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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for STAT1_STAT3_BCL6
Z-value: 1.33
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Transcription factors associated with STAT1_STAT3_BCL6
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000115415.14 | signal transducer and activator of transcription 1 | |
| ENSG00000168610.10 | signal transducer and activator of transcription 3 | |
| ENSG00000113916.13 | BCL6 transcription repressor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BCL6 | hg19_v2_chr3_-_187454281_187454357 | -0.32 | 8.0e-02 | Click! |
| STAT1 | hg19_v2_chr2_-_191878874_191878976 | 0.17 | 3.7e-01 | Click! |
| STAT3 | hg19_v2_chr17_-_40540377_40540481 | -0.11 | 5.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_102668879 Show fit | 6.40 |
ENST00000315274.6
|
matrix metallopeptidase 1 (interstitial collagenase) |
|
| chr12_+_93964746 Show fit | 4.89 |
ENST00000536696.2
|
suppressor of cytokine signaling 2 |
|
| chr5_-_146781153 Show fit | 4.46 |
ENST00000520473.1
|
dihydropyrimidinase-like 3 |
|
| chr7_+_134464414 Show fit | 4.33 |
ENST00000361901.2
|
caldesmon 1 |
|
| chr17_+_2699697 Show fit | 4.32 |
ENST00000254695.8
ENST00000366401.4 ENST00000542807.1 |
RAP1 GTPase activating protein 2 |
|
| chr7_+_134464376 Show fit | 4.22 |
ENST00000454108.1
ENST00000361675.2 |
caldesmon 1 |
|
| chr5_-_140013275 Show fit | 4.15 |
ENST00000512545.1
ENST00000302014.6 ENST00000401743.2 |
CD14 molecule |
|
| chr17_-_76356148 Show fit | 4.00 |
ENST00000587578.1
ENST00000330871.2 |
suppressor of cytokine signaling 3 |
|
| chr20_-_43280361 Show fit | 3.96 |
ENST00000372874.4
|
adenosine deaminase |
|
| chr1_-_153521597 Show fit | 3.92 |
ENST00000368712.1
|
S100 calcium binding protein A3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT1_STAT3_BCL6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.5 | 6.8 | GO:0015816 | glycine transport(GO:0015816) |
| 0.1 | 5.3 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 5.2 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.2 | 4.9 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.9 | 4.6 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.3 | 4.5 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 1.0 | 4.1 | GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 1.3 | 4.0 | GO:0006154 | adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103) |
| 1.0 | 4.0 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.0 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.6 | 8.4 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 7.6 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 4.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 4.7 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 4.4 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.8 | 4.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 3.8 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 3.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.2 | 3.5 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 9.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.6 | 6.8 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.1 | 5.5 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.8 | 4.9 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 1.0 | 4.8 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.1 | 4.8 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.4 | 4.6 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.4 | 4.5 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 4.3 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 8.8 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 8.1 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 5.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 4.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 4.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 3.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 9.5 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.3 | 9.1 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.2 | 8.8 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.3 | 7.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 6.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.4 | 5.3 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 5.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 5.1 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 4.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |