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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SOX21

Z-value: 0.46

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.4 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_953643890.173.6e-01Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_69313145 2.21 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr1_+_152881014 1.19 ENST00000368764.3
ENST00000392667.2
IVL
involucrin
chr11_+_35201826 0.99 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr12_-_89746173 0.88 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr1_-_54303934 0.84 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr4_-_39034542 0.83 ENST00000344606.6
TMEM156
transmembrane protein 156
chr19_+_16308659 0.82 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr15_-_80263506 0.79 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr6_+_31371337 0.78 ENST00000449934.2
ENST00000421350.1
MICA
MHC class I polypeptide-related sequence A
chr19_+_16308711 0.77 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr12_+_123011776 0.71 ENST00000450485.2
ENST00000333479.7
KNTC1
kinetochore associated 1
chr11_+_5410607 0.66 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr7_-_73133959 0.64 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr8_-_143961236 0.50 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1
chr19_+_7030589 0.47 ENST00000329753.5
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr19_-_7040190 0.42 ENST00000381394.4
MBD3L4
methyl-CpG binding domain protein 3-like 4
chrY_+_14813160 0.42 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr1_-_151148492 0.40 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chrX_+_2984874 0.38 ENST00000359361.2
ARSF
arylsulfatase F
chr4_-_177190364 0.38 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr12_+_1099675 0.35 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr14_-_107170409 0.34 ENST00000390633.2
IGHV1-69
immunoglobulin heavy variable 1-69
chr1_+_67632083 0.32 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr9_-_14910990 0.30 ENST00000380881.4
ENST00000422223.2
FREM1
FRAS1 related extracellular matrix 1
chr3_+_57994127 0.28 ENST00000490882.1
ENST00000295956.4
ENST00000358537.3
ENST00000429972.2
ENST00000348383.5
ENST00000357272.4
FLNB
filamin B, beta
chr2_+_3705785 0.28 ENST00000252505.3
ALLC
allantoicase
chr9_-_104249400 0.27 ENST00000374848.3
TMEM246
transmembrane protein 246
chr12_+_20522179 0.26 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chrX_-_39186610 0.25 ENST00000429281.1
ENST00000448597.1
RP11-265P11.2
RP11-265P11.2
chr6_-_3195981 0.25 ENST00000425384.2
ENST00000435043.2
RP1-40E16.9
RP1-40E16.9
chr6_-_112575838 0.24 ENST00000455073.1
LAMA4
laminin, alpha 4
chr18_+_29769978 0.24 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr19_-_2783363 0.24 ENST00000221566.2
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr10_+_5005445 0.22 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr4_-_122854612 0.22 ENST00000264811.5
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr17_-_71410794 0.22 ENST00000424778.1
SDK2
sidekick cell adhesion molecule 2
chr6_-_112575912 0.21 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr4_-_83931862 0.21 ENST00000506560.1
ENST00000442461.2
ENST00000446851.2
ENST00000340417.3
LIN54
lin-54 homolog (C. elegans)
chr16_-_15149828 0.20 ENST00000566419.1
ENST00000568320.1
NTAN1
N-terminal asparagine amidase
chr8_+_26150628 0.20 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr9_+_105757590 0.19 ENST00000374798.3
ENST00000487798.1
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr12_-_10324716 0.19 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr3_-_164875850 0.18 ENST00000472120.1
RP11-747D18.1
RP11-747D18.1
chrX_+_65384052 0.17 ENST00000336279.5
ENST00000458621.1
HEPH
hephaestin
chr17_+_66245341 0.17 ENST00000577985.1
AMZ2
archaelysin family metallopeptidase 2
chr10_-_13276329 0.17 ENST00000378681.3
ENST00000463405.2
UCMA
upper zone of growth plate and cartilage matrix associated
chr12_-_1058685 0.17 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
RAD52
RAD52 homolog (S. cerevisiae)
chr6_+_140175987 0.16 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr15_+_58702742 0.16 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr3_+_37035289 0.16 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr7_-_37026108 0.16 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr3_+_37035263 0.15 ENST00000458205.2
ENST00000539477.1
MLH1
mutL homolog 1
chrX_+_36053908 0.15 ENST00000378660.2
CHDC2
calponin homology domain containing 2
chr20_+_43343886 0.14 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr22_+_23063100 0.14 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr5_-_179045199 0.13 ENST00000523921.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr8_-_19459993 0.12 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr6_-_112575758 0.12 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr17_+_60457914 0.12 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
EFCAB3
EF-hand calcium binding domain 3
chr7_+_2394445 0.11 ENST00000360876.4
ENST00000413917.1
ENST00000397011.2
EIF3B
eukaryotic translation initiation factor 3, subunit B
chr22_+_39353527 0.11 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr4_-_103746683 0.11 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr19_+_42381173 0.11 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr1_+_158901329 0.11 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr9_+_99691286 0.10 ENST00000372322.3
NUTM2G
NUT family member 2G
chr7_+_120702819 0.10 ENST00000423795.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr4_-_103746924 0.10 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_103747011 0.10 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr10_-_71169031 0.10 ENST00000373307.1
TACR2
tachykinin receptor 2
chr19_-_54784937 0.09 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr3_+_37034823 0.09 ENST00000231790.2
ENST00000456676.2
MLH1
mutL homolog 1
chr17_-_18266660 0.08 ENST00000582653.1
ENST00000352886.6
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr1_+_199996733 0.08 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr3_+_141103634 0.07 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr6_-_121655593 0.07 ENST00000398212.2
TBC1D32
TBC1 domain family, member 32
chr22_-_40929812 0.07 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr1_+_146714291 0.07 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
CHD1L
chromodomain helicase DNA binding protein 1-like
chr3_+_38537960 0.07 ENST00000453767.1
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr11_+_114168085 0.06 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr1_-_26394114 0.05 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr6_+_42531798 0.05 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr16_-_15982440 0.05 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
FOPNL
FGFR1OP N-terminal like
chr14_+_50291993 0.04 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr19_+_18682531 0.04 ENST00000596304.1
ENST00000430157.2
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr5_-_95158644 0.04 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr19_-_45737469 0.04 ENST00000413988.1
EXOC3L2
exocyst complex component 3-like 2
chr5_-_95158375 0.04 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chrX_+_52927576 0.03 ENST00000416841.2
FAM156B
family with sequence similarity 156, member B
chr11_-_8285405 0.03 ENST00000335790.3
ENST00000534484.1
LMO1
LIM domain only 1 (rhombotin 1)
chr3_+_38537763 0.02 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr7_-_14942944 0.02 ENST00000403951.2
DGKB
diacylglycerol kinase, beta 90kDa
chr19_+_42381337 0.02 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr3_+_155838337 0.02 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr5_+_175875349 0.01 ENST00000261942.6
FAF2
Fas associated factor family member 2
chrY_+_16634483 0.01 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr10_-_17243579 0.00 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr3_-_155572164 0.00 ENST00000392845.3
ENST00000359479.3
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.3 0.9 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.3 0.8 GO:0070631 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.2 0.6 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.4 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.1 1.0 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.8 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.1 0.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 0.3 GO:0043605 allantoin metabolic process(GO:0000255) cellular amide catabolic process(GO:0043605)
0.1 1.6 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.1 0.3 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.1 0.5 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.3 GO:0071321 cellular response to cGMP(GO:0071321)
0.0 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.9 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.2 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.1 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0 0.2 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.1 GO:1904482 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.0 0.2 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.7 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.2 0.7 GO:1990423 RZZ complex(GO:1990423)
0.2 0.6 GO:0048787 presynaptic active zone membrane(GO:0048787) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 1.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.4 GO:0005715 late recombination nodule(GO:0005715)
0.1 0.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.1 0.2 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 1.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 1.2 GO:0001533 cornified envelope(GO:0001533)
0.0 0.6 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.1 0.3 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.2 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.8 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 0.3 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.1 0.2 GO:0047023 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.1 0.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.9 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.8 GO:0051400 BH domain binding(GO:0051400)
0.0 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.4 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0070905 serine binding(GO:0070905)
0.0 0.1 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.9 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.6 PID FOXM1 PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.9 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels