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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for TAF1
Z-value: 2.09
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Transcription factors associated with TAF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAF1 | hg19_v2_chrX_+_70586082_70586114 | 0.48 | 7.9e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 28.9 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.9 | 26.1 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.7 | 14.4 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 12.9 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.2 | 12.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 8.9 | GO:0043966 | histone H3 acetylation(GO:0043966) |
| 0.2 | 8.3 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.4 | 7.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 1.5 | 7.7 | GO:0007228 | positive regulation of hh target transcription factor activity(GO:0007228) |
| 0.8 | 7.7 | GO:0070269 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) pyroptosis(GO:0070269) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 4.3 | 30.2 | GO:0002177 | manchette(GO:0002177) |
| 0.9 | 16.5 | GO:0036038 | MKS complex(GO:0036038) |
| 0.2 | 13.6 | GO:0030286 | dynein complex(GO:0030286) |
| 0.1 | 12.8 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.6 | 11.6 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.2 | 10.9 | GO:0016592 | mediator complex(GO:0016592) |
| 1.4 | 10.0 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 8.8 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.1 | 8.0 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 31.2 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.3 | 18.8 | GO:0061733 | peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 0.7 | 14.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 12.4 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.7 | 10.1 | GO:0043995 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 10.1 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.2 | 8.9 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 7.8 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 7.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 7.0 | GO:0043175 | RNA polymerase core enzyme binding(GO:0043175) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 10.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 7.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 6.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 6.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 4.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 4.1 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.9 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 2.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 2.8 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.3 | 10.6 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 9.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 7.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 7.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.2 | 7.0 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.2 | 6.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 6.4 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 5.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 5.4 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |