ISMARA results: TBX15

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TBX15_MGA

Z-value: 0.63

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Transcription factors associated with TBX15_MGA

Gene Symbol	Gene ID	Gene Info
TBX15 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000092607.9	T-box transcription factor 15
MGA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000174197.12	MAX dimerization protein MGA

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MGA	hg19_v2_chr15_+_41952591_41952672	-0.50	4.5e-03	Click!
TBX15	hg19_v2_chr1_-_119530428_119530572, hg19_v2_chr1_-_119532127_119532179	0.11	5.5e-01	Click!

Activity profile of TBX15_MGA motif

Sorted Z-values of TBX15_MGA motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_153066998 Show fit	2.56	ENST00000368750.3	SPRR2E Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2E
chr21_+_30502806 Show fit	2.43	ENST00000399928.1 ENST00000399926.1	MAP3K7CL Ensembl NCBI GeneCards UniProt NextProt Show fit	MAP3K7 C-terminal like
chr14_+_75746781 Show fit	2.07	ENST00000555347.1	FOS Ensembl NCBI GeneCards UniProt NextProt Show fit	FBJ murine osteosarcoma viral oncogene homolog
chr4_+_8582287 Show fit	1.57	ENST00000382487.4	GPR78 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 78
chr1_-_153029980 Show fit	1.47	ENST00000392653.2	SPRR2A Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2A
chr7_-_76255444 Show fit	1.43	ENST00000454397.1	POMZP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	POM121 and ZP3 fusion
chr1_-_153044083 Show fit	1.38	ENST00000341611.2	SPRR2B Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2B
chr7_-_27135591 Show fit	1.29	ENST00000343060.4 ENST00000355633.5	HOXA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	homeobox A1
chr18_+_47088401 Show fit	1.27	ENST00000261292.4 ENST00000427224.2 ENST00000580036.1	LIPG Ensembl NCBI GeneCards UniProt NextProt Show fit	lipase, endothelial
chr1_+_15736359 Show fit	1.25	ENST00000375980.4	EFHD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	EF-hand domain family, member D2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX15_MGA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.1	GO:0018149	peptide cross-linking(GO:0018149)
0.0	2.4	GO:0000186	activation of MAPKK activity(GO:0000186)
0.0	2.0	GO:0031424	keratinization(GO:0031424)
0.2	1.9	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	1.9	GO:0060216	definitive hemopoiesis(GO:0060216)
0.2	1.7	GO:1903764	regulation of potassium ion export across plasma membrane(GO:1903764)
0.1	1.6	GO:0021603	cranial nerve formation(GO:0021603)
0.1	1.5	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.0	1.5	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.2	1.4	GO:0035803	egg coat formation(GO:0035803)

Showing 1 to 10 of 203 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.3	GO:0001533	cornified envelope(GO:0001533)
0.3	2.1	GO:0035976	AP1 complex(GO:0035976)
0.1	1.7	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	1.7	GO:0045095	keratin filament(GO:0045095)
0.0	1.7	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.2	1.6	GO:0005955	calcineurin complex(GO:0005955)
0.1	1.5	GO:0043219	lateral loop(GO:0043219)
0.0	1.5	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.1	1.4	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.0	1.2	GO:0034707	chloride channel complex(GO:0034707)

Showing 1 to 10 of 73 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.6	GO:0030280	structural constituent of epidermis(GO:0030280)
0.1	2.4	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	2.1	GO:0070412	R-SMAD binding(GO:0070412)
0.0	1.6	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	1.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.2	1.4	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	1.4	GO:0032190	acrosin binding(GO:0032190)
0.1	1.4	GO:0005549	odorant binding(GO:0005549)
0.1	1.4	GO:0004383	guanylate cyclase activity(GO:0004383)
0.1	1.2	GO:0097016	L27 domain binding(GO:0097016)

Showing 1 to 10 of 127 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	1.9	PID AURORA A PATHWAY	Aurora A signaling
0.0	1.7	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	1.6	PID NOTCH PATHWAY	Notch signaling pathway
0.0	1.4	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	1.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.2	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	1.1	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	1.1	PID NECTIN PATHWAY	Nectin adhesion pathway

Showing 1 to 10 of 31 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.1	1.8	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	1.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	1.4	REACTOME KINESINS	Genes involved in Kinesins
0.0	1.4	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.0	1.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	1.2	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	1.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	1.1	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.1	1.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions

Showing 1 to 10 of 40 entries

Results for TBX15_MGA

Z-value: 0.63

Motif logo

Transcription factors associated with TBX15_MGA

Activity-expression correlation:

Activity profile of TBX15_MGA motif

Sorted Z-values of TBX15_MGA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX15_MGA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: