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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SIX1_SIX3_SIX2

Z-value: 0.54

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Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
SIX1
ENSG00000126778.7 SIX homeobox 1
SIX3
ENSG00000138083.3 SIX homeobox 3
SIX2
ENSG00000170577.7 SIX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX3hg19_v2_chr2_+_45168875_451689160.271.4e-01Click!
SIX2hg19_v2_chr2_-_45236540_45236577-0.086.7e-01Click!
SIX1hg19_v2_chr14_-_61124977_611250370.058.0e-01Click!

Activity profile of SIX1_SIX3_SIX2 motif

Sorted Z-values of SIX1_SIX3_SIX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_58499434 0.86 ENST00000344743.3
ENST00000278400.3
GLYAT
glycine-N-acyltransferase
chr11_-_32452357 0.83 ENST00000379079.2
ENST00000530998.1
WT1
Wilms tumor 1
chr1_-_13115578 0.78 ENST00000414205.2
PRAMEF6
PRAME family member 6
chr20_-_55100981 0.78 ENST00000243913.4
GCNT7
glucosaminyl (N-acetyl) transferase family member 7
chr13_-_46679185 0.74 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr13_-_46679144 0.74 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr1_+_26737253 0.73 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr1_+_26737292 0.71 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chr9_+_12693336 0.70 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr1_-_13117736 0.69 ENST00000376192.5
ENST00000376182.1
PRAMEF6
PRAME family member 6
chr1_+_13359819 0.65 ENST00000376168.1
PRAMEF5
PRAME family member 5
chr7_+_123241908 0.61 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15
ankyrin repeat and SOCS box containing 15
chrX_-_65259914 0.59 ENST00000374737.4
ENST00000455586.2
VSIG4
V-set and immunoglobulin domain containing 4
chrX_-_65259900 0.59 ENST00000412866.2
VSIG4
V-set and immunoglobulin domain containing 4
chr1_-_240906911 0.59 ENST00000431139.2
RP11-80B9.4
RP11-80B9.4
chrX_+_101470280 0.52 ENST00000395088.2
ENST00000330252.5
ENST00000333110.5
NXF2
TCP11X1
nuclear RNA export factor 2
t-complex 11 family, X-linked 1
chr1_+_182419261 0.51 ENST00000294854.8
ENST00000542961.1
RGSL1
regulator of G-protein signaling like 1
chr3_+_118866222 0.50 ENST00000490594.1
RP11-484M3.5
Uncharacterized protein
chr1_+_241695424 0.49 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr19_+_41594377 0.46 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr21_+_27011899 0.45 ENST00000425221.2
JAM2
junctional adhesion molecule 2
chr7_-_14880892 0.43 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr10_-_134331695 0.43 ENST00000455414.1
RP11-432J24.5
RP11-432J24.5
chr2_-_207629997 0.40 ENST00000454776.2
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr2_-_207630033 0.39 ENST00000449792.1
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr15_+_40650408 0.38 ENST00000267889.3
DISP2
dispatched homolog 2 (Drosophila)
chr19_-_58446721 0.38 ENST00000396147.1
ENST00000595569.1
ENST00000599852.1
ENST00000425570.3
ENST00000601593.1
ZNF418
zinc finger protein 418
chr6_-_76203454 0.38 ENST00000237172.7
FILIP1
filamin A interacting protein 1
chr1_-_12946025 0.38 ENST00000235349.5
PRAMEF4
PRAME family member 4
chr8_+_118147498 0.36 ENST00000519688.1
ENST00000456015.2
SLC30A8
solute carrier family 30 (zinc transporter), member 8
chr14_+_22739823 0.36 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr3_+_149191723 0.36 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr1_-_13007420 0.35 ENST00000376189.1
PRAMEF6
PRAME family member 6
chr3_-_46506358 0.32 ENST00000417439.1
ENST00000431944.1
LTF
lactotransferrin
chr11_+_73661364 0.32 ENST00000339764.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr1_-_27998689 0.32 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
IFI6
interferon, alpha-inducible protein 6
chr1_+_241695670 0.31 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr10_-_103603523 0.31 ENST00000370046.1
KCNIP2
Kv channel interacting protein 2
chr12_+_51236703 0.31 ENST00000551456.1
ENST00000398458.3
TMPRSS12
transmembrane (C-terminal) protease, serine 12
chr2_-_105953912 0.31 ENST00000610036.1
RP11-332H14.2
RP11-332H14.2
chr18_+_61575200 0.30 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr1_-_44818599 0.29 ENST00000537474.1
ERI3
ERI1 exoribonuclease family member 3
chr14_+_62462541 0.29 ENST00000430451.2
SYT16
synaptotagmin XVI
chr1_-_108743471 0.28 ENST00000569674.1
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr1_+_160709029 0.28 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr17_-_3030875 0.27 ENST00000328890.2
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr11_+_71791359 0.26 ENST00000419228.1
ENST00000435085.1
ENST00000307198.7
ENST00000538413.1
LRTOMT
leucine rich transmembrane and O-methyltransferase domain containing
chr3_+_42850959 0.26 ENST00000442925.1
ENST00000422265.1
ENST00000497921.1
ENST00000426937.1
ACKR2
KRBOX1
atypical chemokine receptor 2
KRAB box domain containing 1
chr8_-_134115118 0.26 ENST00000395352.3
ENST00000338087.5
SLA
Src-like-adaptor
chr1_-_60539422 0.26 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr11_-_35547151 0.25 ENST00000378878.3
ENST00000529303.1
ENST00000278360.3
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr7_+_138915102 0.25 ENST00000486663.1
UBN2
ubinuclein 2
chr17_-_55911970 0.25 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr10_+_7745232 0.24 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr19_+_11457175 0.24 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr16_+_21695750 0.23 ENST00000388956.4
OTOA
otoancorin
chr10_-_103603568 0.23 ENST00000356640.2
KCNIP2
Kv channel interacting protein 2
chr1_+_160709055 0.23 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr2_-_209010874 0.23 ENST00000260988.4
CRYGB
crystallin, gamma B
chr14_-_24911448 0.23 ENST00000555355.1
ENST00000553343.1
ENST00000556523.1
ENST00000556249.1
ENST00000538105.2
ENST00000555225.1
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr19_-_54872556 0.23 ENST00000444687.1
LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr4_+_70894130 0.22 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
HTN3
histatin 3
chr3_+_111718036 0.22 ENST00000455401.2
TAGLN3
transgelin 3
chr11_-_5364809 0.21 ENST00000300773.2
OR51B5
olfactory receptor, family 51, subfamily B, member 5
chr5_+_161112754 0.21 ENST00000523217.1
GABRA6
gamma-aminobutyric acid (GABA) A receptor, alpha 6
chr1_+_196743912 0.21 ENST00000367425.4
CFHR3
complement factor H-related 3
chr10_+_7745303 0.20 ENST00000429820.1
ENST00000379587.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_+_160709076 0.20 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr3_+_111718173 0.20 ENST00000494932.1
TAGLN3
transgelin 3
chr19_+_11457232 0.20 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr18_-_6929797 0.20 ENST00000581725.1
ENST00000583316.1
LINC00668
long intergenic non-protein coding RNA 668
chr7_-_44198874 0.20 ENST00000395796.3
ENST00000345378.2
GCK
glucokinase (hexokinase 4)
chr3_-_19975665 0.20 ENST00000295824.9
ENST00000389256.4
EFHB
EF-hand domain family, member B
chr21_-_34185944 0.20 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr8_+_99129513 0.19 ENST00000522319.1
ENST00000401707.2
POP1
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chr10_-_103603677 0.19 ENST00000358038.3
KCNIP2
Kv channel interacting protein 2
chr1_+_35225339 0.19 ENST00000339480.1
GJB4
gap junction protein, beta 4, 30.3kDa
chr1_+_40942887 0.19 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr3_+_26735991 0.19 ENST00000456208.2
LRRC3B
leucine rich repeat containing 3B
chr1_-_183387723 0.19 ENST00000287713.6
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr4_+_80748619 0.19 ENST00000504263.1
PCAT4
prostate cancer associated transcript 4 (non-protein coding)
chr6_+_31554636 0.18 ENST00000433492.1
LST1
leukocyte specific transcript 1
chr1_-_207119738 0.18 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr3_+_111717600 0.18 ENST00000273368.4
TAGLN3
transgelin 3
chr8_+_76452097 0.18 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr1_-_157670528 0.18 ENST00000368186.5
ENST00000496769.1
FCRL3
Fc receptor-like 3
chr1_+_78769549 0.18 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr21_-_35883613 0.18 ENST00000337385.3
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chrX_-_72095808 0.17 ENST00000373529.5
DMRTC1
DMRT-like family C1
chr1_-_169337176 0.17 ENST00000472647.1
ENST00000367811.3
NME7
NME/NM23 family member 7
chr12_+_20848486 0.17 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr12_+_20848377 0.17 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr1_+_15256230 0.16 ENST00000376028.4
ENST00000400798.2
KAZN
kazrin, periplakin interacting protein
chr6_-_167797887 0.16 ENST00000476779.2
ENST00000460930.2
ENST00000397829.4
ENST00000366827.2
TCP10
t-complex 10
chr14_-_95942173 0.16 ENST00000334258.5
ENST00000557275.1
ENST00000553340.1
SYNE3
spectrin repeat containing, nuclear envelope family member 3
chr4_+_89299994 0.16 ENST00000264346.7
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr19_+_56459198 0.16 ENST00000291971.3
ENST00000590542.1
NLRP8
NLR family, pyrin domain containing 8
chr17_-_8151353 0.16 ENST00000315684.8
CTC1
CTS telomere maintenance complex component 1
chr19_-_55549624 0.15 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
GP6
glycoprotein VI (platelet)
chr21_+_27011584 0.15 ENST00000400532.1
ENST00000480456.1
ENST00000312957.5
JAM2
junctional adhesion molecule 2
chr19_-_56249740 0.15 ENST00000590200.1
ENST00000332836.2
NLRP9
NLR family, pyrin domain containing 9
chr1_+_207277590 0.15 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr19_+_55476620 0.15 ENST00000543010.1
ENST00000391721.4
ENST00000339757.7
NLRP2
NLR family, pyrin domain containing 2
chr6_+_31554779 0.15 ENST00000376090.2
LST1
leukocyte specific transcript 1
chr5_-_132073210 0.14 ENST00000378735.1
ENST00000378746.4
KIF3A
kinesin family member 3A
chr2_-_220034745 0.14 ENST00000455516.2
ENST00000396775.3
ENST00000295738.7
SLC23A3
solute carrier family 23, member 3
chr11_+_64323428 0.14 ENST00000377581.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr12_+_49121213 0.13 ENST00000548380.1
LINC00935
long intergenic non-protein coding RNA 935
chr8_-_95487272 0.13 ENST00000297592.5
RAD54B
RAD54 homolog B (S. cerevisiae)
chr6_+_88757507 0.13 ENST00000237201.1
SPACA1
sperm acrosome associated 1
chr1_+_6684918 0.13 ENST00000054650.4
THAP3
THAP domain containing, apoptosis associated protein 3
chr6_-_32160622 0.13 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr12_-_57882577 0.13 ENST00000393797.2
ARHGAP9
Rho GTPase activating protein 9
chr17_-_72527605 0.13 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr17_+_6659153 0.13 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr1_-_159046617 0.13 ENST00000368130.4
AIM2
absent in melanoma 2
chr1_-_208084729 0.13 ENST00000310833.7
ENST00000356522.4
CD34
CD34 molecule
chr2_-_25391507 0.12 ENST00000380794.1
POMC
proopiomelanocortin
chr3_-_10452359 0.12 ENST00000452124.1
ATP2B2
ATPase, Ca++ transporting, plasma membrane 2
chr22_+_22936998 0.12 ENST00000390303.2
IGLV3-32
immunoglobulin lambda variable 3-32 (non-functional)
chr12_-_323689 0.12 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr8_-_25902876 0.12 ENST00000520164.1
EBF2
early B-cell factor 2
chr11_+_64323156 0.12 ENST00000377585.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr17_-_33446735 0.12 ENST00000460118.2
ENST00000335858.7
RAD51D
RAD51 paralog D
chr14_+_73563735 0.12 ENST00000532192.1
RBM25
RNA binding motif protein 25
chr14_+_58711539 0.12 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr4_-_156298028 0.12 ENST00000433024.1
ENST00000379248.2
MAP9
microtubule-associated protein 9
chr14_+_22771851 0.12 ENST00000390466.1
TRAV39
T cell receptor alpha variable 39
chrX_+_56259316 0.12 ENST00000468660.1
KLF8
Kruppel-like factor 8
chr11_+_64323098 0.12 ENST00000301891.4
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr10_-_96122682 0.12 ENST00000371361.3
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae)
chr7_-_141541221 0.11 ENST00000350549.3
ENST00000438520.1
PRSS37
protease, serine, 37
chr1_+_13421176 0.11 ENST00000376152.1
PRAMEF9
PRAME family member 9
chr12_-_6798616 0.11 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr17_+_32646055 0.11 ENST00000394620.1
CCL8
chemokine (C-C motif) ligand 8
chrX_-_152864632 0.11 ENST00000406277.2
FAM58A
family with sequence similarity 58, member A
chr12_-_11036844 0.11 ENST00000428168.2
PRH1
proline-rich protein HaeIII subfamily 1
chr19_+_46800289 0.11 ENST00000377670.4
HIF3A
hypoxia inducible factor 3, alpha subunit
chr17_+_4675175 0.11 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chrX_+_8432871 0.11 ENST00000381032.1
ENST00000453306.1
ENST00000444481.1
VCX3B
variable charge, X-linked 3B
chr9_+_132427883 0.11 ENST00000372469.4
PRRX2
paired related homeobox 2
chr6_+_31554962 0.11 ENST00000376092.3
ENST00000376086.3
ENST00000303757.8
ENST00000376093.2
ENST00000376102.3
LST1
leukocyte specific transcript 1
chr1_+_87595542 0.11 ENST00000461990.1
RP5-1052I5.1
long intergenic non-protein coding RNA 1140
chr15_+_75550940 0.11 ENST00000300576.5
GOLGA6C
golgin A6 family, member C
chr21_-_33957805 0.10 ENST00000300258.3
ENST00000472557.1
TCP10L
t-complex 10-like
chr9_+_84603687 0.10 ENST00000344803.2
SPATA31D1
SPATA31 subfamily D, member 1
chr3_+_44754126 0.10 ENST00000449836.1
ENST00000436624.2
ENST00000296091.4
ENST00000411443.1
ZNF502
zinc finger protein 502
chr2_+_219536749 0.10 ENST00000295709.3
ENST00000392106.2
ENST00000392105.3
ENST00000455724.1
STK36
serine/threonine kinase 36
chr3_+_101818088 0.10 ENST00000491959.1
ZPLD1
zona pellucida-like domain containing 1
chr8_+_94767072 0.10 ENST00000452276.1
ENST00000453321.3
ENST00000498673.1
ENST00000518319.1
TMEM67
transmembrane protein 67
chr16_-_15463926 0.10 ENST00000432570.2
NPIPA5
nuclear pore complex interacting protein family, member A5
chrX_+_144908928 0.10 ENST00000408967.2
TMEM257
transmembrane protein 257
chr1_+_120049826 0.10 ENST00000369413.3
ENST00000235547.6
ENST00000528909.1
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr11_-_118436707 0.10 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr18_-_11148587 0.10 ENST00000302079.6
ENST00000580640.1
ENST00000503781.3
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr6_+_31583761 0.10 ENST00000376049.4
AIF1
allograft inflammatory factor 1
chr7_+_142498725 0.10 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr11_+_125365110 0.10 ENST00000527818.1
AP000708.1
AP000708.1
chr13_-_60737898 0.10 ENST00000377908.2
ENST00000400319.1
ENST00000400320.1
ENST00000267215.4
DIAPH3
diaphanous-related formin 3
chr19_+_56116771 0.10 ENST00000568956.1
ZNF865
zinc finger protein 865
chr9_-_79307096 0.10 ENST00000376717.2
ENST00000223609.6
ENST00000443509.2
PRUNE2
prune homolog 2 (Drosophila)
chr7_+_29519486 0.09 ENST00000409041.4
CHN2
chimerin 2
chr5_-_35195338 0.09 ENST00000509839.1
PRLR
prolactin receptor
chr6_+_131894284 0.09 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chr9_+_77230499 0.09 ENST00000396204.2
RORB
RAR-related orphan receptor B
chr12_+_56862301 0.09 ENST00000338146.5
SPRYD4
SPRY domain containing 4
chr14_+_78266408 0.09 ENST00000238561.5
ADCK1
aarF domain containing kinase 1
chr14_+_78266436 0.09 ENST00000557501.1
ENST00000341211.5
ADCK1
aarF domain containing kinase 1
chr12_-_5352315 0.09 ENST00000536518.1
RP11-319E16.1
RP11-319E16.1
chr12_+_100750846 0.09 ENST00000323346.5
SLC17A8
solute carrier family 17 (vesicular glutamate transporter), member 8
chr1_+_38022572 0.09 ENST00000541606.1
DNALI1
dynein, axonemal, light intermediate chain 1
chr3_-_74570291 0.09 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr6_-_150217195 0.09 ENST00000532335.1
RAET1E
retinoic acid early transcript 1E
chr4_+_78829479 0.09 ENST00000504901.1
MRPL1
mitochondrial ribosomal protein L1
chr19_-_48389651 0.09 ENST00000222002.3
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr17_+_35732955 0.09 ENST00000300618.4
C17orf78
chromosome 17 open reading frame 78
chr16_+_88636789 0.08 ENST00000301011.5
ENST00000452588.2
ZC3H18
zinc finger CCCH-type containing 18
chr19_+_16222439 0.08 ENST00000300935.3
RAB8A
RAB8A, member RAS oncogene family
chr16_+_84801852 0.08 ENST00000569925.1
ENST00000567526.1
USP10
ubiquitin specific peptidase 10
chrX_+_114524275 0.08 ENST00000371921.1
ENST00000451986.2
ENST00000371920.3
LUZP4
leucine zipper protein 4
chrX_+_2670066 0.08 ENST00000381174.5
ENST00000419513.2
ENST00000426774.1
XG
Xg blood group
chr1_-_12891264 0.08 ENST00000535591.1
ENST00000437584.1
PRAMEF11
PRAME family member 11
chr12_-_57882498 0.08 ENST00000550288.1
ARHGAP9
Rho GTPase activating protein 9
chr14_-_24615805 0.08 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr17_-_8113542 0.08 ENST00000578549.1
ENST00000535053.1
ENST00000582368.1
AURKB
aurora kinase B
chr1_-_67266939 0.08 ENST00000304526.2
INSL5
insulin-like 5
chr9_-_74675521 0.08 ENST00000377024.3
C9orf57
chromosome 9 open reading frame 57
chr11_+_85339623 0.08 ENST00000358867.6
ENST00000534341.1
ENST00000393375.1
ENST00000531274.1
TMEM126B
transmembrane protein 126B
chr6_-_52710893 0.08 ENST00000284562.2
GSTA5
glutathione S-transferase alpha 5
chr12_-_55378452 0.08 ENST00000449076.1
TESPA1
thymocyte expressed, positive selection associated 1
chr12_-_53594227 0.08 ENST00000550743.2
ITGB7
integrin, beta 7
chr9_+_140032842 0.08 ENST00000371561.3
ENST00000315048.3
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr10_-_47222824 0.08 ENST00000355232.3
AGAP10
ArfGAP with GTPase domain, ankyrin repeat and PH domain 10
chr17_-_6915646 0.08 ENST00000574377.1
ENST00000399541.2
ENST00000399540.2
ENST00000575727.1
ENST00000573939.1
AC027763.2
Uncharacterized protein
chr9_-_6645628 0.08 ENST00000321612.6
GLDC
glycine dehydrogenase (decarboxylating)
chr12_-_15104040 0.07 ENST00000541644.1
ENST00000545895.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr20_+_34824355 0.07 ENST00000397286.3
ENST00000320849.4
ENST00000373932.3
AAR2
AAR2 splicing factor homolog (S. cerevisiae)
chr4_-_156298087 0.07 ENST00000311277.4
MAP9
microtubule-associated protein 9
chr10_-_128210005 0.07 ENST00000284694.7
ENST00000454341.1
ENST00000432642.1
ENST00000392694.1
C10orf90
chromosome 10 open reading frame 90
chr16_-_2581409 0.07 ENST00000567119.1
ENST00000565480.1
ENST00000382350.1
CEMP1
cementum protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.2 0.8 GO:0072299 negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.2 1.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.8 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.3 GO:2000308 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.1 0.7 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.5 GO:0009804 coumarin metabolic process(GO:0009804)
0.1 0.7 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.8 GO:0006108 malate metabolic process(GO:0006108)
0.0 1.3 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.0 0.2 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.1 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.0 0.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.4 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.4 GO:0015747 urate transport(GO:0015747)
0.0 0.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.0 0.2 GO:0051594 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.2 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.1 GO:0046874 quinolinate metabolic process(GO:0046874)
0.0 0.2 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.5 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.1 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.0 0.2 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.0 0.2 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.0 0.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.1 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.1 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.2 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.2 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.1 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 0.1 GO:2000569 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)
0.0 0.1 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.0 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.0 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.1 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.0 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.0 0.1 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 0.0 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.1 GO:0070269 pyroptosis(GO:0070269)
0.0 0.0 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.1 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.0 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.0 0.1 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.3 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.5 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 1.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.2 0.8 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 1.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.2 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 0.2 GO:0032090 Pyrin domain binding(GO:0032090)
0.0 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.0 0.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.4 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.1 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.0 0.5 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0004766 spermidine synthase activity(GO:0004766)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.0 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.2 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.0 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.1 GO:0043199 sulfate binding(GO:0043199)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.1 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis