Project

Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

Navigation
Downloads

Results for SPIB

Z-value: 0.89

Motif logo

Transcription factors associated with SPIB

Gene Symbol Gene ID Gene Info
ENSG00000269404.2 Spi-B transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPIBhg19_v2_chr19_+_50922187_509222150.505.1e-03Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_51471362 9.82 ENST00000376853.4
ENST00000424910.2
kallikrein-related peptidase 6
chr19_-_51471381 9.73 ENST00000594641.1
kallikrein-related peptidase 6
chr1_+_120839412 4.62 ENST00000355228.4
family with sequence similarity 72, member B
chr1_+_206138884 4.22 ENST00000341209.5
ENST00000607379.1
family with sequence similarity 72, member A
chr2_+_113885138 3.28 ENST00000409930.3
interleukin 1 receptor antagonist
chr19_+_48828788 3.17 ENST00000594198.1
ENST00000597279.1
ENST00000593437.1
epithelial membrane protein 3
chr19_+_48828582 2.91 ENST00000270221.6
ENST00000596315.1
epithelial membrane protein 3
chr10_-_121302195 2.75 ENST00000369103.2
regulator of G-protein signaling 10
chr12_+_15699286 2.68 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
protein tyrosine phosphatase, receptor type, O
chr22_-_37640456 2.67 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr19_+_54371114 2.63 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
myeloid-associated differentiation marker
chr2_+_233925064 2.49 ENST00000359570.5
ENST00000538935.1
inositol polyphosphate-5-phosphatase, 145kDa
chr22_-_37640277 2.48 ENST00000401529.3
ENST00000249071.6
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr5_-_39270725 2.35 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr2_-_208031943 2.16 ENST00000421199.1
ENST00000457962.1
Kruppel-like factor 7 (ubiquitous)
chr2_-_190044480 2.15 ENST00000374866.3
collagen, type V, alpha 2
chr7_+_74188309 2.14 ENST00000289473.4
ENST00000433458.1
neutrophil cytosolic factor 1
chr1_-_143913143 2.09 ENST00000400889.1
family with sequence similarity 72, member D
chr1_+_206138457 2.09 ENST00000367128.3
ENST00000431655.2
family with sequence similarity 72, member A
chr22_-_37915535 2.07 ENST00000403299.1
caspase recruitment domain family, member 10
chr3_+_121774202 2.07 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86 molecule
chr19_-_15344243 2.07 ENST00000602233.1
epoxide hydrolase 3
chr1_+_120839005 2.05 ENST00000369390.3
ENST00000452190.1
family with sequence similarity 72, member B
chr3_+_121796697 1.98 ENST00000482356.1
ENST00000393627.2
CD86 molecule
chr16_+_30194916 1.94 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
coronin, actin binding protein, 1A
chr11_+_65408273 1.93 ENST00000394227.3
signal-induced proliferation-associated 1
chr1_+_15736359 1.93 ENST00000375980.4
EF-hand domain family, member D2
chr1_-_43855444 1.75 ENST00000372455.4
mediator complex subunit 8
chr4_-_80994619 1.73 ENST00000404191.1
anthrax toxin receptor 2
chr4_+_8201091 1.71 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3 domain and tetratricopeptide repeats 1
chr4_-_103266626 1.63 ENST00000356736.4
solute carrier family 39 (zinc transporter), member 8
chr14_+_85996471 1.60 ENST00000330753.4
fibronectin leucine rich transmembrane protein 2
chr17_-_5138099 1.60 ENST00000571800.1
ENST00000574081.1
ENST00000399600.4
ENST00000574297.1
SLP adaptor and CSK interacting membrane protein
chrX_+_138612889 1.58 ENST00000218099.2
ENST00000394090.2
coagulation factor IX
chr11_-_64851496 1.52 ENST00000404147.3
ENST00000275517.3
cell division cycle associated 5
chr6_+_31126291 1.51 ENST00000376257.3
ENST00000376255.4
transcription factor 19
chr12_-_122240792 1.49 ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
ENST00000541657.1
AC084018.1
ras homolog family member F (in filopodia)
chrX_-_47489244 1.45 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
complement factor properdin
chr17_-_43487780 1.44 ENST00000532038.1
ENST00000528677.1
Rho GTPase activating protein 27
chr6_-_144385698 1.44 ENST00000444202.1
ENST00000437412.1
pleiomorphic adenoma gene-like 1
chr3_+_98482175 1.43 ENST00000485391.1
ENST00000492254.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr5_+_159848854 1.40 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
pituitary tumor-transforming 1
chr15_-_34629922 1.39 ENST00000559484.1
ENST00000354181.3
ENST00000558589.1
ENST00000458406.2
solute carrier family 12 (potassium/chloride transporter), member 6
chr20_+_62492566 1.37 ENST00000369916.3
abhydrolase domain containing 16B
chr12_-_51785182 1.29 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr2_+_173940163 1.28 ENST00000539448.1
Mitogen-activated protein kinase kinase kinase MLT
chr17_-_43487741 1.24 ENST00000455881.1
Rho GTPase activating protein 27
chr7_+_139529040 1.24 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
thromboxane A synthase 1 (platelet)
chr6_-_11382478 1.22 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
neural precursor cell expressed, developmentally down-regulated 9
chr15_-_34630234 1.18 ENST00000558667.1
ENST00000561120.1
ENST00000559236.1
ENST00000397702.2
solute carrier family 12 (potassium/chloride transporter), member 6
chr16_+_71392616 1.15 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
calbindin 2
chr5_-_140013275 1.12 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14 molecule
chr6_-_167571817 1.12 ENST00000366834.1
G protein-coupled receptor 31
chr9_-_95640218 1.10 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
zinc finger protein 484
chr2_+_173940442 1.08 ENST00000409176.2
ENST00000338983.3
ENST00000431503.2
Mitogen-activated protein kinase kinase kinase MLT
chr15_-_34628951 1.08 ENST00000397707.2
ENST00000560611.1
solute carrier family 12 (potassium/chloride transporter), member 6
chr7_+_139528952 1.07 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
thromboxane A synthase 1 (platelet)
chr12_+_49717081 1.06 ENST00000547807.1
ENST00000551567.1
trophinin associated protein
chr19_+_50919056 1.06 ENST00000599632.1
CTD-2545M3.6
chr10_+_106028605 1.05 ENST00000450629.2
glutathione S-transferase omega 2
chr22_+_37309662 1.04 ENST00000403662.3
ENST00000262825.5
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr17_+_65374075 1.03 ENST00000581322.1
phosphatidylinositol transfer protein, cytoplasmic 1
chrX_-_153637612 1.03 ENST00000369807.1
ENST00000369808.3
deoxyribonuclease I-like 1
chr10_-_74856608 1.02 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
prolyl 4-hydroxylase, alpha polypeptide I
chr19_-_40791211 1.01 ENST00000579047.1
v-akt murine thymoma viral oncogene homolog 2
chr15_-_34610962 1.01 ENST00000290209.5
solute carrier family 12 (potassium/chloride transporter), member 6
chr12_+_49717019 1.00 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
trophinin associated protein
chr17_-_1395954 0.99 ENST00000359786.5
myosin IC
chr6_+_130339710 0.99 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr10_+_106028923 0.98 ENST00000338595.2
glutathione S-transferase omega 2
chr15_-_33360342 0.97 ENST00000558197.1
formin 1
chr2_-_43019698 0.96 ENST00000431905.1
ENST00000294973.6
3-hydroxyanthranilate 3,4-dioxygenase
chr6_-_32145861 0.95 ENST00000336984.6
1-acylglycerol-3-phosphate O-acyltransferase 1
chr6_-_41254403 0.93 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
triggering receptor expressed on myeloid cells 1
chr18_-_31802056 0.92 ENST00000538587.1
nucleolar protein 4
chr17_+_65373531 0.91 ENST00000580974.1
phosphatidylinositol transfer protein, cytoplasmic 1
chr3_-_151047327 0.90 ENST00000325602.5
purinergic receptor P2Y, G-protein coupled, 13
chr3_-_179169330 0.90 ENST00000232564.3
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr5_+_96079240 0.88 ENST00000515663.1
calpastatin
chr16_+_28889801 0.87 ENST00000395503.4
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr17_-_39093672 0.87 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
keratin 23 (histone deacetylase inducible)
chrX_-_40594755 0.87 ENST00000324817.1
mediator complex subunit 14
chr6_-_133079022 0.87 ENST00000525289.1
ENST00000326499.6
vanin 2
chr1_-_47069886 0.85 ENST00000371946.4
ENST00000371945.4
ENST00000428112.2
ENST00000529170.1
MAP kinase interacting serine/threonine kinase 1
chr1_-_47069955 0.83 ENST00000341183.5
ENST00000496619.1
MAP kinase interacting serine/threonine kinase 1
chr20_-_46415341 0.83 ENST00000484875.1
ENST00000361612.4
sulfatase 2
chr13_+_31309645 0.81 ENST00000380490.3
arachidonate 5-lipoxygenase-activating protein
chr10_-_92617671 0.81 ENST00000371721.3
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
chr9_+_112403088 0.80 ENST00000448454.2
paralemmin 2
chr11_+_1860832 0.80 ENST00000252898.7
troponin I type 2 (skeletal, fast)
chr21_-_46340807 0.79 ENST00000397846.3
ENST00000524251.1
ENST00000522688.1
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr12_+_9102632 0.79 ENST00000539240.1
killer cell lectin-like receptor subfamily G, member 1
chr2_-_188419078 0.78 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr11_+_1861399 0.78 ENST00000381905.3
troponin I type 2 (skeletal, fast)
chr16_+_28889703 0.78 ENST00000357084.3
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr7_+_106505696 0.76 ENST00000440650.2
ENST00000496166.1
ENST00000473541.1
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr11_+_60145997 0.76 ENST00000530614.1
ENST00000530027.1
ENST00000530234.2
ENST00000528215.1
ENST00000531787.1
membrane-spanning 4-domains, subfamily A, member 7
membrane-spanning 4-domains, subfamily A, member 14
chr7_+_106505912 0.75 ENST00000359195.3
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr6_+_42952237 0.75 ENST00000485511.1
ENST00000394110.3
ENST00000472118.1
ENST00000461010.1
protein phosphatase 2, regulatory subunit B', delta
chr9_+_34653861 0.74 ENST00000556792.1
ENST00000318041.9
ENST00000378817.4
interleukin 11 receptor, alpha
chr16_+_30960375 0.74 ENST00000318663.4
ENST00000566237.1
ENST00000562699.1
ORAI calcium release-activated calcium modulator 3
chr6_+_69345166 0.73 ENST00000370598.1
brain-specific angiogenesis inhibitor 3
chr11_-_3859089 0.73 ENST00000396979.1
ras homolog family member G
chr20_-_46415297 0.73 ENST00000467815.1
ENST00000359930.4
sulfatase 2
chrX_-_74376108 0.72 ENST00000339447.4
ENST00000373394.3
ENST00000529949.1
ENST00000534524.1
ENST00000253577.3
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr3_-_28390120 0.72 ENST00000334100.6
5-azacytidine induced 2
chr10_-_98031265 0.71 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr6_+_15246501 0.70 ENST00000341776.2
jumonji, AT rich interactive domain 2
chr7_-_129592471 0.70 ENST00000473814.2
ENST00000490974.1
ubiquitin-conjugating enzyme E2H
chr9_-_113800981 0.70 ENST00000538760.1
lysophosphatidic acid receptor 1
chr8_+_27632083 0.70 ENST00000519637.1
establishment of sister chromatid cohesion N-acetyltransferase 2
chr14_-_45431091 0.70 ENST00000579157.1
ENST00000396128.4
ENST00000556500.1
kelch-like family member 28
chr11_-_67120974 0.70 ENST00000539074.1
ENST00000312419.3
polymerase (DNA-directed), delta 4, accessory subunit
chr4_+_177241094 0.69 ENST00000503362.1
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr6_+_116782527 0.69 ENST00000368606.3
ENST00000368605.1
family with sequence similarity 26, member F
chr17_-_37009882 0.69 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
ribosomal protein L23
chr9_+_112403059 0.69 ENST00000374531.2
paralemmin 2
chr6_+_26251835 0.67 ENST00000356350.2
histone cluster 1, H2bh
chr5_+_169064245 0.67 ENST00000256935.8
dedicator of cytokinesis 2
chr12_+_120105558 0.66 ENST00000229328.5
ENST00000541640.1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chrX_+_28605516 0.66 ENST00000378993.1
interleukin 1 receptor accessory protein-like 1
chr2_+_173940668 0.64 ENST00000375213.3
Mitogen-activated protein kinase kinase kinase MLT
chr14_+_67291158 0.64 ENST00000555456.1
gephyrin
chr1_+_22979474 0.63 ENST00000509305.1
complement component 1, q subcomponent, B chain
chr5_+_95997769 0.63 ENST00000338252.3
ENST00000508830.1
calpastatin
chr1_+_209941827 0.63 ENST00000367023.1
TRAF3 interacting protein 3
chr1_+_205473720 0.62 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
cyclin-dependent kinase 18
chr13_-_25745857 0.62 ENST00000381853.3
APC membrane recruitment protein 2
chr7_-_121944491 0.60 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr12_+_10124001 0.60 ENST00000396507.3
ENST00000304361.4
ENST00000434319.2
C-type lectin domain family 12, member A
chr1_-_159893507 0.60 ENST00000368096.1
transgelin 2
chr1_-_231560790 0.59 ENST00000366641.3
egl-9 family hypoxia-inducible factor 1
chr1_+_22979676 0.58 ENST00000432749.2
ENST00000314933.6
complement component 1, q subcomponent, B chain
chr19_+_16254488 0.58 ENST00000588246.1
ENST00000593031.1
hematopoietic SH2 domain containing
chr1_+_161676739 0.58 ENST00000236938.6
ENST00000367959.2
ENST00000546024.1
ENST00000540521.1
ENST00000367949.2
ENST00000350710.3
ENST00000540926.1
Fc receptor-like A
chr11_+_60145967 0.58 ENST00000534016.1
membrane-spanning 4-domains, subfamily A, member 7
chr11_+_131240373 0.58 ENST00000374791.3
ENST00000436745.1
neurotrimin
chr19_+_30863271 0.57 ENST00000355537.3
zinc finger protein 536
chr5_-_142783175 0.57 ENST00000231509.3
ENST00000394464.2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr11_-_64546202 0.57 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
splicing factor 1
chr14_+_85996507 0.57 ENST00000554746.1
fibronectin leucine rich transmembrane protein 2
chr1_+_39456895 0.57 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
akirin 1
chr3_-_16555150 0.56 ENST00000334133.4
raftlin, lipid raft linker 1
chr3_-_28390298 0.56 ENST00000457172.1
5-azacytidine induced 2
chr17_-_76356148 0.55 ENST00000587578.1
ENST00000330871.2
suppressor of cytokine signaling 3
chr3_-_28390415 0.55 ENST00000414162.1
ENST00000420543.2
5-azacytidine induced 2
chr1_-_160616804 0.55 ENST00000538290.1
signaling lymphocytic activation molecule family member 1
chr13_-_36050819 0.54 ENST00000379919.4
mab-21-like 1 (C. elegans)
chr3_-_178984759 0.54 ENST00000349697.2
ENST00000497599.1
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr2_-_241737128 0.54 ENST00000404283.3
kinesin family member 1A
chr1_+_161676983 0.54 ENST00000367957.2
Fc receptor-like A
chr1_+_46713357 0.53 ENST00000442598.1
RAD54-like (S. cerevisiae)
chr1_+_46713404 0.52 ENST00000371975.4
ENST00000469835.1
RAD54-like (S. cerevisiae)
chr6_-_34524049 0.52 ENST00000374037.3
SAM pointed domain containing ETS transcription factor
chr6_-_34524093 0.52 ENST00000544425.1
SAM pointed domain containing ETS transcription factor
chr4_-_47916613 0.51 ENST00000381538.3
ENST00000329043.3
nuclear transcription factor, X-box binding-like 1
chrX_+_79591003 0.51 ENST00000538312.1
family with sequence similarity 46, member D
chr8_+_27632047 0.51 ENST00000397418.2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr10_-_98031310 0.51 ENST00000427367.2
ENST00000413476.2
B-cell linker
chr1_+_161632937 0.51 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr3_-_116163830 0.51 ENST00000333617.4
limbic system-associated membrane protein
chr1_-_20834586 0.51 ENST00000264198.3
mitochondrial E3 ubiquitin protein ligase 1
chr1_-_38325256 0.50 ENST00000373036.4
metal-regulatory transcription factor 1
chr6_+_125304502 0.50 ENST00000519799.1
ENST00000368414.2
ENST00000359704.2
ring finger protein 217
chr8_-_95449155 0.50 ENST00000481490.2
fibrinogen silencer binding protein
chr1_-_175161890 0.50 ENST00000545251.2
ENST00000423313.1
KIAA0040
chr2_+_96991935 0.49 ENST00000361124.4
ENST00000420728.1
ENST00000542887.1
inositol 1,4,5-trisphosphate receptor interacting protein-like 1
chr7_+_23145884 0.49 ENST00000409689.1
ENST00000410047.1
kelch-like family member 7
chr17_-_7835228 0.49 ENST00000303731.4
ENST00000571947.1
ENST00000540486.1
ENST00000572656.1
trafficking protein particle complex 1
chr9_-_21995249 0.49 ENST00000494262.1
cyclin-dependent kinase inhibitor 2A
chr4_-_47916543 0.49 ENST00000507489.1
nuclear transcription factor, X-box binding-like 1
chr2_+_42104692 0.49 ENST00000398796.2
ENST00000442214.1
AC104654.1
chr1_+_40505891 0.47 ENST00000372797.3
ENST00000372802.1
ENST00000449311.1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr3_-_195603566 0.47 ENST00000424563.1
ENST00000411741.1
tyrosine kinase, non-receptor, 2
chr11_-_116658758 0.47 ENST00000227322.3
zinc finger protein 259
chr11_-_58980342 0.46 ENST00000361050.3
macrophage expressed 1
chr6_-_47009996 0.46 ENST00000371243.2
G protein-coupled receptor 110
chr10_-_103578182 0.45 ENST00000439817.1
meningioma expressed antigen 5 (hyaluronidase)
chr17_-_29641084 0.45 ENST00000544462.1
ecotropic viral integration site 2B
chr3_-_186080012 0.45 ENST00000544847.1
ENST00000265022.3
diacylglycerol kinase, gamma 90kDa
chr3_-_176914238 0.45 ENST00000430069.1
ENST00000428970.1
transducin (beta)-like 1 X-linked receptor 1
chr1_-_43638168 0.45 ENST00000431635.2
EBNA1 binding protein 2
chr9_-_99145957 0.45 ENST00000375257.1
ENST00000253270.7
ENST00000375259.4
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr3_-_52273098 0.44 ENST00000499914.2
ENST00000305533.5
ENST00000597542.1
twinfilin actin-binding protein 2
toll-like receptor 9
chr10_+_72238517 0.44 ENST00000263563.6
phosphatase domain containing, paladin 1
chr6_+_142468383 0.44 ENST00000367621.1
ENST00000452973.2
vesicle (multivesicular body) trafficking 1
chr1_-_156675368 0.44 ENST00000368222.3
cellular retinoic acid binding protein 2
chr11_+_60145948 0.44 ENST00000300184.3
ENST00000358246.1
membrane-spanning 4-domains, subfamily A, member 7
chr2_-_71062938 0.43 ENST00000410009.3
CD207 molecule, langerin
chrX_+_78200913 0.43 ENST00000171757.2
purinergic receptor P2Y, G-protein coupled, 10
chr7_-_129592700 0.43 ENST00000472396.1
ENST00000355621.3
ubiquitin-conjugating enzyme E2H
chr2_-_188419200 0.43 ENST00000233156.3
ENST00000426055.1
ENST00000453013.1
ENST00000417013.1
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr1_+_15802594 0.43 ENST00000375910.3
chymotrypsin-like elastase family, member 2B
chr16_-_11363178 0.43 ENST00000312693.3
transition protein 2 (during histone to protamine replacement)
chr8_-_101962777 0.42 ENST00000395951.3
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr14_-_98444461 0.42 ENST00000499006.2
chromosome 14 open reading frame 64
chr5_-_146833222 0.42 ENST00000534907.1
dihydropyrimidinase-like 3
chrX_+_56259316 0.42 ENST00000468660.1
Kruppel-like factor 8
chr12_-_7656357 0.42 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163 molecule
chr11_-_116658695 0.42 ENST00000429220.1
ENST00000444935.1
zinc finger protein 259

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.9 4.7 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.9 2.7 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.9 19.5 GO:0016540 protein autoprocessing(GO:0016540)
0.8 2.5 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.7 2.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.7 2.6 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.6 1.7 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076)
0.5 1.5 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.5 5.2 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.4 2.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.4 1.2 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.4 1.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.4 1.9 GO:0042631 cellular response to water deprivation(GO:0042631)
0.4 3.3 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.4 2.2 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.3 2.8 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.3 1.9 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
0.3 1.1 GO:0071725 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.3 1.1 GO:0002238 response to molecule of fungal origin(GO:0002238) cellular response to molecule of fungal origin(GO:0071226)
0.3 6.8 GO:0032060 bleb assembly(GO:0032060)
0.3 1.5 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897) secretory granule localization(GO:0032252)
0.3 1.0 GO:0071484 response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484)
0.2 0.9 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.2 0.6 GO:0042040 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.2 0.8 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.2 1.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 0.8 GO:0072092 ureteric bud invasion(GO:0072092)
0.2 2.0 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.2 0.4 GO:0001782 B cell homeostasis(GO:0001782)
0.2 1.0 GO:0036016 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.2 1.0 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2 0.9 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.1 1.6 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.6 GO:0001776 leukocyte homeostasis(GO:0001776) lymphocyte homeostasis(GO:0002260)
0.1 1.0 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.4 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 0.7 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.1 0.5 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 1.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.4 GO:0043318 negative regulation of dendritic cell antigen processing and presentation(GO:0002605) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318)
0.1 2.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.6 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 3.0 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 2.0 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 1.4 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 0.4 GO:0032661 regulation of interleukin-18 production(GO:0032661) positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.1 0.3 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 1.5 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 0.3 GO:0043686 co-translational protein modification(GO:0043686)
0.1 0.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.3 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.1 0.8 GO:2001300 lipoxin metabolic process(GO:2001300)
0.1 1.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 2.1 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 0.7 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.5 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 0.6 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.2 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.1 0.9 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 1.0 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 0.8 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 1.7 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0071673 positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.1 0.8 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 0.3 GO:1903803 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.1 0.7 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 0.7 GO:0015886 heme transport(GO:0015886)
0.1 0.3 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.1 0.3 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) positive regulation of retinal ganglion cell axon guidance(GO:1902336) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1 0.2 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1 0.4 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 0.4 GO:0035709 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 2.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.1 0.2 GO:1903973 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.1 0.1 GO:0002838 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.1 0.4 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.1 0.2 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.4 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.7 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.9 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.4 GO:0060613 fat pad development(GO:0060613)
0.0 0.2 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.0 0.4 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.5 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 1.4 GO:0097503 sialylation(GO:0097503)
0.0 0.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.4 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.8 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.1 GO:0097051 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 2.0 GO:1901998 toxin transport(GO:1901998)
0.0 0.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.1 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.0 0.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.5 GO:0035878 nail development(GO:0035878)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.5 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.2 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.7 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.3 GO:0060548 negative regulation of cell death(GO:0060548)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.5 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.5 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.5 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.1 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
0.0 1.4 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.0 1.6 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.9 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.1 GO:0061198 fungiform papilla formation(GO:0061198)
0.0 0.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.1 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.1 GO:0039019 pronephric nephron development(GO:0039019)
0.0 0.8 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 1.1 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 1.0 GO:0006308 DNA catabolic process(GO:0006308)
0.0 1.3 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.2 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.9 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.2 GO:0060022 hard palate development(GO:0060022)
0.0 0.4 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 1.4 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.1 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 0.6 GO:0007398 ectoderm development(GO:0007398)
0.0 0.4 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.5 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 1.4 GO:0006968 cellular defense response(GO:0006968)
0.0 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.1 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.0 1.4 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.2 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.5 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 2.2 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 1.6 GO:0007127 meiosis I(GO:0007127)
0.0 0.0 GO:1990637 response to prolactin(GO:1990637)
0.0 0.1 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.0 0.3 GO:0018105 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.0 0.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.4 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.0 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.1 GO:0006105 succinate metabolic process(GO:0006105)
0.0 0.4 GO:0046039 GTP metabolic process(GO:0046039)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0005588 collagen type V trimer(GO:0005588)
0.4 2.1 GO:0032449 CBM complex(GO:0032449)
0.4 1.5 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.3 2.1 GO:0032010 phagolysosome(GO:0032010)
0.3 1.0 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.2 1.0 GO:0045160 myosin I complex(GO:0045160)
0.2 1.1 GO:0005602 complement component C1 complex(GO:0005602)
0.2 0.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 1.2 GO:0019815 B cell receptor complex(GO:0019815)
0.2 1.0 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.2 1.5 GO:0008278 cohesin complex(GO:0008278)
0.1 1.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.9 GO:0070847 core mediator complex(GO:0070847)
0.1 0.4 GO:0034657 GID complex(GO:0034657)
0.1 0.4 GO:0097362 MCM8-MCM9 complex(GO:0097362)
0.1 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 1.8 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 2.2 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.7 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 1.6 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:0032009 early phagosome(GO:0032009)
0.1 0.6 GO:0097443 sorting endosome(GO:0097443)
0.1 5.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.1 GO:0071159 NF-kappaB complex(GO:0071159)
0.0 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.1 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.2 GO:0005921 gap junction(GO:0005921)
0.0 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 2.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 6.0 GO:0043197 dendritic spine(GO:0043197)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 2.0 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 4.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0046930 pore complex(GO:0046930)
0.0 0.1 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 15.3 GO:0030141 secretory granule(GO:0030141)
0.0 1.6 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.5 GO:0005884 actin filament(GO:0005884)
0.0 4.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.5 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.8 2.3 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.4 4.7 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.4 2.5 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.4 1.4 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.3 2.0 GO:0045174 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.3 0.8 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.3 1.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 1.5 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2 1.1 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.2 1.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 0.6 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.2 1.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 0.9 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.2 0.7 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 2.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 1.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.0 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 0.7 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 2.2 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.4 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.1 0.4 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.1 1.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 1.6 GO:0031014 troponin T binding(GO:0031014)
0.1 0.4 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.5 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.1 3.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.3 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 1.1 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.8 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 2.2 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.4 GO:0039552 RIG-I binding(GO:0039552)
0.1 1.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 4.3 GO:0015026 coreceptor activity(GO:0015026)
0.1 0.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 21.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.7 GO:0015232 heme transporter activity(GO:0015232)
0.1 1.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.4 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 0.9 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 1.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.7 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.6 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.7 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.4 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 1.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.7 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.7 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.3 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.2 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.0 GO:0008198 ferrous iron binding(GO:0008198)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.3 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.5 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0001032 RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.0 0.5 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.4 GO:0019841 retinol binding(GO:0019841)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 4.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 1.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 4.1 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 0.3 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.2 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.3 GO:0048038 quinone binding(GO:0048038)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0032357 oxidized purine DNA binding(GO:0032357)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.6 GO:0044390 ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.0 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.7 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.6 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 21.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 7.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 1.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 4.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 4.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 1.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 1.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 2.7 PID IL1 PATHWAY IL1-mediated signaling events
0.0 2.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.5 PID EPO PATHWAY EPO signaling pathway
0.0 1.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.3 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.5 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID CDC42 PATHWAY CDC42 signaling events
0.0 3.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 3.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 2.9 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.6 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 1.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 1.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.4 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 1.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 2.9 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 0.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 0.8 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 0.4 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.1 3.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.2 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 2.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.2 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.9 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 2.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.7 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 2.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 3.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.3 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.7 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.1 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins