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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SIX4

Z-value: 0.62

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
ENSG00000100625.8 SIX homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX4hg19_v2_chr14_-_61190754_611908520.595.3e-04Click!

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_207119738 4.11 ENST00000356495.4
polymeric immunoglobulin receptor
chr1_+_38022572 2.43 ENST00000541606.1
dynein, axonemal, light intermediate chain 1
chr1_-_151778630 1.65 ENST00000368820.3
leucine rich repeat and Ig domain containing 4
chr12_-_10282836 1.64 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
C-type lectin domain family 7, member A
chr3_-_52488048 1.49 ENST00000232975.3
troponin C type 1 (slow)
chrY_+_22737678 1.44 ENST00000382772.3
eukaryotic translation initiation factor 1A, Y-linked
chrY_+_22737604 1.36 ENST00000361365.2
eukaryotic translation initiation factor 1A, Y-linked
chr16_+_640201 1.21 ENST00000563109.1
RAB40C, member RAS oncogene family
chr12_+_133758115 1.10 ENST00000541009.2
ENST00000592241.1
zinc finger protein 268
chr12_-_10282742 1.05 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
C-type lectin domain family 7, member A
chr12_-_10282681 1.02 ENST00000533022.1
C-type lectin domain family 7, member A
chr12_+_133757995 0.97 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
zinc finger protein 268
chr8_+_144798429 0.92 ENST00000338033.4
ENST00000395107.4
ENST00000395108.2
mitogen-activated protein kinase 15
chr3_+_118866222 0.91 ENST00000490594.1
Uncharacterized protein
chr19_+_13134772 0.81 ENST00000587760.1
ENST00000585575.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_-_130184555 0.74 ENST00000525842.1
zinc finger and BTB domain containing 44
chr14_-_67981916 0.71 ENST00000357461.2
transmembrane protein 229B
chr8_+_144295067 0.70 ENST00000330824.2
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr6_-_76072719 0.69 ENST00000370020.1
filamin A interacting protein 1
chr2_+_219135115 0.66 ENST00000248451.3
ENST00000273077.4
paroxysmal nonkinesigenic dyskinesia
chr11_-_130184470 0.63 ENST00000357899.4
ENST00000397753.1
zinc finger and BTB domain containing 44
chr11_-_96076334 0.61 ENST00000524717.1
mastermind-like 2 (Drosophila)
chr3_+_32147997 0.58 ENST00000282541.5
glycerol-3-phosphate dehydrogenase 1-like
chr1_+_35734562 0.55 ENST00000314607.6
ENST00000373297.2
zinc finger, MYM-type 4
chr1_+_226250379 0.54 ENST00000366815.3
ENST00000366814.3
H3 histone, family 3A
chr1_-_247335269 0.50 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
zinc finger protein 124
chr7_+_69064300 0.48 ENST00000342771.4
autism susceptibility candidate 2
chr6_+_52051171 0.48 ENST00000340057.1
interleukin 17A
chr20_-_52687059 0.48 ENST00000371435.2
ENST00000395961.3
breast carcinoma amplified sequence 1
chr22_-_39268192 0.44 ENST00000216083.6
chromobox homolog 6
chr14_-_92413353 0.44 ENST00000556154.1
fibulin 5
chr8_+_95907993 0.44 ENST00000523378.1
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr6_+_1080164 0.43 ENST00000314040.1
Uncharacterized protein; cDNA FLJ34594 fis, clone KIDNE2009109
chr2_+_128458514 0.42 ENST00000310981.4
SFT2 domain containing 3
chr19_+_13135386 0.40 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_31704282 0.39 ENST00000375784.3
ENST00000375779.2
chloride intracellular channel 1
chr1_+_161123536 0.39 ENST00000368003.5
ubiquitin-fold modifier conjugating enzyme 1
chrX_+_135388147 0.38 ENST00000394141.1
G protein-coupled receptor 112
chr17_-_72527605 0.34 ENST00000392621.1
ENST00000314401.3
CD300 molecule-like family member b
chr19_-_474880 0.33 ENST00000382696.3
ENST00000315489.4
outer dense fiber of sperm tails 3-like 2
chr22_-_30960876 0.33 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
galactose-3-O-sulfotransferase 1
chr3_+_32726620 0.32 ENST00000331889.6
ENST00000328834.5
CCR4-NOT transcription complex, subunit 10
chr1_+_116915855 0.32 ENST00000295598.5
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr1_+_231473743 0.31 ENST00000295050.7
SprT-like N-terminal domain
chr2_-_219134822 0.31 ENST00000444053.1
ENST00000248450.4
angio-associated, migratory cell protein
chr12_+_4829507 0.31 ENST00000252318.2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr4_-_13546632 0.30 ENST00000382438.5
NK3 homeobox 2
chr14_-_67981870 0.30 ENST00000555994.1
transmembrane protein 229B
chr8_-_123139423 0.29 ENST00000523792.1
RP11-398G24.2
chr17_-_61523622 0.28 ENST00000448884.2
ENST00000582297.1
ENST00000582034.1
ENST00000578072.1
ENST00000360793.3
cytochrome b561
chr2_-_219134343 0.28 ENST00000447885.1
ENST00000420660.1
angio-associated, migratory cell protein
chr8_+_132916318 0.27 ENST00000254624.5
ENST00000522709.1
EFR3 homolog A (S. cerevisiae)
chr1_+_160097462 0.27 ENST00000447527.1
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr19_+_19174795 0.27 ENST00000318596.7
solute carrier family 25, member 42
chr9_+_132427883 0.26 ENST00000372469.4
paired related homeobox 2
chr22_-_39268308 0.26 ENST00000407418.3
chromobox homolog 6
chr15_-_20193370 0.25 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr1_+_8378140 0.23 ENST00000377479.2
solute carrier family 45, member 1
chr10_+_88414338 0.23 ENST00000241891.5
ENST00000443292.1
opsin 4
chr19_+_35417939 0.23 ENST00000601142.1
ENST00000426813.2
zinc finger protein 30
chr4_-_84255935 0.23 ENST00000513463.1
heparanase
chr10_+_88414298 0.23 ENST00000372071.2
opsin 4
chr5_-_1295104 0.22 ENST00000334602.6
ENST00000508104.2
ENST00000310581.5
ENST00000296820.5
telomerase reverse transcriptase
chr7_-_121944491 0.22 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr19_+_35417844 0.22 ENST00000601957.1
zinc finger protein 30
chr13_+_33160553 0.22 ENST00000315596.10
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr13_-_78492955 0.22 ENST00000446573.1
endothelin receptor type B
chr12_-_4488872 0.20 ENST00000237837.1
fibroblast growth factor 23
chr11_-_18956556 0.19 ENST00000302797.3
MAS-related GPR, member X1
chr1_-_154934200 0.19 ENST00000368457.2
pygopus family PHD finger 2
chr11_-_35547572 0.19 ENST00000378880.2
peptidase domain containing associated with muscle regeneration 1
chr19_-_47128294 0.17 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
prostaglandin I2 (prostacyclin) receptor (IP)
chr17_+_7465216 0.16 ENST00000321337.7
SUMO1/sentrin/SMT3 specific peptidase 3
chr12_-_58135903 0.16 ENST00000257897.3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_+_156611704 0.15 ENST00000329117.5
brevican
chrX_+_108780347 0.14 ENST00000372103.1
nuclear transport factor 2-like export factor 2
chr7_+_69064566 0.13 ENST00000403018.2
autism susceptibility candidate 2
chr15_+_41245160 0.13 ENST00000444189.2
ENST00000446533.3
ChaC, cation transport regulator homolog 1 (E. coli)
chr4_-_2420335 0.12 ENST00000503000.1
zinc finger, FYVE domain containing 28
chrX_+_54466829 0.12 ENST00000375151.4
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chrX_-_119763835 0.11 ENST00000371313.2
ENST00000304661.5
C1GALT1-specific chaperone 1
chr1_+_156611960 0.10 ENST00000361588.5
brevican
chr10_+_26505179 0.09 ENST00000376261.3
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_+_26737253 0.08 ENST00000326279.6
lin-28 homolog A (C. elegans)
chr1_-_114414316 0.08 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr3_-_183967296 0.08 ENST00000455059.1
ENST00000445626.2
ALG3, alpha-1,3- mannosyltransferase
chr8_+_56014949 0.06 ENST00000327381.6
XK, Kell blood group complex subunit-related family, member 4
chr17_+_56232494 0.06 ENST00000268912.5
olfactory receptor, family 4, subfamily D, member 1
chr1_+_26737292 0.05 ENST00000254231.4
lin-28 homolog A (C. elegans)
chr10_+_26505594 0.05 ENST00000259271.3
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr6_-_41040195 0.05 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
O-acyl-ADP-ribose deacylase 1
chr10_+_7860460 0.05 ENST00000344293.5
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr11_+_2415061 0.04 ENST00000481687.1
CD81 molecule
chr7_+_97361218 0.04 ENST00000319273.5
tachykinin, precursor 1
chr5_-_78365437 0.04 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
dimethylglycine dehydrogenase
chr20_+_57875457 0.04 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
endothelin 3
chr7_-_99063769 0.04 ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000430982.1
ENST00000555673.1
ENST00000413834.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
pentatricopeptide repeat domain 1
ATP5J2-PTCD1 readthrough
chrX_+_56100757 0.03 ENST00000433279.1
Uncharacterized protein
chr11_+_7273181 0.03 ENST00000318881.6
synaptotagmin IX
chr3_-_49158218 0.03 ENST00000417901.1
ENST00000306026.5
ENST00000434032.2
ubiquitin specific peptidase 19
chr7_+_97361388 0.03 ENST00000350485.4
ENST00000346867.4
tachykinin, precursor 1
chr3_+_72200408 0.03 ENST00000473713.1
long intergenic non-protein coding RNA 870
chr2_-_180427304 0.02 ENST00000336917.5
zinc finger protein 385B
chr1_-_231473578 0.02 ENST00000360394.2
ENST00000366645.1
exocyst complex component 8
chr3_-_87325612 0.02 ENST00000561167.1
ENST00000560656.1
ENST00000344265.3
POU class 1 homeobox 1
chr20_+_57875658 0.01 ENST00000371025.3
endothelin 3
chr1_-_42800860 0.01 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
forkhead box J3
chr14_-_106692191 0.01 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr5_+_85913721 0.01 ENST00000247655.3
ENST00000509578.1
ENST00000515763.1
cytochrome c oxidase subunit VIIc
chr2_+_120687335 0.01 ENST00000544261.1
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr17_-_39684550 0.01 ENST00000455635.1
ENST00000361566.3
keratin 19
chr15_+_59279851 0.01 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
ring finger protein 111
chr11_-_5364809 0.01 ENST00000300773.2
olfactory receptor, family 51, subfamily B, member 5
chr7_-_26578407 0.00 ENST00000242109.3
KIAA0087

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.1 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.7 2.1 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.4 1.5 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.2 0.7 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 0.6 GO:0098582 innate vocalization behavior(GO:0098582)
0.2 0.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.2 3.7 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.6 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.7 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.1 0.5 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.3 GO:0015880 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.1 0.2 GO:1900369 transcription, RNA-templated(GO:0001172) negative regulation of RNA interference(GO:1900369)
0.1 0.2 GO:0042369 vitamin D catabolic process(GO:0042369)
0.1 0.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.6 GO:1903416 response to glycoside(GO:1903416)
0.1 0.4 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.2 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.9 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 0.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.1 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.0 0.3 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 1.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.0 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.0 0.0 GO:0043128 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.0 0.3 GO:0070987 error-free translesion synthesis(GO:0070987)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.1 0.2 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.0 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 4.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 2.4 GO:0030286 dynein complex(GO:0030286)
0.0 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.2 0.7 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 1.5 GO:0031013 troponin I binding(GO:0031013)
0.1 3.7 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 2.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.7 GO:0008035 high-density lipoprotein particle binding(GO:0008035) lipase binding(GO:0035473)
0.1 0.3 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 0.2 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 0.3 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 0.5 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 0.2 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.1 0.2 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.1 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.6 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.3 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.9 GO:0004707 MAP kinase activity(GO:0004707)
0.0 2.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.0 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.0 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 3.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME OPSINS Genes involved in Opsins
0.0 1.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases