Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for SMAD4
Z-value: 1.48
Motif logo
Transcription factors associated with SMAD4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD4 | hg19_v2_chr18_+_48556470_48556640 | -0.71 | 1.2e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51456321 Show fit | 7.65 |
ENST00000391809.2
|
kallikrein-related peptidase 5 |
|
| chr19_-_51456344 Show fit | 7.07 |
ENST00000336334.3
ENST00000593428.1 |
kallikrein-related peptidase 5 |
|
| chr19_-_51456198 Show fit | 4.90 |
ENST00000594846.1
|
kallikrein-related peptidase 5 |
|
| chr1_+_152956549 Show fit | 3.72 |
ENST00000307122.2
|
small proline-rich protein 1A |
|
| chr19_-_11688447 Show fit | 3.13 |
ENST00000590420.1
|
acid phosphatase 5, tartrate resistant |
|
| chrX_-_48328551 Show fit | 3.08 |
ENST00000376876.3
|
solute carrier family 38, member 5 |
|
| chr1_-_28520447 Show fit | 3.05 |
ENST00000539896.1
|
platelet-activating factor receptor |
|
| chrX_-_48328631 Show fit | 3.00 |
ENST00000429543.1
ENST00000317669.5 |
solute carrier family 38, member 5 |
|
| chr1_+_45212074 Show fit | 3.00 |
ENST00000372217.1
|
kinesin family member 2C |
|
| chr5_+_148521381 Show fit | 2.99 |
ENST00000504238.1
|
actin binding LIM protein family, member 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 19.6 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.1 | 10.2 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.1 | 10.1 | GO:0070268 | cornification(GO:0070268) |
| 0.5 | 6.4 | GO:0015816 | glycine transport(GO:0015816) |
| 1.2 | 6.0 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.6 | 5.8 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.3 | 5.7 | GO:1901748 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.1 | 5.6 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 5.6 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 1.8 | 5.5 | GO:1902565 | positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 20.4 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 12.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 10.8 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 10.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 9.9 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.4 | 8.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 8.6 | GO:0044297 | cell body(GO:0044297) |
| 0.0 | 7.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 6.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.3 | 4.9 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 6.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.5 | 6.7 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.6 | 6.4 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.3 | 6.3 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 1.2 | 5.9 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 0.6 | 5.8 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.3 | 5.7 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 1.1 | 5.6 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.0 | 5.6 | GO:0045296 | cadherin binding(GO:0045296) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 7.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 5.4 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 4.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 4.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.5 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 4.1 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 4.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 4.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.0 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.2 | 6.3 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.3 | 5.9 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 5.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 5.2 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 4.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 4.5 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 4.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 4.1 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 4.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |