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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SHOX

Z-value: 0.64

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Transcription factors associated with SHOX

Gene Symbol Gene ID Gene Info
SHOX
ENSG00000185960.8 short stature homeobox
SHOX
ENSGR0000185960.8 short stature homeobox

Activity profile of SHOX motif

Sorted Z-values of SHOX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_152131703 2.42 ENST00000316073.3
RPTN
repetin
chr1_-_152386732 2.12 ENST00000271835.3
CRNN
cornulin
chr4_+_69313145 1.62 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr3_+_186353756 1.26 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
FETUB
fetuin B
chr4_-_69111401 1.20 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr4_-_57547870 1.18 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr4_-_57547454 1.18 ENST00000556376.2
HOPX
HOP homeobox
chr7_-_14026063 0.85 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chr2_-_68052694 0.77 ENST00000457448.1
AC010987.6
AC010987.6
chr20_+_2276639 0.76 ENST00000381458.5
TGM3
transglutaminase 3
chr7_-_25268104 0.75 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr12_-_89746173 0.70 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr20_-_21494654 0.67 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr11_-_111794446 0.67 ENST00000527950.1
CRYAB
crystallin, alpha B
chr13_-_36050819 0.64 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chrX_+_99839799 0.63 ENST00000373031.4
TNMD
tenomodulin
chr13_+_78109884 0.60 ENST00000377246.3
ENST00000349847.3
SCEL
sciellin
chr13_+_78109804 0.59 ENST00000535157.1
SCEL
sciellin
chr12_-_57328187 0.59 ENST00000293502.1
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr19_-_51538118 0.55 ENST00000529888.1
KLK12
kallikrein-related peptidase 12
chr8_-_101661887 0.53 ENST00000311812.2
SNX31
sorting nexin 31
chr19_-_51538148 0.52 ENST00000319590.4
ENST00000250351.4
KLK12
kallikrein-related peptidase 12
chr19_-_51537982 0.52 ENST00000525263.1
KLK12
kallikrein-related peptidase 12
chr6_-_9933500 0.51 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr12_-_10282742 0.51 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr12_-_10282681 0.50 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr13_-_86373536 0.50 ENST00000400286.2
SLITRK6
SLIT and NTRK-like family, member 6
chr12_+_26348582 0.50 ENST00000535504.1
SSPN
sarcospan
chr1_+_244515930 0.48 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr2_+_171034646 0.48 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr3_-_191000172 0.46 ENST00000427544.2
UTS2B
urotensin 2B
chr4_+_66536248 0.45 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr10_-_36812323 0.44 ENST00000543053.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr18_-_31803169 0.44 ENST00000590712.1
NOL4
nucleolar protein 4
chr4_+_71458012 0.42 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr1_+_214161854 0.42 ENST00000435016.1
PROX1
prospero homeobox 1
chr19_-_36001113 0.42 ENST00000434389.1
DMKN
dermokine
chr17_+_59489112 0.41 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr6_-_32908792 0.41 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr7_-_92777606 0.41 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr10_-_56560939 0.41 ENST00000373955.1
PCDH15
protocadherin-related 15
chr12_-_86650045 0.39 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_+_143635067 0.38 ENST00000264170.4
KYNU
kynureninase
chr1_+_40713573 0.38 ENST00000372766.3
TMCO2
transmembrane and coiled-coil domains 2
chr15_+_75080883 0.38 ENST00000567571.1
CSK
c-src tyrosine kinase
chr19_-_51523412 0.38 ENST00000391805.1
ENST00000599077.1
KLK10
kallikrein-related peptidase 10
chr5_+_31193847 0.37 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr1_-_185597619 0.36 ENST00000608417.1
ENST00000436955.1
GS1-204I12.1
GS1-204I12.1
chr12_+_26348246 0.35 ENST00000422622.2
SSPN
sarcospan
chr12_-_10282836 0.35 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr18_-_31802056 0.35 ENST00000538587.1
NOL4
nucleolar protein 4
chr19_-_51522955 0.35 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr6_-_32157947 0.35 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr12_-_16761007 0.34 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_-_93107443 0.34 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_+_26348429 0.34 ENST00000242729.2
SSPN
sarcospan
chr18_+_28898052 0.33 ENST00000257192.4
DSG1
desmoglein 1
chr1_+_206557366 0.33 ENST00000414007.1
ENST00000419187.2
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr4_+_71108300 0.33 ENST00000304954.3
CSN3
casein kappa
chr20_+_3776371 0.33 ENST00000245960.5
CDC25B
cell division cycle 25B
chr19_-_51523275 0.32 ENST00000309958.3
KLK10
kallikrein-related peptidase 10
chr1_-_94586651 0.31 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr12_+_1099675 0.31 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr14_-_98444461 0.30 ENST00000499006.2
C14orf64
chromosome 14 open reading frame 64
chr2_+_210444142 0.30 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr17_-_64225508 0.30 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr11_-_121986923 0.29 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr9_+_12693336 0.29 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr17_-_39150385 0.29 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr21_-_31538971 0.29 ENST00000286808.3
CLDN17
claudin 17
chr2_-_40680578 0.29 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr9_-_3469181 0.28 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr12_+_28410128 0.28 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr1_+_209878182 0.28 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr3_+_149191723 0.28 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr11_-_69633792 0.28 ENST00000334134.2
FGF3
fibroblast growth factor 3
chr1_+_153746683 0.27 ENST00000271857.2
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr19_+_34287751 0.27 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
KCTD15
potassium channel tetramerization domain containing 15
chr15_+_93443419 0.27 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr2_+_159825143 0.27 ENST00000454300.1
ENST00000263635.6
TANC1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr2_+_158114051 0.27 ENST00000259056.4
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr17_+_39411636 0.26 ENST00000394008.1
KRTAP9-9
keratin associated protein 9-9
chr4_-_20985632 0.26 ENST00000359001.5
KCNIP4
Kv channel interacting protein 4
chr17_-_40337470 0.26 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr17_-_39191107 0.26 ENST00000344363.5
KRTAP1-3
keratin associated protein 1-3
chr8_+_21899898 0.26 ENST00000518533.1
ENST00000359441.3
FGF17
fibroblast growth factor 17
chr5_+_119867159 0.26 ENST00000505123.1
PRR16
proline rich 16
chr3_+_157154578 0.26 ENST00000295927.3
PTX3
pentraxin 3, long
chr8_+_50824233 0.25 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr12_-_51422017 0.25 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr4_-_122085469 0.25 ENST00000057513.3
TNIP3
TNFAIP3 interacting protein 3
chr5_+_125758865 0.25 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr17_+_39261584 0.24 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chr18_+_57567180 0.24 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr9_+_125133315 0.24 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr18_-_500692 0.23 ENST00000400256.3
COLEC12
collectin sub-family member 12
chr5_+_125758813 0.23 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr1_+_153747746 0.23 ENST00000368661.3
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr1_-_68698222 0.23 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr17_-_38911580 0.22 ENST00000312150.4
KRT25
keratin 25
chrX_+_107288239 0.22 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr17_+_42634844 0.22 ENST00000315323.3
FZD2
frizzled family receptor 2
chr7_-_92747269 0.22 ENST00000446617.1
ENST00000379958.2
SAMD9
sterile alpha motif domain containing 9
chr7_-_23510086 0.21 ENST00000258729.3
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr14_+_22977587 0.21 ENST00000390504.1
TRAJ33
T cell receptor alpha joining 33
chr8_-_93107696 0.21 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_+_33061543 0.21 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
TCP11L1
t-complex 11, testis-specific-like 1
chr4_-_39979576 0.21 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr11_-_108093329 0.21 ENST00000278612.8
NPAT
nuclear protein, ataxia-telangiectasia locus
chr14_-_72458326 0.21 ENST00000542853.1
AC005477.1
AC005477.1
chr16_+_57279004 0.20 ENST00000219204.3
ARL2BP
ADP-ribosylation factor-like 2 binding protein
chr7_-_22233442 0.20 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr16_+_12059050 0.20 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_+_107288197 0.20 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr12_-_16759711 0.20 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr18_-_31803435 0.20 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
NOL4
nucleolar protein 4
chrX_+_139791917 0.19 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632
chr3_+_130569429 0.19 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr6_+_41021027 0.19 ENST00000244669.2
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr15_-_55562582 0.19 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr3_-_113897899 0.19 ENST00000383673.2
ENST00000295881.7
DRD3
dopamine receptor D3
chr18_-_3219847 0.19 ENST00000261606.7
MYOM1
myomesin 1
chr2_+_162272605 0.19 ENST00000389554.3
TBR1
T-box, brain, 1
chr1_+_101003687 0.19 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr2_-_163008903 0.19 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chrX_-_19988382 0.19 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr2_+_223162866 0.18 ENST00000295226.1
CCDC140
coiled-coil domain containing 140
chr4_-_109541539 0.18 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr7_+_100136811 0.18 ENST00000300176.4
ENST00000262935.4
AGFG2
ArfGAP with FG repeats 2
chr3_+_130569592 0.18 ENST00000533801.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr17_-_27418537 0.18 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chrX_+_134654540 0.18 ENST00000370752.4
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr4_-_186696425 0.17 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr20_+_30697298 0.17 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr8_-_139926236 0.17 ENST00000303045.6
ENST00000435777.1
COL22A1
collagen, type XXII, alpha 1
chr2_-_208031943 0.17 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr3_+_115342349 0.17 ENST00000393780.3
GAP43
growth associated protein 43
chr1_+_160370344 0.17 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr13_-_28545276 0.17 ENST00000381020.7
CDX2
caudal type homeobox 2
chr14_+_32798462 0.17 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr7_-_22234381 0.17 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_-_68698197 0.17 ENST00000370973.2
ENST00000370971.1
WLS
wntless Wnt ligand secretion mediator
chr17_-_39280419 0.17 ENST00000394014.1
KRTAP4-12
keratin associated protein 4-12
chr2_-_145278475 0.17 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr4_+_71457970 0.16 ENST00000322937.6
AMBN
ameloblastin (enamel matrix protein)
chr18_-_44181442 0.16 ENST00000398722.4
LOXHD1
lipoxygenase homology domains 1
chr17_-_72527605 0.16 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr4_-_143226979 0.16 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr14_+_22309368 0.16 ENST00000390433.1
TRAV12-1
T cell receptor alpha variable 12-1
chr6_+_47749718 0.16 ENST00000489301.2
ENST00000371211.2
ENST00000393699.2
OPN5
opsin 5
chr11_+_62496114 0.16 ENST00000532583.1
TTC9C
tetratricopeptide repeat domain 9C
chr18_+_22040620 0.16 ENST00000426880.2
HRH4
histamine receptor H4
chr7_+_97361218 0.15 ENST00000319273.5
TAC1
tachykinin, precursor 1
chr14_+_57671888 0.15 ENST00000391612.1
AL391152.1
AL391152.1
chr4_-_143227088 0.15 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chrX_-_153602991 0.15 ENST00000369850.3
ENST00000422373.1
FLNA
filamin A, alpha
chr14_+_32798547 0.15 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr7_+_97361388 0.15 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1
chr11_+_75526212 0.15 ENST00000356136.3
UVRAG
UV radiation resistance associated
chr16_-_18887627 0.15 ENST00000563235.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr12_+_54348618 0.15 ENST00000243103.3
HOXC12
homeobox C12
chr5_-_126409159 0.15 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr12_+_19358228 0.14 ENST00000424268.1
ENST00000543806.1
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr13_-_84456527 0.14 ENST00000377084.2
SLITRK1
SLIT and NTRK-like family, member 1
chr8_+_107738343 0.14 ENST00000521592.1
OXR1
oxidation resistance 1
chr18_+_22040593 0.14 ENST00000256906.4
HRH4
histamine receptor H4
chr11_-_124190184 0.14 ENST00000357438.2
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr10_-_29923893 0.14 ENST00000355867.4
SVIL
supervillin
chr3_-_52090461 0.14 ENST00000296483.6
ENST00000495880.1
DUSP7
dual specificity phosphatase 7
chr1_-_11024258 0.14 ENST00000418570.2
C1orf127
chromosome 1 open reading frame 127
chr3_-_33686743 0.14 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr15_-_55562479 0.14 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr18_-_30353025 0.14 ENST00000359358.4
KLHL14
kelch-like family member 14
chr3_+_111393501 0.14 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr7_-_111032971 0.14 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr11_-_117748138 0.14 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr8_+_98900132 0.14 ENST00000520016.1
MATN2
matrilin 2
chr4_-_152149033 0.13 ENST00000514152.1
SH3D19
SH3 domain containing 19
chr3_-_157824292 0.13 ENST00000483851.2
SHOX2
short stature homeobox 2
chr10_-_1779663 0.13 ENST00000381312.1
ADARB2
adenosine deaminase, RNA-specific, B2 (non-functional)
chrX_-_13835147 0.13 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr4_+_78432907 0.13 ENST00000286758.4
CXCL13
chemokine (C-X-C motif) ligand 13
chr8_+_107738240 0.13 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr3_-_33686925 0.13 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr6_-_111927062 0.13 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr12_-_53994805 0.13 ENST00000328463.7
ATF7
activating transcription factor 7
chr15_-_55563072 0.13 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr15_+_58430567 0.13 ENST00000536493.1
AQP9
aquaporin 9
chr17_-_10452929 0.13 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr17_-_38821373 0.12 ENST00000394052.3
KRT222
keratin 222
chr11_-_117747607 0.12 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr15_+_58430368 0.12 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr2_+_169926047 0.12 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_-_130080977 0.12 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr5_+_126984710 0.12 ENST00000379445.3
CTXN3
cortexin 3
chr5_+_101569696 0.12 ENST00000597120.1
AC008948.1
AC008948.1
chr12_-_118797475 0.12 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr15_+_58702742 0.12 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chrX_+_108779004 0.12 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr10_+_74451883 0.12 ENST00000373053.3
ENST00000357157.6
MCU
mitochondrial calcium uniporter

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.2 0.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.7 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.7 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1 0.4 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.4 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.4 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.3 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1 0.7 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.3 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.1 0.3 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.1 0.4 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.7 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 0.5 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 1.6 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.4 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.4 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.1 0.2 GO:0061743 motor learning(GO:0061743)
0.1 0.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 2.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.7 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.3 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.1 0.3 GO:0015692 lead ion transport(GO:0015692)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.5 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.4 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.2 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.3 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.2 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 1.1 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.7 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.3 GO:0050957 equilibrioception(GO:0050957)
0.0 0.1 GO:2001027 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.2 GO:0021764 amygdala development(GO:0021764)
0.0 0.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.3 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 4.0 GO:0070268 cornification(GO:0070268)
0.0 0.3 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.3 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 1.2 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.0 GO:0003162 atrioventricular node development(GO:0003162)
0.0 0.6 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.4 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:1901994 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.1 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.0 0.0 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.1 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0 0.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.1 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.0 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.0 0.1 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.1 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059) positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.8 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0045095 keratin filament(GO:0045095)
0.1 0.2 GO:0031523 Myb complex(GO:0031523)
0.1 0.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.3 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 4.0 GO:0001533 cornified envelope(GO:0001533)
0.1 0.3 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.7 GO:0097512 cardiac myofibril(GO:0097512)
0.0 1.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.6 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.1 GO:0005882 intermediate filament(GO:0005882)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.0 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.1 0.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.6 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.4 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.2 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 1.6 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.3 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 0.3 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.0 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.0 0.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 0.3 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.8 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.4 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 5.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.0 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.0 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.6 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME OPSINS Genes involved in Opsins
0.0 0.5 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition