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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SIX5_SMARCC2_HCFC1
Z-value: 1.82
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Transcription factors associated with SIX5_SMARCC2_HCFC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000177045.6 | SIX homeobox 5 | |
| ENSG00000139613.7 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 | |
| ENSG00000172534.9 | host cell factor C1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMARCC2 | hg19_v2_chr12_-_56583332_56583369 | 0.48 | 7.9e-03 | Click! |
| SIX5 | hg19_v2_chr19_-_46272106_46272115 | -0.20 | 2.8e-01 | Click! |
| HCFC1 | hg19_v2_chrX_-_153236819_153236978, hg19_v2_chrX_-_153236620_153236684, hg19_v2_chrX_-_153237258_153237295 | 0.16 | 4.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.9 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.4 | 7.7 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.2 | 6.2 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.1 | 6.2 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.7 | 5.3 | GO:1903751 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.2 | 5.3 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.1 | 5.2 | GO:0048678 | response to axon injury(GO:0048678) |
| 1.2 | 4.8 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 0.2 | 4.7 | GO:1901663 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 1.5 | 4.4 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 9.7 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.2 | 6.7 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 6.4 | GO:0005929 | cilium(GO:0005929) |
| 0.1 | 5.9 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.2 | 5.5 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.4 | 5.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 4.8 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 4.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.2 | 4.0 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.4 | 3.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 55.9 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.2 | 10.5 | GO:0070888 | E-box binding(GO:0070888) |
| 1.1 | 10.1 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 3.1 | 9.3 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 0.2 | 6.0 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.4 | 5.3 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 4.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.4 | 4.5 | GO:0031419 | cobalamin binding(GO:0031419) |
| 1.5 | 4.4 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.0 | 3.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 4.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 3.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 3.1 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 2.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.2 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 2.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 1.8 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.6 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 1.3 | PID ARF6 PATHWAY | Arf6 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 5.9 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.2 | 3.9 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 2.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 2.4 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 2.3 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 1.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 1.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.7 | REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | Genes involved in Formation of the HIV-1 Early Elongation Complex |