ISMARA results: SOX3

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SOX3_SOX2

Z-value: 1.70

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Transcription factors associated with SOX3_SOX2

Gene Symbol	Gene ID	Gene Info
SOX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000134595.6	SRY-box transcription factor 3
SOX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000181449.2	SRY-box transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SOX2	hg19_v2_chr3_+_181429704_181429722	-0.61	3.2e-04	Click!
SOX3	hg19_v2_chrX_-_139587225_139587234	0.21	2.6e-01	Click!

Activity profile of SOX3_SOX2 motif

Sorted Z-values of SOX3_SOX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_1748214 Show fit	8.75	ENST00000433670.1 ENST00000425171.1 ENST00000252804.4	PXDN Ensembl NCBI GeneCards UniProt NextProt Show fit	peroxidasin homolog (Drosophila)
chr6_-_30654977 Show fit	7.89	ENST00000399199.3	PPP1R18 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory subunit 18
chr1_-_205419053 Show fit	5.99	ENST00000367154.1	LEMD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	LEM domain containing 1
chr19_-_49864746 Show fit	5.60	ENST00000598810.1	TEAD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	TEA domain family member 2
chr1_-_153029980 Show fit	5.35	ENST00000392653.2	SPRR2A Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2A
chr19_-_51472823 Show fit	5.06	ENST00000310157.2	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6
chr10_-_105845674 Show fit	4.72	ENST00000353479.5 ENST00000369733.3	COL17A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type XVII, alpha 1
chr15_-_74495188 Show fit	4.28	ENST00000563965.1 ENST00000395105.4	STRA6 Ensembl NCBI GeneCards UniProt NextProt Show fit	stimulated by retinoic acid 6
chr4_-_80993717 Show fit	4.16	ENST00000307333.7	ANTXR2 Ensembl NCBI GeneCards UniProt NextProt Show fit	anthrax toxin receptor 2
chr2_-_216257849 Show fit	4.12	ENST00000456923.1	FN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	fibronectin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX3_SOX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.2	GO:0018149	peptide cross-linking(GO:0018149)
0.2	10.6	GO:1901998	toxin transport(GO:1901998)
0.9	9.8	GO:0097070	ductus arteriosus closure(GO:0097070)
0.3	9.4	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
0.7	7.8	GO:0070574	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.3	7.6	GO:0030903	notochord development(GO:0030903)
0.3	7.6	GO:0051764	actin crosslink formation(GO:0051764)
0.3	6.6	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.1	6.6	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.3	5.5	GO:0016540	protein autoprocessing(GO:0016540)

Showing 1 to 10 of 563 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	15.1	GO:0001533	cornified envelope(GO:0001533)
0.1	11.0	GO:0005871	kinesin complex(GO:0005871)
0.4	10.8	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	10.5	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.1	8.3	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	8.0	GO:0009897	external side of plasma membrane(GO:0009897)
1.9	7.5	GO:0071149	TEAD-2-YAP complex(GO:0071149)
0.0	6.4	GO:0005882	intermediate filament(GO:0005882)
0.0	5.7	GO:0070821	tertiary granule membrane(GO:0070821)
0.1	5.5	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)

Showing 1 to 10 of 229 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.7	GO:0003777	microtubule motor activity(GO:0003777)
2.0	10.0	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	8.9	GO:0017124	SH3 domain binding(GO:0017124)
0.1	8.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.2	7.7	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	7.6	GO:0016504	peptidase activator activity(GO:0016504)
0.2	7.1	GO:0001223	transcription coactivator binding(GO:0001223)
0.3	6.4	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.4	6.3	GO:0045499	chemorepellent activity(GO:0045499)
0.2	6.2	GO:0005523	tropomyosin binding(GO:0005523)

Showing 1 to 10 of 358 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	10.5	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.2	9.1	NABA COLLAGENS	Genes encoding collagen proteins
0.1	9.1	PID AURORA B PATHWAY	Aurora B signaling
0.1	8.4	PID LKB1 PATHWAY	LKB1 signaling events
0.1	8.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	6.7	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	6.5	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	6.4	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.4	6.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 10 of 66 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	12.0	REACTOME KINESINS	Genes involved in Kinesins
0.1	9.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.3	8.4	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	8.0	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3	7.7	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	7.5	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2	4.9	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	4.9	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	4.8	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis

Showing 1 to 10 of 115 entries

Results for SOX3_SOX2

Z-value: 1.70

Motif logo

Transcription factors associated with SOX3_SOX2

Activity-expression correlation:

Activity profile of SOX3_SOX2 motif

Sorted Z-values of SOX3_SOX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX3_SOX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: