ISMARA results: SHOX2

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SHOX2_HOXC5

Z-value: 0.57

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Transcription factors associated with SHOX2_HOXC5

Gene Symbol	Gene ID	Gene Info
SHOX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000168779.15	short stature homeobox 2
HOXC5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000172789.3	homeobox C5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SHOX2	hg19_v2_chr3_-_157823839_157824078	0.24	2.0e-01	Click!
HOXC5	hg19_v2_chr12_+_54426637_54426637	0.13	5.0e-01	Click!

Activity profile of SHOX2_HOXC5 motif

Sorted Z-values of SHOX2_HOXC5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_6779326 Show fit	2.66	ENST00000417112.1	RP11-554I8.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-554I8.2
chr2_+_102953608 Show fit	2.34	ENST00000311734.2 ENST00000409584.1	IL1RL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 1 receptor-like 1
chr1_-_197115818 Show fit	2.13	ENST00000367409.4 ENST00000294732.7	ASPM Ensembl NCBI GeneCards UniProt NextProt Show fit	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr12_-_10978957 Show fit	1.83	ENST00000240619.2	TAS2R10 Ensembl NCBI GeneCards UniProt NextProt Show fit	taste receptor, type 2, member 10
chr5_+_150639360 Show fit	1.73	ENST00000523004.1	GM2A Ensembl NCBI GeneCards UniProt NextProt Show fit	GM2 ganglioside activator
chr19_+_42212501 Show fit	1.59	ENST00000398599.4	CEACAM5 Ensembl NCBI GeneCards UniProt NextProt Show fit	carcinoembryonic antigen-related cell adhesion molecule 5
chr5_-_9630463 Show fit	1.53	ENST00000382492.2	TAS2R1 Ensembl NCBI GeneCards UniProt NextProt Show fit	taste receptor, type 2, member 1
chr12_-_95510743 Show fit	1.49	ENST00000551521.1	FGD6 Ensembl NCBI GeneCards UniProt NextProt Show fit	FYVE, RhoGEF and PH domain containing 6
chr11_+_35201826 Show fit	1.45	ENST00000531873.1	CD44 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD44 molecule (Indian blood group)
chr19_+_42212526 Show fit	1.40	ENST00000598976.1 ENST00000435837.2 ENST00000221992.6 ENST00000405816.1	CEA Ensembl NCBI GeneCards UniProt NextProt Show fit CEACAM5 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein carcinoembryonic antigen-related cell adhesion molecule 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX2_HOXC5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.1	GO:0006958	complement activation, classical pathway(GO:0006958)
0.1	3.4	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	3.3	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1	3.1	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0	3.1	GO:0018149	peptide cross-linking(GO:0018149)
0.1	2.9	GO:0010832	negative regulation of myotube differentiation(GO:0010832)
0.0	2.9	GO:0031424	keratinization(GO:0031424)
0.0	2.8	GO:0046847	filopodium assembly(GO:0046847)
0.1	2.5	GO:0001829	trophectodermal cell differentiation(GO:0001829)
0.4	2.3	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)

Showing 1 to 10 of 328 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	GO:0001533	cornified envelope(GO:0001533)
0.0	3.4	GO:0001726	ruffle(GO:0001726)
0.1	3.0	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	2.6	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	2.1	GO:0036449	microtubule minus-end(GO:0036449)
0.4	1.7	GO:0005889	hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0	1.7	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	1.7	GO:0072562	blood microparticle(GO:0072562)
0.1	1.6	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	1.6	GO:0008180	COP9 signalosome(GO:0008180)

Showing 1 to 10 of 137 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	3.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	3.6	GO:0005549	odorant binding(GO:0005549)
0.2	3.3	GO:0033038	bitter taste receptor activity(GO:0033038)
0.2	3.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.1	3.1	GO:0003823	antigen binding(GO:0003823)
0.0	2.9	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3	2.6	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.3	2.5	GO:0034235	GPI anchor binding(GO:0034235)
0.8	2.3	GO:0002113	interleukin-33 binding(GO:0002113)

Showing 1 to 10 of 216 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.2	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	2.4	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.9	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	1.7	PID PLK1 PATHWAY	PLK1 signaling events
0.1	1.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.4	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	1.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	1.3	PID EPHB FWD PATHWAY	EPHB forward signaling
0.1	1.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 10 of 41 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	3.6	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	3.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	3.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.1	2.8	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	2.6	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	2.5	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	2.4	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	2.4	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	1.9	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends

Showing 1 to 10 of 76 entries

Results for SHOX2_HOXC5

Z-value: 0.57

Motif logo

Transcription factors associated with SHOX2_HOXC5

Activity-expression correlation:

Activity profile of SHOX2_HOXC5 motif

Sorted Z-values of SHOX2_HOXC5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX2_HOXC5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: