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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SP3
Z-value: 1.47
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Transcription factors associated with SP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP3 | hg19_v2_chr2_-_174828892_174828972 | 0.21 | 2.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.8 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.2 | 11.0 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 1.1 | 10.0 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 2.3 | 9.3 | GO:0009447 | putrescine catabolic process(GO:0009447) |
| 0.2 | 9.3 | GO:0051310 | metaphase plate congression(GO:0051310) |
| 0.6 | 8.4 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.5 | 8.3 | GO:0071459 | protein localization to chromosome, centromeric region(GO:0071459) |
| 0.1 | 8.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.1 | 7.7 | GO:0000725 | recombinational repair(GO:0000725) |
| 2.5 | 7.4 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 94.2 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 63.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 24.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.0 | 23.0 | GO:0030055 | cell-substrate junction(GO:0030055) |
| 0.3 | 22.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 19.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 14.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 13.5 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 12.9 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 12.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 41.6 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 16.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 11.3 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 10.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 10.2 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.1 | 9.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 9.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.4 | 8.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 1.7 | 8.3 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
| 0.3 | 8.0 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 15.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 14.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 11.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 11.4 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 10.3 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.1 | 8.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 8.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 7.9 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 7.2 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.6 | 16.1 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.4 | 13.2 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.4 | 11.6 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.4 | 11.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 11.4 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.3 | 10.2 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 10.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 9.9 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.2 | 9.7 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |