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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SOX13_SOX12
Z-value: 1.27
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Transcription factors associated with SOX13_SOX12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX13 | hg19_v2_chr1_+_204042723_204042784 | 0.34 | 6.2e-02 | Click! |
| SOX12 | hg19_v2_chr20_+_306177_306211 | 0.21 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_102928009 Show fit | 14.71 |
ENST00000404917.2
ENST00000447231.1 |
interleukin 1 receptor-like 1 |
|
| chr10_+_118187379 Show fit | 5.12 |
ENST00000369230.3
|
pancreatic lipase-related protein 3 |
|
| chr12_-_91505608 Show fit | 4.58 |
ENST00000266718.4
|
lumican |
|
| chr4_-_69111401 Show fit | 4.36 |
ENST00000332644.5
|
transmembrane protease, serine 11B |
|
| chr4_-_57547454 Show fit | 3.92 |
ENST00000556376.2
|
HOP homeobox |
|
| chr4_-_74864386 Show fit | 3.78 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr1_+_152975488 Show fit | 3.22 |
ENST00000542696.1
|
small proline-rich protein 3 |
|
| chr7_+_100770328 Show fit | 3.11 |
ENST00000223095.4
ENST00000445463.2 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
|
| chr1_-_153433120 Show fit | 3.06 |
ENST00000368723.3
|
S100 calcium binding protein A7 |
|
| chr1_+_153388993 Show fit | 3.01 |
ENST00000368729.4
|
S100 calcium binding protein A7A |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX13_SOX12
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 15.1 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.1 | 10.3 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.2 | 8.2 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.9 | 5.3 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction(GO:0010751) |
| 0.1 | 4.8 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.7 | 4.6 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.7 | 4.4 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.0 | 4.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.2 | 4.2 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.2 | 3.9 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 10.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.3 | 7.6 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 6.1 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.4 | 5.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 5.3 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 5.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.3 | 4.6 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 4.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.5 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 15.1 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.0 | 11.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 11.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 10.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 10.3 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.3 | 7.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.2 | 5.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 5.3 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.7 | 4.4 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.3 | 4.2 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 7.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 5.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 5.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 5.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 4.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 4.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 4.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.7 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.5 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 5.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 5.0 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 4.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 4.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 4.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 4.1 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 3.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 3.3 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 2.7 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |