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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SIX6

Z-value: 0.54

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
SIX6
ENSG00000184302.6 SIX homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX6hg19_v2_chr14_+_60975644_609756730.301.1e-01Click!

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_80263506 1.22 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr12_-_28122980 0.91 ENST00000395868.3
ENST00000534890.1
PTHLH
parathyroid hormone-like hormone
chr2_-_88427568 0.87 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr12_-_121477039 0.84 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr8_+_67405438 0.80 ENST00000305454.3
C8orf46
chromosome 8 open reading frame 46
chr12_-_28123206 0.71 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chr12_-_121476959 0.70 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr3_-_111314230 0.67 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr3_+_8543393 0.65 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1
LIM and cysteine-rich domains 1
chr6_+_146348782 0.64 ENST00000361719.2
ENST00000392299.2
GRM1
glutamate receptor, metabotropic 1
chr19_-_44031375 0.56 ENST00000292147.2
ETHE1
ethylmalonic encephalopathy 1
chr9_-_21142144 0.54 ENST00000380229.2
IFNW1
interferon, omega 1
chr6_+_146348810 0.52 ENST00000492807.2
GRM1
glutamate receptor, metabotropic 1
chr12_+_119616447 0.51 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr3_+_8543561 0.49 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr12_-_14849470 0.48 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr2_-_239140011 0.45 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
AC016757.3
Protein LOC151174
chr22_-_19137796 0.45 ENST00000086933.2
GSC2
goosecoid homeobox 2
chr8_+_1993152 0.41 ENST00000262113.4
MYOM2
myomesin 2
chr6_-_26285737 0.40 ENST00000377727.1
ENST00000289352.1
HIST1H4H
histone cluster 1, H4h
chr13_-_20080080 0.39 ENST00000400103.2
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr8_+_1993173 0.39 ENST00000523438.1
MYOM2
myomesin 2
chr10_+_91061712 0.39 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr8_+_67104323 0.37 ENST00000518412.1
ENST00000518035.1
ENST00000517725.1
LINC00967
long intergenic non-protein coding RNA 967
chr14_+_20937538 0.37 ENST00000361505.5
ENST00000553591.1
PNP
purine nucleoside phosphorylase
chr12_-_71512027 0.33 ENST00000549357.1
CTD-2021H9.3
Uncharacterized protein
chr22_+_18721427 0.33 ENST00000342888.3
AC008132.1
Uncharacterized protein
chr12_-_10978957 0.32 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr19_-_14628645 0.32 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_+_63063152 0.32 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr1_-_36235559 0.31 ENST00000251195.5
CLSPN
claspin
chr1_+_86934526 0.31 ENST00000394711.1
CLCA1
chloride channel accessory 1
chr21_-_19775973 0.30 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr1_+_21880560 0.30 ENST00000425315.2
ALPL
alkaline phosphatase, liver/bone/kidney
chr14_+_21510385 0.29 ENST00000298690.4
RNASE7
ribonuclease, RNase A family, 7
chr9_-_100707116 0.29 ENST00000259456.3
HEMGN
hemogen
chr1_-_161193349 0.29 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr22_-_17302589 0.28 ENST00000331428.5
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr15_+_58430567 0.27 ENST00000536493.1
AQP9
aquaporin 9
chr16_-_87350970 0.26 ENST00000567970.1
C16orf95
chromosome 16 open reading frame 95
chr6_-_108145499 0.26 ENST00000369020.3
ENST00000369022.2
SCML4
sex comb on midleg-like 4 (Drosophila)
chr19_+_46000479 0.25 ENST00000456399.2
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr19_-_1650666 0.24 ENST00000588136.1
TCF3
transcription factor 3
chr5_+_40909354 0.24 ENST00000313164.9
C7
complement component 7
chr16_+_72090053 0.24 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
HP
haptoglobin
chr13_+_34392200 0.24 ENST00000434425.1
RFC3
replication factor C (activator 1) 3, 38kDa
chr15_+_58430368 0.24 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr7_+_117251671 0.23 ENST00000468795.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr5_-_78281775 0.23 ENST00000396151.3
ENST00000565165.1
ARSB
arylsulfatase B
chr4_-_71532339 0.23 ENST00000254801.4
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr8_-_124553437 0.23 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr6_-_26043885 0.23 ENST00000357905.2
HIST1H2BB
histone cluster 1, H2bb
chr9_-_23821842 0.22 ENST00000544538.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr4_+_88532028 0.22 ENST00000282478.7
DSPP
dentin sialophosphoprotein
chr14_-_46185155 0.21 ENST00000555442.1
RP11-369C8.1
RP11-369C8.1
chr13_-_46679185 0.21 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr18_-_69246167 0.21 ENST00000566582.1
RP11-510D19.1
RP11-510D19.1
chr1_-_161015752 0.21 ENST00000435396.1
ENST00000368021.3
USF1
upstream transcription factor 1
chrX_-_18238999 0.20 ENST00000380033.4
ENST00000380030.3
BEND2
BEN domain containing 2
chr4_-_123377880 0.20 ENST00000226730.4
IL2
interleukin 2
chr11_+_74699703 0.20 ENST00000529024.1
ENST00000544263.1
NEU3
sialidase 3 (membrane sialidase)
chr8_+_26247878 0.20 ENST00000518611.1
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr2_+_85822857 0.20 ENST00000306368.4
ENST00000414390.1
ENST00000456023.1
RNF181
ring finger protein 181
chrY_-_16098393 0.20 ENST00000250825.4
VCY
variable charge, Y-linked
chr13_-_46679144 0.20 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr2_+_89184868 0.19 ENST00000390243.2
IGKV4-1
immunoglobulin kappa variable 4-1
chr9_-_21351377 0.19 ENST00000380210.1
IFNA6
interferon, alpha 6
chr12_-_121476750 0.18 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr17_-_67057114 0.18 ENST00000370732.2
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr1_+_145413268 0.18 ENST00000421822.2
ENST00000336751.5
ENST00000497365.1
ENST00000475797.1
HFE2
hemochromatosis type 2 (juvenile)
chr18_-_69246186 0.18 ENST00000568095.1
RP11-510D19.1
RP11-510D19.1
chr2_-_134326009 0.17 ENST00000409261.1
ENST00000409213.1
NCKAP5
NCK-associated protein 5
chr3_+_151531810 0.17 ENST00000232892.7
AADAC
arylacetamide deacetylase
chrY_+_16168097 0.17 ENST00000250823.4
VCY1B
variable charge, Y-linked 1B
chr10_-_61720640 0.17 ENST00000521074.1
ENST00000444900.1
C10orf40
chromosome 10 open reading frame 40
chr4_-_13546632 0.16 ENST00000382438.5
NKX3-2
NK3 homeobox 2
chr5_-_177207634 0.16 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chr6_+_47749718 0.15 ENST00000489301.2
ENST00000371211.2
ENST00000393699.2
OPN5
opsin 5
chr2_-_228497888 0.15 ENST00000264387.4
ENST00000409066.1
C2orf83
chromosome 2 open reading frame 83
chr9_-_67786624 0.14 ENST00000455764.2
FAM27E3
family with sequence similarity 27, member E3
chr3_-_196242233 0.14 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr22_+_18043133 0.14 ENST00000327451.6
ENST00000399813.1
SLC25A18
solute carrier family 25 (glutamate carrier), member 18
chr2_-_208989225 0.14 ENST00000264376.4
CRYGD
crystallin, gamma D
chrX_+_8433376 0.13 ENST00000440654.2
ENST00000381029.4
VCX3B
variable charge, X-linked 3B
chr7_-_141957847 0.13 ENST00000552471.1
ENST00000547058.2
PRSS58
protease, serine, 58
chr1_-_159684371 0.13 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr9_-_100684845 0.12 ENST00000375119.3
C9orf156
chromosome 9 open reading frame 156
chr5_+_55147205 0.12 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr1_+_112016414 0.12 ENST00000343534.5
ENST00000369718.3
C1orf162
chromosome 1 open reading frame 162
chr17_-_67057047 0.12 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr2_+_62132781 0.12 ENST00000311832.5
COMMD1
copper metabolism (Murr1) domain containing 1
chr1_+_160709076 0.12 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr7_-_44530479 0.11 ENST00000355451.7
NUDCD3
NudC domain containing 3
chr11_+_30253410 0.11 ENST00000533718.1
FSHB
follicle stimulating hormone, beta polypeptide
chrX_-_77225135 0.11 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr19_-_16008880 0.10 ENST00000011989.7
ENST00000221700.6
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr10_+_81891416 0.10 ENST00000372270.2
PLAC9
placenta-specific 9
chr6_+_26204825 0.10 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr2_+_62132800 0.09 ENST00000538736.1
COMMD1
copper metabolism (Murr1) domain containing 1
chr16_-_52119019 0.09 ENST00000561513.1
ENST00000565742.1
LINC00919
long intergenic non-protein coding RNA 919
chr4_-_70826725 0.09 ENST00000353151.3
CSN2
casein beta
chr14_+_21525981 0.09 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chrY_-_24038660 0.09 ENST00000382677.3
RBMY1D
RNA binding motif protein, Y-linked, family 1, member D
chr4_+_113739244 0.09 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ANK2
ankyrin 2, neuronal
chr18_+_55018044 0.08 ENST00000324000.3
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr16_-_20364122 0.08 ENST00000396138.4
ENST00000577168.1
UMOD
uromodulin
chr8_+_84824920 0.08 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr9_-_139642968 0.08 ENST00000341206.4
LCN6
lipocalin 6
chr10_-_75008620 0.08 ENST00000372950.4
DNAJC9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr6_-_26018007 0.08 ENST00000244573.3
HIST1H1A
histone cluster 1, H1a
chr11_+_122709200 0.08 ENST00000227348.4
CRTAM
cytotoxic and regulatory T cell molecule
chr1_+_40942887 0.08 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr1_+_159557607 0.07 ENST00000255040.2
APCS
amyloid P component, serum
chr4_-_139051839 0.07 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
LINC00616
long intergenic non-protein coding RNA 616
chr1_+_160709055 0.07 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr15_+_69857515 0.07 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chrX_-_53350522 0.07 ENST00000396435.3
ENST00000375368.5
IQSEC2
IQ motif and Sec7 domain 2
chrY_+_23698778 0.06 ENST00000303902.5
RBMY1A1
RNA binding motif protein, Y-linked, family 1, member A1
chrX_-_118699325 0.06 ENST00000320339.4
ENST00000371594.4
ENST00000536133.1
CXorf56
chromosome X open reading frame 56
chr1_-_182369751 0.06 ENST00000367565.1
TEDDM1
transmembrane epididymal protein 1
chr2_-_77749474 0.06 ENST00000409093.1
ENST00000409088.3
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr19_+_3136115 0.06 ENST00000262958.3
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr11_+_59807748 0.06 ENST00000278855.2
ENST00000532905.1
PLAC1L
oocyte secreted protein 2
chr10_+_45495898 0.05 ENST00000298299.3
ZNF22
zinc finger protein 22
chr1_-_150669604 0.05 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr6_+_37012607 0.05 ENST00000423336.1
COX6A1P2
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr1_-_13673511 0.05 ENST00000344998.3
ENST00000334600.6
PRAMEF14
PRAME family member 14
chr1_+_234509186 0.05 ENST00000366615.4
COA6
cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
chr12_+_40787194 0.05 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr5_+_175490540 0.05 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr18_+_50278430 0.05 ENST00000578080.1
ENST00000582875.1
ENST00000412726.1
DCC
deleted in colorectal carcinoma
chr16_-_20364030 0.04 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
UMOD
uromodulin
chr1_+_31885963 0.04 ENST00000373709.3
SERINC2
serine incorporator 2
chr1_-_157014865 0.04 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr3_-_107596910 0.03 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635
long intergenic non-protein coding RNA 635
chr9_-_14910990 0.03 ENST00000380881.4
ENST00000422223.2
FREM1
FRAS1 related extracellular matrix 1
chr20_+_54987168 0.03 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr5_+_115420688 0.02 ENST00000274458.4
COMMD10
COMM domain containing 10
chr12_-_122018859 0.02 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
KDM2B
lysine (K)-specific demethylase 2B
chr20_+_54987305 0.02 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr6_-_26189304 0.01 ENST00000340756.2
HIST1H4D
histone cluster 1, H4d
chr3_-_53916202 0.01 ENST00000335754.3
ACTR8
ARP8 actin-related protein 8 homolog (yeast)
chr14_+_22948510 0.00 ENST00000390483.1
TRAJ56
T cell receptor alpha joining 56
chr16_-_21868978 0.00 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
NPIPB4
nuclear pore complex interacting protein family, member B4
chr19_+_55235969 0.00 ENST00000402254.2
ENST00000538269.1
ENST00000541392.1
ENST00000291860.1
ENST00000396284.2
KIR3DL1
KIR3DL3
KIR2DL4
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.4 GO:0046495 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.1 0.4 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1 0.5 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.3 GO:0071529 cementum mineralization(GO:0071529)
0.1 0.8 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.3 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.6 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 0.9 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 0.2 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.1 0.2 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.1 0.2 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.1 1.8 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.3 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 1.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0044793 negative regulation by host of viral process(GO:0044793)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.3 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 0.2 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.7 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.2 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.1 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.1 GO:1903487 regulation of lactation(GO:1903487)
0.0 0.1 GO:0036309 protein localization to M-band(GO:0036309) regulation of SA node cell action potential(GO:0098907)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.2 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 1.7 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.0 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.2 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.2 GO:0006883 cellular sodium ion homeostasis(GO:0006883)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.1 0.9 GO:0045179 apical cortex(GO:0045179)
0.1 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.3 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.3 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 1.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.5 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.9 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.4 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.4 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 0.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 0.2 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.1 0.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 1.2 GO:0051400 BH domain binding(GO:0051400)
0.1 1.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.7 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.1 GO:0052870 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.0 0.8 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.2 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134) glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.3 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.6 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.0 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.2 PID BCR 5PATHWAY BCR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 2.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport