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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for STAT6

Z-value: 0.78

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Transcription factors associated with STAT6

Gene Symbol Gene ID Gene Info
STAT6
ENSG00000166888.6 signal transducer and activator of transcription 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT6hg19_v2_chr12_-_57505121_575052160.144.8e-01Click!

Activity profile of STAT6 motif

Sorted Z-values of STAT6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_205391178 9.83 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1
LEM domain containing 1
chrX_+_135251783 3.14 ENST00000394153.2
FHL1
four and a half LIM domains 1
chrX_+_135252050 2.86 ENST00000449474.1
ENST00000345434.3
FHL1
four and a half LIM domains 1
chrX_+_135251835 2.85 ENST00000456445.1
FHL1
four and a half LIM domains 1
chr2_+_113885138 2.68 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr10_+_102106829 2.53 ENST00000370355.2
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr2_-_31440377 2.18 ENST00000444918.2
ENST00000403897.3
CAPN14
calpain 14
chr11_-_128457446 1.98 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr17_-_17740325 1.77 ENST00000338854.5
SREBF1
sterol regulatory element binding transcription factor 1
chr11_+_76745385 1.63 ENST00000533140.1
ENST00000354301.5
ENST00000528622.1
B3GNT6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
chr4_+_54966198 1.60 ENST00000326902.2
ENST00000503800.1
GSX2
GS homeobox 2
chr9_+_36572851 1.58 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
MELK
maternal embryonic leucine zipper kinase
chr22_+_44464923 1.53 ENST00000404989.1
PARVB
parvin, beta
chrX_-_106960285 1.48 ENST00000503515.1
ENST00000372397.2
TSC22D3
TSC22 domain family, member 3
chr8_+_49984894 1.45 ENST00000522267.1
ENST00000399653.4
ENST00000303202.8
C8orf22
chromosome 8 open reading frame 22
chr1_-_160616804 1.41 ENST00000538290.1
SLAMF1
signaling lymphocytic activation molecule family member 1
chr2_-_190044480 1.36 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr11_+_65082289 1.29 ENST00000279249.2
CDC42EP2
CDC42 effector protein (Rho GTPase binding) 2
chr12_+_9144626 1.23 ENST00000543895.1
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr14_+_55034599 1.19 ENST00000392067.3
ENST00000357634.3
SAMD4A
sterile alpha motif domain containing 4A
chr19_+_38924316 1.13 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chr1_-_76398077 1.10 ENST00000284142.6
ASB17
ankyrin repeat and SOCS box containing 17
chr17_-_17740287 1.06 ENST00000355815.4
ENST00000261646.5
SREBF1
sterol regulatory element binding transcription factor 1
chr1_-_8086343 1.00 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
ERRFI1
ERBB receptor feedback inhibitor 1
chr16_+_30075463 1.00 ENST00000562168.1
ENST00000569545.1
ALDOA
aldolase A, fructose-bisphosphate
chr2_+_191792376 0.98 ENST00000409428.1
ENST00000409215.1
GLS
glutaminase
chr8_+_11666649 0.98 ENST00000528643.1
ENST00000525777.1
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr18_-_24445664 0.96 ENST00000578776.1
AQP4
aquaporin 4
chr14_-_69446034 0.94 ENST00000193403.6
ACTN1
actinin, alpha 1
chr17_-_39507064 0.94 ENST00000007735.3
KRT33A
keratin 33A
chr1_+_150245099 0.88 ENST00000369099.3
C1orf54
chromosome 1 open reading frame 54
chr1_-_241803679 0.86 ENST00000331838.5
OPN3
opsin 3
chr6_-_27880174 0.85 ENST00000303324.2
OR2B2
olfactory receptor, family 2, subfamily B, member 2
chr2_+_182756915 0.85 ENST00000428267.2
SSFA2
sperm specific antigen 2
chr16_+_30075595 0.84 ENST00000563060.2
ALDOA
aldolase A, fructose-bisphosphate
chr11_-_67981046 0.84 ENST00000402789.1
ENST00000402185.2
ENST00000458496.1
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr6_-_30524951 0.83 ENST00000376621.3
GNL1
guanine nucleotide binding protein-like 1
chr1_+_150245177 0.82 ENST00000369098.3
C1orf54
chromosome 1 open reading frame 54
chr1_-_41328018 0.82 ENST00000372638.2
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr1_-_209824643 0.77 ENST00000391911.1
ENST00000415782.1
LAMB3
laminin, beta 3
chr16_+_30075783 0.76 ENST00000412304.2
ALDOA
aldolase A, fructose-bisphosphate
chr12_+_6493319 0.75 ENST00000536876.1
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr3_-_98235962 0.75 ENST00000513873.1
CLDND1
claudin domain containing 1
chr19_+_2785458 0.73 ENST00000307741.6
ENST00000585338.1
THOP1
thimet oligopeptidase 1
chr6_+_30525051 0.72 ENST00000376557.3
PRR3
proline rich 3
chr11_+_112832133 0.72 ENST00000524665.1
NCAM1
neural cell adhesion molecule 1
chr2_+_173600514 0.70 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr4_-_120988229 0.69 ENST00000296509.6
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
chr2_+_173600565 0.69 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr3_+_140981456 0.69 ENST00000504264.1
ACPL2
acid phosphatase-like 2
chr3_-_10149907 0.68 ENST00000450660.2
ENST00000524279.1
FANCD2OS
FANCD2 opposite strand
chr3_+_158787041 0.67 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr2_+_219745020 0.66 ENST00000258411.3
WNT10A
wingless-type MMTV integration site family, member 10A
chr6_+_38690622 0.66 ENST00000327475.6
DNAH8
dynein, axonemal, heavy chain 8
chr3_+_189507523 0.65 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chr4_+_72897521 0.65 ENST00000308744.6
ENST00000344413.5
NPFFR2
neuropeptide FF receptor 2
chr2_+_68961934 0.64 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr6_-_117150198 0.64 ENST00000310357.3
ENST00000368549.3
ENST00000530250.1
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr3_-_73673991 0.64 ENST00000308537.4
ENST00000263666.4
PDZRN3
PDZ domain containing ring finger 3
chr20_+_58251716 0.63 ENST00000355648.4
PHACTR3
phosphatase and actin regulator 3
chr2_+_68961905 0.62 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr18_-_24445729 0.58 ENST00000383168.4
AQP4
aquaporin 4
chr9_-_131486367 0.58 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr1_+_214163033 0.57 ENST00000607425.1
PROX1
prospero homeobox 1
chr2_-_204400113 0.57 ENST00000319170.5
RAPH1
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr11_-_14379997 0.56 ENST00000526063.1
ENST00000532814.1
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr1_+_32608566 0.56 ENST00000545542.1
KPNA6
karyopherin alpha 6 (importin alpha 7)
chr9_-_14910990 0.55 ENST00000380881.4
ENST00000422223.2
FREM1
FRAS1 related extracellular matrix 1
chr3_+_158991025 0.54 ENST00000337808.6
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr8_-_42623747 0.53 ENST00000534622.1
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr3_+_189507432 0.52 ENST00000354600.5
TP63
tumor protein p63
chr2_+_202316392 0.51 ENST00000194530.3
ENST00000392249.2
STRADB
STE20-related kinase adaptor beta
chr2_-_134326009 0.51 ENST00000409261.1
ENST00000409213.1
NCKAP5
NCK-associated protein 5
chr12_-_71031220 0.51 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr5_+_74011328 0.51 ENST00000513336.1
HEXB
hexosaminidase B (beta polypeptide)
chr12_-_54779511 0.50 ENST00000551109.1
ENST00000546970.1
ZNF385A
zinc finger protein 385A
chr8_-_42623924 0.49 ENST00000276410.2
CHRNA6
cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr6_-_41254403 0.49 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
TREM1
triggering receptor expressed on myeloid cells 1
chr19_-_54604083 0.48 ENST00000391761.1
ENST00000356532.3
ENST00000359649.4
ENST00000358375.4
ENST00000391760.1
ENST00000351806.4
OSCAR
osteoclast associated, immunoglobulin-like receptor
chr12_-_71031185 0.48 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr16_-_29757272 0.48 ENST00000329410.3
C16orf54
chromosome 16 open reading frame 54
chr6_-_41168920 0.47 ENST00000483722.1
TREML2
triggering receptor expressed on myeloid cells-like 2
chr11_-_60719213 0.47 ENST00000227880.3
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chrX_-_138914394 0.47 ENST00000327569.3
ENST00000361648.2
ENST00000370543.1
ENST00000359686.2
ATP11C
ATPase, class VI, type 11C
chr7_+_129015484 0.46 ENST00000490911.1
AHCYL2
adenosylhomocysteinase-like 2
chr15_+_91643442 0.45 ENST00000394232.1
SV2B
synaptic vesicle glycoprotein 2B
chr5_+_126984710 0.45 ENST00000379445.3
CTXN3
cortexin 3
chr15_+_89402148 0.45 ENST00000560601.1
ACAN
aggrecan
chr10_-_24770632 0.45 ENST00000596413.1
AL353583.1
AL353583.1
chr17_+_7384721 0.45 ENST00000412468.2
SLC35G6
solute carrier family 35, member G6
chr2_+_182756615 0.44 ENST00000431877.2
ENST00000320370.7
SSFA2
sperm specific antigen 2
chr1_-_205649580 0.42 ENST00000367145.3
SLC45A3
solute carrier family 45, member 3
chr1_-_68299130 0.42 ENST00000370982.3
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr3_+_35682913 0.41 ENST00000449196.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr2_+_131769256 0.40 ENST00000355771.3
ARHGEF4
Rho guanine nucleotide exchange factor (GEF) 4
chr1_+_26759295 0.39 ENST00000430232.1
DHDDS
dehydrodolichyl diphosphate synthase
chr1_-_179834311 0.39 ENST00000553856.1
IFRG15
Homo sapiens torsin A interacting protein 2 (TOR1AIP2), transcript variant 1, mRNA.
chr8_+_9953214 0.38 ENST00000382490.5
MSRA
methionine sulfoxide reductase A
chr22_+_38201114 0.37 ENST00000340857.2
H1F0
H1 histone family, member 0
chr12_-_82152444 0.37 ENST00000549325.1
ENST00000550584.2
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr16_-_67753206 0.36 ENST00000268797.7
GFOD2
glucose-fructose oxidoreductase domain containing 2
chr20_+_42574317 0.36 ENST00000358131.5
TOX2
TOX high mobility group box family member 2
chr14_-_37642016 0.35 ENST00000331299.5
SLC25A21
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
chr2_+_197504278 0.35 ENST00000272831.7
ENST00000389175.4
ENST00000472405.2
ENST00000423093.2
CCDC150
coiled-coil domain containing 150
chr8_+_9953061 0.33 ENST00000522907.1
ENST00000528246.1
MSRA
methionine sulfoxide reductase A
chr12_-_53097247 0.33 ENST00000341809.3
ENST00000537195.1
KRT77
keratin 77
chr11_+_112832090 0.32 ENST00000533760.1
NCAM1
neural cell adhesion molecule 1
chr12_+_44152740 0.32 ENST00000440781.2
ENST00000431837.1
ENST00000550616.1
ENST00000448290.2
ENST00000551736.1
IRAK4
interleukin-1 receptor-associated kinase 4
chr15_+_67841330 0.31 ENST00000354498.5
MAP2K5
mitogen-activated protein kinase kinase 5
chr11_-_58980342 0.31 ENST00000361050.3
MPEG1
macrophage expressed 1
chr11_+_65101225 0.30 ENST00000528416.1
ENST00000415073.2
ENST00000252268.4
DPF2
D4, zinc and double PHD fingers family 2
chr8_-_82359662 0.30 ENST00000519260.1
ENST00000256103.2
PMP2
peripheral myelin protein 2
chr6_-_32821599 0.30 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_116850174 0.28 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
FAM26D
family with sequence similarity 26, member D
chr5_+_138609441 0.28 ENST00000509990.1
ENST00000506147.1
ENST00000512107.1
MATR3
matrin 3
chr15_+_85525205 0.28 ENST00000394553.1
ENST00000339708.5
PDE8A
phosphodiesterase 8A
chrX_-_50386648 0.27 ENST00000460112.3
SHROOM4
shroom family member 4
chr1_+_42619070 0.26 ENST00000372581.1
GUCA2B
guanylate cyclase activator 2B (uroguanylin)
chr7_+_112120908 0.26 ENST00000439068.2
ENST00000312849.4
ENST00000429049.1
LSMEM1
leucine-rich single-pass membrane protein 1
chr4_-_116034979 0.26 ENST00000264363.2
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr1_+_12123414 0.25 ENST00000263932.2
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr3_-_57233966 0.24 ENST00000473921.1
ENST00000295934.3
HESX1
HESX homeobox 1
chr6_-_11232891 0.24 ENST00000379433.5
ENST00000379446.5
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr10_+_98064085 0.23 ENST00000419175.1
ENST00000371174.2
DNTT
DNA nucleotidylexotransferase
chr17_+_34538310 0.23 ENST00000444414.1
ENST00000378350.4
ENST00000389068.5
ENST00000588929.1
ENST00000589079.1
ENST00000589336.1
ENST00000400702.4
ENST00000591167.1
ENST00000586598.1
ENST00000591637.1
ENST00000378352.4
ENST00000358756.5
CCL4L1
chemokine (C-C motif) ligand 4-like 1
chr12_+_56435637 0.23 ENST00000356464.5
ENST00000552361.1
RPS26
ribosomal protein S26
chr14_+_38677123 0.23 ENST00000267377.2
SSTR1
somatostatin receptor 1
chr7_-_76829125 0.23 ENST00000248598.5
FGL2
fibrinogen-like 2
chr17_-_62308087 0.23 ENST00000583097.1
TEX2
testis expressed 2
chr9_+_131464767 0.22 ENST00000291906.4
PKN3
protein kinase N3
chr5_+_147258266 0.22 ENST00000296694.4
SCGB3A2
secretoglobin, family 3A, member 2
chr1_-_108735440 0.22 ENST00000370041.4
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr7_-_122840015 0.22 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr1_+_202431859 0.22 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr16_-_67694597 0.21 ENST00000393919.4
ENST00000219251.8
ACD
adrenocortical dysplasia homolog (mouse)
chr3_+_51575596 0.21 ENST00000409535.2
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr4_+_166300084 0.21 ENST00000402744.4
CPE
carboxypeptidase E
chr2_-_16804320 0.21 ENST00000355549.2
FAM49A
family with sequence similarity 49, member A
chr9_-_100000957 0.20 ENST00000366109.2
ENST00000607322.1
RP11-498P14.5
RP11-498P14.5
chr2_-_203735484 0.20 ENST00000420558.1
ENST00000418208.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr9_-_111619239 0.20 ENST00000374667.3
ACTL7B
actin-like 7B
chrX_+_102192200 0.19 ENST00000218249.5
RAB40AL
RAB40A, member RAS oncogene family-like
chr2_+_103378472 0.19 ENST00000412401.2
TMEM182
transmembrane protein 182
chr3_+_121311966 0.18 ENST00000338040.4
FBXO40
F-box protein 40
chr14_-_46185155 0.18 ENST00000555442.1
RP11-369C8.1
RP11-369C8.1
chr12_-_6451235 0.18 ENST00000440083.2
ENST00000162749.2
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr9_-_3469181 0.17 ENST00000366116.2
AL365202.1
Uncharacterized protein
chr17_+_7461613 0.17 ENST00000438470.1
ENST00000436057.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr13_-_74708372 0.17 ENST00000377666.4
KLF12
Kruppel-like factor 12
chr12_+_52282001 0.17 ENST00000340970.4
ANKRD33
ankyrin repeat domain 33
chr9_+_90112590 0.16 ENST00000472284.1
DAPK1
death-associated protein kinase 1
chr12_-_82152420 0.16 ENST00000552948.1
ENST00000548586.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr6_+_84222220 0.16 ENST00000369700.3
PRSS35
protease, serine, 35
chr8_+_97506033 0.16 ENST00000518385.1
SDC2
syndecan 2
chr1_+_89246647 0.16 ENST00000544045.1
PKN2
protein kinase N2
chr17_+_34640031 0.15 ENST00000339270.6
ENST00000482104.1
CCL4L2
chemokine (C-C motif) ligand 4-like 2
chr8_-_117886955 0.15 ENST00000297338.2
RAD21
RAD21 homolog (S. pombe)
chr12_+_52281744 0.15 ENST00000301190.6
ENST00000538991.1
ANKRD33
ankyrin repeat domain 33
chr2_+_234686976 0.15 ENST00000389758.3
MROH2A
maestro heat-like repeat family member 2A
chrX_-_100546314 0.14 ENST00000356784.1
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr9_-_135996537 0.14 ENST00000372050.3
ENST00000372047.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr12_+_6493199 0.14 ENST00000228918.4
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr12_-_82153087 0.14 ENST00000547623.1
ENST00000549396.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr21_+_17792672 0.13 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478
chr17_+_34639793 0.12 ENST00000394465.2
ENST00000394463.2
ENST00000378342.4
CCL4L2
chemokine (C-C motif) ligand 4-like 2
chr22_-_29457832 0.12 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr20_+_42136308 0.12 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr15_-_23932437 0.11 ENST00000331837.4
NDN
necdin, melanoma antigen (MAGE) family member
chr19_+_13229126 0.11 ENST00000292431.4
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr18_-_51107372 0.11 ENST00000565170.1
RP11-202D1.2
RP11-202D1.2
chr11_+_63655987 0.11 ENST00000509502.2
ENST00000512060.1
MARK2
MAP/microtubule affinity-regulating kinase 2
chr5_+_150051149 0.11 ENST00000523553.1
MYOZ3
myozenin 3
chr15_+_25200074 0.10 ENST00000390687.4
ENST00000584968.1
ENST00000346403.6
ENST00000554227.2
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr5_-_88119580 0.10 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chr12_+_80730292 0.10 ENST00000298820.3
OTOGL
otogelin-like
chr15_+_69857515 0.10 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr17_-_34890665 0.10 ENST00000586007.1
MYO19
myosin XIX
chr9_+_90112117 0.09 ENST00000358077.5
DAPK1
death-associated protein kinase 1
chr1_-_173572181 0.09 ENST00000536496.1
ENST00000367714.3
SLC9C2
solute carrier family 9, member C2 (putative)
chr2_-_204400013 0.09 ENST00000374489.2
ENST00000374488.2
ENST00000308091.4
ENST00000453034.1
ENST00000420371.1
RAPH1
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr20_+_57209828 0.08 ENST00000598340.1
MGC4294
HCG1785561; MGC4294 protein; Uncharacterized protein
chr19_+_15052301 0.08 ENST00000248072.3
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr1_+_152691998 0.08 ENST00000368775.2
C1orf68
chromosome 1 open reading frame 68
chr17_+_7461849 0.07 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr11_-_8964580 0.07 ENST00000325884.1
ASCL3
achaete-scute family bHLH transcription factor 3
chr7_-_75401513 0.07 ENST00000005180.4
CCL26
chemokine (C-C motif) ligand 26
chr17_+_7462031 0.07 ENST00000380535.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr3_+_141121164 0.06 ENST00000510338.1
ENST00000504673.1
ZBTB38
zinc finger and BTB domain containing 38
chr17_+_7461781 0.06 ENST00000349228.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr2_+_234526272 0.06 ENST00000373450.4
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr15_+_91643173 0.06 ENST00000545111.2
SV2B
synaptic vesicle glycoprotein 2B
chr9_+_90112741 0.06 ENST00000469640.2
DAPK1
death-associated protein kinase 1
chr17_+_7461580 0.05 ENST00000483039.1
ENST00000396542.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr8_+_104311059 0.05 ENST00000358755.4
ENST00000523739.1
ENST00000540287.1
FZD6
frizzled family receptor 6
chr7_-_15726296 0.05 ENST00000262041.5
MEOX2
mesenchyme homeobox 2
chr10_-_61122220 0.05 ENST00000422313.2
ENST00000435852.2
ENST00000442566.3
ENST00000373868.2
ENST00000277705.6
ENST00000373867.3
ENST00000419214.2
FAM13C
family with sequence similarity 13, member C
chr4_+_71337834 0.04 ENST00000304887.5
MUC7
mucin 7, secreted
chr14_+_22520762 0.04 ENST00000390449.3
TRAV21
T cell receptor alpha variable 21
chr2_-_175462456 0.03 ENST00000409891.1
ENST00000410117.1
WIPF1
WAS/WASL interacting protein family, member 1
chrX_+_100878079 0.03 ENST00000471229.2
ARMCX3
armadillo repeat containing, X-linked 3

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.5 1.4 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.5 1.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.4 1.6 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.3 2.7 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3 2.8 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.2 2.0 GO:0030578 PML body organization(GO:0030578)
0.2 0.9 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.2 1.0 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 1.0 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.2 0.6 GO:0043049 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 1.5 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.2 1.5 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 1.4 GO:0031017 exocrine pancreas development(GO:0031017)
0.1 2.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.4 GO:0015766 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 0.4 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.1 8.8 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 1.0 GO:1903243 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.1 0.5 GO:0007619 courtship behavior(GO:0007619)
0.1 0.5 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.5 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.1 1.1 GO:0071313 cellular response to caffeine(GO:0071313)
0.1 1.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.3 GO:0032679 TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
0.1 0.3 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1 0.3 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 0.2 GO:0060381 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.1 0.7 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.1 0.7 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.7 GO:0030091 protein repair(GO:0030091)
0.1 0.4 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.1 0.9 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.5 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 1.5 GO:0006833 water transport(GO:0006833)
0.0 0.2 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.9 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:0030070 insulin processing(GO:0030070)
0.0 0.4 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 0.9 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.7 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.2 GO:0030916 otic vesicle formation(GO:0030916)
0.0 0.6 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.0 0.5 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 1.0 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.3 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 1.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0 0.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.3 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.3 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 1.2 GO:0006968 cellular defense response(GO:0006968)
0.0 0.5 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.2 GO:0071550 death-inducing signaling complex assembly(GO:0071550) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.2 GO:0015866 ADP transport(GO:0015866)
0.0 0.2 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.4 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.1 GO:0070980 biphenyl catabolic process(GO:0070980)
0.0 0.6 GO:0043086 negative regulation of catalytic activity(GO:0043086)
0.0 0.3 GO:2000678 negative regulation of transcription regulatory region DNA binding(GO:2000678)
0.0 0.7 GO:0014047 glutamate secretion(GO:0014047)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0005588 collagen type V trimer(GO:0005588)
0.2 1.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 0.8 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.9 GO:0005916 fascia adherens(GO:0005916)
0.1 0.7 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 2.6 GO:0031430 M band(GO:0031430)
0.0 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 2.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.2 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.0 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 11.2 GO:0005925 focal adhesion(GO:0005925)
0.0 0.2 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.6 GO:0000791 euchromatin(GO:0000791)
0.0 1.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 1.3 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.6 2.8 GO:0032810 sterol response element binding(GO:0032810)
0.5 1.6 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.5 2.5 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.3 1.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.2 1.0 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.2 2.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.3 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.0 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.5 GO:0043426 MRF binding(GO:0043426)
0.1 0.7 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.4 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 0.4 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 0.5 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.1 1.5 GO:0015250 water channel activity(GO:0015250)
0.1 0.5 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.9 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 0.6 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.9 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.5 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 2.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0031628 opioid receptor binding(GO:0031628)
0.0 2.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 9.8 GO:0044325 ion channel binding(GO:0044325)
0.0 1.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.3 GO:0046979 TAP2 binding(GO:0046979)
0.0 0.1 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 1.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.0 1.4 GO:0030552 cAMP binding(GO:0030552)
0.0 1.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.4 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.2 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 2.3 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.6 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.6 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 3.0 PID IL1 PATHWAY IL1-mediated signaling events
0.0 4.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.1 PID FGF PATHWAY FGF signaling pathway
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.8 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 2.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.9 REACTOME OPSINS Genes involved in Opsins
0.1 1.0 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.0 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 2.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 3.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 2.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.7 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.5 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.4 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters