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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SREBF2

Z-value: 0.68

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.631.7e-04Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_151561085 4.68 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr1_+_55505184 3.25 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr4_+_75230853 3.13 ENST00000244869.2
EREG
epiregulin
chr8_+_26435359 3.01 ENST00000311151.5
DPYSL2
dihydropyrimidinase-like 2
chr19_+_11200038 2.41 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr6_-_53213587 2.27 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
ELOVL5
ELOVL fatty acid elongase 5
chr20_+_33464238 2.15 ENST00000360596.2
ACSS2
acyl-CoA synthetase short-chain family member 2
chr20_+_33464407 1.93 ENST00000253382.5
ACSS2
acyl-CoA synthetase short-chain family member 2
chr2_-_26205340 1.73 ENST00000264712.3
KIF3C
kinesin family member 3C
chr18_-_21166841 1.73 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr9_+_126131131 1.67 ENST00000373629.2
CRB2
crumbs homolog 2 (Drosophila)
chr10_-_74856608 1.48 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr5_-_43313574 1.44 ENST00000325110.6
ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr10_-_3827417 1.39 ENST00000497571.1
ENST00000542957.1
KLF6
Kruppel-like factor 6
chr3_-_98620500 1.35 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr17_-_40075197 1.30 ENST00000590770.1
ENST00000590151.1
ACLY
ATP citrate lyase
chr17_-_40075219 1.26 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ACLY
ATP citrate lyase
chr19_-_11308190 1.18 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
KANK2
KN motif and ankyrin repeat domains 2
chr1_-_42384343 1.12 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr17_-_39274606 1.09 ENST00000391413.2
KRTAP4-11
keratin associated protein 4-11
chr3_+_160117418 0.97 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
SMC4
structural maintenance of chromosomes 4
chr11_+_2923499 0.96 ENST00000449793.2
SLC22A18
solute carrier family 22, member 18
chr3_+_5020801 0.95 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr11_+_2923619 0.90 ENST00000380574.1
SLC22A18
solute carrier family 22, member 18
chr11_+_2923423 0.88 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr14_-_35183886 0.85 ENST00000298159.6
CFL2
cofilin 2 (muscle)
chr6_-_53213780 0.78 ENST00000304434.6
ENST00000370918.4
ELOVL5
ELOVL fatty acid elongase 5
chr19_+_55591743 0.76 ENST00000588359.1
ENST00000245618.5
EPS8L1
EPS8-like 1
chr10_-_3827371 0.64 ENST00000469435.1
KLF6
Kruppel-like factor 6
chr7_-_44580861 0.61 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr3_+_188889737 0.61 ENST00000345063.3
TPRG1
tumor protein p63 regulated 1
chr6_+_41604747 0.56 ENST00000419164.1
ENST00000373051.2
MDFI
MyoD family inhibitor
chr6_+_43968306 0.56 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr22_+_42229100 0.55 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr12_-_53343602 0.52 ENST00000546897.1
ENST00000552551.1
KRT8
keratin 8
chr3_+_46742823 0.49 ENST00000326431.3
TMIE
transmembrane inner ear
chr3_-_171528227 0.47 ENST00000356327.5
ENST00000342215.6
ENST00000340989.4
ENST00000351298.4
PLD1
phospholipase D1, phosphatidylcholine-specific
chr5_+_137774706 0.41 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr6_-_32151999 0.33 ENST00000375069.3
ENST00000538695.1
ENST00000438221.2
ENST00000375065.5
ENST00000450110.1
ENST00000375067.3
ENST00000375056.2
AGER
advanced glycosylation end product-specific receptor
chr6_-_31926208 0.32 ENST00000454913.1
ENST00000436289.2
NELFE
negative elongation factor complex member E
chr6_-_32083106 0.32 ENST00000442721.1
TNXB
tenascin XB
chr17_-_41738931 0.31 ENST00000329168.3
ENST00000549132.1
MEOX1
mesenchyme homeobox 1
chr5_-_39425068 0.31 ENST00000515700.1
ENST00000339788.6
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chrX_+_47229982 0.30 ENST00000377073.3
ZNF157
zinc finger protein 157
chr6_+_69942298 0.30 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr6_-_32152064 0.25 ENST00000375076.4
ENST00000375070.3
AGER
advanced glycosylation end product-specific receptor
chr12_+_50344516 0.24 ENST00000199280.3
ENST00000550862.1
AQP2
aquaporin 2 (collecting duct)
chr6_-_32152020 0.22 ENST00000375055.2
AGER
advanced glycosylation end product-specific receptor
chr1_+_197237352 0.21 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
CRB1
crumbs homolog 1 (Drosophila)
chr5_-_107703556 0.19 ENST00000496714.1
FBXL17
F-box and leucine-rich repeat protein 17
chr19_-_18392422 0.18 ENST00000252818.3
JUND
jun D proto-oncogene
chr2_-_219925189 0.14 ENST00000295731.6
IHH
indian hedgehog
chr17_-_15168624 0.14 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
PMP22
peripheral myelin protein 22
chr6_+_79577189 0.14 ENST00000369940.2
IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr9_+_100745615 0.13 ENST00000339399.4
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr19_-_46285736 0.13 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chr19_+_36266417 0.10 ENST00000378944.5
ENST00000007510.4
ARHGAP33
Rho GTPase activating protein 33
chr15_+_33010175 0.10 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1
gremlin 1, DAN family BMP antagonist
chr14_-_74960030 0.09 ENST00000553490.1
ENST00000557510.1
NPC2
Niemann-Pick disease, type C2
chr14_-_74959994 0.09 ENST00000238633.2
ENST00000434013.2
NPC2
Niemann-Pick disease, type C2
chr17_+_65040678 0.08 ENST00000226021.3
CACNG1
calcium channel, voltage-dependent, gamma subunit 1
chr6_-_39902160 0.08 ENST00000340692.5
MOCS1
molybdenum cofactor synthesis 1
chr14_-_74959978 0.07 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr1_+_247582097 0.06 ENST00000391827.2
NLRP3
NLR family, pyrin domain containing 3
chr19_+_36266433 0.05 ENST00000314737.5
ARHGAP33
Rho GTPase activating protein 33
chr2_+_27435734 0.04 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr8_+_21882244 0.03 ENST00000289820.6
ENST00000381530.5
NPM2
nucleophosmin/nucleoplasmin 2
chr17_+_73257945 0.02 ENST00000579002.1
MRPS7
mitochondrial ribosomal protein S7
chr9_+_131452239 0.02 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr1_-_155232047 0.00 ENST00000302631.3
SCAMP3
secretory carrier membrane protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
1.0 3.1 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
1.0 4.1 GO:0019413 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.6 2.4 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.4 1.2 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3 3.1 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 4.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.3 2.7 GO:0046618 drug export(GO:0046618)
0.3 1.7 GO:0014028 notochord formation(GO:0014028)
0.3 0.8 GO:1904603 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.2 1.7 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.1 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 2.6 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 1.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 1.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.6 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 1.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.4 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 0.3 GO:0061056 sclerotome development(GO:0061056)
0.1 0.3 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 0.8 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.2 GO:0071288 cellular response to mercury ion(GO:0071288)
0.1 0.8 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.0 0.5 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.0 0.1 GO:1900158 negative regulation of osteoclast proliferation(GO:0090291) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.6 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.6 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 1.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.3 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 2.6 GO:0030516 regulation of axon extension(GO:0030516)
0.0 2.0 GO:0030183 B cell differentiation(GO:0030183)
0.0 1.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:1990666 PCSK9-LDLR complex(GO:1990666)
1.0 3.1 GO:0097447 dendritic tree(GO:0097447)
0.4 1.5 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 1.0 GO:0000796 condensin complex(GO:0000796)
0.1 0.3 GO:0032021 NELF complex(GO:0032021)
0.0 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 2.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 1.3 GO:0097542 ciliary tip(GO:0097542)
0.0 1.6 GO:0045095 keratin filament(GO:0045095)
0.0 2.8 GO:0001650 fibrillar center(GO:0001650)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.2 GO:0031902 late endosome membrane(GO:0031902)
0.0 4.8 GO:0005938 cell cortex(GO:0005938)
0.0 0.0 GO:0000229 cytoplasmic chromosome(GO:0000229)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
1.0 3.0 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.8 4.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.7 4.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.5 2.4 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.5 2.7 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.3 3.1 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 1.7 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.3 4.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 0.8 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.2 1.5 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 0.9 GO:0043426 MRF binding(GO:0043426)
0.1 0.5 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 0.8 GO:0042608 T cell receptor binding(GO:0042608)
0.0 1.7 GO:0015248 sterol transporter activity(GO:0015248)
0.0 2.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.2 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 2.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.0 PID AURORA B PATHWAY Aurora B signaling
0.0 0.8 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 5.6 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 2.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 3.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.7 REACTOME KINESINS Genes involved in Kinesins
0.0 1.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA