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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SOX8

Z-value: 0.79

Motif logo

Transcription factors associated with SOX8

Gene Symbol Gene ID Gene Info
ENSG00000005513.9 SRY-box transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX8hg19_v2_chr16_+_1031762_10318080.039.0e-01Click!

Activity profile of SOX8 motif

Sorted Z-values of SOX8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_160279207 2.90 ENST00000327245.5
ATPase, class V, type 10B
chr6_-_32498046 2.73 ENST00000374975.3
major histocompatibility complex, class II, DR beta 5
chr6_-_52668605 2.70 ENST00000334575.5
glutathione S-transferase alpha 1
chr4_-_100356551 2.57 ENST00000209665.4
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr6_+_32605195 2.42 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chr12_-_10282836 2.34 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
C-type lectin domain family 7, member A
chr14_-_106642049 2.07 ENST00000390605.2
immunoglobulin heavy variable 1-18
chr2_+_26624775 2.04 ENST00000288710.2
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr13_+_43355683 1.95 ENST00000537894.1
family with sequence similarity 216, member B
chr4_-_100356291 1.94 ENST00000476959.1
ENST00000482593.1
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr12_-_71551652 1.79 ENST00000546561.1
tetraspanin 8
chr5_+_140227048 1.77 ENST00000532602.1
protocadherin alpha 9
chr12_-_10282742 1.71 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
C-type lectin domain family 7, member A
chr5_+_140602904 1.63 ENST00000515856.2
ENST00000239449.4
protocadherin beta 14
chr12_-_10282681 1.62 ENST00000533022.1
C-type lectin domain family 7, member A
chr7_+_48494660 1.56 ENST00000411975.1
ENST00000544596.1
ATP-binding cassette, sub-family A (ABC1), member 13
chr1_+_12806141 1.43 ENST00000288048.5
chromosome 1 open reading frame 158
chr5_+_140186647 1.42 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
protocadherin alpha 4
chr3_-_193272741 1.32 ENST00000392443.3
ATPase type 13A4
chr15_-_65715401 1.28 ENST00000352385.2
immunoglobulin superfamily, DCC subclass, member 4
chr16_+_57392684 1.26 ENST00000219235.4
chemokine (C-C motif) ligand 22
chr16_+_82068830 1.13 ENST00000199936.4
hydroxysteroid (17-beta) dehydrogenase 2
chr2_-_32489922 1.12 ENST00000402280.1
NLR family, CARD domain containing 4
chr16_+_618837 1.05 ENST00000409439.2
phosphatidylinositol glycan anchor biosynthesis, class Q
chr6_+_32605134 0.99 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
major histocompatibility complex, class II, DQ alpha 1
chr2_+_233527443 0.96 ENST00000410095.1
EF-hand domain family, member D1
chr14_+_22580233 0.87 ENST00000390454.2
T cell receptor alpha variable 25
chr6_-_52710893 0.86 ENST00000284562.2
glutathione S-transferase alpha 5
chr12_+_21207503 0.84 ENST00000545916.1
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr10_+_7745232 0.83 ENST00000358415.4
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_88414338 0.82 ENST00000241891.5
ENST00000443292.1
opsin 4
chr1_+_13516066 0.81 ENST00000332192.6
PRAME family member 21
chr12_-_39837192 0.80 ENST00000361961.3
ENST00000395670.3
kinesin family member 21A
chr5_-_179499108 0.80 ENST00000521389.1
ring finger protein 130
chr10_+_88414298 0.79 ENST00000372071.2
opsin 4
chr5_-_179499086 0.78 ENST00000261947.4
ring finger protein 130
chr2_-_175711133 0.76 ENST00000409597.1
ENST00000413882.1
chimerin 1
chr19_-_45681482 0.76 ENST00000592647.1
ENST00000006275.4
ENST00000588062.1
ENST00000585934.1
trafficking protein particle complex 6A
chr12_-_15104040 0.75 ENST00000541644.1
ENST00000545895.1
Rho GDP dissociation inhibitor (GDI) beta
chr21_-_43735628 0.70 ENST00000291525.10
ENST00000518498.1
trefoil factor 3 (intestinal)
chr18_-_53253112 0.70 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
transcription factor 4
chr4_+_89299994 0.69 ENST00000264346.7
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr18_-_53253323 0.68 ENST00000540999.1
ENST00000563888.2
transcription factor 4
chrX_-_151999269 0.66 ENST00000370277.3
centrin, EF-hand protein, 2
chr16_+_21244986 0.66 ENST00000311620.5
ankyrin repeat and sterile alpha motif domain containing 4B
chr13_+_97928395 0.64 ENST00000445661.2
muscleblind-like splicing regulator 2
chr2_+_204801471 0.63 ENST00000316386.6
ENST00000435193.1
inducible T-cell co-stimulator
chr4_-_70518941 0.63 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr8_+_21915368 0.62 ENST00000265800.5
ENST00000517418.1
dematin actin binding protein
chr16_+_53241854 0.61 ENST00000565803.1
chromodomain helicase DNA binding protein 9
chr2_-_28113965 0.60 ENST00000302188.3
ribokinase
chr6_-_110011704 0.60 ENST00000448084.2
adenylate kinase 9
chr18_-_5396271 0.59 ENST00000579951.1
erythrocyte membrane protein band 4.1-like 3
chr6_-_110011718 0.59 ENST00000532976.1
adenylate kinase 9
chr4_-_75695366 0.58 ENST00000512743.1
betacellulin
chr1_-_48937838 0.56 ENST00000371847.3
spermatogenesis associated 6
chr10_-_1779663 0.55 ENST00000381312.1
adenosine deaminase, RNA-specific, B2 (non-functional)
chr1_+_110577229 0.54 ENST00000369795.3
ENST00000369794.2
striatin interacting protein 1
chr6_-_150217195 0.53 ENST00000532335.1
retinoic acid early transcript 1E
chr17_+_2240916 0.52 ENST00000574563.1
small G protein signaling modulator 2
chr20_-_44176013 0.52 ENST00000555685.1
epididymal peptidase inhibitor
chr16_+_57769635 0.52 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
katanin p80 (WD repeat containing) subunit B 1
chr3_-_165555200 0.51 ENST00000479451.1
ENST00000540653.1
ENST00000488954.1
ENST00000264381.3
butyrylcholinesterase
chr15_-_89755034 0.51 ENST00000563254.1
retinaldehyde binding protein 1
chr3_-_49851313 0.50 ENST00000333486.3
ubiquitin-like modifier activating enzyme 7
chr7_+_64126535 0.50 ENST00000344930.3
zinc finger protein 107
chr13_+_108922228 0.50 ENST00000542136.1
tumor necrosis factor (ligand) superfamily, member 13b
chr17_-_7145475 0.50 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABA(A) receptor-associated protein
chr22_-_42466782 0.50 ENST00000396398.3
ENST00000403363.1
ENST00000402937.1
N-acetylgalactosaminidase, alpha-
chr20_+_48807351 0.50 ENST00000303004.3
CCAAT/enhancer binding protein (C/EBP), beta
chr18_-_77711625 0.48 ENST00000357575.4
ENST00000590381.1
ENST00000397778.2
PQ loop repeat containing 1
chr6_+_80129989 0.48 ENST00000429444.1
RP1-232L24.3
chr17_-_34313685 0.48 ENST00000435911.2
ENST00000586216.1
ENST00000394509.4
chemokine (C-C motif) ligand 14
chr2_-_159237472 0.47 ENST00000409187.1
coiled-coil domain containing 148
chr11_-_77791156 0.47 ENST00000281031.4
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
chr4_-_141348999 0.47 ENST00000325617.5
calmegin
chr17_-_19648683 0.46 ENST00000573368.1
ENST00000457500.2
aldehyde dehydrogenase 3 family, member A1
chr20_+_32150140 0.46 ENST00000344201.3
ENST00000346541.3
ENST00000397800.1
ENST00000397798.2
ENST00000492345.1
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr1_+_231114795 0.46 ENST00000310256.2
ENST00000366658.2
ENST00000450711.1
ENST00000435927.1
ARV1 homolog (S. cerevisiae)
chr19_+_1269324 0.45 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
cold inducible RNA binding protein
chr16_+_22308717 0.45 ENST00000299853.5
ENST00000564209.1
ENST00000565358.1
ENST00000418581.2
ENST00000564883.1
ENST00000359210.4
ENST00000563024.1
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr3_-_146213722 0.45 ENST00000336685.2
ENST00000489015.1
phospholipid scramblase 2
chr12_-_15103621 0.44 ENST00000536592.1
Rho GDP dissociation inhibitor (GDI) beta
chr2_+_170550944 0.44 ENST00000359744.3
ENST00000438838.1
ENST00000438710.1
ENST00000449906.1
ENST00000498202.2
ENST00000272797.4
phosphatase, orphan 2
kelch-like family member 23
chr3_-_129147432 0.44 ENST00000503957.1
ENST00000505956.1
ENST00000326085.3
EF-hand calcium binding domain 12
chr1_-_67142710 0.44 ENST00000502413.2
Uncharacterized protein
chr7_-_92855762 0.43 ENST00000453812.2
ENST00000394468.2
HEPACAM family member 2
chr3_+_137906109 0.42 ENST00000481646.1
ENST00000469044.1
ENST00000491704.1
ENST00000461600.1
armadillo repeat containing 8
chr3_-_186288097 0.42 ENST00000446782.1
TBCC domain containing 1
chr12_-_100660833 0.42 ENST00000551642.1
ENST00000416321.1
ENST00000550587.1
ENST00000549249.1
DEP domain containing 4
chr2_-_207024233 0.41 ENST00000423725.1
ENST00000233190.6
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr17_-_66597530 0.41 ENST00000592554.1
family with sequence similarity 20, member A
chr12_-_8693539 0.40 ENST00000299663.3
C-type lectin domain family 4, member E
chr3_+_38347427 0.39 ENST00000273173.4
solute carrier family 22, member 14
chr5_+_118965244 0.39 ENST00000515256.1
ENST00000509264.1
family with sequence similarity 170, member A
chr15_+_34261089 0.38 ENST00000383263.5
cholinergic receptor, muscarinic 5
chr20_-_44176060 0.38 ENST00000354280.4
ENST00000504988.1
epididymal peptidase inhibitor
EPPIN-WFDC6 readthrough
chr19_+_19144384 0.38 ENST00000392335.2
ENST00000535612.1
ENST00000537263.1
ENST00000540707.1
ENST00000541725.1
ENST00000269932.6
ENST00000546344.1
ENST00000540792.1
ENST00000536098.1
ENST00000541898.1
ENST00000543877.1
armadillo repeat containing 6
chr7_-_38289173 0.38 ENST00000436911.2
T cell receptor gamma constant 2
chr1_+_112016414 0.37 ENST00000343534.5
ENST00000369718.3
chromosome 1 open reading frame 162
chr14_+_95078714 0.37 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr11_+_10477733 0.37 ENST00000528723.1
adenosine monophosphate deaminase 3
chr6_-_49712147 0.37 ENST00000433368.2
ENST00000354620.4
cysteine-rich secretory protein 3
chr3_-_187455680 0.36 ENST00000438077.1
B-cell CLL/lymphoma 6
chr15_+_43885252 0.35 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
creatine kinase, mitochondrial 1B
chr9_-_130661916 0.35 ENST00000373142.1
ENST00000373146.1
ENST00000373144.3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr18_+_61575200 0.35 ENST00000238508.3
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr12_-_9760482 0.35 ENST00000229402.3
killer cell lectin-like receptor subfamily B, member 1
chr6_-_31689456 0.35 ENST00000495859.1
ENST00000375819.2
lymphocyte antigen 6 complex, locus G6C
chr8_+_1993173 0.35 ENST00000523438.1
myomesin 2
chr17_-_47723943 0.35 ENST00000510476.1
ENST00000503676.1
speckle-type POZ protein
chr2_+_97203082 0.34 ENST00000454558.2
AT rich interactive domain 5A (MRF1-like)
chr17_-_34207295 0.34 ENST00000463941.1
ENST00000293272.3
chemokine (C-C motif) ligand 5
chr3_-_54962100 0.34 ENST00000273286.5
leucine-rich repeats and transmembrane domains 1
chr15_+_43985084 0.34 ENST00000434505.1
ENST00000411750.1
creatine kinase, mitochondrial 1A
chr19_-_37697976 0.34 ENST00000588873.1
Uncharacterized protein; Zinc finger protein 585B
chr20_-_5426332 0.34 ENST00000420529.1
long intergenic non-protein coding RNA 658
chr7_+_80275752 0.34 ENST00000419819.2
CD36 molecule (thrombospondin receptor)
chr8_+_1993152 0.34 ENST00000262113.4
myomesin 2
chr12_-_10151773 0.33 ENST00000298527.6
ENST00000348658.4
C-type lectin domain family 1, member B
chr9_+_99690592 0.33 ENST00000354649.3
NUT family member 2G
chr6_-_49712123 0.33 ENST00000263045.4
cysteine-rich secretory protein 3
chr9_+_2157655 0.33 ENST00000452193.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr10_-_87551311 0.32 ENST00000536331.1
glutamate receptor, ionotropic, delta 1
chr8_-_11873043 0.32 ENST00000527396.1
Protein LOC101060662
chr17_-_43339474 0.32 ENST00000331780.4
spermatogenesis associated 32
chr12_+_14927270 0.32 ENST00000544848.1
H2A histone family, member J
chr17_+_41132564 0.32 ENST00000361677.1
ENST00000589705.1
RUN domain containing 1
chr3_+_185080908 0.31 ENST00000265026.3
mitogen-activated protein kinase kinase kinase 13
chr1_-_112106578 0.31 ENST00000369717.4
adenosine A3 receptor
chr1_+_13742808 0.31 ENST00000602960.1
PRAME family member 20
chr17_+_34087888 0.31 ENST00000586491.1
ENST00000588628.1
ENST00000285023.4
chromosome 17 open reading frame 50
chr1_-_48937821 0.30 ENST00000396199.3
spermatogenesis associated 6
chr4_-_69111401 0.30 ENST00000332644.5
transmembrane protease, serine 11B
chr12_-_8693469 0.30 ENST00000545274.1
ENST00000446457.2
C-type lectin domain family 4, member E
chr12_-_50101003 0.30 ENST00000550488.1
formin-like 3
chr15_+_62853562 0.30 ENST00000561311.1
talin 2
chr10_-_49482907 0.30 ENST00000374201.3
ENST00000407470.4
FERM and PDZ domain containing 2
chr7_+_79998864 0.29 ENST00000435819.1
CD36 molecule (thrombospondin receptor)
chr17_-_43339453 0.29 ENST00000543122.1
spermatogenesis associated 32
chr7_-_32529973 0.29 ENST00000410044.1
ENST00000409987.1
ENST00000409782.1
ENST00000450169.2
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr17_-_38938786 0.29 ENST00000301656.3
keratin 27
chr8_-_20040638 0.29 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
solute carrier family 18 (vesicular monoamine transporter), member 1
chr19_-_8213753 0.28 ENST00000601739.1
fibrillin 3
chr3_+_142342228 0.28 ENST00000337777.3
plastin 1
chr9_-_130533615 0.28 ENST00000373277.4
SH2 domain containing 3C
chr11_+_57435219 0.27 ENST00000527985.1
ENST00000287169.3
zinc finger, DHHC-type containing 5
chr22_-_50708781 0.27 ENST00000449719.2
ENST00000330651.6
mitogen-activated protein kinase 11
chr16_+_31271274 0.27 ENST00000287497.8
ENST00000544665.3
integrin, alpha M (complement component 3 receptor 3 subunit)
chr2_+_219646462 0.27 ENST00000258415.4
cytochrome P450, family 27, subfamily A, polypeptide 1
chr6_+_147527103 0.27 ENST00000179882.6
syntaxin binding protein 5 (tomosyn)
chr7_-_27169801 0.27 ENST00000511914.1
homeobox A4
chr12_-_57443886 0.26 ENST00000300119.3
myosin IA
chr6_-_159421198 0.26 ENST00000252655.1
ENST00000297262.3
ENST00000367069.2
radial spoke 3 homolog (Chlamydomonas)
chr7_+_80275621 0.26 ENST00000426978.1
ENST00000432207.1
CD36 molecule (thrombospondin receptor)
chr2_-_170550877 0.26 ENST00000447353.1
coiled-coil domain containing 173
chr1_-_85930246 0.26 ENST00000426972.3
dimethylarginine dimethylaminohydrolase 1
chr14_+_22573582 0.26 ENST00000390453.1
T cell receptor alpha variable 24
chrX_-_117107542 0.25 ENST00000371878.1
kelch-like family member 13
chr3_+_157154578 0.25 ENST00000295927.3
pentraxin 3, long
chr1_-_231005310 0.24 ENST00000470540.1
chromosome 1 open reading frame 198
chr3_+_35683651 0.24 ENST00000187397.4
cAMP-regulated phosphoprotein, 21kDa
chr11_-_129062093 0.24 ENST00000310343.9
Rho GTPase activating protein 32
chr16_-_90096309 0.24 ENST00000408886.2
chromosome 16 open reading frame 3
chr6_-_76072719 0.23 ENST00000370020.1
filamin A interacting protein 1
chr6_-_32160622 0.23 ENST00000487761.1
ENST00000375040.3
G-protein signaling modulator 3
chr20_-_23807358 0.22 ENST00000304725.2
cystatin SA
chr10_-_36813162 0.22 ENST00000440465.1
nicotinamide phosphoribosyltransferase-like
chr8_+_107738240 0.22 ENST00000449762.2
ENST00000297447.6
oxidation resistance 1
chr4_-_122854193 0.22 ENST00000513531.1
transient receptor potential cation channel, subfamily C, member 3
chr14_-_106471723 0.22 ENST00000390595.2
immunoglobulin heavy variable 1-3
chr19_-_6333614 0.22 ENST00000301452.4
alkaline ceramidase 1
chr15_-_72563585 0.21 ENST00000287196.9
ENST00000260376.7
poly (ADP-ribose) polymerase family, member 6
chrX_-_117107680 0.21 ENST00000447671.2
ENST00000262820.3
kelch-like family member 13
chr4_+_86525299 0.21 ENST00000512201.1
Rho GTPase activating protein 24
chr5_-_159846399 0.21 ENST00000297151.4
SLU7 splicing factor homolog (S. cerevisiae)
chr11_-_96076334 0.21 ENST00000524717.1
mastermind-like 2 (Drosophila)
chr1_-_112106556 0.20 ENST00000443498.1
adenosine A3 receptor
chr3_+_148545586 0.20 ENST00000282957.4
ENST00000468341.1
carboxypeptidase B1 (tissue)
chr4_+_40192656 0.20 ENST00000505618.1
ras homolog family member H
chr7_-_122342988 0.19 ENST00000434824.1
ring finger protein 148
chr3_-_49459878 0.19 ENST00000546031.1
ENST00000458307.2
ENST00000430521.1
aminomethyltransferase
chr12_+_133066137 0.19 ENST00000434748.2
fibrosin-like 1
chr8_+_52730143 0.19 ENST00000415643.1
Uncharacterized protein
chr1_+_161475208 0.19 ENST00000367972.4
ENST00000271450.6
Fc fragment of IgG, low affinity IIa, receptor (CD32)
chr6_-_7313381 0.19 ENST00000489567.1
ENST00000479365.1
ENST00000462112.1
ENST00000397511.2
ENST00000534851.1
ENST00000474597.1
ENST00000244763.4
signal sequence receptor, alpha
chr1_+_161736072 0.19 ENST00000367942.3
activating transcription factor 6
chr7_-_122342966 0.19 ENST00000447240.1
ring finger protein 148
chr22_-_36903069 0.19 ENST00000216187.6
ENST00000423980.1
FAD-dependent oxidoreductase domain containing 2
chr4_-_144940477 0.18 ENST00000513128.1
ENST00000429670.2
ENST00000502664.1
glycophorin B (MNS blood group)
chr16_+_30387141 0.18 ENST00000566955.1
myosin light chain, phosphorylatable, fast skeletal muscle
chr19_+_1524072 0.18 ENST00000454744.2
polo-like kinase 5
chr14_+_52327350 0.18 ENST00000555472.1
ENST00000556766.1
guanine nucleotide binding protein (G protein), gamma 2
chr1_+_26496362 0.17 ENST00000374266.5
ENST00000270812.5
zinc finger protein 593
chr3_+_186288454 0.17 ENST00000265028.3
DnaJ (Hsp40) homolog, subfamily B, member 11
chr3_-_49459865 0.17 ENST00000427987.1
aminomethyltransferase
chrX_+_100474906 0.17 ENST00000541709.1
dystrophin related protein 2
chr8_+_107738343 0.17 ENST00000521592.1
oxidation resistance 1
chr15_+_72410629 0.16 ENST00000340912.4
ENST00000544171.1
SUMO/sentrin specific peptidase family member 8
chr5_+_32788945 0.16 ENST00000326958.1
AC026703.1

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.4 1.2 GO:0061565 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.3 5.7 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.2 0.7 GO:1904106 protein localization to microvillus(GO:1904106)
0.2 0.5 GO:0014016 neuroblast differentiation(GO:0014016)
0.2 1.2 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.4 GO:0044691 tooth eruption(GO:0044691)
0.1 0.5 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 0.9 GO:1901318 negative regulation of sperm motility(GO:1901318)
0.1 0.9 GO:0072564 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.4 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.1 0.6 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 1.1 GO:0070269 pyroptosis(GO:0070269)
0.1 0.8 GO:1903232 melanosome assembly(GO:1903232)
0.1 2.3 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 0.6 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 2.9 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.5 GO:0031296 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.1 0.3 GO:0090287 regulation of cellular response to growth factor stimulus(GO:0090287)
0.1 0.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 2.0 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.1 1.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.5 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1 0.6 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.4 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)
0.1 1.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.4 GO:0006196 AMP catabolic process(GO:0006196)
0.1 0.3 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.3 GO:1902896 terminal web assembly(GO:1902896)
0.1 0.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.5 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:1902824 positive regulation of late endosome to lysosome transport(GO:1902824)
0.0 0.7 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 6.0 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.3 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
0.0 1.1 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 1.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0010446 response to alkaline pH(GO:0010446)
0.0 0.2 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 2.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0019566 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.2 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.1 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.0 0.5 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.3 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0001694 histamine biosynthetic process(GO:0001694)
0.0 0.1 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 1.7 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.5 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.0 0.9 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.6 GO:0035810 positive regulation of urine volume(GO:0035810)
0.0 0.5 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.0 0.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.2 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.5 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.1 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.0 0.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.7 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.0 0.5 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0001172 transcription, RNA-templated(GO:0001172)
0.0 0.8 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:1901382 chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0 0.3 GO:0006527 arginine catabolic process(GO:0006527) negative regulation of vascular permeability(GO:0043116)
0.0 2.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0002347 response to tumor cell(GO:0002347)
0.0 0.1 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.2 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.0 0.1 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.0 0.3 GO:0030220 platelet formation(GO:0030220)
0.0 0.5 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 0.0 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 0.9 GO:0097224 sperm connecting piece(GO:0097224)
0.1 1.1 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.1 0.4 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 1.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.9 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.6 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.0 2.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.3 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.6 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0032982 myosin filament(GO:0032982)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.3 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 1.6 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.3 2.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.3 1.1 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.2 3.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 6.6 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.7 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 0.5 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 1.2 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.1 2.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.4 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.3 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.4 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.1 2.7 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.5 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 2.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.9 GO:0032027 myosin light chain binding(GO:0032027)
0.1 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 0.2 GO:0000035 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
0.1 0.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.4 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 2.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.5 GO:0015925 galactosidase activity(GO:0015925)
0.0 1.7 GO:0008009 chemokine activity(GO:0008009)
0.0 0.2 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.1 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.5 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.1 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 1.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.0 0.5 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.2 GO:0033989 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.0 0.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 1.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.3 GO:0001851 complement component C3b binding(GO:0001851)
0.0 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.0 0.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.4 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 0.2 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 0.6 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.0 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0019784 SUMO-specific protease activity(GO:0016929) NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.6 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.3 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.6 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.4 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 6.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.6 REACTOME OPSINS Genes involved in Opsins
0.1 3.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 2.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)