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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SOX4

Z-value: 0.65

Motif logo

Transcription factors associated with SOX4

Gene Symbol Gene ID Gene Info
ENSG00000124766.4 SRY-box transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX4hg19_v2_chr6_+_21593972_21594071-0.096.2e-01Click!

Activity profile of SOX4 motif

Sorted Z-values of SOX4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_74495188 2.37 ENST00000563965.1
ENST00000395105.4
stimulated by retinoic acid 6
chr10_-_105845674 2.19 ENST00000353479.5
ENST00000369733.3
collagen, type XVII, alpha 1
chr14_+_75746781 1.93 ENST00000555347.1
FBJ murine osteosarcoma viral oncogene homolog
chr7_+_134551583 1.71 ENST00000435928.1
caldesmon 1
chr2_-_208031542 1.68 ENST00000423015.1
Kruppel-like factor 7 (ubiquitous)
chr2_-_1748214 1.56 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
peroxidasin homolog (Drosophila)
chr4_-_69111401 1.56 ENST00000332644.5
transmembrane protease, serine 11B
chr2_+_33172221 1.56 ENST00000354476.3
latent transforming growth factor beta binding protein 1
chrX_-_153599578 1.55 ENST00000360319.4
ENST00000344736.4
filamin A, alpha
chr22_+_31477296 1.53 ENST00000426927.1
ENST00000440425.1
ENST00000358743.1
ENST00000347557.2
ENST00000333137.7
smoothelin
chr15_+_63335899 1.42 ENST00000561266.1
tropomyosin 1 (alpha)
chr4_+_54966198 1.22 ENST00000326902.2
ENST00000503800.1
GS homeobox 2
chrX_+_69509927 1.22 ENST00000374403.3
kinesin family member 4A
chr7_-_107643674 1.21 ENST00000222399.6
laminin, beta 1
chr2_-_9143786 1.19 ENST00000462696.1
ENST00000305997.3
membrane bound O-acyltransferase domain containing 2
chr7_+_134464376 1.18 ENST00000454108.1
ENST00000361675.2
caldesmon 1
chr2_-_85641162 1.17 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
capping protein (actin filament), gelsolin-like
chr7_+_134464414 1.16 ENST00000361901.2
caldesmon 1
chr11_-_10829851 1.11 ENST00000532082.1
eukaryotic translation initiation factor 4 gamma, 2
chr20_-_56284816 1.01 ENST00000395819.3
ENST00000341744.3
prostate transmembrane protein, androgen induced 1
chr4_-_140544386 0.96 ENST00000561977.1
RP11-308D13.3
chr11_+_125496619 0.96 ENST00000532669.1
ENST00000278916.3
checkpoint kinase 1
chr2_+_33172012 0.95 ENST00000404816.2
latent transforming growth factor beta binding protein 1
chr10_+_17272608 0.91 ENST00000421459.2
vimentin
chr15_-_70390191 0.90 ENST00000559191.1
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr12_-_95611149 0.88 ENST00000549499.1
ENST00000343958.4
ENST00000546711.1
FYVE, RhoGEF and PH domain containing 6
chr18_+_56530794 0.86 ENST00000590285.1
ENST00000586085.1
ENST00000589288.1
zinc finger protein 532
chr3_-_197024965 0.85 ENST00000392382.2
discs, large homolog 1 (Drosophila)
chr7_+_139528952 0.81 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
thromboxane A synthase 1 (platelet)
chr1_+_42928945 0.80 ENST00000428554.2
coiled-coil domain containing 30
chr13_-_24007815 0.79 ENST00000382298.3
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr3_+_50649302 0.78 ENST00000446044.1
mitogen-activated protein kinase-activated protein kinase 3
chr22_-_50524298 0.77 ENST00000311597.5
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_+_209602771 0.77 ENST00000440276.1
MIR205 host gene (non-protein coding)
chr12_-_109915098 0.77 ENST00000542858.1
ENST00000542262.1
ENST00000424763.2
potassium channel tetramerization domain containing 10
chr3_-_197024394 0.76 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
discs, large homolog 1 (Drosophila)
chrX_-_15683147 0.75 ENST00000380342.3
transmembrane protein 27
chr3_+_141105235 0.75 ENST00000503809.1
zinc finger and BTB domain containing 38
chr12_+_95611516 0.74 ENST00000436874.1
vezatin, adherens junctions transmembrane protein
chr5_-_76788317 0.74 ENST00000296679.4
WD repeat domain 41
chr20_-_17511962 0.73 ENST00000377873.3
beaded filament structural protein 1, filensin
chr1_+_109419596 0.72 ENST00000435987.1
ENST00000264126.3
G-protein signaling modulator 2
chr20_-_13971255 0.67 ENST00000284951.5
ENST00000378072.5
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr14_-_71276211 0.67 ENST00000381250.4
ENST00000555993.2
mitogen-activated protein kinase kinase kinase 9
chr16_+_14980632 0.67 ENST00000565655.1
NODAL modulator 1
chr1_+_244998918 0.66 ENST00000366528.3
COX20 cytochrome C oxidase assembly factor
chr11_-_10830463 0.65 ENST00000527419.1
ENST00000530211.1
ENST00000530702.1
ENST00000524932.1
ENST00000532570.1
eukaryotic translation initiation factor 4 gamma, 2
chr3_-_197025447 0.65 ENST00000346964.2
ENST00000357674.4
ENST00000314062.3
ENST00000448528.2
ENST00000419553.1
discs, large homolog 1 (Drosophila)
chr5_-_39425290 0.64 ENST00000545653.1
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr8_-_42623747 0.64 ENST00000534622.1
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr1_-_93645818 0.61 ENST00000370280.1
ENST00000479918.1
transmembrane emp24 protein transport domain containing 5
chr5_-_76788024 0.61 ENST00000515253.1
ENST00000414719.2
ENST00000507654.1
ENST00000514559.1
ENST00000511791.1
WD repeat domain 41
chr1_+_68150744 0.60 ENST00000370986.4
ENST00000370985.3
growth arrest and DNA-damage-inducible, alpha
chr22_-_36357671 0.59 ENST00000408983.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr5_-_39425222 0.59 ENST00000320816.6
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr8_-_42623924 0.58 ENST00000276410.2
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr6_+_41040678 0.57 ENST00000341376.6
ENST00000353205.5
nuclear transcription factor Y, alpha
chr12_+_95611569 0.56 ENST00000261219.6
ENST00000551472.1
ENST00000552821.1
vezatin, adherens junctions transmembrane protein
chr7_+_23146271 0.56 ENST00000545771.1
kelch-like family member 7
chr2_+_105050794 0.55 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
long intergenic non-protein coding RNA 1102
chr4_-_139163491 0.55 ENST00000280612.5
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr8_-_6783588 0.55 ENST00000297436.2
defensin, alpha 6, Paneth cell-specific
chr7_-_99699538 0.54 ENST00000343023.6
ENST00000303887.5
minichromosome maintenance complex component 7
chr4_+_118955500 0.54 ENST00000296499.5
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr10_-_99052382 0.53 ENST00000453547.2
ENST00000316676.8
ENST00000358308.3
ENST00000466484.1
ENST00000358531.4
ARHGAP19-SLIT1 readthrough (NMD candidate)
Rho GTPase activating protein 19
chr1_-_26233423 0.52 ENST00000357865.2
stathmin 1
chr11_-_67981295 0.51 ENST00000405515.1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr1_-_155880672 0.50 ENST00000609492.1
ENST00000368322.3
Ras-like without CAAX 1
chr17_+_25621102 0.49 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WD repeat and SOCS box containing 1
chr9_+_77230499 0.48 ENST00000396204.2
RAR-related orphan receptor B
chr1_+_228337553 0.48 ENST00000366714.2
gap junction protein, gamma 2, 47kDa
chr15_+_78730622 0.48 ENST00000560440.1
iron-responsive element binding protein 2
chr5_-_39425068 0.47 ENST00000515700.1
ENST00000339788.6
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr3_-_50649192 0.47 ENST00000443053.2
ENST00000348721.3
cytokine inducible SH2-containing protein
chr15_-_70390213 0.46 ENST00000557997.1
ENST00000317509.8
ENST00000442299.2
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr14_+_32798547 0.46 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr10_+_18948311 0.46 ENST00000377275.3
ADP-ribosylation factor-like 5B
chr12_+_70760056 0.45 ENST00000258111.4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chrX_+_65384052 0.45 ENST00000336279.5
ENST00000458621.1
hephaestin
chr4_+_2819883 0.45 ENST00000511747.1
ENST00000503393.2
SH3-domain binding protein 2
chr7_-_27219849 0.43 ENST00000396344.4
homeobox A10
chr5_+_140767452 0.43 ENST00000519479.1
protocadherin gamma subfamily B, 4
chr3_-_99833333 0.43 ENST00000354552.3
ENST00000331335.5
ENST00000398326.2
filamin A interacting protein 1-like
chr17_+_80416050 0.42 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
nuclear prelamin A recognition factor
chr15_+_81293254 0.42 ENST00000267984.2
mesoderm development candidate 1
chr6_-_127840021 0.41 ENST00000465909.2
SOGA family member 3
chr1_-_152297679 0.41 ENST00000368799.1
filaggrin
chr1_-_243418621 0.41 ENST00000366544.1
ENST00000366543.1
centrosomal protein 170kDa
chr2_+_11679963 0.40 ENST00000263834.5
growth regulation by estrogen in breast cancer 1
chr1_-_243418344 0.40 ENST00000366542.1
centrosomal protein 170kDa
chr14_+_32798462 0.40 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chrX_+_65384182 0.40 ENST00000441993.2
ENST00000419594.1
hephaestin
chr22_+_27017921 0.39 ENST00000354760.3
crystallin, beta A4
chr7_-_148581360 0.39 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
enhancer of zeste homolog 2 (Drosophila)
chr4_+_78079570 0.39 ENST00000509972.1
cyclin G2
chr13_+_34392200 0.38 ENST00000434425.1
replication factor C (activator 1) 3, 38kDa
chr1_+_28844778 0.38 ENST00000411533.1
regulator of chromosome condensation 1
chr14_-_73493784 0.38 ENST00000553891.1
zinc finger, FYVE domain containing 1
chr4_+_78079450 0.38 ENST00000395640.1
ENST00000512918.1
cyclin G2
chr7_-_35293740 0.37 ENST00000408931.3
T-box 20
chr2_-_20425158 0.36 ENST00000381150.1
syndecan 1
chr4_-_22444733 0.36 ENST00000508133.1
G protein-coupled receptor 125
chr2_+_223536428 0.36 ENST00000446656.3
monoacylglycerol O-acyltransferase 1
chr7_-_111032971 0.35 ENST00000450877.1
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr12_-_48963829 0.34 ENST00000301046.2
ENST00000549817.1
lactalbumin, alpha-
chrX_-_128977364 0.34 ENST00000371064.3
zinc finger, DHHC-type containing 9
chr19_-_59031118 0.34 ENST00000600990.1
zinc finger and BTB domain containing 45
chr14_-_73493825 0.33 ENST00000318876.5
ENST00000556143.1
zinc finger, FYVE domain containing 1
chr1_+_156052354 0.33 ENST00000368301.2
lamin A/C
chr17_+_27573875 0.32 ENST00000225387.3
crystallin, beta A1
chr4_+_78078304 0.32 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
cyclin G2
chr17_-_72358001 0.32 ENST00000375366.3
BTB (POZ) domain containing 17
chr13_-_110959478 0.32 ENST00000543140.1
ENST00000375820.4
collagen, type IV, alpha 1
chr19_-_59030921 0.32 ENST00000354590.3
ENST00000596739.1
zinc finger and BTB domain containing 45
chr11_-_94965667 0.31 ENST00000542176.1
ENST00000278499.2
sestrin 3
chr20_+_30598231 0.31 ENST00000300415.8
ENST00000262659.8
cerebral cavernous malformation 2-like
chr14_-_60097297 0.31 ENST00000395090.1
reticulon 1
chr6_-_89927151 0.31 ENST00000454853.2
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr8_+_9911778 0.30 ENST00000317173.4
ENST00000441698.2
methionine sulfoxide reductase A
chr7_-_148581251 0.30 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
enhancer of zeste homolog 2 (Drosophila)
chr10_-_99393208 0.30 ENST00000307450.6
MORN repeat containing 4
chr11_-_64013663 0.30 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr8_-_6420759 0.30 ENST00000523120.1
angiopoietin 2
chr7_-_42276612 0.29 ENST00000395925.3
ENST00000437480.1
GLI family zinc finger 3
chr17_+_27920486 0.29 ENST00000394859.3
ankyrin repeat domain 13B
chr14_-_51027838 0.29 ENST00000555216.1
mitogen-activated protein kinase kinase kinase kinase 5
chr5_-_135701164 0.28 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
transient receptor potential cation channel, subfamily C, member 7
chr21_+_30671690 0.28 ENST00000399921.1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr6_-_41040268 0.28 ENST00000373154.2
ENST00000244558.9
ENST00000464633.1
ENST00000424266.2
ENST00000479950.1
ENST00000482515.1
O-acyl-ADP-ribose deacylase 1
chr4_-_109089573 0.28 ENST00000265165.1
lymphoid enhancer-binding factor 1
chr16_+_6069586 0.28 ENST00000547372.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_-_1243392 0.28 ENST00000354700.5
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr19_+_56111680 0.28 ENST00000301073.3
zinc finger protein 524
chr8_-_6420565 0.27 ENST00000338312.6
angiopoietin 2
chr9_-_39239171 0.27 ENST00000358144.2
contactin associated protein-like 3
chr19_+_9296279 0.27 ENST00000344248.2
olfactory receptor, family 7, subfamily D, member 2
chr10_+_11206925 0.26 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CUGBP, Elav-like family member 2
chr16_+_6069072 0.26 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr12_-_99288536 0.26 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ankyrin repeat and sterile alpha motif domain containing 1B
chr1_+_47799542 0.26 ENST00000471289.2
ENST00000450808.2
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr3_+_132757215 0.25 ENST00000321871.6
ENST00000393130.3
ENST00000514894.1
ENST00000512662.1
transmembrane protein 108
chr4_-_109090106 0.25 ENST00000379951.2
lymphoid enhancer-binding factor 1
chr4_+_71588372 0.25 ENST00000536664.1
RUN and FYVE domain containing 3
chr1_-_1243252 0.25 ENST00000353662.3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr16_-_48281305 0.25 ENST00000356608.2
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr6_-_123957942 0.25 ENST00000398178.3
triadin
chr15_-_34502197 0.23 ENST00000557877.1
katanin p80 subunit B-like 1
chrX_-_69509738 0.23 ENST00000374454.1
ENST00000239666.4
PDZ domain containing 11
chr6_-_123958141 0.22 ENST00000334268.4
triadin
chrX_+_12993336 0.22 ENST00000380635.1
thymosin beta 4, X-linked
chr4_+_54243798 0.22 ENST00000337488.6
ENST00000358575.5
ENST00000507922.1
factor interacting with PAPOLA and CPSF1
chr1_+_93645314 0.21 ENST00000343253.7
coiled-coil domain containing 18
chr14_+_24521202 0.21 ENST00000334420.7
ENST00000342740.5
leucine rich repeat containing 16B
chr4_-_164534657 0.21 ENST00000339875.5
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr14_-_57960545 0.21 ENST00000526336.1
ENST00000216445.3
chromosome 14 open reading frame 105
chr2_+_172543919 0.20 ENST00000452242.1
ENST00000340296.4
dynein, cytoplasmic 1, intermediate chain 2
chr6_-_41040195 0.20 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
O-acyl-ADP-ribose deacylase 1
chr3_+_57875711 0.20 ENST00000442599.2
sarcolemma associated protein
chr20_-_62610982 0.20 ENST00000369886.3
ENST00000450107.1
sterile alpha motif domain containing 10
chr10_+_73724123 0.20 ENST00000373115.4
carbohydrate (chondroitin 6) sulfotransferase 3
chr8_-_16043780 0.20 ENST00000445506.2
macrophage scavenger receptor 1
chr20_+_58630972 0.20 ENST00000313426.1
chromosome 20 open reading frame 197
chr10_+_11207438 0.19 ENST00000609692.1
ENST00000354897.3
CUGBP, Elav-like family member 2
chr2_-_106015527 0.19 ENST00000344213.4
ENST00000358129.4
four and a half LIM domains 2
chr13_+_39612442 0.18 ENST00000470258.1
ENST00000379600.3
NHL repeat containing 3
chr17_+_9066252 0.18 ENST00000436734.1
netrin 1
chr8_+_80523962 0.18 ENST00000518491.1
stathmin-like 2
chr2_+_172544294 0.18 ENST00000358002.6
ENST00000435234.1
ENST00000443458.1
ENST00000412370.1
dynein, cytoplasmic 1, intermediate chain 2
chr8_-_80993010 0.17 ENST00000537855.1
ENST00000520527.1
ENST00000517427.1
ENST00000448733.2
ENST00000379097.3
tumor protein D52
chr8_-_8751068 0.17 ENST00000276282.6
malignant fibrous histiocytoma amplified sequence 1
chr4_+_106629929 0.17 ENST00000512828.1
ENST00000394730.3
ENST00000507281.1
ENST00000515279.1
glutathione S-transferase, C-terminal domain containing
chr16_-_3068171 0.17 ENST00000572154.1
ENST00000328796.4
claudin 6
chrX_+_51927919 0.17 ENST00000416960.1
melanoma antigen family D, 4
chr12_+_8666126 0.16 ENST00000299665.2
C-type lectin domain family 4, member D
chr12_-_95945246 0.16 ENST00000258499.3
ubiquitin specific peptidase 44
chr12_-_10251603 0.16 ENST00000457018.2
C-type lectin domain family 1, member A
chr1_-_167883353 0.16 ENST00000545172.1
adenylate cyclase 10 (soluble)
chr15_+_75940218 0.16 ENST00000308527.5
sorting nexin 33
chr8_+_79428539 0.16 ENST00000352966.5
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr7_-_88425025 0.15 ENST00000297203.2
chromosome 7 open reading frame 62
chr1_-_173572181 0.15 ENST00000536496.1
ENST00000367714.3
solute carrier family 9, member C2 (putative)
chr3_+_39509070 0.15 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
myelin-associated oligodendrocyte basic protein
chr19_-_55690758 0.15 ENST00000590851.1
synaptotagmin V
chr1_+_40713573 0.14 ENST00000372766.3
transmembrane and coiled-coil domains 2
chr7_+_115850547 0.14 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
testis derived transcript (3 LIM domains)
chr1_+_47137544 0.14 ENST00000564373.1
testis expressed 38
chr15_+_78730531 0.13 ENST00000258886.8
iron-responsive element binding protein 2
chr2_-_100721923 0.13 ENST00000356421.2
AF4/FMR2 family, member 3
chr1_+_47137445 0.13 ENST00000569393.1
ENST00000334122.4
ENST00000415500.1
testis expressed 38
chr12_+_93963590 0.13 ENST00000340600.2
suppressor of cytokine signaling 2
chr14_+_101299520 0.13 ENST00000455531.1
maternally expressed 3 (non-protein coding)
chr14_+_35761580 0.13 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
proteasome (prosome, macropain) subunit, alpha type, 6
chr11_+_46402744 0.13 ENST00000533952.1
midkine (neurite growth-promoting factor 2)
chr3_+_141106643 0.12 ENST00000514251.1
zinc finger and BTB domain containing 38
chr7_+_99699179 0.12 ENST00000438383.1
ENST00000429084.1
ENST00000359593.4
ENST00000439416.1
adaptor-related protein complex 4, mu 1 subunit
chr2_+_172543967 0.12 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
dynein, cytoplasmic 1, intermediate chain 2
chr3_+_111260954 0.12 ENST00000283285.5
CD96 molecule
chr6_+_22146851 0.12 ENST00000606197.1
cancer susceptibility candidate 15 (non-protein coding)
chr9_-_139642968 0.11 ENST00000341206.4
lipocalin 6
chrX_-_110655391 0.11 ENST00000356915.2
ENST00000356220.3
doublecortin

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0061143 alveolar primary septum development(GO:0061143)
0.4 1.7 GO:0035026 leading edge cell differentiation(GO:0035026)
0.4 1.5 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.3 3.8 GO:1905031 regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905031)
0.3 1.2 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.3 0.9 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.3 2.5 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 1.9 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 0.7 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.2 0.7 GO:0031291 Ran protein signal transduction(GO:0031291)
0.2 1.4 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.2 1.0 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 0.5 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.4 GO:0035922 pulmonary valve formation(GO:0003193) visceral motor neuron differentiation(GO:0021524) foramen ovale closure(GO:0035922)
0.1 0.4 GO:0048627 myoblast development(GO:0048627)
0.1 0.5 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.4 GO:0061300 cerebellum vasculature development(GO:0061300)
0.1 0.3 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.1 0.3 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 0.5 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.3 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 1.6 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.3 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.1 1.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 2.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.7 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 0.6 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.8 GO:0031340 positive regulation of vesicle fusion(GO:0031340) regulation of SNARE complex assembly(GO:0035542)
0.1 0.9 GO:0044351 macropinocytosis(GO:0044351)
0.1 0.2 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 0.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 0.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.4 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 1.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 0.8 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.6 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 1.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.5 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.8 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.5 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.2 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 1.2 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.1 GO:1900737 regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737)
0.0 0.3 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 1.2 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.3 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.3 GO:0030091 protein repair(GO:0030091)
0.0 0.5 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.3 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.3 GO:0038203 TORC2 signaling(GO:0038203) negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0030421 defecation(GO:0030421)
0.0 0.5 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 1.2 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 1.5 GO:0006826 iron ion transport(GO:0006826)
0.0 0.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.4 GO:0060065 uterus development(GO:0060065)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 1.4 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.4 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.1 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.5 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.2 GO:0015865 purine nucleotide transport(GO:0015865)
0.0 1.5 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 0.1 GO:0075071 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0031523 Myb complex(GO:0031523)
0.4 1.2 GO:0005607 laminin-2 complex(GO:0005607)
0.3 3.8 GO:0030478 actin cap(GO:0030478)
0.2 1.9 GO:0035976 AP1 complex(GO:0035976)
0.2 0.8 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.2 1.7 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 2.3 GO:0043219 lateral loop(GO:0043219)
0.1 1.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.4 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 1.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 2.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 2.2 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.8 GO:0070852 cell body fiber(GO:0070852)
0.1 0.7 GO:0005638 lamin filament(GO:0005638)
0.1 1.4 GO:0032059 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.1 1.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 1.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0045120 pronucleus(GO:0045120)
0.0 0.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0072517 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.0 0.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 1.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 2.0 GO:0005882 intermediate filament(GO:0005882)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0050436 microfibril binding(GO:0050436)
0.4 1.6 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.3 1.6 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.3 0.8 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.2 2.3 GO:0097016 L27 domain binding(GO:0097016)
0.2 0.6 GO:0030350 iron-responsive element binding(GO:0030350)
0.2 0.7 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 1.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.9 GO:1990254 keratin filament binding(GO:1990254)
0.1 4.1 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.5 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.8 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 1.2 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.1 0.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.3 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.7 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 1.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.4 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 0.3 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 2.4 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 0.3 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.5 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.1 2.9 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.2 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.4 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 1.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 1.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.5 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.7 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 2.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.5 GO:0030674 protein binding, bridging(GO:0030674) binding, bridging(GO:0060090)
0.0 0.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.8 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 1.3 GO:0017022 myosin binding(GO:0017022)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 1.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.4 PID AURORA B PATHWAY Aurora B signaling
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.0 PID ATR PATHWAY ATR signaling pathway
0.0 4.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.7 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 2.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 1.0 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.2 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.2 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.9 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.5 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 2.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.0 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.4 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.9 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.4 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.0 1.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.5 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type