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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for SRF
Z-value: 1.61
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Transcription factors associated with SRF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRF | hg19_v2_chr6_+_43139037_43139094 | 0.04 | 8.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_151561506 Show fit | 12.98 |
ENST00000253332.1
|
A kinase (PRKA) anchor protein 12 |
|
| chr6_+_151561085 Show fit | 9.25 |
ENST00000402676.2
|
A kinase (PRKA) anchor protein 12 |
|
| chr5_+_137801160 Show fit | 8.88 |
ENST00000239938.4
|
early growth response 1 |
|
| chr11_-_65667997 Show fit | 8.78 |
ENST00000312562.2
ENST00000534222.1 |
FOS-like antigen 1 |
|
| chr11_-_65667884 Show fit | 7.43 |
ENST00000448083.2
ENST00000531493.1 ENST00000532401.1 |
FOS-like antigen 1 |
|
| chr14_-_94443105 Show fit | 7.11 |
ENST00000555019.1
|
ankyrin repeat and SOCS box containing 2 |
|
| chr19_-_15344243 Show fit | 6.49 |
ENST00000602233.1
|
epoxide hydrolase 3 |
|
| chr14_+_75745477 Show fit | 6.45 |
ENST00000303562.4
ENST00000554617.1 ENST00000554212.1 ENST00000535987.1 ENST00000555242.1 |
FBJ murine osteosarcoma viral oncogene homolog |
|
| chr12_+_4382917 Show fit | 6.44 |
ENST00000261254.3
|
cyclin D2 |
|
| chr2_-_161056762 Show fit | 5.77 |
ENST00000428609.2
ENST00000409967.2 |
integrin, beta 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 22.2 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 2.7 | 16.2 | GO:0007296 | vitellogenesis(GO:0007296) |
| 2.3 | 13.7 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 1.0 | 10.7 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 3.0 | 8.9 | GO:0050720 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) |
| 0.8 | 6.5 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.0 | 6.5 | GO:0019216 | regulation of lipid metabolic process(GO:0019216) |
| 0.3 | 6.4 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.1 | 5.8 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 1.4 | 5.6 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 22.7 | GO:0005938 | cell cortex(GO:0005938) |
| 0.1 | 16.2 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 3.6 | 10.7 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.1 | 7.2 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.9 | 7.1 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 0.8 | 6.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.3 | 6.5 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 1.1 | 6.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 5.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 1.3 | 22.2 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 10.7 | GO:0001618 | virus receptor activity(GO:0001618) |
| 1.8 | 8.9 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.1 | 6.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 5.4 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |
| 1.3 | 5.3 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.0 | 5.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.3 | 5.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.4 | 4.2 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 22.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.4 | 10.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 8.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 7.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 6.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 6.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 5.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 4.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 3.8 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 13.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 12.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 7.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 7.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 6.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 4.5 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 4.2 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.1 | 3.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 3.1 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |