Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for SP4_PML
Z-value: 1.39
Motif logo
Transcription factors associated with SP4_PML
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PML | hg19_v2_chr15_+_74287035_74287117 | 0.49 | 6.0e-03 | Click! |
| SP4 | hg19_v2_chr7_+_21467642_21467671 | -0.16 | 4.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_708910 Show fit | 5.79 |
ENST00000264560.7
|
paralemmin |
|
| chr19_+_709101 Show fit | 5.62 |
ENST00000338448.5
|
paralemmin |
|
| chr22_+_39853258 Show fit | 5.58 |
ENST00000341184.6
|
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase |
|
| chr1_+_205538105 Show fit | 5.23 |
ENST00000367147.4
ENST00000539267.1 |
major facilitator superfamily domain containing 4 |
|
| chr3_-_45267760 Show fit | 4.60 |
ENST00000503771.1
|
transmembrane protein 158 (gene/pseudogene) |
|
| chr7_-_158380371 Show fit | 4.47 |
ENST00000389418.4
ENST00000389416.4 |
protein tyrosine phosphatase, receptor type, N polypeptide 2 |
|
| chr5_-_180018540 Show fit | 4.33 |
ENST00000292641.3
|
secretoglobin, family 3A, member 1 |
|
| chr3_+_13590619 Show fit | 4.09 |
ENST00000404922.3
|
fibulin 2 |
|
| chr7_-_158380465 Show fit | 4.02 |
ENST00000389413.3
ENST00000409483.1 |
protein tyrosine phosphatase, receptor type, N polypeptide 2 |
|
| chr3_+_13590636 Show fit | 3.94 |
ENST00000295760.7
|
fibulin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP4_PML
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 13.7 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
| 1.4 | 11.5 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
| 0.2 | 10.3 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.2 | 10.1 | GO:0099601 | regulation of neurotransmitter receptor activity(GO:0099601) |
| 0.0 | 10.0 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.2 | 9.2 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.2 | 7.8 | GO:0033572 | transferrin transport(GO:0033572) |
| 1.8 | 7.3 | GO:0072139 | glomerular parietal epithelial cell differentiation(GO:0072139) |
| 1.2 | 7.0 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.4 | 6.8 | GO:0071420 | cellular response to histamine(GO:0071420) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 66.3 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 19.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 18.2 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 15.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 15.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 14.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 13.7 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.0 | 12.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.6 | 12.7 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.2 | 12.2 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 11.0 | GO:0031750 | D3 dopamine receptor binding(GO:0031750) |
| 0.0 | 10.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.5 | 10.6 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 9.9 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 9.3 | GO:0002020 | protease binding(GO:0002020) |
| 0.3 | 9.1 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 8.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 8.0 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 7.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 7.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 19.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 13.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 12.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 12.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.5 | 11.9 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 10.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 8.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 8.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 7.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.2 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.3 | 10.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 10.2 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 9.4 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 8.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.4 | 8.2 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.2 | 8.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 7.8 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.1 | 7.2 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 6.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |