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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SPDEF
Z-value: 0.89
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Transcription factors associated with SPDEF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPDEF | hg19_v2_chr6_-_34524093_34524135 | 0.58 | 8.7e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPDEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.7 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.8 | 2.3 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.1 | 2.0 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.6 | 1.8 | GO:0090149 | mitochondrial membrane fission(GO:0090149) |
| 0.3 | 1.8 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.0 | 1.8 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 1.8 | GO:0006305 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.0 | 1.7 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.2 | 1.6 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.1 | 1.5 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 3.6 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 2.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 2.3 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.1 | 2.0 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 2.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 1.8 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 1.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.6 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.5 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 3.4 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 3.2 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 2.6 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.3 | 2.3 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.1 | 2.0 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 2.0 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 1.8 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 1.4 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 1.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.7 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.5 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 1.1 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 1.0 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.7 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 3.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 2.6 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.0 | 2.3 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.0 | 1.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 1.6 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 1.5 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 1.5 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 1.3 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.3 | REACTOME KINESINS | Genes involved in Kinesins |