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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SPDEF

Z-value: 0.89

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Transcription factors associated with SPDEF

Gene Symbol Gene ID Gene Info
SPDEF
ENSG00000124664.6 SAM pointed domain containing ETS transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPDEFhg19_v2_chr6_-_34524093_345241350.588.7e-04Click!

Activity profile of SPDEF motif

Sorted Z-values of SPDEF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_84630053 2.30 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_84630645 2.29 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_+_153701081 1.97 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
ARFIP1
ADP-ribosylation factor interacting protein 1
chr12_-_123201337 1.80 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr5_+_110074685 1.78 ENST00000355943.3
ENST00000447245.2
SLC25A46
solute carrier family 25, member 46
chr12_-_123187890 1.77 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr6_-_43484621 1.72 ENST00000506469.1
ENST00000503972.1
YIPF3
Yip1 domain family, member 3
chr16_+_77225071 1.64 ENST00000439557.2
ENST00000545553.1
MON1B
MON1 secretory trafficking family member B
chr6_-_43484718 1.59 ENST00000372422.2
YIPF3
Yip1 domain family, member 3
chr11_-_58345569 1.56 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr5_-_114961673 1.54 ENST00000333314.3
TMED7-TICAM2
TMED7-TICAM2 readthrough
chr2_+_48667983 1.51 ENST00000449090.2
PPP1R21
protein phosphatase 1, regulatory subunit 21
chr20_-_48532046 1.45 ENST00000543716.1
SPATA2
spermatogenesis associated 2
chr4_-_153700864 1.44 ENST00000304337.2
TIGD4
tigger transposable element derived 4
chr1_+_169337172 1.41 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
BLZF1
basic leucine zipper nuclear factor 1
chr8_+_15397732 1.37 ENST00000382020.4
ENST00000506802.1
ENST00000509380.1
ENST00000503731.1
TUSC3
tumor suppressor candidate 3
chrX_+_69509927 1.35 ENST00000374403.3
KIF4A
kinesin family member 4A
chr2_+_48667898 1.34 ENST00000281394.4
ENST00000294952.8
PPP1R21
protein phosphatase 1, regulatory subunit 21
chrX_+_47444613 1.32 ENST00000445623.1
TIMP1
TIMP metallopeptidase inhibitor 1
chr3_-_37217756 1.22 ENST00000440230.1
ENST00000421276.2
ENST00000421307.1
ENST00000354379.4
LRRFIP2
leucine rich repeat (in FLII) interacting protein 2
chr6_-_30524951 1.16 ENST00000376621.3
GNL1
guanine nucleotide binding protein-like 1
chr7_+_93551011 1.16 ENST00000248564.5
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chrX_-_153775426 1.16 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr19_+_41257084 1.14 ENST00000601393.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr19_+_41256764 1.14 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr19_+_19496728 1.12 ENST00000537887.1
ENST00000417582.2
GATAD2A
GATA zinc finger domain containing 2A
chr15_+_91473403 1.11 ENST00000394275.2
UNC45A
unc-45 homolog A (C. elegans)
chr5_+_86564739 1.09 ENST00000456692.2
ENST00000512763.1
ENST00000506290.1
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr19_-_4723761 1.06 ENST00000597849.1
ENST00000598800.1
ENST00000602161.1
ENST00000597726.1
ENST00000601130.1
ENST00000262960.9
DPP9
dipeptidyl-peptidase 9
chr20_-_48532019 1.00 ENST00000289431.5
SPATA2
spermatogenesis associated 2
chr14_+_105212297 0.99 ENST00000556623.1
ENST00000555674.1
ADSSL1
adenylosuccinate synthase like 1
chr1_+_110091189 0.96 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr19_-_52674896 0.95 ENST00000322146.8
ENST00000597065.1
ZNF836
zinc finger protein 836
chr6_+_30525051 0.95 ENST00000376557.3
PRR3
proline rich 3
chr9_-_34458531 0.95 ENST00000379089.1
ENST00000379087.1
ENST00000379084.1
ENST00000379081.1
ENST00000379080.1
ENST00000422409.1
ENST00000379078.1
ENST00000445726.1
ENST00000297620.4
FAM219A
family with sequence similarity 219, member A
chr1_+_65886244 0.93 ENST00000344610.8
LEPR
leptin receptor
chr19_-_1650666 0.89 ENST00000588136.1
TCF3
transcription factor 3
chr14_-_23058063 0.86 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
DAD1
defender against cell death 1
chr6_+_30524663 0.86 ENST00000376560.3
PRR3
proline rich 3
chr12_+_70760056 0.84 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr1_-_28969517 0.82 ENST00000263974.4
ENST00000373824.4
TAF12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr10_+_75504105 0.82 ENST00000535742.1
ENST00000546025.1
ENST00000345254.4
ENST00000540668.1
ENST00000339365.2
ENST00000411652.2
SEC24C
SEC24 family member C
chr8_-_101964265 0.79 ENST00000395958.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr7_+_77428066 0.78 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
PHTF2
putative homeodomain transcription factor 2
chr18_-_47807829 0.77 ENST00000585672.1
ENST00000457839.2
ENST00000353909.3
ENST00000339998.6
ENST00000398493.1
MBD1
methyl-CpG binding domain protein 1
chr13_+_46039037 0.77 ENST00000349995.5
COG3
component of oligomeric golgi complex 3
chr17_-_45908875 0.77 ENST00000351111.2
ENST00000414011.1
MRPL10
mitochondrial ribosomal protein L10
chr12_-_57914275 0.75 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
DDIT3
DNA-damage-inducible transcript 3
chr19_-_1174226 0.75 ENST00000587024.1
ENST00000361757.3
SBNO2
strawberry notch homolog 2 (Drosophila)
chr6_-_41254403 0.75 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
TREM1
triggering receptor expressed on myeloid cells 1
chr19_-_52674696 0.75 ENST00000597252.1
ZNF836
zinc finger protein 836
chr12_+_109490370 0.74 ENST00000257548.5
ENST00000536723.1
ENST00000536393.1
USP30
ubiquitin specific peptidase 30
chr15_-_55700216 0.73 ENST00000569205.1
CCPG1
cell cycle progression 1
chr7_+_77428149 0.72 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr14_+_75348592 0.71 ENST00000334220.4
DLST
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr15_-_64648273 0.71 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
CSNK1G1
casein kinase 1, gamma 1
chrX_-_131352152 0.71 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr20_-_34252847 0.70 ENST00000317619.3
ENST00000397446.1
ENST00000397445.1
ENST00000397443.1
ENST00000430570.1
ENST00000439806.2
ENST00000437340.1
ENST00000435161.1
ENST00000431148.1
CPNE1
RBM12
copine I
RNA binding motif protein 12
chr4_+_141445311 0.70 ENST00000323570.3
ENST00000511887.2
ELMOD2
ELMO/CED-12 domain containing 2
chr15_-_91565743 0.70 ENST00000535843.1
VPS33B
vacuolar protein sorting 33 homolog B (yeast)
chr19_+_19496624 0.69 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A
GATA zinc finger domain containing 2A
chr16_+_77224732 0.69 ENST00000569610.1
ENST00000248248.3
ENST00000567291.1
ENST00000320859.6
ENST00000563612.1
ENST00000563279.1
MON1B
MON1 secretory trafficking family member B
chr2_+_118846008 0.69 ENST00000245787.4
INSIG2
insulin induced gene 2
chr17_+_18218587 0.69 ENST00000406438.3
SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
chr7_+_44240520 0.68 ENST00000496112.1
ENST00000223369.2
YKT6
YKT6 v-SNARE homolog (S. cerevisiae)
chr14_-_69263043 0.68 ENST00000408913.2
ZFP36L1
ZFP36 ring finger protein-like 1
chr22_+_38201114 0.67 ENST00000340857.2
H1F0
H1 histone family, member 0
chr12_+_29302119 0.65 ENST00000536681.3
FAR2
fatty acyl CoA reductase 2
chr12_+_102513950 0.63 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chrX_+_53078273 0.63 ENST00000332582.4
GPR173
G protein-coupled receptor 173
chr14_+_74417192 0.63 ENST00000554320.1
COQ6
coenzyme Q6 monooxygenase
chr12_+_102514019 0.63 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr6_+_101847105 0.62 ENST00000369137.3
ENST00000318991.6
GRIK2
glutamate receptor, ionotropic, kainate 2
chr15_-_91565770 0.61 ENST00000535906.1
ENST00000333371.3
VPS33B
vacuolar protein sorting 33 homolog B (yeast)
chr8_+_8860314 0.59 ENST00000250263.7
ENST00000519292.1
ERI1
exoribonuclease 1
chrX_+_49091920 0.59 ENST00000376227.3
CCDC22
coiled-coil domain containing 22
chr20_+_49126881 0.59 ENST00000371621.3
ENST00000541713.1
PTPN1
protein tyrosine phosphatase, non-receptor type 1
chr1_-_193028426 0.58 ENST00000367450.3
ENST00000530098.2
ENST00000367451.4
ENST00000367448.1
ENST00000367449.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr2_-_219537134 0.58 ENST00000295704.2
RNF25
ring finger protein 25
chr14_-_24701539 0.57 ENST00000534348.1
ENST00000524927.1
ENST00000250495.5
NEDD8-MDP1
NEDD8
NEDD8-MDP1 readthrough
neural precursor cell expressed, developmentally down-regulated 8
chr16_+_25123041 0.57 ENST00000399069.3
ENST00000380966.4
LCMT1
leucine carboxyl methyltransferase 1
chr2_+_162016827 0.56 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr1_-_43638168 0.56 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr14_+_67826709 0.55 ENST00000256383.4
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr9_-_132586378 0.55 ENST00000351698.4
TOR1A
torsin family 1, member A (torsin A)
chr16_-_70557430 0.54 ENST00000393612.4
ENST00000564653.1
ENST00000323786.5
COG4
component of oligomeric golgi complex 4
chr1_+_39456895 0.53 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr17_-_7835228 0.52 ENST00000303731.4
ENST00000571947.1
ENST00000540486.1
ENST00000572656.1
TRAPPC1
trafficking protein particle complex 1
chr11_-_57089671 0.52 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr12_+_22199108 0.51 ENST00000229329.2
CMAS
cytidine monophosphate N-acetylneuraminic acid synthetase
chr9_-_34126730 0.51 ENST00000361264.4
DCAF12
DDB1 and CUL4 associated factor 12
chr6_-_139309378 0.50 ENST00000450536.2
ENST00000258062.5
REPS1
RALBP1 associated Eps domain containing 1
chr7_+_100273736 0.50 ENST00000412215.1
ENST00000393924.1
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr14_-_75593708 0.50 ENST00000557673.1
ENST00000238616.5
NEK9
NIMA-related kinase 9
chr11_-_33183048 0.49 ENST00000438862.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chrX_-_154299501 0.49 ENST00000369476.3
ENST00000369484.3
MTCP1
CMC4
mature T-cell proliferation 1
C-x(9)-C motif containing 4
chr5_-_114961858 0.49 ENST00000282382.4
ENST00000456936.3
ENST00000408996.4
TMED7-TICAM2
TMED7
TICAM2
TMED7-TICAM2 readthrough
transmembrane emp24 protein transport domain containing 7
toll-like receptor adaptor molecule 2
chr6_+_31515337 0.47 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr3_-_156272924 0.47 ENST00000467789.1
ENST00000265044.2
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr6_+_37787262 0.47 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr8_+_22462532 0.46 ENST00000389279.3
CCAR2
cell cycle and apoptosis regulator 2
chr12_+_120972147 0.46 ENST00000325954.4
ENST00000542438.1
RNF10
ring finger protein 10
chr15_+_41186609 0.45 ENST00000220509.5
VPS18
vacuolar protein sorting 18 homolog (S. cerevisiae)
chr11_-_33183006 0.44 ENST00000524827.1
ENST00000323959.4
ENST00000431742.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr18_+_21033239 0.44 ENST00000581585.1
ENST00000577501.1
RIOK3
RIO kinase 3
chr12_+_123868320 0.44 ENST00000402868.3
ENST00000330479.4
SETD8
SET domain containing (lysine methyltransferase) 8
chr1_-_20987851 0.44 ENST00000464364.1
ENST00000602624.2
DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr4_+_159593271 0.43 ENST00000512251.1
ENST00000511912.1
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr16_+_67233007 0.43 ENST00000360833.1
ENST00000393997.2
ELMO3
engulfment and cell motility 3
chr1_-_161102421 0.43 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
DEDD
death effector domain containing
chr16_+_23652773 0.43 ENST00000563998.1
ENST00000568589.1
ENST00000568272.1
DCTN5
dynactin 5 (p25)
chr22_+_44351301 0.43 ENST00000350028.4
SAMM50
SAMM50 sorting and assembly machinery component
chr11_-_64410787 0.41 ENST00000301894.2
NRXN2
neurexin 2
chr16_-_28503357 0.41 ENST00000333496.9
ENST00000561505.1
ENST00000567963.1
ENST00000354630.5
ENST00000355477.5
ENST00000357076.5
ENST00000565688.1
ENST00000359984.7
CLN3
ceroid-lipofuscinosis, neuronal 3
chr7_+_98923505 0.41 ENST00000432884.2
ENST00000262942.5
ARPC1A
actin related protein 2/3 complex, subunit 1A, 41kDa
chr1_-_193028632 0.41 ENST00000421683.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr16_-_28503327 0.41 ENST00000535392.1
ENST00000395653.4
CLN3
ceroid-lipofuscinosis, neuronal 3
chr10_-_119806085 0.40 ENST00000355624.3
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chrX_-_152486108 0.40 ENST00000356661.5
MAGEA1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
chr8_+_22462145 0.40 ENST00000308511.4
ENST00000523801.1
ENST00000521301.1
CCAR2
cell cycle and apoptosis regulator 2
chr3_-_156272872 0.40 ENST00000476217.1
SSR3
signal sequence receptor, gamma (translocon-associated protein gamma)
chr1_-_20987982 0.40 ENST00000375048.3
DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr16_-_28503080 0.39 ENST00000565316.1
ENST00000565778.1
ENST00000357857.9
ENST00000568558.1
ENST00000357806.7
CLN3
ceroid-lipofuscinosis, neuronal 3
chr5_+_158690089 0.39 ENST00000296786.6
UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr11_+_128563652 0.39 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr7_+_128379449 0.39 ENST00000479257.1
CALU
calumenin
chr14_+_74416989 0.39 ENST00000334571.2
ENST00000554920.1
COQ6
coenzyme Q6 monooxygenase
chr1_-_28415204 0.39 ENST00000373871.3
EYA3
eyes absent homolog 3 (Drosophila)
chr20_-_2451395 0.39 ENST00000339610.6
ENST00000381342.2
ENST00000438552.2
SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
chr11_+_124492749 0.39 ENST00000531667.1
ENST00000441174.3
ENST00000375005.4
TBRG1
transforming growth factor beta regulator 1
chr1_-_193028621 0.38 ENST00000367455.4
ENST00000367454.1
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr16_+_67233412 0.38 ENST00000477898.1
ELMO3
engulfment and cell motility 3
chr19_+_58898627 0.38 ENST00000598098.1
ENST00000598495.1
ENST00000196551.3
ENST00000596046.1
RPS5
ribosomal protein S5
chr18_+_21032781 0.38 ENST00000339486.3
RIOK3
RIO kinase 3
chr15_-_65282232 0.38 ENST00000416889.2
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr11_-_46722117 0.38 ENST00000311956.4
ARHGAP1
Rho GTPase activating protein 1
chr20_-_42839378 0.38 ENST00000255174.2
OSER1
oxidative stress responsive serine-rich 1
chr1_-_20987889 0.37 ENST00000415136.2
DDOST
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr4_-_83812248 0.37 ENST00000514326.1
ENST00000505434.1
ENST00000503058.1
ENST00000348405.4
ENST00000505984.1
ENST00000513858.1
ENST00000508479.1
ENST00000443462.2
ENST00000508502.1
ENST00000509142.1
ENST00000432794.1
ENST00000448323.1
ENST00000326950.5
ENST00000311785.7
SEC31A
SEC31 homolog A (S. cerevisiae)
chr4_+_159593418 0.37 ENST00000507475.1
ENST00000307738.5
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr1_+_86934526 0.36 ENST00000394711.1
CLCA1
chloride channel accessory 1
chr6_-_150039170 0.36 ENST00000458696.2
ENST00000392273.3
LATS1
large tumor suppressor kinase 1
chr2_-_128784846 0.36 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
SAP130
Sin3A-associated protein, 130kDa
chr2_+_162016804 0.36 ENST00000392749.2
ENST00000440506.1
TANK
TRAF family member-associated NFKB activator
chr4_-_83812402 0.36 ENST00000395310.2
SEC31A
SEC31 homolog A (S. cerevisiae)
chr7_+_91875508 0.35 ENST00000265742.3
ANKIB1
ankyrin repeat and IBR domain containing 1
chr17_-_8066250 0.35 ENST00000488857.1
ENST00000481878.1
ENST00000316509.6
ENST00000498285.1
VAMP2
RP11-599B13.6
vesicle-associated membrane protein 2 (synaptobrevin 2)
Uncharacterized protein
chr4_-_10118348 0.34 ENST00000502702.1
WDR1
WD repeat domain 1
chr4_+_93225550 0.34 ENST00000282020.4
GRID2
glutamate receptor, ionotropic, delta 2
chr3_-_196669298 0.33 ENST00000411704.1
ENST00000452404.2
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr12_-_102513843 0.33 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr15_-_80215984 0.33 ENST00000485386.1
ENST00000479961.1
ST20
ST20-MTHFS
suppressor of tumorigenicity 20
ST20-MTHFS readthrough
chr22_+_44351419 0.33 ENST00000396202.3
SAMM50
SAMM50 sorting and assembly machinery component
chr15_+_43663257 0.32 ENST00000260383.7
ENST00000564079.1
TUBGCP4
tubulin, gamma complex associated protein 4
chr1_-_28415075 0.31 ENST00000373863.3
ENST00000436342.2
ENST00000540618.1
ENST00000545175.1
EYA3
eyes absent homolog 3 (Drosophila)
chr3_-_32022733 0.31 ENST00000438237.2
ENST00000396556.2
OSBPL10
oxysterol binding protein-like 10
chr2_+_162016916 0.31 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr14_+_24701819 0.31 ENST00000560139.1
ENST00000559910.1
GMPR2
guanosine monophosphate reductase 2
chr15_-_65282274 0.31 ENST00000204566.2
SPG21
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr2_+_101618965 0.31 ENST00000456292.1
ENST00000409711.1
ENST00000441435.1
RPL31
ribosomal protein L31
chr8_-_57906362 0.30 ENST00000262644.4
IMPAD1
inositol monophosphatase domain containing 1
chr14_+_24701628 0.30 ENST00000355299.4
ENST00000559836.1
GMPR2
guanosine monophosphate reductase 2
chr1_+_901847 0.30 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
PLEKHN1
pleckstrin homology domain containing, family N member 1
chr18_+_19321281 0.29 ENST00000261537.6
MIB1
mindbomb E3 ubiquitin protein ligase 1
chr13_+_25670268 0.28 ENST00000281589.3
PABPC3
poly(A) binding protein, cytoplasmic 3
chr1_+_213224572 0.28 ENST00000543470.1
ENST00000366960.3
ENST00000366959.3
ENST00000543354.1
RPS6KC1
ribosomal protein S6 kinase, 52kDa, polypeptide 1
chr8_-_100025238 0.28 ENST00000521696.1
RP11-410L14.2
RP11-410L14.2
chr1_-_67896009 0.27 ENST00000370990.5
SERBP1
SERPINE1 mRNA binding protein 1
chr1_-_111506562 0.27 ENST00000485275.2
ENST00000369763.4
LRIF1
ligand dependent nuclear receptor interacting factor 1
chr15_-_55700522 0.26 ENST00000564092.1
ENST00000310958.6
CCPG1
cell cycle progression 1
chr6_+_33257346 0.26 ENST00000374606.5
ENST00000374610.2
ENST00000374607.1
PFDN6
prefoldin subunit 6
chr22_+_22020273 0.26 ENST00000412327.1
ENST00000335025.8
ENST00000398831.3
ENST00000492445.2
ENST00000458567.1
ENST00000406385.1
PPIL2
peptidylprolyl isomerase (cyclophilin)-like 2
chr17_-_18218237 0.26 ENST00000542570.1
TOP3A
topoisomerase (DNA) III alpha
chrX_-_48814810 0.26 ENST00000376488.3
ENST00000396743.3
ENST00000156084.4
OTUD5
OTU domain containing 5
chr4_-_44728559 0.25 ENST00000509756.1
ENST00000507917.1
ENST00000295448.3
GNPDA2
glucosamine-6-phosphate deaminase 2
chr15_-_65809581 0.25 ENST00000341861.5
DPP8
dipeptidyl-peptidase 8
chr14_+_35761580 0.25 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr14_-_24711470 0.24 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr6_+_43484760 0.24 ENST00000372389.3
ENST00000372344.2
ENST00000304004.3
ENST00000423780.1
POLR1C
polymerase (RNA) I polypeptide C, 30kDa
chr3_+_100428188 0.24 ENST00000418917.2
ENST00000490574.1
TFG
TRK-fused gene
chr15_+_54901540 0.23 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chrX_-_69509738 0.23 ENST00000374454.1
ENST00000239666.4
PDZD11
PDZ domain containing 11
chr7_-_135662056 0.23 ENST00000393085.3
ENST00000435723.1
MTPN
myotrophin
chrX_+_123480375 0.23 ENST00000360027.4
SH2D1A
SH2 domain containing 1A
chr2_+_3383439 0.23 ENST00000382110.2
ENST00000324266.5
TRAPPC12
trafficking protein particle complex 12
chr3_-_196669371 0.23 ENST00000427641.2
ENST00000321256.5
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr2_+_65454926 0.22 ENST00000542850.1
ENST00000377982.4
ACTR2
ARP2 actin-related protein 2 homolog (yeast)
chr11_+_576494 0.22 ENST00000533464.1
ENST00000413872.2
ENST00000416188.2
PHRF1
PHD and ring finger domains 1
chr3_-_133380731 0.22 ENST00000260810.5
TOPBP1
topoisomerase (DNA) II binding protein 1
chr5_-_177580855 0.22 ENST00000514354.1
ENST00000511078.1
NHP2
NHP2 ribonucleoprotein
chr5_-_177580933 0.22 ENST00000274606.3
NHP2
NHP2 ribonucleoprotein
chr20_+_60962143 0.22 ENST00000343986.4
RPS21
ribosomal protein S21
chr17_-_18218270 0.22 ENST00000321105.5
TOP3A
topoisomerase (DNA) III alpha
chr17_-_62658186 0.21 ENST00000262435.9
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr14_-_74416829 0.21 ENST00000534936.1
FAM161B
family with sequence similarity 161, member B
chr10_-_120840309 0.21 ENST00000369144.3
EIF3A
eukaryotic translation initiation factor 3, subunit A
chr15_+_80987617 0.21 ENST00000258884.4
ENST00000558464.1
ABHD17C
abhydrolase domain containing 17C
chr14_+_35761540 0.21 ENST00000261479.4
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr7_+_114562616 0.21 ENST00000448022.1
MDFIC
MyoD family inhibitor domain containing
chr20_+_34287194 0.21 ENST00000374078.1
ENST00000374077.3
ROMO1
reactive oxygen species modulator 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SPDEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0019085 early viral transcription(GO:0019085)
0.7 4.7 GO:0097338 response to clozapine(GO:0097338)
0.6 1.8 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.4 1.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.3 1.2 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.3 1.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.2 0.7 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.2 0.7 GO:1904582 regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582)
0.2 1.1 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 1.3 GO:0070889 platelet alpha granule organization(GO:0070889)
0.2 0.8 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.2 1.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 1.0 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.2 0.6 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.2 1.6 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2 0.6 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.2 0.5 GO:1903423 positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423)
0.2 0.5 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.2 0.7 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.2 0.7 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.2 0.7 GO:0016333 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.2 0.8 GO:2000015 negative regulation of CREB transcription factor activity(GO:0032792) regulation of determination of dorsal identity(GO:2000015)
0.1 1.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 0.6 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 0.7 GO:0071105 response to interleukin-11(GO:0071105)
0.1 0.7 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.1 0.9 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.7 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.1 GO:1902164 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.2 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.1 1.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 2.0 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 0.7 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 0.5 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.1 0.4 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.1 1.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.9 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 0.9 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.1 0.8 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 0.6 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.2 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732) translation reinitiation(GO:0002188)
0.1 0.5 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.1 0.7 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.1 0.8 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.8 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.1 1.4 GO:0021670 lateral ventricle development(GO:0021670)
0.1 0.2 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.1 0.4 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.1 0.4 GO:0043307 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil activation(GO:0043307) eosinophil degranulation(GO:0043308)
0.1 0.5 GO:0010624 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.1 0.2 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.1 0.4 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.1 0.8 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.3 GO:0006021 inositol biosynthetic process(GO:0006021)
0.1 1.1 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.0 0.8 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0001827 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.8 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.6 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 1.0 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.3 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.8 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.3 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 1.7 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.7 GO:0050851 antigen receptor-mediated signaling pathway(GO:0050851)
0.0 0.1 GO:0018282 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.8 GO:0043101 purine-containing compound salvage(GO:0043101)
0.0 0.5 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 1.2 GO:0198738 Wnt signaling pathway(GO:0016055) cell-cell signaling by wnt(GO:0198738)
0.0 1.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.3 GO:0051715 cytolysis in other organism(GO:0051715)
0.0 1.4 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.6 GO:0045116 protein neddylation(GO:0045116)
0.0 0.6 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 1.0 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.7 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.1 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.1 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 1.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.8 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.9 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 1.1 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.0 0.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.5 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.4 GO:0003091 renal water homeostasis(GO:0003091)
0.0 0.5 GO:0000732 strand displacement(GO:0000732)
0.0 1.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.1 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.4 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.0 0.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.2 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.8 GO:0007077 mitotic nuclear envelope disassembly(GO:0007077)
0.0 0.1 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:1904382 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0044609 DBIRD complex(GO:0044609)
0.3 0.8 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.2 4.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 3.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 0.6 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 0.7 GO:0005846 nuclear cap binding complex(GO:0005846)
0.2 0.7 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.7 GO:0042643 actomyosin, actin portion(GO:0042643)
0.1 0.8 GO:1902560 GMP reductase complex(GO:1902560)
0.1 1.5 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 1.0 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 0.5 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.1 2.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.0 GO:0097443 sorting endosome(GO:0097443)
0.1 0.4 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.5 GO:0042588 zymogen granule(GO:0042588)
0.1 0.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.4 GO:0090661 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1 1.3 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.4 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 2.3 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 1.8 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 0.8 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.1 0.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.8 GO:0000124 SAGA complex(GO:0000124)
0.0 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.6 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 1.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.3 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.7 GO:0097440 apical dendrite(GO:0097440)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.6 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.8 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.2 GO:0035749 myelin sheath adaxonal region(GO:0035749) lateral loop(GO:0043219)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 2.0 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 1.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.2 GO:0005901 caveola(GO:0005901)
0.0 0.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.3 1.0 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.3 2.3 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.3 0.8 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.3 4.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.2 3.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 1.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 0.6 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.2 0.7 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 0.9 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.8 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.7 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.3 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 0.4 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.1 1.0 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 1.1 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.1 0.6 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.6 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.1 2.0 GO:0030275 LRR domain binding(GO:0030275)
0.1 1.4 GO:0070628 proteasome binding(GO:0070628)
0.1 0.8 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.1 0.3 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1 0.8 GO:0089720 caspase binding(GO:0089720)
0.1 0.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 2.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.4 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0031071 cysteine desulfurase activity(GO:0031071)
0.0 0.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.6 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.0 GO:0071949 FAD binding(GO:0071949)
0.0 0.5 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.7 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.5 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 1.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.6 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 1.2 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 2.6 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 3.2 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.1 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.7 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 1.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 ST GAQ PATHWAY G alpha q Pathway
0.0 0.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.7 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.5 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.7 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.6 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.1 1.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.8 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 1.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.2 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.6 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 1.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.7 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 2.3 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 3.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.4 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 1.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination