Project

Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

Navigation
Downloads

Results for SMAD2

Z-value: 0.69

Motif logo

logo of

Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
SMAD2
ENSG00000175387.11 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg19_v2_chr18_-_45457478_45457517-0.212.7e-01Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_6740802 1.64 ENST00000431922.1
LPAR5
lysophosphatidic acid receptor 5
chrX_-_107018969 1.57 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr12_+_53443963 1.52 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr10_+_72972281 1.48 ENST00000335350.6
UNC5B
unc-5 homolog B (C. elegans)
chrX_-_48328551 1.40 ENST00000376876.3
SLC38A5
solute carrier family 38, member 5
chrX_-_48328631 1.37 ENST00000429543.1
ENST00000317669.5
SLC38A5
solute carrier family 38, member 5
chr22_+_24891210 1.35 ENST00000382760.2
UPB1
ureidopropionase, beta
chr9_+_125137565 1.34 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr12_-_47473642 1.26 ENST00000266581.4
AMIGO2
adhesion molecule with Ig-like domain 2
chr2_+_113735575 1.25 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr12_-_47473425 1.24 ENST00000550413.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr1_-_9189229 1.20 ENST00000377411.4
GPR157
G protein-coupled receptor 157
chr12_+_47473369 1.17 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr2_-_72375167 1.16 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr11_-_107729887 1.09 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr12_-_47473557 1.03 ENST00000321382.3
AMIGO2
adhesion molecule with Ig-like domain 2
chr16_+_28889801 1.01 ENST00000395503.4
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr7_-_102257139 0.99 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RASA4
RAS p21 protein activator 4
chr16_+_31483374 0.98 ENST00000394863.3
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr16_+_28889703 0.95 ENST00000357084.3
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr19_-_11688447 0.88 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chrX_-_107019181 0.86 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr1_-_149908710 0.84 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11
myotubularin related protein 11
chr17_-_7297519 0.83 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr1_-_155270770 0.83 ENST00000392414.3
PKLR
pyruvate kinase, liver and RBC
chr19_-_44285401 0.81 ENST00000262888.3
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr12_+_101188547 0.80 ENST00000546991.1
ENST00000392979.3
ANO4
anoctamin 4
chr21_-_36259445 0.79 ENST00000399240.1
RUNX1
runt-related transcription factor 1
chr12_+_53443680 0.77 ENST00000314250.6
ENST00000451358.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr19_-_14224969 0.77 ENST00000589994.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr12_-_53207842 0.76 ENST00000458244.2
KRT4
keratin 4
chr1_-_149908217 0.74 ENST00000369140.3
MTMR11
myotubularin related protein 11
chr3_+_130569592 0.73 ENST00000533801.2
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr11_+_117857063 0.73 ENST00000227752.3
ENST00000541785.1
ENST00000545409.1
IL10RA
interleukin 10 receptor, alpha
chr12_+_101188718 0.73 ENST00000299222.9
ENST00000392977.3
ANO4
anoctamin 4
chr20_+_43343476 0.72 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2
chr17_-_7297833 0.69 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr16_-_70719925 0.68 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr12_+_1800179 0.67 ENST00000357103.4
ADIPOR2
adiponectin receptor 2
chr11_-_107590383 0.67 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr9_+_34990219 0.67 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr20_+_43343517 0.66 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr20_+_43343886 0.65 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr22_-_44287875 0.64 ENST00000438734.1
ENST00000597664.1
ENST00000216177.4
ENST00000593866.1
ENST00000381198.2
PNPLA5
patatin-like phospholipase domain containing 5
chr4_-_39979576 0.62 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr22_+_48027423 0.61 ENST00000423737.1
RP11-191L9.4
RP11-191L9.4
chr7_-_102158157 0.58 ENST00000541662.1
ENST00000306682.6
ENST00000465829.1
RASA4B
RAS p21 protein activator 4B
chr4_-_41216492 0.57 ENST00000503503.1
ENST00000509446.1
ENST00000503264.1
ENST00000508707.1
ENST00000508593.1
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chrX_+_38420783 0.56 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr8_+_82192501 0.55 ENST00000297258.6
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr4_-_41216473 0.54 ENST00000513140.1
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr3_+_50316458 0.53 ENST00000316436.3
LSMEM2
leucine-rich single-pass membrane protein 2
chr1_+_36772691 0.53 ENST00000312808.4
ENST00000505871.1
SH3D21
SH3 domain containing 21
chr20_+_30598231 0.52 ENST00000300415.8
ENST00000262659.8
CCM2L
cerebral cavernous malformation 2-like
chr17_+_73629500 0.50 ENST00000375215.3
SMIM5
small integral membrane protein 5
chr1_-_155271213 0.48 ENST00000342741.4
PKLR
pyruvate kinase, liver and RBC
chr5_-_64064508 0.47 ENST00000513458.4
SREK1IP1
SREK1-interacting protein 1
chr22_-_37823468 0.47 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr16_-_56459354 0.47 ENST00000290649.5
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase
chr9_-_137809718 0.46 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr8_-_125384927 0.45 ENST00000297632.6
TMEM65
transmembrane protein 65
chr6_-_143771799 0.45 ENST00000237283.8
ADAT2
adenosine deaminase, tRNA-specific 2
chr16_-_4987065 0.44 ENST00000590782.2
ENST00000345988.2
PPL
periplakin
chr5_+_70751442 0.44 ENST00000358731.4
ENST00000380675.2
BDP1
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr6_+_6588902 0.44 ENST00000230568.4
LY86
lymphocyte antigen 86
chr4_-_41216619 0.43 ENST00000508676.1
ENST00000506352.1
ENST00000295974.8
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr11_+_2923423 0.43 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr3_+_194406603 0.43 ENST00000329759.4
FAM43A
family with sequence similarity 43, member A
chr19_+_56186606 0.42 ENST00000085079.7
EPN1
epsin 1
chr1_+_36771946 0.41 ENST00000373139.2
ENST00000453908.2
ENST00000426732.2
SH3D21
SH3 domain containing 21
chr2_-_228028829 0.40 ENST00000396625.3
ENST00000329662.7
COL4A4
collagen, type IV, alpha 4
chr12_-_8765446 0.40 ENST00000537228.1
ENST00000229335.6
AICDA
activation-induced cytidine deaminase
chr19_+_56186557 0.40 ENST00000270460.6
EPN1
epsin 1
chr6_+_41010293 0.39 ENST00000373161.1
ENST00000373158.2
ENST00000470917.1
TSPO2
translocator protein 2
chr17_-_1389419 0.38 ENST00000575158.1
MYO1C
myosin IC
chr6_+_30689401 0.37 ENST00000396389.1
ENST00000396384.1
TUBB
tubulin, beta class I
chr13_+_96743093 0.36 ENST00000376705.2
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr2_-_220174166 0.36 ENST00000409251.3
ENST00000451506.1
ENST00000295718.2
ENST00000446182.1
PTPRN
protein tyrosine phosphatase, receptor type, N
chr9_+_125281420 0.36 ENST00000340750.1
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr17_-_46623441 0.35 ENST00000330070.4
HOXB2
homeobox B2
chr20_-_36889127 0.35 ENST00000279024.4
KIAA1755
KIAA1755
chr11_-_101454658 0.34 ENST00000344327.3
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr12_-_29936731 0.34 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr6_+_34482630 0.34 ENST00000538621.1
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr1_-_44497118 0.33 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr12_+_68042517 0.33 ENST00000393555.3
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr1_-_44482979 0.33 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr10_-_14372870 0.33 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr4_-_103749205 0.32 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr20_-_48532046 0.32 ENST00000543716.1
SPATA2
spermatogenesis associated 2
chr3_+_130569429 0.31 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr14_-_57277163 0.31 ENST00000555006.1
OTX2
orthodenticle homeobox 2
chr17_+_3627185 0.31 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr4_-_103749179 0.31 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr1_-_1243252 0.30 ENST00000353662.3
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr9_+_140145713 0.29 ENST00000388931.3
ENST00000412566.1
C9orf173
chromosome 9 open reading frame 173
chr2_-_73053126 0.29 ENST00000272427.6
ENST00000410104.1
EXOC6B
exocyst complex component 6B
chr17_-_58469474 0.29 ENST00000300896.4
USP32
ubiquitin specific peptidase 32
chr4_-_114682597 0.29 ENST00000394524.3
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr7_-_105516923 0.28 ENST00000478915.1
ATXN7L1
ataxin 7-like 1
chr21_-_38639813 0.28 ENST00000309117.6
ENST00000398998.1
DSCR3
Down syndrome critical region gene 3
chr9_-_14910990 0.28 ENST00000380881.4
ENST00000422223.2
FREM1
FRAS1 related extracellular matrix 1
chr14_-_57277178 0.27 ENST00000339475.5
ENST00000554559.1
ENST00000555804.1
OTX2
orthodenticle homeobox 2
chr12_-_57410304 0.27 ENST00000441881.1
ENST00000458521.2
TAC3
tachykinin 3
chr20_+_36888551 0.27 ENST00000418004.1
ENST00000451435.1
BPI
bactericidal/permeability-increasing protein
chr1_+_28052518 0.27 ENST00000530324.1
ENST00000234549.7
ENST00000373949.1
ENST00000010299.6
FAM76A
family with sequence similarity 76, member A
chr9_-_73029540 0.27 ENST00000377126.2
KLF9
Kruppel-like factor 9
chr9_-_136006496 0.26 ENST00000372062.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr8_-_95907423 0.26 ENST00000396133.3
ENST00000308108.4
CCNE2
cyclin E2
chr11_-_3859089 0.26 ENST00000396979.1
RHOG
ras homolog family member G
chr4_+_93225550 0.26 ENST00000282020.4
GRID2
glutamate receptor, ionotropic, delta 2
chr3_-_195163803 0.26 ENST00000326793.6
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr16_+_2198604 0.26 ENST00000210187.6
RAB26
RAB26, member RAS oncogene family
chr17_+_30593195 0.26 ENST00000431505.2
ENST00000269051.4
ENST00000538145.1
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr10_-_75193308 0.26 ENST00000299432.2
MSS51
MSS51 mitochondrial translational activator
chr3_+_52529346 0.25 ENST00000321725.6
STAB1
stabilin 1
chr19_+_11466062 0.24 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr20_+_35974532 0.24 ENST00000373578.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr14_+_81421355 0.24 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr19_+_15619299 0.24 ENST00000269703.3
CYP4F22
cytochrome P450, family 4, subfamily F, polypeptide 22
chrX_+_153029633 0.23 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
PLXNB3
plexin B3
chr2_-_74667612 0.23 ENST00000305557.5
ENST00000233330.6
RTKN
rhotekin
chr14_+_81421861 0.23 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr1_+_2407754 0.23 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2
phospholipase C, eta 2
chr9_+_101867359 0.23 ENST00000374994.4
TGFBR1
transforming growth factor, beta receptor 1
chr3_-_195603566 0.23 ENST00000424563.1
ENST00000411741.1
TNK2
tyrosine kinase, non-receptor, 2
chr5_+_33441053 0.23 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
TARS
threonyl-tRNA synthetase
chr9_+_101867387 0.23 ENST00000374990.2
ENST00000552516.1
TGFBR1
transforming growth factor, beta receptor 1
chr17_-_58469687 0.22 ENST00000590133.1
USP32
ubiquitin specific peptidase 32
chr15_+_68570062 0.22 ENST00000306917.4
FEM1B
fem-1 homolog b (C. elegans)
chr21_+_46066331 0.22 ENST00000334670.8
KRTAP10-11
keratin associated protein 10-11
chr12_-_57472522 0.21 ENST00000379391.3
ENST00000300128.4
TMEM194A
transmembrane protein 194A
chr10_+_105314881 0.20 ENST00000437579.1
NEURL
neuralized E3 ubiquitin protein ligase 1
chr20_+_1875942 0.20 ENST00000358771.4
SIRPA
signal-regulatory protein alpha
chr9_-_34523027 0.19 ENST00000399775.2
ENHO
energy homeostasis associated
chr10_-_102046098 0.19 ENST00000441611.1
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr2_+_191045656 0.19 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chr5_+_133861339 0.19 ENST00000282605.4
ENST00000361895.2
ENST00000402835.1
PHF15
jade family PHD finger 2
chr20_+_34680620 0.18 ENST00000430276.1
ENST00000373950.2
ENST00000452261.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr4_-_185139062 0.18 ENST00000296741.2
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr13_+_25670268 0.18 ENST00000281589.3
PABPC3
poly(A) binding protein, cytoplasmic 3
chr12_-_22094336 0.18 ENST00000326684.4
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr17_-_40761375 0.18 ENST00000543197.1
ENST00000309428.5
FAM134C
family with sequence similarity 134, member C
chr6_-_134861089 0.18 ENST00000606039.1
RP11-557H15.4
RP11-557H15.4
chr6_+_99282570 0.17 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr12_-_71003568 0.17 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB
protein tyrosine phosphatase, receptor type, B
chr10_+_105315102 0.17 ENST00000369777.2
NEURL
neuralized E3 ubiquitin protein ligase 1
chr22_+_29876197 0.17 ENST00000310624.6
NEFH
neurofilament, heavy polypeptide
chr10_-_102046417 0.16 ENST00000370372.2
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr20_-_48532019 0.16 ENST00000289431.5
SPATA2
spermatogenesis associated 2
chr12_+_110338323 0.16 ENST00000312777.5
ENST00000536408.2
TCHP
trichoplein, keratin filament binding
chr22_+_31518938 0.16 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr1_+_15783222 0.16 ENST00000359621.4
CELA2A
chymotrypsin-like elastase family, member 2A
chr2_-_17981462 0.15 ENST00000402989.1
ENST00000428868.1
SMC6
structural maintenance of chromosomes 6
chrX_-_47489244 0.15 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
CFP
complement factor properdin
chr4_-_56458374 0.15 ENST00000295645.4
PDCL2
phosducin-like 2
chr7_+_107384579 0.15 ENST00000222597.2
ENST00000415884.2
CBLL1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr9_+_15422702 0.15 ENST00000380821.3
ENST00000421710.1
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr4_-_103749313 0.15 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr17_-_40337470 0.15 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr1_-_160040038 0.14 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr1_+_15802594 0.14 ENST00000375910.3
CELA2B
chymotrypsin-like elastase family, member 2B
chr12_-_120554534 0.14 ENST00000538903.1
ENST00000534951.1
RAB35
RAB35, member RAS oncogene family
chr1_-_211752073 0.13 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr13_+_114238997 0.13 ENST00000538138.1
ENST00000375370.5
TFDP1
transcription factor Dp-1
chr1_+_226411319 0.13 ENST00000542034.1
ENST00000366810.5
MIXL1
Mix paired-like homeobox
chr19_+_11466167 0.13 ENST00000591608.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr12_+_7037461 0.13 ENST00000396684.2
ATN1
atrophin 1
chr17_-_58469591 0.13 ENST00000589335.1
USP32
ubiquitin specific peptidase 32
chr12_+_93965609 0.13 ENST00000549887.1
ENST00000551556.1
SOCS2
suppressor of cytokine signaling 2
chr1_+_100111479 0.12 ENST00000263174.4
PALMD
palmdelphin
chr4_-_103749105 0.12 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr12_+_93965451 0.12 ENST00000548537.1
SOCS2
suppressor of cytokine signaling 2
chr14_-_106494587 0.12 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr17_-_3571934 0.12 ENST00000225525.3
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr8_+_11561660 0.10 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4
GATA binding protein 4
chr1_+_100111580 0.10 ENST00000605497.1
PALMD
palmdelphin
chr4_+_102268904 0.10 ENST00000527564.1
ENST00000529296.1
AP001816.1
Uncharacterized protein
chr16_+_2286726 0.10 ENST00000382437.4
ENST00000569184.1
DNASE1L2
deoxyribonuclease I-like 2
chr13_-_27334879 0.10 ENST00000405846.3
GPR12
G protein-coupled receptor 12
chr14_-_106478603 0.10 ENST00000390596.2
IGHV4-4
immunoglobulin heavy variable 4-4
chr11_+_74951948 0.10 ENST00000562197.2
TPBGL
trophoblast glycoprotein-like
chr22_+_22764088 0.10 ENST00000390299.2
IGLV1-40
immunoglobulin lambda variable 1-40
chr20_-_23066953 0.10 ENST00000246006.4
CD93
CD93 molecule
chr5_-_150521192 0.09 ENST00000523714.1
ENST00000521749.1
ANXA6
annexin A6
chr20_-_56284816 0.09 ENST00000395819.3
ENST00000341744.3
PMEPA1
prostate transmembrane protein, androgen induced 1
chr4_-_113437328 0.09 ENST00000313341.3
NEUROG2
neurogenin 2
chr1_+_185703513 0.09 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr6_-_159466042 0.09 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr19_+_51645556 0.09 ENST00000601682.1
ENST00000317643.6
ENST00000305628.7
ENST00000600577.1
SIGLEC7
sialic acid binding Ig-like lectin 7
chr21_+_45993606 0.08 ENST00000400374.3
KRTAP10-4
keratin associated protein 10-4
chr6_-_159466136 0.08 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr19_-_6481776 0.08 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr17_-_15165854 0.08 ENST00000395936.1
ENST00000395938.2
PMP22
peripheral myelin protein 22
chr9_+_33524240 0.07 ENST00000290943.6
ANKRD18B
ankyrin repeat domain 18B
chr19_-_43383819 0.07 ENST00000312439.6
ENST00000403380.3
PSG1
pregnancy specific beta-1-glycoprotein 1
chr7_-_130418888 0.07 ENST00000310992.4
KLF14
Kruppel-like factor 14
chr4_-_164534657 0.07 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr17_+_40761660 0.06 ENST00000251413.3
ENST00000591509.1
TUBG1
tubulin, gamma 1
chr5_+_64064748 0.06 ENST00000381070.3
ENST00000508024.1
CWC27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.4 1.2 GO:0035981 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.3 1.4 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.3 2.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 3.4 GO:0015816 glycine transport(GO:0015816)
0.2 0.7 GO:1901877 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.2 1.5 GO:0061590 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.2 1.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.2 0.9 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 0.5 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 1.0 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.2 1.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.2 0.5 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.4 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.1 0.4 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.1 0.4 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 1.0 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.5 GO:1905071 proepicardium development(GO:0003342) septum transversum development(GO:0003343) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.1 0.3 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.1 1.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.2 GO:0060019 radial glial cell differentiation(GO:0060019)
0.1 0.7 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 0.6 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.1 0.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.8 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.8 GO:0046541 saliva secretion(GO:0046541)
0.1 0.2 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.1 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.2 GO:0048936 neurofilament bundle assembly(GO:0033693) peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 3.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 0.1 GO:0003285 septum secundum development(GO:0003285)
0.1 0.8 GO:1901621 cellular response to parathyroid hormone stimulus(GO:0071374) negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.4 GO:0046618 drug export(GO:0046618)
0.0 0.4 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 0.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.3 GO:0051414 response to cortisol(GO:0051414)
0.0 0.3 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0 0.2 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.4 GO:0002097 tRNA wobble base modification(GO:0002097)
0.0 0.2 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 1.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 1.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.3 GO:1901725 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) regulation of histone deacetylase activity(GO:1901725) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.9 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.3 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.1 GO:0097501 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0 0.3 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.4 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.3 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 1.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.2 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.8 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0 0.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.2 GO:0035635 entry of bacterium into host cell(GO:0035635)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.4 GO:0045160 myosin I complex(GO:0045160)
0.1 2.0 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.3 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 1.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.5 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.3 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.2 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.2 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 1.0 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)
0.0 0.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.3 GO:0000178 exosome (RNase complex)(GO:0000178)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.3 1.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.3 3.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 2.4 GO:0043426 MRF binding(GO:0043426)
0.2 1.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.2 0.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 0.5 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.4 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.1 0.4 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 1.0 GO:0048495 Roundabout binding(GO:0048495)
0.1 3.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.7 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.4 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.1 0.9 GO:0008199 ferric iron binding(GO:0008199)
0.1 0.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.2 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.1 1.0 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 1.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.2 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.3 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.7 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.3 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.7 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.0 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.0 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 2.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 2.0 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.9 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.5 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors