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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SPIC
Z-value: 0.93
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Transcription factors associated with SPIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIC | hg19_v2_chr12_+_101869096_101869199 | 0.14 | 4.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.0 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 1.1 | 6.6 | GO:0002760 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 1.4 | 4.2 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.1 | 3.8 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 3.8 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 1.1 | 3.4 | GO:0036058 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
| 0.0 | 3.2 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 1.0 | 3.0 | GO:0060559 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
| 0.5 | 2.8 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.2 | 2.7 | GO:0051639 | actin filament network formation(GO:0051639) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.6 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.2 | 4.9 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 4.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 4.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 3.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 3.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 3.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.2 | 2.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 2.4 | GO:0072562 | blood microparticle(GO:0072562) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 4.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 3.9 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 3.9 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.1 | 3.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 3.5 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 3.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 2.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 2.7 | GO:0051400 | BH domain binding(GO:0051400) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 8.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 8.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 5.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 4.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 2.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 2.1 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 2.1 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 5.4 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 3.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 3.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 2.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 2.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 2.7 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 2.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.4 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |