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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for SRF

Z-value: 1.61

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Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
SRF
ENSG00000112658.6 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg19_v2_chr6_+_43139037_431390940.048.4e-01Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_151561506 12.98 ENST00000253332.1
AKAP12
A kinase (PRKA) anchor protein 12
chr6_+_151561085 9.25 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_137801160 8.88 ENST00000239938.4
EGR1
early growth response 1
chr11_-_65667997 8.78 ENST00000312562.2
ENST00000534222.1
FOSL1
FOS-like antigen 1
chr11_-_65667884 7.43 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1
FOS-like antigen 1
chr14_-_94443105 7.11 ENST00000555019.1
ASB2
ankyrin repeat and SOCS box containing 2
chr19_-_15344243 6.49 ENST00000602233.1
EPHX3
epoxide hydrolase 3
chr14_+_75745477 6.45 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr12_+_4382917 6.44 ENST00000261254.3
CCND2
cyclin D2
chr2_-_161056762 5.77 ENST00000428609.2
ENST00000409967.2
ITGB6
integrin, beta 6
chr19_-_15343773 5.76 ENST00000435261.1
ENST00000594042.1
EPHX3
epoxide hydrolase 3
chr2_+_74120094 5.74 ENST00000409731.3
ENST00000345517.3
ENST00000409918.1
ENST00000442912.1
ENST00000409624.1
ACTG2
actin, gamma 2, smooth muscle, enteric
chr19_+_54372639 5.60 ENST00000391769.2
MYADM
myeloid-associated differentiation marker
chrX_-_153602991 5.32 ENST00000369850.3
ENST00000422373.1
FLNA
filamin A, alpha
chr19_+_16178317 4.92 ENST00000344824.6
ENST00000538887.1
TPM4
tropomyosin 4
chr2_-_161056802 4.90 ENST00000283249.2
ENST00000409872.1
ITGB6
integrin, beta 6
chr10_+_112257596 4.68 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr5_+_150404904 4.17 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr10_-_90712520 3.97 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr7_+_143078652 3.82 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr1_+_167599330 3.72 ENST00000367854.3
ENST00000361496.3
RCSD1
RCSD domain containing 1
chr12_+_75874460 3.71 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr10_-_17659234 3.69 ENST00000466335.1
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr12_+_75874580 3.50 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr8_-_143696833 3.49 ENST00000356613.2
ARC
activity-regulated cytoskeleton-associated protein
chr2_-_208031943 3.40 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr11_-_65626753 3.25 ENST00000526975.1
ENST00000531413.1
CFL1
cofilin 1 (non-muscle)
chr9_+_131644781 3.24 ENST00000259324.5
LRRC8A
leucine rich repeat containing 8 family, member A
chr1_-_168106536 3.16 ENST00000537209.1
ENST00000361697.2
ENST00000546300.1
ENST00000367835.1
GPR161
G protein-coupled receptor 161
chr4_+_87928413 3.13 ENST00000544085.1
AFF1
AF4/FMR2 family, member 1
chr22_-_36784035 3.07 ENST00000216181.5
MYH9
myosin, heavy chain 9, non-muscle
chr7_-_107643674 3.06 ENST00000222399.6
LAMB1
laminin, beta 1
chr18_+_61143994 2.90 ENST00000382771.4
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr10_-_29923893 2.81 ENST00000355867.4
SVIL
supervillin
chr10_-_17659357 2.75 ENST00000326961.6
ENST00000361271.3
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr2_-_112237835 2.75 ENST00000442293.1
ENST00000439494.1
MIR4435-1HG
MIR4435-1 host gene (non-protein coding)
chr19_+_45971246 2.69 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr4_+_87928140 2.68 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr22_-_36357671 2.49 ENST00000408983.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_-_229569834 2.48 ENST00000366684.3
ENST00000366683.2
ACTA1
actin, alpha 1, skeletal muscle
chr6_-_88411911 2.46 ENST00000257787.5
AKIRIN2
akirin 2
chr5_-_176923846 2.43 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr2_+_191792376 2.25 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr2_-_106054952 2.24 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr1_+_16085244 2.12 ENST00000400773.1
FBLIM1
filamin binding LIM protein 1
chr3_-_99595037 2.12 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr3_-_123339418 2.11 ENST00000583087.1
MYLK
myosin light chain kinase
chr11_-_65626797 2.11 ENST00000525451.2
CFL1
cofilin 1 (non-muscle)
chr5_-_176923803 2.10 ENST00000506161.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr2_+_87769459 2.10 ENST00000414030.1
ENST00000437561.1
LINC00152
long intergenic non-protein coding RNA 152
chr3_-_123339343 2.04 ENST00000578202.1
MYLK
myosin light chain kinase
chr17_-_72358001 2.03 ENST00000375366.3
BTBD17
BTB (POZ) domain containing 17
chr19_-_17356697 2.02 ENST00000291442.3
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr17_-_79481666 1.99 ENST00000575659.1
ACTG1
actin, gamma 1
chr11_-_2162468 1.89 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr19_+_1026298 1.87 ENST00000263097.4
CNN2
calponin 2
chr19_+_1026566 1.74 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
CNN2
calponin 2
chr17_-_41132410 1.72 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr2_-_106015491 1.69 ENST00000408995.1
ENST00000393353.3
ENST00000322142.8
FHL2
four and a half LIM domains 2
chr20_+_35169885 1.68 ENST00000279022.2
ENST00000346786.2
MYL9
myosin, light chain 9, regulatory
chr15_+_33603147 1.62 ENST00000415757.3
ENST00000389232.4
RYR3
ryanodine receptor 3
chr1_+_11994715 1.61 ENST00000449038.1
ENST00000376369.3
ENST00000429000.2
ENST00000196061.4
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr2_-_106015527 1.60 ENST00000344213.4
ENST00000358129.4
FHL2
four and a half LIM domains 2
chr9_-_35691017 1.58 ENST00000378292.3
TPM2
tropomyosin 2 (beta)
chr7_-_27183263 1.57 ENST00000222726.3
HOXA5
homeobox A5
chr8_-_22550815 1.56 ENST00000317216.2
EGR3
early growth response 3
chr3_-_99594948 1.55 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr19_+_52102540 1.55 ENST00000601315.1
AC018755.17
AC018755.17
chr12_-_11548496 1.55 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2
PRB1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr15_-_35088340 1.54 ENST00000290378.4
ACTC1
actin, alpha, cardiac muscle 1
chr15_+_83776324 1.54 ENST00000379390.6
ENST00000379386.4
ENST00000565774.1
ENST00000565982.1
TM6SF1
transmembrane 6 superfamily member 1
chr11_-_2162162 1.50 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr16_-_11375179 1.47 ENST00000312511.3
PRM1
protamine 1
chr5_-_179050660 1.37 ENST00000519056.1
ENST00000506721.1
ENST00000503105.1
ENST00000504348.1
ENST00000508103.1
ENST00000510431.1
ENST00000515158.1
ENST00000393432.4
ENST00000442819.2
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr7_-_121944491 1.35 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr17_-_4890919 1.34 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
CAMTA2
calmodulin binding transcription activator 2
chr3_-_46904946 1.29 ENST00000292327.4
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr3_-_46904918 1.26 ENST00000395869.1
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr12_-_50616382 1.20 ENST00000552783.1
LIMA1
LIM domain and actin binding 1
chr19_-_35166604 1.19 ENST00000601241.1
SCGB2B2
secretoglobin, family 2B, member 2
chr8_+_125954281 1.17 ENST00000510897.2
ENST00000533286.1
LINC00964
long intergenic non-protein coding RNA 964
chr1_+_50574585 1.17 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr7_-_94285472 1.16 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE
sarcoglycan, epsilon
chr7_-_94285402 1.14 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chr6_+_27107053 1.12 ENST00000354348.2
HIST1H4I
histone cluster 1, H4i
chr12_-_50616122 1.07 ENST00000552823.1
ENST00000552909.1
LIMA1
LIM domain and actin binding 1
chr8_+_97597148 1.06 ENST00000521590.1
SDC2
syndecan 2
chr2_-_172087824 1.06 ENST00000521943.1
TLK1
tousled-like kinase 1
chr7_-_94285511 1.04 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr11_+_86667117 1.03 ENST00000531827.1
RP11-736K20.6
RP11-736K20.6
chr6_-_123957942 1.02 ENST00000398178.3
TRDN
triadin
chr2_-_209118974 1.00 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr12_+_62654119 0.99 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr5_+_66254698 0.96 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr18_-_54318353 0.94 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr17_-_4890649 0.92 ENST00000361571.5
CAMTA2
calmodulin binding transcription activator 2
chr6_-_99797522 0.91 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr4_-_10118469 0.90 ENST00000499869.2
WDR1
WD repeat domain 1
chr11_-_71823266 0.88 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr6_-_123958141 0.88 ENST00000334268.4
TRDN
triadin
chr5_+_137774706 0.87 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr12_+_62654155 0.86 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15
ubiquitin specific peptidase 15
chr5_-_33892046 0.85 ENST00000352040.3
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr7_+_112120908 0.82 ENST00000439068.2
ENST00000312849.4
ENST00000429049.1
LSMEM1
leucine-rich single-pass membrane protein 1
chr1_-_11907829 0.82 ENST00000376480.3
NPPA
natriuretic peptide A
chr7_-_44180884 0.81 ENST00000458240.1
ENST00000223364.3
MYL7
myosin, light chain 7, regulatory
chr5_-_142000883 0.79 ENST00000359370.6
FGF1
fibroblast growth factor 1 (acidic)
chr4_-_10118573 0.78 ENST00000382452.2
ENST00000382451.2
WDR1
WD repeat domain 1
chr7_-_5570229 0.76 ENST00000331789.5
ACTB
actin, beta
chr12_+_54426637 0.75 ENST00000312492.2
HOXC5
homeobox C5
chr10_+_75757863 0.74 ENST00000372755.3
ENST00000211998.4
ENST00000417648.2
VCL
vinculin
chr7_-_44180673 0.68 ENST00000457314.1
ENST00000447951.1
ENST00000431007.1
MYL7
myosin, light chain 7, regulatory
chr10_+_96162242 0.66 ENST00000225235.4
TBC1D12
TBC1 domain family, member 12
chr17_+_3379284 0.63 ENST00000263080.2
ASPA
aspartoacylase
chr3_-_190167571 0.63 ENST00000354905.2
TMEM207
transmembrane protein 207
chr8_-_101965559 0.61 ENST00000353245.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr5_+_40679584 0.61 ENST00000302472.3
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr4_-_109087872 0.58 ENST00000510624.1
LEF1
lymphoid enhancer-binding factor 1
chr17_-_55911970 0.58 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr6_+_158402860 0.57 ENST00000367122.2
ENST00000367121.3
ENST00000355585.4
ENST00000367113.4
SYNJ2
synaptojanin 2
chr11_-_71823715 0.55 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr11_-_71823796 0.55 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr8_+_53850991 0.52 ENST00000331251.3
NPBWR1
neuropeptides B/W receptor 1
chr3_-_185641681 0.50 ENST00000259043.7
TRA2B
transformer 2 beta homolog (Drosophila)
chr19_+_35861831 0.50 ENST00000454971.1
GPR42
G protein-coupled receptor 42 (gene/pseudogene)
chr2_+_219283815 0.47 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr19_-_45826125 0.47 ENST00000221476.3
CKM
creatine kinase, muscle
chr19_-_47975417 0.47 ENST00000236877.6
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr22_+_38004473 0.45 ENST00000414350.3
ENST00000343632.4
GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr16_+_86229728 0.44 ENST00000601250.1
LINC01082
long intergenic non-protein coding RNA 1082
chr17_-_79479789 0.42 ENST00000571691.1
ENST00000571721.1
ENST00000573283.1
ENST00000575842.1
ENST00000575087.1
ENST00000570382.1
ENST00000331925.2
ACTG1
actin, gamma 1
chr10_+_114043493 0.42 ENST00000369422.3
TECTB
tectorin beta
chr1_+_47881744 0.36 ENST00000335071.2
FOXE3
forkhead box E3
chrX_-_103499602 0.36 ENST00000372588.4
ESX1
ESX homeobox 1
chr5_+_92919043 0.35 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr11_+_117070037 0.34 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN
transgelin
chr22_+_38004832 0.33 ENST00000405147.3
ENST00000429218.1
ENST00000325180.8
ENST00000337437.4
GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr17_-_4871085 0.30 ENST00000575142.1
ENST00000206020.3
SPAG7
sperm associated antigen 7
chr2_-_96811170 0.30 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr8_-_101965146 0.28 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr3_+_9834227 0.27 ENST00000287613.7
ENST00000397261.3
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr11_+_34073195 0.26 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr3_+_9834179 0.25 ENST00000498623.2
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr15_-_55581954 0.24 ENST00000336787.1
RAB27A
RAB27A, member RAS oncogene family
chr20_-_62258394 0.24 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chrX_-_11284095 0.23 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chrX_+_22056165 0.23 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr6_-_159466136 0.21 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr16_+_30077055 0.20 ENST00000564595.2
ENST00000569798.1
ALDOA
aldolase A, fructose-bisphosphate
chr9_+_140772226 0.18 ENST00000277551.2
ENST00000371372.1
ENST00000277549.5
ENST00000371363.1
ENST00000371357.1
ENST00000371355.4
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr17_-_41132010 0.18 ENST00000409103.1
ENST00000360221.4
PTGES3L-AARSD1
PTGES3L-AARSD1 readthrough
chr3_+_9834758 0.17 ENST00000485273.1
ENST00000433034.1
ENST00000397256.1
ARPC4
ARPC4-TTLL3
actin related protein 2/3 complex, subunit 4, 20kDa
ARPC4-TTLL3 readthrough
chr17_-_27949911 0.17 ENST00000492276.2
ENST00000345068.5
ENST00000584602.1
CORO6
coronin 6
chr2_-_128432639 0.17 ENST00000545738.2
ENST00000355119.4
ENST00000409808.2
LIMS2
LIM and senescent cell antigen-like domains 2
chr16_+_30077098 0.15 ENST00000395240.3
ENST00000566846.1
ALDOA
aldolase A, fructose-bisphosphate
chr13_+_27825446 0.11 ENST00000311549.6
RPL21
ribosomal protein L21
chr1_-_152332480 0.10 ENST00000388718.5
FLG2
filaggrin family member 2
chr3_+_143690640 0.09 ENST00000315691.3
C3orf58
chromosome 3 open reading frame 58
chr18_-_3220106 0.08 ENST00000356443.4
ENST00000400569.3
MYOM1
myomesin 1
chr6_-_105585022 0.07 ENST00000314641.5
BVES
blood vessel epicardial substance
chr18_+_54318616 0.06 ENST00000254442.3
WDR7
WD repeat domain 7
chr19_+_48958766 0.02 ENST00000342291.2
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chr2_-_231989808 0.01 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 GO:0050720 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
2.7 16.2 GO:0007296 vitellogenesis(GO:0007296)
2.3 13.7 GO:0090131 mesenchyme migration(GO:0090131)
1.5 22.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.4 5.6 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
1.1 5.5 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
1.0 10.7 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.9 5.3 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.9 3.5 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.8 6.5 GO:0001661 conditioned taste aversion(GO:0001661)
0.8 5.4 GO:2000814 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.8 3.1 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.7 4.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.5 1.6 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.5 1.6 GO:0060435 bronchiole development(GO:0060435)
0.5 1.9 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.5 1.8 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.5 4.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.5 2.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.4 3.4 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.4 1.7 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.4 3.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.3 3.1 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
0.3 1.0 GO:0006097 glyoxylate cycle(GO:0006097)
0.3 4.7 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.3 3.7 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.3 6.4 GO:0071481 cellular response to X-ray(GO:0071481)
0.3 2.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 1.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.6 GO:0006533 aspartate catabolic process(GO:0006533)
0.2 3.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 0.6 GO:2000417 negative regulation of eosinophil migration(GO:2000417)
0.2 1.6 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.2 1.1 GO:0008218 bioluminescence(GO:0008218)
0.2 0.9 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.2 0.8 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.2 1.6 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.2 2.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.4 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 1.2 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 2.7 GO:0051412 response to corticosterone(GO:0051412)
0.1 0.6 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 2.0 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 1.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 0.5 GO:1902896 terminal web assembly(GO:1902896)
0.1 2.0 GO:0050961 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 0.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 2.6 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 5.8 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 2.9 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.1 0.9 GO:0090168 Golgi reassembly(GO:0090168)
0.1 4.5 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 5.6 GO:0070527 platelet aggregation(GO:0070527)
0.1 1.7 GO:0014887 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.1 2.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.5 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.2 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 3.6 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 1.5 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.5 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 2.3 GO:0031529 ruffle organization(GO:0031529)
0.0 0.2 GO:0018094 protein polyglycylation(GO:0018094)
0.0 3.7 GO:0030038 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 2.5 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 2.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0060931 sinoatrial node cell development(GO:0060931)
0.0 0.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 3.7 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.7 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 3.1 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 6.5 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.0 0.8 GO:1901998 toxin transport(GO:1901998)
0.0 0.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 3.2 GO:0007160 cell-matrix adhesion(GO:0007160)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.7 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
1.8 5.3 GO:0031523 Myb complex(GO:0031523)
1.1 6.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
1.0 3.1 GO:0005607 laminin-2 complex(GO:0005607)
0.9 7.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.8 6.5 GO:0035976 AP1 complex(GO:0035976)
0.7 4.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.6 3.2 GO:0042643 actomyosin, actin portion(GO:0042643)
0.6 3.1 GO:0097513 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.5 4.8 GO:0032982 myosin filament(GO:0032982)
0.4 3.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.3 6.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 2.8 GO:0036449 microtubule minus-end(GO:0036449)
0.2 3.2 GO:0097433 dense body(GO:0097433)
0.2 24.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.9 GO:0030314 junctional membrane complex(GO:0030314)
0.2 0.5 GO:0032432 actin filament bundle(GO:0032432)
0.1 5.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 16.2 GO:0042734 presynaptic membrane(GO:0042734)
0.1 5.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 7.2 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 0.7 GO:0005916 fascia adherens(GO:0005916)
0.1 4.8 GO:0031672 A band(GO:0031672)
0.1 22.7 GO:0005938 cell cortex(GO:0005938)
0.1 1.6 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 2.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 4.0 GO:0005884 actin filament(GO:0005884)
0.0 1.6 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 3.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.8 GO:0042629 mast cell granule(GO:0042629)
0.0 4.0 GO:0043197 dendritic spine(GO:0043197)
0.0 0.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.5 GO:0000786 nucleosome(GO:0000786)
0.0 3.8 GO:0055037 recycling endosome(GO:0055037)
0.0 2.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 8.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.3 5.3 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
1.3 22.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.6 2.6 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.5 1.6 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.5 2.3 GO:0004359 glutaminase activity(GO:0004359)
0.4 4.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.4 1.6 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.4 4.2 GO:0008430 selenium binding(GO:0008430)
0.3 1.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.3 5.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 1.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.2 3.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 2.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 3.1 GO:0043495 protein anchor(GO:0043495)
0.1 6.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 1.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 10.7 GO:0001618 virus receptor activity(GO:0001618)
0.1 2.1 GO:0031005 filamin binding(GO:0031005)
0.1 0.6 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.1 3.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.6 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 0.6 GO:0004046 aminoacylase activity(GO:0004046)
0.1 0.9 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.5 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.5 GO:0004985 opioid receptor activity(GO:0004985)
0.1 2.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.8 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 23.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 0.5 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.8 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 2.5 GO:0043531 ADP binding(GO:0043531)
0.0 2.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 5.4 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 3.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 1.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.5 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 2.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 2.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 5.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.2 GO:0051015 actin filament binding(GO:0051015)
0.0 2.8 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 22.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.4 10.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 23.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 8.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 5.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 6.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 4.5 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 6.0 PID AP1 PATHWAY AP-1 transcription factor network
0.1 7.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.9 PID IGF1 PATHWAY IGF1 pathway
0.0 1.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.8 PID FGF PATHWAY FGF signaling pathway
0.0 1.8 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 22.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 4.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 0.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 6.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 13.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 7.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 12.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 0.6 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.9 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 1.1 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 7.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.8 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 2.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane