ISMARA results: SMAD1

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SMAD1

Z-value: 2.45

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Transcription factors associated with SMAD1

Gene Symbol	Gene ID	Gene Info
SMAD1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000170365.5	SMAD family member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SMAD1	hg19_v2_chr4_+_146402925_146402957, hg19_v2_chr4_+_146403912_146403972	-0.72	8.0e-06	Click!

Activity profile of SMAD1 motif

Sorted Z-values of SMAD1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_51471381 Show fit	31.40	ENST00000594641.1	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6
chr19_-_51456321 Show fit	24.70	ENST00000391809.2	KLK5 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 5
chr19_-_51471362 Show fit	24.62	ENST00000376853.4 ENST00000424910.2	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6
chr19_-_51472031 Show fit	24.61	ENST00000391808.1	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6
chr19_-_51456198 Show fit	19.76	ENST00000594846.1	KLK5 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 5
chr19_-_51456344 Show fit	17.79	ENST00000336334.3 ENST00000593428.1	KLK5 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 5
chr19_-_51466681 Show fit	16.06	ENST00000456750.2	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6
chr2_-_113594279 Show fit	10.49	ENST00000416750.1 ENST00000418817.1 ENST00000263341.2	IL1B Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 1, beta
chrX_-_48328551 Show fit	10.29	ENST00000376876.3	SLC38A5 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 38, member 5
chr19_+_6531010 Show fit	9.17	ENST00000245817.3	TNFSF9 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor (ligand) superfamily, member 9

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.1	112.1	GO:0016540	protein autoprocessing(GO:0016540)
10.4	62.1	GO:0002803	positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.5	57.2	GO:0070268	cornification(GO:0070268)
4.8	24.1	GO:0061143	alveolar primary septum development(GO:0061143)
1.3	22.7	GO:1901750	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
1.4	19.0	GO:0015816	glycine transport(GO:0015816)
0.5	17.3	GO:0014046	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.7	17.1	GO:0001829	trophectodermal cell differentiation(GO:0001829)
0.2	15.0	GO:0006910	phagocytosis, recognition(GO:0006910)
3.6	14.4	GO:0006218	uridine catabolic process(GO:0006218)

Showing 1 to 10 of 1,251 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	141.5	GO:0030141	secretory granule(GO:0030141)
8.9	62.3	GO:0097209	epidermal lamellar body(GO:0097209)
0.1	50.3	GO:0015629	actin cytoskeleton(GO:0015629)
0.6	39.2	GO:0001533	cornified envelope(GO:0001533)
0.9	21.5	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.0	15.1	GO:0030055	cell-substrate junction(GO:0030055)
0.2	15.0	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3	14.8	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.2	14.2	GO:0045095	keratin filament(GO:0045095)
0.1	13.3	GO:0005811	lipid particle(GO:0005811)

Showing 1 to 10 of 388 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	232.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	38.7	GO:0030695	GTPase regulator activity(GO:0030695)
0.1	28.4	GO:0030674	protein binding, bridging(GO:0030674)
0.2	23.3	GO:0008307	structural constituent of muscle(GO:0008307)
1.3	22.7	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.1	21.8	GO:0051015	actin filament binding(GO:0051015)
0.2	20.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	20.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
1.7	18.9	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.5	18.2	GO:0051183	vitamin transporter activity(GO:0051183)

Showing 1 to 10 of 748 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	121.8	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.2	66.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	64.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9	29.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	19.6	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.2	14.9	PID NOTCH PATHWAY	Notch signaling pathway
0.4	13.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.5	12.4	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2	12.4	PID AURORA B PATHWAY	Aurora B signaling
0.2	12.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Showing 1 to 10 of 126 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	23.1	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.4	18.6	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.3	18.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.4	17.4	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
1.0	16.9	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	16.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	16.3	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.4	15.2	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.3	14.9	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.7	13.6	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation

Showing 1 to 10 of 203 entries

Results for SMAD1

Z-value: 2.45

Motif logo

Transcription factors associated with SMAD1

Activity-expression correlation:

Activity profile of SMAD1 motif

Sorted Z-values of SMAD1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: