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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for STAT5A
Z-value: 0.85
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Transcription factors associated with STAT5A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT5A | hg19_v2_chr17_+_40440481_40440561 | 0.71 | 1.1e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT5A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.7 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.3 | 8.6 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 6.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.8 | 3.9 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.0 | 3.7 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 0.2 | 3.6 | GO:1902260 | negative regulation of protein targeting to membrane(GO:0090315) negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.0 | 3.5 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.5 | 3.3 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 0.0 | 3.1 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 0.3 | 3.0 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 4.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 4.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 3.4 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.8 | 3.1 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.0 | 3.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 2.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 2.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 2.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 2.0 | GO:0005879 | axonemal microtubule(GO:0005879) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.7 | GO:0019864 | IgG binding(GO:0019864) |
| 0.4 | 6.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.3 | 4.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 1.0 | 4.0 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.2 | 3.9 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 3.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 3.4 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.0 | 3.3 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
| 0.2 | 3.1 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.2 | 2.9 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.8 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 1.9 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 1.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.2 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.2 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 3.0 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.3 | 2.9 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.2 | 2.6 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 2.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 2.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 2.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 2.1 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.2 | 2.0 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.1 | 2.0 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |