.1
ERG
v-ets avian erythroblastosis virus E26 oncogene homolog
chr3_+_100328433 0.50 ENST00000273352.3
GPR128
G protein-coupled receptor 128
chr8_+_27183033 0.50 ENST00000420218.2
PTK2B
protein tyrosine kinase 2 beta
chr1_-_168513229 0.50 ENST00000367819.2
XCL2
chemokine (C motif) ligand 2
chrX_+_47441712 0.50 ENST00000218388.4
ENST00000377018.2
ENST00000456754.2
ENST00000377017.1
ENST00000441738.1
TIMP1
TIMP metallopeptidase inhibitor 1
chr1_-_25291475 0.49 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr2_+_228678550 0.49 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr12_+_79439405 0.48 ENST00000552744.1
SYT1
synaptotagmin I
chr17_-_29648761 0.48 ENST00000247270.3
ENST00000462804.2
EVI2A
ecotropic viral integration site 2A
chrX_-_70838306 0.47 ENST00000373691.4
ENST00000373693.3
CXCR3
chemokine (C-X-C motif) receptor 3
chr14_+_85996507 0.47 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr19_-_49496557 0.47 ENST00000323798.3
ENST00000541188.1
ENST00000544287.1
ENST00000540532.1
ENST00000263276.6
GYS1
glycogen synthase 1 (muscle)
chr11_-_66103867 0.47 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chrX_-_15872914 0.47 ENST00000380291.1
ENST00000545766.1
ENST00000421527.2
ENST00000329235.2
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr21_+_31768348 0.46 ENST00000355459.2
KRTAP13-1
keratin associated protein 13-1
chr1_-_173174681 0.46 ENST00000367718.1
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr14_-_85996332 0.46 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr1_+_110453514 0.46 ENST00000369802.3
ENST00000420111.2
CSF1
colony stimulating factor 1 (macrophage)
chr11_-_1643368 0.46 ENST00000399682.1
KRTAP5-4
keratin associated protein 5-4
chr2_+_37571717 0.45 ENST00000338415.3
ENST00000404976.1
QPCT
glutaminyl-peptide cyclotransferase
chr3_+_156799587 0.45 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chr11_+_60995849 0.45 ENST00000537932.1
PGA4
pepsinogen 4, group I (pepsinogen A)
chr2_+_90077680 0.45 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr9_-_35103105 0.45 ENST00000452248.2
ENST00000356493.5
STOML2
stomatin (EPB72)-like 2
chr19_-_14785698 0.44 ENST00000344373.4
ENST00000595472.1
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr2_+_37571845 0.44 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr19_-_14785622 0.43 ENST00000443157.2
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr10_+_25463951 0.43 ENST00000376351.3
GPR158
G protein-coupled receptor 158
chr11_-_35287243 0.43 ENST00000464522.2
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_-_34524049 0.42 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr5_+_135496675 0.42 ENST00000507637.1
SMAD5
SMAD family member 5
chr7_+_120628731 0.41 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr20_+_36405665 0.41 ENST00000373469.1
CTNNBL1
catenin, beta like 1
chr19_-_14785674 0.41 ENST00000253673.5
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr6_-_34524093 0.41 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr17_-_73840415 0.41 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D
unc-13 homolog D (C. elegans)
chr1_-_114414316 0.40 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr3_+_121902511 0.39 ENST00000490131.1
CASR
calcium-sensing receptor
chr19_+_41882598 0.39 ENST00000447302.2
ENST00000544232.1
ENST00000542945.1
ENST00000540732.1
TMEM91
CTC-435M10.3
transmembrane protein 91
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Uncharacterized protein
chr6_-_114664180 0.39 ENST00000312719.5
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr3_-_71179988 0.39 ENST00000491238.1
FOXP1
forkhead box P1
chr12_-_71031220 0.39 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr3_-_98241760 0.39 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
CLDND1
claudin domain containing 1
chr17_-_41623075 0.39 ENST00000545089.1
ETV4
ets variant 4
chr6_-_42418999 0.39 ENST00000340840.2
ENST00000354325.2
TRERF1
transcriptional regulating factor 1
chr2_+_182850551 0.38 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr1_-_153348067 0.38 ENST00000368737.3
S100A12
S100 calcium binding protein A12
chr13_-_62001982 0.38 ENST00000409186.1
PCDH20
protocadherin 20
chr8_+_21899898 0.37 ENST00000518533.1
ENST00000359441.3
FGF17
fibroblast growth factor 17
chr12_+_15125954 0.37 ENST00000266395.2
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr3_-_150920979 0.36 ENST00000309180.5
ENST00000480322.1
GPR171
G protein-coupled receptor 171
chrX_+_37639264 0.36 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr3_-_33686743 0.36 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr11_+_61015594 0.35 ENST00000451616.2
PGA5
pepsinogen 5, group I (pepsinogen A)
chr19_-_14048804 0.35 ENST00000254320.3
ENST00000586075.1
PODNL1
podocan-like 1
chr19_-_14049184 0.35 ENST00000339560.5
PODNL1
podocan-like 1
chr2_-_158300556 0.35 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr3_+_189507523 0.34 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chr11_-_2323089 0.34 ENST00000456145.2
C11orf21
chromosome 11 open reading frame 21
chr1_+_110453203 0.34 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr1_-_150978953 0.34 ENST00000493834.2
FAM63A
family with sequence similarity 63, member A
chr3_+_132843652 0.33 ENST00000508711.1
TMEM108
transmembrane protein 108
chr3_-_71179699 0.33 ENST00000497355.1
FOXP1
forkhead box P1
chr19_-_51220176 0.33 ENST00000359082.3
ENST00000293441.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr11_-_2323290 0.33 ENST00000381153.3
C11orf21
chromosome 11 open reading frame 21
chr8_-_134072593 0.32 ENST00000427060.2
SLA
Src-like-adaptor
chr17_-_41623009 0.32 ENST00000393664.2
ETV4
ets variant 4
chr5_+_54398463 0.32 ENST00000274306.6
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr17_-_47287928 0.32 ENST00000507680.1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr1_-_157522180 0.31 ENST00000356953.4
ENST00000368188.2
ENST00000368190.3
ENST00000368189.3
FCRL5
Fc receptor-like 5
chr11_-_66104237 0.31 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr21_+_35552978 0.31 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310
long intergenic non-protein coding RNA 310
chr1_+_111772314 0.31 ENST00000466741.1
ENST00000477185.2
CHI3L2
chitinase 3-like 2
chr14_-_70655684 0.30 ENST00000356921.2
ENST00000381269.2
ENST00000357887.3
SLC8A3
solute carrier family 8 (sodium/calcium exchanger), member 3
chr5_-_94417314 0.30 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr6_-_52109335 0.30 ENST00000336123.4
IL17F
interleukin 17F
chr10_-_29811456 0.30 ENST00000535393.1
SVIL
supervillin
chr2_+_202937972 0.30 ENST00000541917.1
ENST00000295844.3
AC079354.1
uncharacterized protein KIAA2012
chr18_-_35145728 0.30 ENST00000361795.5
ENST00000603232.1
CELF4
CUGBP, Elav-like family member 4
chr6_+_160327974 0.30 ENST00000252660.4
MAS1
MAS1 oncogene
chr1_-_150979333 0.29 ENST00000312210.5
FAM63A
family with sequence similarity 63, member A
chr3_-_147124547 0.29 ENST00000491672.1
ENST00000383075.3
ZIC4
Zic family member 4
chr1_+_50569575 0.29 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr1_-_182641367 0.29 ENST00000508450.1
RGS8
regulator of G-protein signaling 8
chr1_-_175161890 0.29 ENST00000545251.2
ENST00000423313.1
KIAA0040
KIAA0040
chr10_+_89420706 0.29 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr2_+_202316392 0.29 ENST00000194530.3
ENST00000392249.2
STRADB
STE20-related kinase adaptor beta
chr7_-_87104963 0.29 ENST00000359206.3
ENST00000358400.3
ENST00000265723.4
ABCB4
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr12_+_75874984 0.28 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr1_+_230193521 0.28 ENST00000543760.1
GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
chr17_-_2169425 0.28 ENST00000570606.1
ENST00000354901.4
SMG6
SMG6 nonsense mediated mRNA decay factor
chr8_-_60031762 0.28 ENST00000361421.1
TOX
thymocyte selection-associated high mobility group box
chr13_-_38172863 0.28 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr13_-_28674693 0.28 ENST00000537084.1
ENST00000241453.7
ENST00000380982.4
FLT3
fms-related tyrosine kinase 3
chr4_-_10686373 0.28 ENST00000442825.2
CLNK
cytokine-dependent hematopoietic cell linker
chr15_+_73976545 0.28 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
CD276
CD276 molecule
chr6_+_116692102 0.28 ENST00000359564.2
DSE
dermatan sulfate epimerase
chr1_-_184006611 0.27 ENST00000546159.1
COLGALT2
collagen beta(1-O)galactosyltransferase 2
chr20_+_54987168 0.27 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr9_+_118916082 0.27 ENST00000328252.3
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr3_+_136676851 0.27 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr12_-_10542617 0.27 ENST00000240618.6
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr17_-_41836153 0.27 ENST00000301691.2
SOST
sclerostin
chr7_+_102389434 0.26 ENST00000409231.3
ENST00000418198.1
FAM185A
family with sequence similarity 185, member A
chr3_+_51575596 0.26 ENST00000409535.2
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr12_-_16759711 0.26 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_111772435 0.26 ENST00000524472.1
CHI3L2
chitinase 3-like 2
chr12_-_103889731 0.26 ENST00000552578.1
ENST00000548048.1
ENST00000315192.8
ENST00000548883.1
ENST00000378113.2
C12orf42
chromosome 12 open reading frame 42
chr20_+_54987305 0.26 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr16_+_30075463 0.25 ENST00000562168.1
ENST00000569545.1
ALDOA
aldolase A, fructose-bisphosphate
chr9_-_34048873 0.25 ENST00000449054.1
ENST00000379239.4
ENST00000539807.1
ENST00000379238.1
ENST00000418786.2
ENST00000360802.1
ENST00000412543.1
UBAP2
ubiquitin associated protein 2
chr17_+_75447326 0.25 ENST00000591088.1
SEPT9
septin 9
chr6_+_42584847 0.25 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr14_+_97263641 0.25 ENST00000216639.3
VRK1
vaccinia related kinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.3 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.5 1.9 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.4 2.2 GO:1904141 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.4 1.3 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.4 1.6 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.4 1.1 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.3 2.6 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.3 1.3 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.3 3.1 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.3 1.8 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.3 3.0 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 0.9 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.3 0.8 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.2 0.7 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.2 2.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.2 2.0 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 0.8 GO:0061743 motor learning(GO:0061743)
0.2 0.6 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 0.9 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.2 0.5 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.2 0.8 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.2 0.5 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.2 0.5 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.2 1.3 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.4 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.1 0.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.8 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 0.4 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1 0.8 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.1 1.0 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 0.4 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 1.0 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 1.6 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.3 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.1 0.8 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.9 GO:0030578 PML body organization(GO:0030578)
0.1 0.3 GO:0050894 determination of affect(GO:0050894)
0.1 0.3 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.3 GO:1901656 cellular response to mycotoxin(GO:0036146) glycoside transport(GO:1901656) cellular response to bile acid(GO:1903413)
0.1 0.4 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.3 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.1 1.5 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.3 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.1 0.3 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.1 0.6 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.3 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.3 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 3.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.5 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.1 0.8 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.1 0.7 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.1 2.3 GO:0097320 membrane tubulation(GO:0097320)
0.1 0.2 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.6 GO:0051414 response to cortisol(GO:0051414)
0.1 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.7 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.1 0.3 GO:0042109 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.1 0.2 GO:0032827 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.1 0.9 GO:0097106 postsynaptic density organization(GO:0097106)
0.1 0.3 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.8 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.3 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 0.5 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.4 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.4 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.3 GO:0032571 response to vitamin K(GO:0032571)
0.1 0.8 GO:0046541 saliva secretion(GO:0046541)
0.1 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 1.1 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 0.5 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.1 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.7 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 1.0 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0070836 caveola assembly(GO:0070836)
0.0 0.7 GO:1901072 glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.3 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.2 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.1 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.0 0.4 GO:0072513 semicircular canal morphogenesis(GO:0048752) positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 1.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.4 GO:0043320 natural killer cell degranulation(GO:0043320)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.4 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.3 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.3 GO:0090166 histone H3-S10 phosphorylation(GO:0043987) Golgi disassembly(GO:0090166)
0.0 0.5 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.8 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.5 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.2 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.3 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.6 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 2.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.2 GO:0003383 apical constriction(GO:0003383)
0.0 0.2 GO:0071104 response to interleukin-9(GO:0071104)
0.0 0.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.2 GO:0007566 embryo implantation(GO:0007566)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.1 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.2 GO:0071895 odontoblast differentiation(GO:0071895)
0.0 0.2 GO:2000821 regulation of grooming behavior(GO:2000821)
0.0 0.3 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.0 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.6 GO:0001771 immunological synapse formation(GO:0001771)
0.0 0.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.5 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.0 0.1 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.1 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.0 0.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.3 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.6 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.0 GO:0060585 nitric oxide transport(GO:0030185) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.2 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.8 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.3 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.3 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.1 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.7 GO:0033120 positive regulation of RNA splicing(GO:0033120)
0.0 0.3 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.2 GO:0007625 grooming behavior(GO:0007625)
0.0 0.7 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.1 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.6 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.2 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.2 GO:0002097 tRNA wobble base modification(GO:0002097)
0.0 0.6 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.7 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.0 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.1 GO:0007162 negative regulation of cell adhesion(GO:0007162)
0.0 0.4 GO:2001044 regulation of integrin-mediated signaling pathway(GO:2001044)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.8 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.2 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.2 GO:0090656 t-circle formation(GO:0090656)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 0.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.2 1.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 0.5 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.1 3.1 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.5 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 2.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.9 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.3 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 0.7 GO:0097486 multivesicular body lumen(GO:0097486)
0.1 2.4 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.9 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 2.6 GO:0002102 podosome(GO:0002102)
0.0 7.2 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.5 GO:0045120 pronucleus(GO:0045120)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.2 GO:0030673 axolemma(GO:0030673)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.0 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.8 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.2 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.4 GO:0000974 Prp19 complex(GO:0000974)
0.0 1.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.4 GO:0031105 septin complex(GO:0031105)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 2.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.3 GO:0010369 chromocenter(GO:0010369)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.3 GO:1990254 keratin filament binding(GO:1990254)
0.6 2.9 GO:0050436 microfibril binding(GO:0050436)
0.5 1.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 1.0 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.3 3.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.3 0.9 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.3 2.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.2 2.0 GO:0043426 MRF binding(GO:0043426)
0.2 0.8 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.2 1.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 0.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 2.6 GO:0045499 chemorepellent activity(GO:0045499)
0.2 0.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.4 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.6 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 1.0 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.3 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 0.8 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.3 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 1.1 GO:0009374 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.1 0.3 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1 1.9 GO:0043422 protein kinase B binding(GO:0043422)
0.1 0.5 GO:0042835 BRE binding(GO:0042835)
0.1 0.3 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 0.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.6 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.1 1.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.5 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 0.3 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 0.2 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.2 GO:0016019 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.1 0.3 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 0.2 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.4 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.2 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 1.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.8 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.6 GO:0004568 chitinase activity(GO:0004568)
0.0 0.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.3 GO:0004945 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 1.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 1.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0030395 lactose binding(GO:0030395)
0.0 0.1 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.3 GO:0003924 GTPase activity(GO:0003924)
0.0 2.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 2.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 0.2 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.1 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.0 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.9 GO:0005518 collagen binding(GO:0005518)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.4 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.6 GO:0008083 growth factor activity(GO:0008083)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.7 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.7 GO:0043621 protein self-association(GO:0043621)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.0 GO:0046848 hydroxyapatite binding(GO:0046848)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.1 PID AURORA B PATHWAY Aurora B signaling
0.1 3.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.7 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 2.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.2 PID FGF PATHWAY FGF signaling pathway
0.0 3.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.1 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 1.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID ALK2 PATHWAY ALK2 signaling events
0.0 3.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.7 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.9 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.8 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.3 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID IL6 7 PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 5.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 3.0 REACTOME KINESINS Genes involved in Kinesins
0.1 1.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 1.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.0 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.2 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.6 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.3 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.8 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease