ISMARA results: SIN3A

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SIN3A_CHD1

Z-value: 1.95

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Transcription factors associated with SIN3A_CHD1

Gene Symbol	Gene ID	Gene Info
SIN3A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000169375.11	SIN3 transcription regulator family member A
CHD1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000153922.6	chromodomain helicase DNA binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SIN3A	hg19_v2_chr15_-_75743915_75743933, hg19_v2_chr15_-_75748115_75748126	0.55	1.8e-03	Click!
CHD1	hg19_v2_chr5_-_98262240_98262240	-0.01	9.7e-01	Click!

Activity profile of SIN3A_CHD1 motif

Sorted Z-values of SIN3A_CHD1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_19988462 Show fit	24.70	ENST00000344838.4	EFHB Ensembl NCBI GeneCards UniProt NextProt Show fit	EF-hand domain family, member B
chr4_-_7044657 Show fit	14.65	ENST00000310085.4	CCDC96 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 96
chr16_-_66959429 Show fit	14.39	ENST00000420652.1 ENST00000299759.6	RRAD Ensembl NCBI GeneCards UniProt NextProt Show fit	Ras-related associated with diabetes
chr13_+_35516390 Show fit	14.11	ENST00000540320.1 ENST00000400445.3 ENST00000310336.4	NBEA Ensembl NCBI GeneCards UniProt NextProt Show fit	neurobeachin
chr19_-_7990991 Show fit	13.90	ENST00000318978.4	CTXN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cortexin 1
chr16_-_52580920 Show fit	11.56	ENST00000219746.9	TOX3 Ensembl NCBI GeneCards UniProt NextProt Show fit	TOX high mobility group box family member 3
chr17_+_55333876 Show fit	11.14	ENST00000284073.2	MSI2 Ensembl NCBI GeneCards UniProt NextProt Show fit	musashi RNA-binding protein 2
chr4_+_72052964 Show fit	10.01	ENST00000264485.5 ENST00000425175.1	SLC4A4 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr11_-_75379612 Show fit	8.62	ENST00000526740.1	MAP6 Ensembl NCBI GeneCards UniProt NextProt Show fit	microtubule-associated protein 6
chrX_+_16964794 Show fit	8.46	ENST00000357277.3	REPS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RALBP1 associated Eps domain containing 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SIN3A_CHD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	14.4	GO:1901842	negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1	12.4	GO:0030449	regulation of complement activation(GO:0030449)
1.1	11.2	GO:0021853	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.5	11.1	GO:0036158	outer dynein arm assembly(GO:0036158)
0.1	10.8	GO:0030901	midbrain development(GO:0030901)
0.1	10.5	GO:0032418	lysosome localization(GO:0032418)
1.2	9.8	GO:0048105	establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
1.0	9.7	GO:0060267	positive regulation of respiratory burst(GO:0060267)
1.8	8.9	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.3	8.8	GO:1901741	positive regulation of myoblast fusion(GO:1901741)

Showing 1 to 10 of 973 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	25.9	GO:0016605	PML body(GO:0016605)
0.1	15.0	GO:0000118	histone deacetylase complex(GO:0000118)
0.1	12.2	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.1	11.1	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.5	10.6	GO:0032591	dendritic spine membrane(GO:0032591)
0.5	10.4	GO:0005858	axonemal dynein complex(GO:0005858)
0.1	9.9	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	9.8	GO:0005923	bicellular tight junction(GO:0005923)
2.4	9.7	GO:0060187	cell pole(GO:0060187)
0.4	9.6	GO:0030992	intraciliary transport particle B(GO:0030992)

Showing 1 to 10 of 321 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	34.2	GO:0003677	DNA binding(GO:0003677)
0.1	28.7	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1	23.3	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2	14.2	GO:0061733	peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.4	14.0	GO:0008266	poly(U) RNA binding(GO:0008266)
1.3	13.8	GO:0034056	estrogen response element binding(GO:0034056)
1.0	13.5	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.4	12.9	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.5	11.7	GO:0045504	dynein heavy chain binding(GO:0045504)
0.1	10.1	GO:0033613	activating transcription factor binding(GO:0033613)

Showing 1 to 10 of 518 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	20.1	PID ALK2 PATHWAY	ALK2 signaling events
0.1	16.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.2	15.4	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.2	9.7	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	9.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	8.2	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	7.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	7.6	PID ARF6 PATHWAY	Arf6 signaling events
0.1	6.8	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	5.8	PID CD40 PATHWAY	CD40/CD40L signaling

Showing 1 to 10 of 63 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.3	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2	9.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.3	9.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.2	8.9	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.2	8.2	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2	8.1	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3	7.9	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.1	7.2	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	6.7	REACTOME DNA REPAIR	Genes involved in DNA Repair
0.2	6.5	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling

Showing 1 to 10 of 116 entries

Results for SIN3A_CHD1

Z-value: 1.95

Motif logo

Transcription factors associated with SIN3A_CHD1

Activity-expression correlation:

Activity profile of SIN3A_CHD1 motif

Sorted Z-values of SIN3A_CHD1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SIN3A_CHD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: