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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for RXRG
Z-value: 1.61
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Transcription factors associated with RXRG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RXRG | hg19_v2_chr1_-_165414414_165414433 | -0.28 | 1.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RXRG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.8 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 3.3 | 10.0 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
| 1.2 | 9.4 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.1 | 7.9 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.8 | 6.7 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.4 | 6.6 | GO:0071459 | protein localization to chromosome, centromeric region(GO:0071459) |
| 1.9 | 5.7 | GO:0045659 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 1.8 | 5.3 | GO:1903609 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
| 0.5 | 5.3 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 5.3 | GO:0031424 | keratinization(GO:0031424) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 16.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 10.3 | GO:0005819 | spindle(GO:0005819) |
| 0.7 | 8.9 | GO:0005642 | annulate lamellae(GO:0005642) |
| 1.4 | 7.1 | GO:0009368 | endopeptidase Clp complex(GO:0009368) |
| 0.1 | 7.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 6.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 6.2 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.1 | 6.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 6.0 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.0 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 13.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 11.3 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 10.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 8.2 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 6.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 6.7 | GO:0002020 | protease binding(GO:0002020) |
| 1.0 | 5.7 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 1.4 | 5.6 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.2 | 5.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.6 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 13.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 5.7 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.2 | 5.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.3 | 4.9 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 4.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 4.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 3.8 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 3.7 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.5 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.3 | 10.5 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.3 | 9.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.3 | 7.1 | REACTOME SHC MEDIATED SIGNALLING | Genes involved in SHC-mediated signalling |
| 0.2 | 6.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 5.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.2 | 5.6 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 5.0 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 4.9 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 4.9 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |