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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for TBX1
Z-value: 1.28
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Transcription factors associated with TBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX1 | hg19_v2_chr22_+_19744226_19744226 | 0.29 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_31488433 Show fit | 4.82 |
ENST00000455608.1
|
smoothelin |
|
| chr2_-_31637560 Show fit | 4.00 |
ENST00000379416.3
|
xanthine dehydrogenase |
|
| chrY_+_2709527 Show fit | 3.45 |
ENST00000250784.8
|
ribosomal protein S4, Y-linked 1 |
|
| chr15_-_80263506 Show fit | 2.65 |
ENST00000335661.6
|
BCL2-related protein A1 |
|
| chr6_+_151662815 Show fit | 2.57 |
ENST00000359755.5
|
A kinase (PRKA) anchor protein 12 |
|
| chrY_+_2709906 Show fit | 2.47 |
ENST00000430575.1
|
ribosomal protein S4, Y-linked 1 |
|
| chr9_+_139847347 Show fit | 2.36 |
ENST00000371632.3
|
lipocalin 12 |
|
| chr1_-_153066998 Show fit | 2.32 |
ENST00000368750.3
|
small proline-rich protein 2E |
|
| chr19_-_51487282 Show fit | 2.25 |
ENST00000595820.1
ENST00000597707.1 ENST00000336317.4 |
kallikrein-related peptidase 7 |
|
| chr1_-_153029980 Show fit | 2.09 |
ENST00000392653.2
|
small proline-rich protein 2A |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 5.5 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 5.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 1.2 | 4.6 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 0.2 | 4.4 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.7 | 3.9 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.0 | 3.9 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.1 | 3.7 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 3.2 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.4 | 3.1 | GO:0038060 | nitric oxide-cGMP-mediated signaling pathway(GO:0038060) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 5.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 5.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 5.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 5.0 | GO:0005844 | polysome(GO:0005844) |
| 0.3 | 3.9 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.6 | 3.7 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.4 | 3.4 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.1 | 3.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 3.1 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 6.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 5.4 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.5 | 4.1 | GO:0043546 | molybdopterin cofactor binding(GO:0043546) |
| 0.6 | 3.8 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.0 | 3.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 3.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 3.3 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 3.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 2.9 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 5.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 4.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 3.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 2.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 2.0 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 6.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 6.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 5.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 4.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 4.0 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 3.8 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 3.4 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 3.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.3 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |