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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for TBX2
Z-value: 0.66
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Transcription factors associated with TBX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX2 | hg19_v2_chr17_+_59477233_59477263 | 0.09 | 6.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_76255444 Show fit | 2.67 |
ENST00000454397.1
|
POM121 and ZP3 fusion |
|
| chr9_+_33750667 Show fit | 2.05 |
ENST00000457896.1
ENST00000342836.4 ENST00000429677.3 |
protease, serine, 3 |
|
| chr9_+_33750515 Show fit | 2.02 |
ENST00000361005.5
|
protease, serine, 3 |
|
| chr1_+_20915409 Show fit | 1.72 |
ENST00000375071.3
|
cytidine deaminase |
|
| chr2_-_31637560 Show fit | 1.34 |
ENST00000379416.3
|
xanthine dehydrogenase |
|
| chr11_-_28129656 Show fit | 1.29 |
ENST00000263181.6
|
kinesin family member 18A |
|
| chr10_+_54074033 Show fit | 1.28 |
ENST00000373970.3
|
dickkopf WNT signaling pathway inhibitor 1 |
|
| chr7_-_27135591 Show fit | 1.22 |
ENST00000343060.4
ENST00000355633.5 |
homeobox A1 |
|
| chr14_-_55658323 Show fit | 1.19 |
ENST00000554067.1
ENST00000247191.2 |
discs, large (Drosophila) homolog-associated protein 5 |
|
| chr10_+_95256356 Show fit | 1.16 |
ENST00000371485.3
|
centrosomal protein 55kDa |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.7 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.4 | 2.3 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.1 | 2.3 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.7 | 2.0 | GO:0019858 | cytosine metabolic process(GO:0019858) |
| 0.0 | 2.0 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.4 | 1.3 | GO:1904956 | regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
| 0.3 | 1.3 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 0.1 | 1.3 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.3 | 1.2 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.1 | 1.2 | GO:0021603 | cranial nerve formation(GO:0021603) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 2.3 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 1.3 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 1.2 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.1 | 1.2 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 1.2 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.1 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.2 | 1.0 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.1 | 1.0 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 1.0 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 2.9 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.1 | 2.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.2 | 1.7 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 1.4 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 1.3 | GO:0043546 | molybdopterin cofactor binding(GO:0043546) |
| 0.0 | 1.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.4 | 1.2 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.0 | 1.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 1.0 | GO:0034040 | lipid-transporting ATPase activity(GO:0034040) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.5 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 1.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.9 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.8 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 2.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.7 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 1.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 1.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.2 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 1.2 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 1.0 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.0 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |