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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SMAD3

Z-value: 0.85

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Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
SMAD3
ENSG00000166949.11 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD3hg19_v2_chr15_+_67420441_674206060.154.2e-01Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_26240561 1.46 ENST00000377745.2
HIST1H4F
histone cluster 1, H4f
chr4_-_177116772 1.45 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr6_+_116937636 1.40 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A
radial spoke head 4 homolog A (Chlamydomonas)
chr6_+_26217159 1.22 ENST00000303910.2
HIST1H2AE
histone cluster 1, H2ae
chr7_-_142247606 1.20 ENST00000390361.3
TRBV7-3
T cell receptor beta variable 7-3
chr14_+_96858433 1.17 ENST00000267584.4
AK7
adenylate kinase 7
chr1_-_60539405 1.16 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr1_-_60539422 1.15 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr19_-_11688500 1.12 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr6_-_26124138 1.11 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc
chr1_-_36906474 1.07 ENST00000433045.2
OSCP1
organic solute carrier partner 1
chr2_-_220110187 0.97 ENST00000295759.7
ENST00000392089.2
GLB1L
galactosidase, beta 1-like
chr2_-_220110111 0.97 ENST00000428427.1
ENST00000356283.3
ENST00000432839.1
ENST00000424620.1
GLB1L
galactosidase, beta 1-like
chr19_-_55691472 0.94 ENST00000537500.1
SYT5
synaptotagmin V
chr19_-_55691614 0.93 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr6_+_146920097 0.91 ENST00000397944.3
ENST00000522242.1
ADGB
androglobin
chr6_+_146920116 0.91 ENST00000367493.3
ADGB
androglobin
chr6_-_27775694 0.89 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chr18_+_44526786 0.86 ENST00000245121.5
ENST00000356157.7
KATNAL2
katanin p60 subunit A-like 2
chr16_+_699319 0.85 ENST00000549091.1
ENST00000293879.4
WDR90
WD repeat domain 90
chr6_+_26273144 0.84 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chr6_-_26216872 0.82 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr16_-_30773372 0.81 ENST00000545825.1
ENST00000541260.1
C16orf93
chromosome 16 open reading frame 93
chr6_+_27100811 0.81 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr1_-_9129895 0.80 ENST00000473209.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr16_+_618837 0.77 ENST00000409439.2
PIGQ
phosphatidylinositol glycan anchor biosynthesis, class Q
chr3_+_125687987 0.70 ENST00000514116.1
ENST00000251776.4
ENST00000504401.1
ENST00000513830.1
ENST00000508088.1
ROPN1B
rhophilin associated tail protein 1B
chr12_+_110906169 0.66 ENST00000377673.5
FAM216A
family with sequence similarity 216, member A
chr6_+_27114861 0.63 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chr17_-_34195862 0.60 ENST00000592980.1
ENST00000587626.1
C17orf66
chromosome 17 open reading frame 66
chr6_-_27860956 0.59 ENST00000359611.2
HIST1H2AM
histone cluster 1, H2am
chr17_-_34195889 0.58 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr15_+_71184931 0.58 ENST00000560369.1
ENST00000260382.5
LRRC49
leucine rich repeat containing 49
chrX_-_48328631 0.57 ENST00000429543.1
ENST00000317669.5
SLC38A5
solute carrier family 38, member 5
chrX_-_48328551 0.57 ENST00000376876.3
SLC38A5
solute carrier family 38, member 5
chr4_+_55524085 0.55 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr5_+_52776228 0.55 ENST00000256759.3
FST
follistatin
chr19_-_11688447 0.53 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chr6_-_27100529 0.52 ENST00000607124.1
ENST00000339812.2
ENST00000541790.1
HIST1H2BJ
histone cluster 1, H2bj
chr6_+_26124373 0.51 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr6_-_27782548 0.48 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr19_+_51728316 0.45 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr1_-_226129189 0.45 ENST00000366820.5
LEFTY2
left-right determination factor 2
chr1_-_226129083 0.43 ENST00000420304.2
LEFTY2
left-right determination factor 2
chr2_-_208031943 0.42 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr2_-_49381572 0.38 ENST00000454032.1
ENST00000304421.4
FSHR
follicle stimulating hormone receptor
chr14_-_106494587 0.38 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr16_+_25228242 0.38 ENST00000219660.5
AQP8
aquaporin 8
chr5_+_79950463 0.36 ENST00000265081.6
MSH3
mutS homolog 3
chr2_+_96991033 0.36 ENST00000420176.1
ENST00000536814.1
ENST00000439118.2
ITPRIPL1
inositol 1,4,5-trisphosphate receptor interacting protein-like 1
chr2_-_49381646 0.35 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr19_+_41594377 0.35 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr6_+_27775899 0.35 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr6_-_26285737 0.34 ENST00000377727.1
ENST00000289352.1
HIST1H4H
histone cluster 1, H4h
chr11_+_33563821 0.32 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chr1_+_149804218 0.32 ENST00000610125.1
HIST2H4A
histone cluster 2, H4a
chr3_-_112565703 0.31 ENST00000488794.1
CD200R1L
CD200 receptor 1-like
chr3_+_126243126 0.30 ENST00000319340.2
CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr6_-_27806117 0.29 ENST00000330180.2
HIST1H2AK
histone cluster 1, H2ak
chr17_-_56621665 0.28 ENST00000321691.3
C17orf47
chromosome 17 open reading frame 47
chr2_-_79313973 0.26 ENST00000454188.1
REG1B
regenerating islet-derived 1 beta
chr3_-_123710893 0.26 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
ROPN1
rhophilin associated tail protein 1
chr6_-_52441713 0.26 ENST00000182527.3
TRAM2
translocation associated membrane protein 2
chr1_+_59762642 0.25 ENST00000371218.4
ENST00000303721.7
FGGY
FGGY carbohydrate kinase domain containing
chr16_+_56703737 0.25 ENST00000569155.1
MT1H
metallothionein 1H
chr4_-_90759440 0.24 ENST00000336904.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr1_+_153388993 0.23 ENST00000368729.4
S100A7A
S100 calcium binding protein A7A
chr9_+_100069933 0.22 ENST00000529487.1
CCDC180
coiled-coil domain containing 180
chrX_-_46618490 0.21 ENST00000328306.4
SLC9A7
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
chr6_+_27861190 0.21 ENST00000303806.4
HIST1H2BO
histone cluster 1, H2bo
chr4_-_186696425 0.21 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
SORBS2
sorbin and SH3 domain containing 2
chr16_+_56703703 0.21 ENST00000332374.4
MT1H
metallothionein 1H
chr9_+_21967137 0.21 ENST00000441769.2
C9orf53
chromosome 9 open reading frame 53
chr10_-_90712520 0.20 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr13_-_60738003 0.20 ENST00000400330.1
ENST00000400324.4
DIAPH3
diaphanous-related formin 3
chr18_+_43753974 0.19 ENST00000282059.6
ENST00000321319.6
C18orf25
chromosome 18 open reading frame 25
chr3_+_141103634 0.19 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr22_-_36013368 0.19 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
MB
myoglobin
chr4_+_186990298 0.18 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr11_+_124824000 0.17 ENST00000529051.1
ENST00000344762.5
CCDC15
coiled-coil domain containing 15
chr19_-_35166604 0.17 ENST00000601241.1
SCGB2B2
secretoglobin, family 2B, member 2
chr6_+_27806319 0.17 ENST00000606613.1
ENST00000396980.3
HIST1H2BN
histone cluster 1, H2bn
chr1_-_44482979 0.16 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr6_-_27114577 0.16 ENST00000356950.1
ENST00000396891.4
HIST1H2BK
histone cluster 1, H2bk
chr2_-_105030466 0.16 ENST00000449772.1
AC068535.3
AC068535.3
chr14_-_100625932 0.15 ENST00000553834.1
DEGS2
delta(4)-desaturase, sphingolipid 2
chr15_-_83316254 0.15 ENST00000567678.1
ENST00000450751.2
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr12_+_49212514 0.15 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr4_-_39033963 0.15 ENST00000381938.3
TMEM156
transmembrane protein 156
chr19_-_13947099 0.14 ENST00000587762.1
MIR24-2
microRNA 24-2
chr6_+_27782788 0.14 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr3_+_51741072 0.14 ENST00000395052.3
GRM2
glutamate receptor, metabotropic 2
chr14_+_93389425 0.14 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr16_-_3350614 0.13 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr4_+_2813946 0.12 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr8_-_101117847 0.12 ENST00000523287.1
ENST00000519092.1
RGS22
regulator of G-protein signaling 22
chr5_-_68628543 0.11 ENST00000396496.2
ENST00000511257.1
ENST00000383374.2
CCDC125
coiled-coil domain containing 125
chrX_-_62571220 0.11 ENST00000374884.2
SPIN4
spindlin family, member 4
chr6_-_46922659 0.11 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chr1_+_209602771 0.10 ENST00000440276.1
MIR205HG
MIR205 host gene (non-protein coding)
chr1_+_52682052 0.10 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr20_+_44036620 0.10 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr20_+_44036900 0.10 ENST00000443296.1
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr12_+_50135588 0.10 ENST00000423828.1
ENST00000550445.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr4_+_2814011 0.10 ENST00000502260.1
ENST00000435136.2
SH3BP2
SH3-domain binding protein 2
chr9_+_37486005 0.10 ENST00000377792.3
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chrX_-_62571187 0.09 ENST00000335144.3
SPIN4
spindlin family, member 4
chr17_-_39093672 0.09 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr9_+_37485932 0.09 ENST00000377798.4
ENST00000442009.2
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr1_-_9129631 0.09 ENST00000377414.3
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr18_+_13611763 0.09 ENST00000585931.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr2_+_75061108 0.09 ENST00000290573.2
HK2
hexokinase 2
chr11_-_133402410 0.09 ENST00000524381.1
OPCML
opioid binding protein/cell adhesion molecule-like
chr7_-_22862406 0.09 ENST00000372879.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr9_+_72658490 0.09 ENST00000377182.4
MAMDC2
MAM domain containing 2
chr4_-_38666430 0.08 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr11_-_46142615 0.08 ENST00000529734.1
ENST00000323180.6
PHF21A
PHD finger protein 21A
chr12_+_96588143 0.08 ENST00000228741.3
ENST00000547249.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr14_+_24600484 0.08 ENST00000267426.5
FITM1
fat storage-inducing transmembrane protein 1
chr6_-_26033796 0.07 ENST00000259791.2
HIST1H2AB
histone cluster 1, H2ab
chr14_+_96858454 0.07 ENST00000555570.1
AK7
adenylate kinase 7
chr7_+_139529040 0.07 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr7_+_139528952 0.07 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr11_+_35211511 0.07 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr19_-_51192661 0.06 ENST00000391813.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr4_+_40337340 0.06 ENST00000310169.2
CHRNA9
cholinergic receptor, nicotinic, alpha 9 (neuronal)
chr7_-_22862448 0.06 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr12_+_50135351 0.06 ENST00000549445.1
ENST00000550951.1
ENST00000549385.1
ENST00000548713.1
ENST00000548201.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chrX_-_110513703 0.06 ENST00000324068.1
CAPN6
calpain 6
chr2_-_136594740 0.06 ENST00000264162.2
LCT
lactase
chr12_+_26111823 0.06 ENST00000381352.3
ENST00000535907.1
ENST00000405154.2
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr20_-_43280361 0.06 ENST00000372874.4
ADA
adenosine deaminase
chr19_-_37958086 0.05 ENST00000592490.1
ENST00000392149.2
ZNF569
zinc finger protein 569
chr1_-_89357179 0.05 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
GTF2B
general transcription factor IIB
chr16_+_30483962 0.05 ENST00000356798.6
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr8_-_101118210 0.05 ENST00000360863.6
RGS22
regulator of G-protein signaling 22
chr2_+_16080659 0.05 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr9_-_14910990 0.05 ENST00000380881.4
ENST00000422223.2
FREM1
FRAS1 related extracellular matrix 1
chr10_+_94451574 0.05 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr18_+_77623668 0.05 ENST00000316249.3
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr17_+_36452989 0.05 ENST00000312513.5
ENST00000582535.1
MRPL45
mitochondrial ribosomal protein L45
chr12_+_14927270 0.05 ENST00000544848.1
H2AFJ
H2A histone family, member J
chr12_+_50135327 0.05 ENST00000549966.1
ENST00000547832.1
ENST00000547187.1
ENST00000548894.1
ENST00000546914.1
ENST00000552699.1
ENST00000267115.5
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr5_-_41870621 0.05 ENST00000196371.5
OXCT1
3-oxoacid CoA transferase 1
chr21_+_33031935 0.05 ENST00000270142.6
ENST00000389995.4
SOD1
superoxide dismutase 1, soluble
chr2_+_220110177 0.05 ENST00000409638.3
ENST00000396738.2
ENST00000409516.3
STK16
serine/threonine kinase 16
chr8_+_38586068 0.04 ENST00000443286.2
ENST00000520340.1
ENST00000518415.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr11_+_116700600 0.04 ENST00000227667.3
APOC3
apolipoprotein C-III
chr6_+_30850697 0.04 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1
discoidin domain receptor tyrosine kinase 1
chr6_-_11807277 0.04 ENST00000379415.2
ADTRP
androgen-dependent TFPI-regulating protein
chr1_+_25757376 0.04 ENST00000399766.3
ENST00000399763.3
ENST00000374343.4
TMEM57
transmembrane protein 57
chr11_+_116700614 0.04 ENST00000375345.1
APOC3
apolipoprotein C-III
chr11_+_72983246 0.04 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr20_+_24449821 0.03 ENST00000376862.3
SYNDIG1
synapse differentiation inducing 1
chr11_+_117070037 0.03 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN
transgelin
chr10_+_118350468 0.03 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr18_+_13612613 0.03 ENST00000586765.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr5_+_140625147 0.03 ENST00000231173.3
PCDHB15
protocadherin beta 15
chr11_-_72145426 0.03 ENST00000535990.1
ENST00000437826.2
ENST00000340729.5
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr10_+_118350522 0.03 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr16_+_30484021 0.03 ENST00000358164.5
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chrX_-_101410762 0.03 ENST00000543160.1
ENST00000333643.3
BEX5
brain expressed, X-linked 5
chr1_+_153190053 0.02 ENST00000368744.3
PRR9
proline rich 9
chr5_+_55147205 0.02 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr20_-_60795296 0.02 ENST00000340177.5
HRH3
histamine receptor H3
chr1_-_8877692 0.02 ENST00000400908.2
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr9_+_44867571 0.02 ENST00000377548.2
RP11-160N1.10
RP11-160N1.10
chr14_-_24551195 0.02 ENST00000560550.1
NRL
neural retina leucine zipper
chr13_-_114898016 0.01 ENST00000542651.1
ENST00000334062.7
RASA3
RAS p21 protein activator 3
chr1_+_202385953 0.01 ENST00000466968.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr19_+_42724423 0.01 ENST00000301215.3
ENST00000597945.1
ZNF526
zinc finger protein 526
chr4_-_157563459 0.01 ENST00000504237.1
ENST00000511399.1
RP11-171N4.2
Uncharacterized protein
chr14_+_53196872 0.00 ENST00000442123.2
ENST00000354586.4
STYX
serine/threonine/tyrosine interacting protein
chr6_+_26204825 0.00 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr6_+_123038689 0.00 ENST00000354275.2
ENST00000368446.1
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 0.6 GO:0038162 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.2 0.7 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.1 1.3 GO:0015816 glycine transport(GO:0015816)
0.1 1.8 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.5 GO:0015755 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.1 0.4 GO:0009804 coumarin metabolic process(GO:0009804)
0.1 0.6 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.2 GO:0051620 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.2 GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.0 0.2 GO:0034343 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.1 GO:0061110 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.0 1.9 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.4 GO:0051096 positive regulation of helicase activity(GO:0051096)
0.0 0.2 GO:0060701 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.2 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.7 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.8 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.0 0.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 1.4 GO:0035082 axoneme assembly(GO:0035082)
0.0 2.5 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.1 GO:0050894 determination of affect(GO:0050894)
0.0 1.2 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.0 0.5 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.9 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.0 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.0 0.1 GO:0072656 negative regulation of mitochondrial membrane permeability(GO:0035795) maintenance of protein location in mitochondrion(GO:0072656) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.2 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.4 GO:0006833 water transport(GO:0006833)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0001534 radial spoke(GO:0001534)
0.4 1.9 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.4 GO:0032302 MutSbeta complex(GO:0032302)
0.1 5.7 GO:0000786 nucleosome(GO:0000786)
0.1 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 1.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.9 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 0.7 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.2 1.2 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.4 GO:0032181 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1 1.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.7 GO:0008199 ferric iron binding(GO:0008199)
0.1 0.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.5 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 0.8 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.3 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.1 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 1.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.6 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.6 GO:0048185 activin binding(GO:0048185)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 1.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0031877 somatostatin receptor binding(GO:0031877)
0.0 0.4 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.7 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.1 GO:0015266 protein channel activity(GO:0015266)
0.0 0.0 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.7 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.8 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.9 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 2.1 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters