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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SREBF1_TFE3
Z-value: 1.40
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Transcription factors associated with SREBF1_TFE3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SREBF1 | hg19_v2_chr17_-_17740287_17740316 | -0.65 | 9.1e-05 | Click! |
| TFE3 | hg19_v2_chrX_-_48901012_48901050 | -0.27 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_10764509 Show fit | 13.74 |
ENST00000591501.1
|
ILF3 antisense RNA 1 (head to head) |
|
| chr1_-_207119738 Show fit | 8.85 |
ENST00000356495.4
|
polymeric immunoglobulin receptor |
|
| chr12_+_50355647 Show fit | 8.57 |
ENST00000293599.6
|
aquaporin 5 |
|
| chr22_+_31003133 Show fit | 6.23 |
ENST00000405742.3
|
transcobalamin II |
|
| chr22_+_31002779 Show fit | 6.10 |
ENST00000215838.3
|
transcobalamin II |
|
| chr3_-_19988462 Show fit | 6.04 |
ENST00000344838.4
|
EF-hand domain family, member B |
|
| chr12_-_63328817 Show fit | 5.76 |
ENST00000228705.6
|
protein phosphatase, Mg2+/Mn2+ dependent, 1H |
|
| chr9_-_138391692 Show fit | 5.46 |
ENST00000429260.2
|
chromosome 9 open reading frame 116 |
|
| chr2_+_120187465 Show fit | 5.33 |
ENST00000409826.1
ENST00000417645.1 |
transmembrane protein 37 |
|
| chr1_-_161337662 Show fit | 4.48 |
ENST00000367974.1
|
chromosome 1 open reading frame 192 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SREBF1_TFE3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 18.2 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 1.7 | 16.5 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.5 | 10.6 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.7 | 9.0 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
| 1.7 | 8.6 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 1.8 | 7.4 | GO:0002086 | diaphragm contraction(GO:0002086) |
| 0.6 | 7.1 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.3 | 5.9 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.6 | 5.1 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.5 | 4.9 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 37.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 10.2 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 9.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 9.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 9.0 | GO:0005930 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.1 | 8.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.2 | 8.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.6 | 6.8 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 6.0 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.5 | 5.0 | GO:0036157 | outer dynein arm(GO:0036157) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 16.5 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.5 | 9.1 | GO:0015250 | water channel activity(GO:0015250) |
| 1.1 | 8.8 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.0 | 8.8 | GO:0001047 | core promoter binding(GO:0001047) |
| 2.1 | 8.3 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.4 | 8.0 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.4 | 8.0 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 2.5 | 7.4 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.2 | 7.1 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.1 | 6.4 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 14.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 10.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 8.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 7.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 7.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 6.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 4.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 4.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 3.6 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.1 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 6.8 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.2 | 6.6 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 6.2 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 4.5 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.1 | 4.3 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 4.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 4.2 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 4.0 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 3.7 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |