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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SOX30

Z-value: 0.43

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Transcription factors associated with SOX30

Gene Symbol Gene ID Gene Info
SOX30
ENSG00000039600.6 SRY-box transcription factor 30

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX30hg19_v2_chr5_-_157079428_157079452,
hg19_v2_chr5_-_157079372_157079395		-0.242.1e-01Click!

Activity profile of SOX30 motif

Sorted Z-values of SOX30 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_28270795 2.07 ENST00000545014.1
ARMC4
armadillo repeat containing 4
chr3_-_19988462 1.55 ENST00000344838.4
EFHB
EF-hand domain family, member B
chr6_+_131958436 1.54 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr1_+_47489240 1.38 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr6_-_139613269 1.23 ENST00000358430.3
TXLNB
taxilin beta
chr12_-_10282836 1.19 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr3_+_181429704 0.89 ENST00000431565.2
ENST00000325404.1
SOX2
SRY (sex determining region Y)-box 2
chr4_-_70725856 0.88 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr8_+_24151553 0.73 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr4_+_77356248 0.73 ENST00000296043.6
SHROOM3
shroom family member 3
chr5_-_160279207 0.71 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr11_+_63137251 0.67 ENST00000310969.4
ENST00000279178.3
SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr6_-_134639180 0.63 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr10_+_35415851 0.61 ENST00000374726.3
CREM
cAMP responsive element modulator
chr12_-_10282742 0.58 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr12_-_10282681 0.57 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr2_+_232573208 0.57 ENST00000409115.3
PTMA
prothymosin, alpha
chr11_-_75236867 0.56 ENST00000376282.3
ENST00000336898.3
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr8_+_105352050 0.53 ENST00000297581.2
DCSTAMP
dendrocyte expressed seven transmembrane protein
chr2_+_232573222 0.53 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chr11_-_85430204 0.50 ENST00000389958.3
ENST00000527794.1
SYTL2
synaptotagmin-like 2
chr5_+_140235469 0.50 ENST00000506939.2
ENST00000307360.5
PCDHA10
protocadherin alpha 10
chr2_-_157198860 0.49 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr11_-_85430163 0.48 ENST00000529581.1
ENST00000533577.1
SYTL2
synaptotagmin-like 2
chr10_+_70480963 0.48 ENST00000265872.6
ENST00000535016.1
ENST00000538031.1
ENST00000543719.1
ENST00000539539.1
ENST00000543225.1
ENST00000536012.1
ENST00000494903.2
CCAR1
cell division cycle and apoptosis regulator 1
chrX_-_117107542 0.41 ENST00000371878.1
KLHL13
kelch-like family member 13
chr8_+_24151620 0.40 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr4_-_87028478 0.37 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr6_+_126240442 0.36 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr11_+_36317830 0.32 ENST00000530639.1
PRR5L
proline rich 5 like
chr5_+_170288856 0.29 ENST00000523189.1
RANBP17
RAN binding protein 17
chr11_-_85430088 0.28 ENST00000533057.1
ENST00000533892.1
SYTL2
synaptotagmin-like 2
chr22_-_30970560 0.25 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr22_+_46449674 0.23 ENST00000381051.2
FLJ27365
hsa-mir-4763
chr1_-_85930246 0.23 ENST00000426972.3
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr13_-_41593425 0.22 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_-_92855762 0.22 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr5_+_139175380 0.22 ENST00000274710.3
PSD2
pleckstrin and Sec7 domain containing 2
chr15_-_52944231 0.21 ENST00000546305.2
FAM214A
family with sequence similarity 214, member A
chr6_-_49712123 0.21 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chrX_-_24690771 0.20 ENST00000379145.1
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chrY_+_15016013 0.20 ENST00000360160.4
ENST00000454054.1
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr2_+_179184955 0.19 ENST00000315022.2
OSBPL6
oxysterol binding protein-like 6
chr1_+_244998602 0.19 ENST00000411948.2
COX20
COX20 cytochrome C oxidase assembly factor
chr11_-_102323740 0.19 ENST00000398136.2
TMEM123
transmembrane protein 123
chr1_+_93913713 0.19 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr1_-_26324534 0.17 ENST00000374284.1
ENST00000441420.1
ENST00000374282.3
PAFAH2
platelet-activating factor acetylhydrolase 2, 40kDa
chr5_+_140729649 0.17 ENST00000523390.1
PCDHGB1
protocadherin gamma subfamily B, 1
chr3_+_140981456 0.17 ENST00000504264.1
ACPL2
acid phosphatase-like 2
chr4_+_113152978 0.15 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr1_-_167883327 0.15 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
ADCY10
adenylate cyclase 10 (soluble)
chr14_+_36295504 0.15 ENST00000216807.7
BRMS1L
breast cancer metastasis-suppressor 1-like
chr5_-_146461027 0.15 ENST00000394410.2
ENST00000508267.1
ENST00000504198.1
PPP2R2B
protein phosphatase 2, regulatory subunit B, beta
chr11_-_102323489 0.14 ENST00000361236.3
TMEM123
transmembrane protein 123
chr11_-_18548426 0.14 ENST00000357193.3
ENST00000536719.1
TSG101
tumor susceptibility 101
chr2_-_158182410 0.14 ENST00000419116.2
ENST00000410096.1
ERMN
ermin, ERM-like protein
chr17_-_38821373 0.13 ENST00000394052.3
KRT222
keratin 222
chr14_-_90420862 0.13 ENST00000556005.1
ENST00000555872.1
EFCAB11
EF-hand calcium binding domain 11
chr18_+_7946941 0.13 ENST00000444013.1
PTPRM
protein tyrosine phosphatase, receptor type, M
chr14_-_90421028 0.12 ENST00000267544.9
ENST00000316738.7
ENST00000538485.2
ENST00000556609.1
EFCAB11
EF-hand calcium binding domain 11
chr12_+_80750134 0.12 ENST00000546620.1
OTOGL
otogelin-like
chr1_+_240255166 0.12 ENST00000319653.9
FMN2
formin 2
chr12_-_10251576 0.12 ENST00000315330.4
CLEC1A
C-type lectin domain family 1, member A
chr10_+_35416090 0.12 ENST00000354759.3
CREM
cAMP responsive element modulator
chr3_-_165555200 0.12 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
BCHE
butyrylcholinesterase
chr11_+_125365110 0.12 ENST00000527818.1
AP000708.1
AP000708.1
chr1_+_185014496 0.11 ENST00000367510.3
RNF2
ring finger protein 2
chr5_+_140787600 0.11 ENST00000520790.1
PCDHGB6
protocadherin gamma subfamily B, 6
chr5_+_38148582 0.11 ENST00000508853.1
CTD-2207A17.1
CTD-2207A17.1
chr10_+_35416223 0.11 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
CREM
cAMP responsive element modulator
chr1_-_21503337 0.11 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr10_+_35415719 0.10 ENST00000474362.1
ENST00000374721.3
CREM
cAMP responsive element modulator
chr1_-_156828810 0.10 ENST00000368195.3
INSRR
insulin receptor-related receptor
chr5_+_140593509 0.10 ENST00000341948.4
PCDHB13
protocadherin beta 13
chr5_+_140772381 0.10 ENST00000398604.2
PCDHGA8
protocadherin gamma subfamily A, 8
chr17_+_67498538 0.10 ENST00000589647.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr1_-_167883353 0.09 ENST00000545172.1
ADCY10
adenylate cyclase 10 (soluble)
chr1_+_40942887 0.09 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr16_+_20499024 0.09 ENST00000593357.1
AC137056.1
Uncharacterized protein; cDNA FLJ34659 fis, clone KIDNE2018863
chr11_-_102576537 0.09 ENST00000260229.4
MMP27
matrix metallopeptidase 27
chr19_-_44439387 0.08 ENST00000269973.5
ZNF45
zinc finger protein 45
chr4_+_54243862 0.08 ENST00000306932.6
FIP1L1
factor interacting with PAPOLA and CPSF1
chr12_-_10251539 0.08 ENST00000420265.2
CLEC1A
C-type lectin domain family 1, member A
chr4_+_71457970 0.07 ENST00000322937.6
AMBN
ameloblastin (enamel matrix protein)
chr2_-_37899323 0.07 ENST00000295324.3
ENST00000457889.1
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr12_-_10251603 0.07 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr17_+_47448102 0.06 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr6_+_22146851 0.06 ENST00000606197.1
CASC15
cancer susceptibility candidate 15 (non-protein coding)
chr1_+_185703513 0.06 ENST00000271588.4
ENST00000367492.2
HMCN1
hemicentin 1
chr10_+_35415978 0.06 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
CREM
cAMP responsive element modulator
chr2_+_99953816 0.05 ENST00000289371.6
EIF5B
eukaryotic translation initiation factor 5B
chr6_-_11779174 0.05 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr6_-_11779014 0.05 ENST00000229583.5
ADTRP
androgen-dependent TFPI-regulating protein
chr5_-_134734901 0.05 ENST00000312469.4
ENST00000423969.2
H2AFY
H2A histone family, member Y
chr4_+_71458012 0.05 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr10_+_35484793 0.04 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr3_-_18466026 0.04 ENST00000417717.2
SATB1
SATB homeobox 1
chr2_-_162931052 0.04 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr19_-_17375541 0.04 ENST00000252597.3
USHBP1
Usher syndrome 1C binding protein 1
chr3_-_8686479 0.03 ENST00000544814.1
ENST00000427408.1
SSUH2
ssu-2 homolog (C. elegans)
chr8_+_42195972 0.02 ENST00000532157.1
ENST00000265421.4
ENST00000520008.1
POLB
polymerase (DNA directed), beta
chr14_+_52456193 0.02 ENST00000261700.3
C14orf166
chromosome 14 open reading frame 166
chr4_-_176733897 0.02 ENST00000393658.2
GPM6A
glycoprotein M6A
chr14_+_52456327 0.01 ENST00000556760.1
C14orf166
chromosome 14 open reading frame 166
chr7_-_142176790 0.01 ENST00000390369.2
TRBV7-4
T cell receptor beta variable 7-4 (gene/pseudogene)

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.3 0.9 GO:0006711 estrogen catabolic process(GO:0006711)
0.2 0.5 GO:0034238 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241)
0.2 0.5 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 2.1 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.1 2.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.9 GO:0001714 endodermal cell fate specification(GO:0001714)
0.1 1.3 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 0.6 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.7 GO:0015747 urate transport(GO:0015747)
0.1 0.2 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.0 0.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:2000395 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.6 GO:0048505 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0 0.1 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.0 0.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.6 GO:0045176 apical protein localization(GO:0045176)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.1 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.3 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.1 GO:0071469 cellular response to alkaline pH(GO:0071469)
0.0 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.2 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 1.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0003351 epithelial cilium movement(GO:0003351)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 GO:0097546 ciliary base(GO:0097546)
0.0 0.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.2 0.6 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 0.9 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1 2.3 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.4 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 1.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.4 GO:0070330 aromatase activity(GO:0070330)
0.1 1.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.7 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.2 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.0 0.9 GO:0035198 miRNA binding(GO:0035198)
0.0 0.2 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.6 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.1 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.0 PID FOXO PATHWAY FoxO family signaling
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins