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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SP1
Z-value: 1.60
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Transcription factors associated with SP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg19_v2_chr12_+_53774423_53774658 | 0.50 | 5.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51504411 Show fit | 4.50 |
ENST00000593490.1
|
kallikrein-related peptidase 8 |
|
| chr2_+_70142232 Show fit | 3.62 |
ENST00000540449.1
|
MAX dimerization protein 1 |
|
| chr16_+_67465016 Show fit | 3.32 |
ENST00000326152.5
|
hydroxysteroid (11-beta) dehydrogenase 2 |
|
| chr17_-_42277203 Show fit | 3.08 |
ENST00000587097.1
|
ataxin 7-like 3 |
|
| chr2_+_24272543 Show fit | 3.02 |
ENST00000380991.4
|
FK506 binding protein 1B, 12.6 kDa |
|
| chr6_+_37137939 Show fit | 2.98 |
ENST00000373509.5
|
pim-1 oncogene |
|
| chr15_+_90777424 Show fit | 2.74 |
ENST00000561433.1
ENST00000559204.1 ENST00000558291.1 |
GDP-D-glucose phosphorylase 1 |
|
| chr2_+_24272576 Show fit | 2.51 |
ENST00000380986.4
ENST00000452109.1 |
FK506 binding protein 1B, 12.6 kDa |
|
| chr20_+_58179582 Show fit | 2.29 |
ENST00000371015.1
ENST00000395639.4 |
phosphatase and actin regulator 3 |
|
| chr11_-_2906979 Show fit | 2.24 |
ENST00000380725.1
ENST00000313407.6 ENST00000430149.2 ENST00000440480.2 ENST00000414822.3 |
cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.3 | 7.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 7.3 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.9 | 7.0 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.5 | 5.5 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.3 | 5.1 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.8 | 4.8 | GO:0030421 | defecation(GO:0030421) |
| 0.1 | 4.8 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.3 | 4.7 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.4 | 4.6 | GO:1900223 | positive regulation of beta-amyloid clearance(GO:1900223) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.9 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 16.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 14.2 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 12.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 12.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 11.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 11.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 8.8 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 7.8 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 7.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 15.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 12.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 11.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 8.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 8.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.3 | 7.7 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 7.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 7.4 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 7.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 11.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 11.7 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.1 | 11.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 10.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 9.3 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 8.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 7.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 7.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 6.7 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.4 | 9.2 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 9.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 8.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 7.5 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 7.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 7.1 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 7.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 6.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 6.5 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |