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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TBX2

Z-value: 0.66

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Transcription factors associated with TBX2

Gene Symbol Gene ID Gene Info
TBX2
ENSG00000121068.9 T-box transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX2hg19_v2_chr17_+_59477233_594772630.096.4e-01Click!

Activity profile of TBX2 motif

Sorted Z-values of TBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_76255444 2.67 ENST00000454397.1
POMZP3
POM121 and ZP3 fusion
chr9_+_33750667 2.05 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
PRSS3
protease, serine, 3
chr9_+_33750515 2.02 ENST00000361005.5
PRSS3
protease, serine, 3
chr1_+_20915409 1.72 ENST00000375071.3
CDA
cytidine deaminase
chr2_-_31637560 1.34 ENST00000379416.3
XDH
xanthine dehydrogenase
chr11_-_28129656 1.29 ENST00000263181.6
KIF18A
kinesin family member 18A
chr10_+_54074033 1.28 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr7_-_27135591 1.22 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr14_-_55658323 1.19 ENST00000554067.1
ENST00000247191.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr10_+_95256356 1.16 ENST00000371485.3
CEP55
centrosomal protein 55kDa
chr1_-_200589859 1.10 ENST00000367350.4
KIF14
kinesin family member 14
chr14_-_55658252 1.09 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr1_-_205391178 1.06 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1
LEM domain containing 1
chr2_-_216003127 1.03 ENST00000412081.1
ENST00000272895.7
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr1_+_15736359 0.97 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr2_-_169769787 0.95 ENST00000451987.1
SPC25
SPC25, NDC80 kinetochore complex component
chr21_+_30502806 0.89 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr14_-_100841670 0.86 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr13_+_109248500 0.85 ENST00000356711.2
MYO16
myosin XVI
chr17_-_34122596 0.82 ENST00000250144.8
MMP28
matrix metallopeptidase 28
chr17_-_7493390 0.79 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SOX15
SRY (sex determining region Y)-box 15
chr20_+_25388293 0.79 ENST00000262460.4
ENST00000429262.2
GINS1
GINS complex subunit 1 (Psf1 homolog)
chr3_+_160117087 0.78 ENST00000357388.3
SMC4
structural maintenance of chromosomes 4
chr7_-_99527243 0.78 ENST00000312891.2
GJC3
gap junction protein, gamma 3, 30.2kDa
chr10_+_94833642 0.78 ENST00000224356.4
ENST00000394139.1
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chrX_+_99899180 0.78 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr8_-_124428569 0.77 ENST00000521903.1
ATAD2
ATPase family, AAA domain containing 2
chr1_-_150780757 0.77 ENST00000271651.3
CTSK
cathepsin K
chr5_-_39270725 0.76 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYB
FYN binding protein
chr11_-_58345569 0.76 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr19_-_43702231 0.75 ENST00000597374.1
ENST00000599371.1
PSG4
pregnancy specific beta-1-glycoprotein 4
chr5_+_150639360 0.72 ENST00000523004.1
GM2A
GM2 ganglioside activator
chr17_+_39868577 0.71 ENST00000329402.3
GAST
gastrin
chr3_+_185431080 0.70 ENST00000296270.1
C3orf65
chromosome 3 open reading frame 65
chr21_-_31869451 0.69 ENST00000334058.2
KRTAP19-4
keratin associated protein 19-4
chr4_+_8582287 0.69 ENST00000382487.4
GPR78
G protein-coupled receptor 78
chr11_-_7847519 0.67 ENST00000328375.1
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr19_-_44174330 0.67 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr12_+_75874984 0.66 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr2_+_53994927 0.66 ENST00000295304.4
CHAC2
ChaC, cation transport regulator homolog 2 (E. coli)
chr10_+_81967456 0.65 ENST00000422847.1
LINC00857
long intergenic non-protein coding RNA 857
chr17_+_76210367 0.64 ENST00000592734.1
ENST00000587746.1
BIRC5
baculoviral IAP repeat containing 5
chrX_+_70503037 0.64 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr17_-_2966901 0.64 ENST00000575751.1
OR1D5
olfactory receptor, family 1, subfamily D, member 5
chr12_+_57853918 0.63 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI1
GLI family zinc finger 1
chr12_+_1099675 0.62 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr1_+_28586006 0.62 ENST00000253063.3
SESN2
sestrin 2
chr9_+_34990219 0.62 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr22_-_38699003 0.59 ENST00000451964.1
CSNK1E
casein kinase 1, epsilon
chr19_-_6670128 0.58 ENST00000245912.3
TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr1_+_101702417 0.58 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chr7_-_142120321 0.57 ENST00000390377.1
TRBV7-7
T cell receptor beta variable 7-7
chr8_+_22857048 0.57 ENST00000251822.6
RHOBTB2
Rho-related BTB domain containing 2
chr5_-_175395283 0.56 ENST00000513482.1
ENST00000265097.4
THOC3
THO complex 3
chr20_+_44509857 0.56 ENST00000372523.1
ENST00000372520.1
ZSWIM1
zinc finger, SWIM-type containing 1
chr3_-_119379719 0.55 ENST00000493094.1
POPDC2
popeye domain containing 2
chr7_+_143013198 0.55 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr1_-_67519782 0.54 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr17_+_26662730 0.54 ENST00000226225.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr9_+_125281420 0.53 ENST00000340750.1
OR1J4
olfactory receptor, family 1, subfamily J, member 4
chr1_+_209878182 0.52 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr12_+_93965609 0.52 ENST00000549887.1
ENST00000551556.1
SOCS2
suppressor of cytokine signaling 2
chr2_+_136343820 0.52 ENST00000410054.1
R3HDM1
R3H domain containing 1
chr19_-_44174305 0.52 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chrX_+_16804544 0.51 ENST00000380122.5
ENST00000398155.4
TXLNG
taxilin gamma
chr3_+_101818088 0.49 ENST00000491959.1
ZPLD1
zona pellucida-like domain containing 1
chr11_+_55653396 0.49 ENST00000244891.3
TRIM51
tripartite motif-containing 51
chr19_-_36001286 0.47 ENST00000602679.1
ENST00000492341.2
ENST00000472252.2
ENST00000602781.1
ENST00000402589.2
ENST00000458071.1
ENST00000436012.1
ENST00000443640.1
ENST00000450261.1
ENST00000467637.1
ENST00000480502.1
ENST00000474928.1
ENST00000414866.2
ENST00000392206.2
ENST00000488892.1
DMKN
dermokine
chr22_-_32334403 0.47 ENST00000543051.1
C22orf24
chromosome 22 open reading frame 24
chr3_+_101498269 0.47 ENST00000491511.2
NXPE3
neurexophilin and PC-esterase domain family, member 3
chr6_-_26124138 0.47 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc
chr1_+_35246775 0.46 ENST00000373366.2
GJB3
gap junction protein, beta 3, 31kDa
chr10_+_118187379 0.46 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chr11_-_112034831 0.46 ENST00000280357.7
IL18
interleukin 18 (interferon-gamma-inducing factor)
chr5_-_9630463 0.46 ENST00000382492.2
TAS2R1
taste receptor, type 2, member 1
chr3_-_150996239 0.45 ENST00000309170.3
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr1_-_205744205 0.45 ENST00000446390.2
RAB7L1
RAB7, member RAS oncogene family-like 1
chr1_+_76540386 0.45 ENST00000328299.3
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr2_+_105050794 0.44 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr20_+_36012051 0.43 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr6_-_160166218 0.43 ENST00000537657.1
SOD2
superoxide dismutase 2, mitochondrial
chr7_+_27282319 0.43 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr12_+_96252706 0.43 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr1_-_22263790 0.43 ENST00000374695.3
HSPG2
heparan sulfate proteoglycan 2
chr11_-_119599794 0.43 ENST00000264025.3
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr12_+_21525818 0.43 ENST00000240652.3
ENST00000542023.1
ENST00000537593.1
IAPP
islet amyloid polypeptide
chr2_+_234601512 0.42 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr11_-_85779971 0.42 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr14_-_35183755 0.42 ENST00000555765.1
CFL2
cofilin 2 (muscle)
chr20_-_656437 0.41 ENST00000488788.2
RP5-850E9.3
Uncharacterized protein
chr3_+_26664291 0.41 ENST00000396641.2
LRRC3B
leucine rich repeat containing 3B
chr11_-_16430399 0.41 ENST00000528252.1
SOX6
SRY (sex determining region Y)-box 6
chr1_-_28969517 0.40 ENST00000263974.4
ENST00000373824.4
TAF12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr12_+_1800179 0.40 ENST00000357103.4
ADIPOR2
adiponectin receptor 2
chr7_+_132333553 0.39 ENST00000332558.4
AC009365.3
AC009365.3
chr21_-_31859755 0.39 ENST00000334055.3
KRTAP19-2
keratin associated protein 19-2
chr4_-_142199943 0.38 ENST00000514347.1
RP11-586L23.1
RP11-586L23.1
chr15_+_93447675 0.38 ENST00000536619.1
CHD2
chromodomain helicase DNA binding protein 2
chr11_-_93474645 0.37 ENST00000532455.1
TAF1D
TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
chr19_-_47353547 0.37 ENST00000601498.1
AP2S1
adaptor-related protein complex 2, sigma 1 subunit
chr15_+_90319557 0.37 ENST00000341735.3
MESP2
mesoderm posterior 2 homolog (mouse)
chr13_+_34392185 0.36 ENST00000380071.3
RFC3
replication factor C (activator 1) 3, 38kDa
chr12_+_65672423 0.36 ENST00000355192.3
ENST00000308259.5
ENST00000540804.1
ENST00000535664.1
ENST00000541189.1
MSRB3
methionine sulfoxide reductase B3
chr20_+_816695 0.36 ENST00000246100.3
FAM110A
family with sequence similarity 110, member A
chr20_-_44516256 0.36 ENST00000372519.3
SPATA25
spermatogenesis associated 25
chr7_+_107220660 0.35 ENST00000465919.1
ENST00000445771.2
ENST00000479917.1
ENST00000421217.1
ENST00000457837.1
BCAP29
B-cell receptor-associated protein 29
chr16_-_79634595 0.34 ENST00000326043.4
ENST00000393350.1
MAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr19_-_41256207 0.34 ENST00000598485.2
ENST00000470681.1
ENST00000339153.3
ENST00000598729.1
C19orf54
chromosome 19 open reading frame 54
chr1_-_79472365 0.34 ENST00000370742.3
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr5_-_64858944 0.34 ENST00000508421.1
ENST00000510693.1
ENST00000514814.1
ENST00000515497.1
ENST00000396679.1
CENPK
centromere protein K
chr11_+_108535752 0.34 ENST00000322536.3
DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr3_-_46249878 0.33 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr12_+_57610562 0.33 ENST00000349394.5
NXPH4
neurexophilin 4
chr1_-_153585539 0.33 ENST00000368706.4
S100A16
S100 calcium binding protein A16
chr1_+_202995611 0.33 ENST00000367240.2
PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr5_+_82767583 0.33 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr11_+_120081475 0.33 ENST00000328965.4
OAF
OAF homolog (Drosophila)
chrX_-_119709637 0.33 ENST00000404115.3
CUL4B
cullin 4B
chr20_+_825275 0.33 ENST00000541082.1
FAM110A
family with sequence similarity 110, member A
chr7_+_107220899 0.32 ENST00000379117.2
ENST00000473124.1
BCAP29
B-cell receptor-associated protein 29
chr1_-_111174054 0.32 ENST00000369770.3
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr16_+_58010339 0.32 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr6_-_110500905 0.32 ENST00000392587.2
WASF1
WAS protein family, member 1
chr14_-_51411194 0.32 ENST00000544180.2
PYGL
phosphorylase, glycogen, liver
chr4_-_73434498 0.32 ENST00000286657.4
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chrX_-_7066159 0.31 ENST00000486446.2
ENST00000412827.2
ENST00000424830.2
ENST00000381077.5
ENST00000540122.1
HDHD1
haloacid dehalogenase-like hydrolase domain containing 1
chr9_+_40028620 0.31 ENST00000426179.1
AL353791.1
AL353791.1
chr2_+_33701286 0.31 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_156105878 0.31 ENST00000508500.1
LMNA
lamin A/C
chr6_+_168418553 0.31 ENST00000354419.2
ENST00000351261.3
KIF25
kinesin family member 25
chr2_+_201994208 0.31 ENST00000440180.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr8_+_27631903 0.31 ENST00000305188.8
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr4_+_140222609 0.31 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr16_+_640201 0.31 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr8_-_49834299 0.30 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr12_+_26205496 0.30 ENST00000537946.1
ENST00000541218.1
ENST00000282884.9
ENST00000545413.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr19_-_17958771 0.30 ENST00000534444.1
JAK3
Janus kinase 3
chr11_+_112832133 0.30 ENST00000524665.1
NCAM1
neural cell adhesion molecule 1
chr11_+_69455855 0.30 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr20_+_58630972 0.30 ENST00000313426.1
C20orf197
chromosome 20 open reading frame 197
chr17_-_39968406 0.30 ENST00000393928.1
LEPREL4
leprecan-like 4
chr14_+_21236586 0.30 ENST00000326783.3
EDDM3B
epididymal protein 3B
chr22_-_22221900 0.30 ENST00000215832.6
ENST00000398822.3
MAPK1
mitogen-activated protein kinase 1
chr8_+_87111059 0.29 ENST00000285393.3
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr12_-_53614043 0.29 ENST00000338561.5
RARG
retinoic acid receptor, gamma
chr14_+_21525981 0.29 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr10_-_23003460 0.29 ENST00000376573.4
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr2_-_219031709 0.29 ENST00000295683.2
CXCR1
chemokine (C-X-C motif) receptor 1
chrX_-_133930285 0.29 ENST00000486347.1
ENST00000343004.5
FAM122B
family with sequence similarity 122B
chr13_-_52027134 0.28 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr9_-_103115185 0.28 ENST00000374902.4
TEX10
testis expressed 10
chr9_-_123676827 0.28 ENST00000546084.1
TRAF1
TNF receptor-associated factor 1
chr1_+_67632083 0.28 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr7_+_144052381 0.28 ENST00000498580.1
ENST00000056217.5
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr2_-_75796837 0.28 ENST00000233712.1
EVA1A
eva-1 homolog A (C. elegans)
chr8_+_7801144 0.28 ENST00000443676.1
ZNF705B
zinc finger protein 705B
chr21_-_46962379 0.28 ENST00000311124.4
ENST00000380010.4
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr5_+_66124590 0.28 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr19_-_51875894 0.27 ENST00000600427.1
ENST00000595217.1
ENST00000221978.5
NKG7
natural killer cell group 7 sequence
chr19_-_39523165 0.27 ENST00000509137.2
ENST00000292853.4
FBXO27
F-box protein 27
chr14_+_95027772 0.27 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr11_+_28129795 0.27 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
METTL15
methyltransferase like 15
chr11_-_66112555 0.27 ENST00000425825.2
ENST00000359957.3
BRMS1
breast cancer metastasis suppressor 1
chr10_-_5060147 0.27 ENST00000604507.1
AKR1C2
aldo-keto reductase family 1, member C2
chr4_+_153701081 0.26 ENST00000451320.2
ENST00000429148.2
ENST00000353617.2
ENST00000405727.2
ENST00000356064.3
ARFIP1
ADP-ribosylation factor interacting protein 1
chr12_-_49351228 0.26 ENST00000541959.1
ENST00000447318.2
ARF3
ADP-ribosylation factor 3
chr4_-_69111401 0.26 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr19_-_46526304 0.26 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr5_+_57787254 0.25 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GAPT
GRB2-binding adaptor protein, transmembrane
chr5_+_54320078 0.25 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr1_-_161102213 0.25 ENST00000458050.2
DEDD
death effector domain containing
chr22_+_38597889 0.25 ENST00000338483.2
ENST00000538320.1
ENST00000538999.1
ENST00000441709.1
MAFF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr12_+_65672702 0.25 ENST00000538045.1
ENST00000535239.1
MSRB3
methionine sulfoxide reductase B3
chr8_+_22422749 0.25 ENST00000523900.1
SORBS3
sorbin and SH3 domain containing 3
chr6_-_26108355 0.25 ENST00000338379.4
HIST1H1T
histone cluster 1, H1t
chr1_-_47779762 0.24 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
STIL
SCL/TAL1 interrupting locus
chr6_+_41888926 0.24 ENST00000230340.4
BYSL
bystin-like
chr15_+_69373184 0.23 ENST00000558147.1
ENST00000440444.1
LINC00277
long intergenic non-protein coding RNA 277
chr3_+_148447887 0.23 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
AGTR1
angiotensin II receptor, type 1
chr19_-_10426663 0.23 ENST00000541276.1
ENST00000393708.3
ENST00000494368.1
FDX1L
ferredoxin 1-like
chr19_+_50270219 0.23 ENST00000354293.5
ENST00000359032.5
AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr12_-_53614155 0.23 ENST00000543726.1
RARG
retinoic acid receptor, gamma
chr19_-_41942344 0.22 ENST00000594660.1
ATP5SL
ATP5S-like
chr22_-_42915788 0.22 ENST00000323013.6
RRP7A
ribosomal RNA processing 7 homolog A (S. cerevisiae)
chr4_-_47916543 0.22 ENST00000507489.1
NFXL1
nuclear transcription factor, X-box binding-like 1
chr17_-_8059638 0.22 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1
period circadian clock 1
chr9_+_34329493 0.22 ENST00000379158.2
ENST00000346365.4
ENST00000379155.5
NUDT2
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr4_+_155484103 0.22 ENST00000302068.4
FGB
fibrinogen beta chain
chr1_+_44444865 0.22 ENST00000372324.1
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr19_-_10213335 0.21 ENST00000592641.1
ENST00000253109.4
ANGPTL6
angiopoietin-like 6
chr6_-_137815524 0.21 ENST00000367734.2
OLIG3
oligodendrocyte transcription factor 3
chr3_+_129262057 0.21 ENST00000324382.2
H1FOO
H1 histone family, member O, oocyte-specific
chr20_-_50418947 0.21 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr16_-_58718611 0.21 ENST00000564100.1
ENST00000570101.1
SLC38A7
solute carrier family 38, member 7
chr17_-_10741762 0.21 ENST00000580256.2
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr12_+_4714145 0.21 ENST00000545342.1
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr12_-_11091862 0.21 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chr3_+_99536663 0.21 ENST00000421999.2
ENST00000463526.1
CMSS1
cms1 ribosomal small subunit homolog (yeast)
chr14_-_75643296 0.20 ENST00000303575.4
TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr6_+_116692102 0.20 ENST00000359564.2
DSE
dermatan sulfate epimerase

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0019858 cytosine metabolic process(GO:0019858)
0.4 2.7 GO:0035803 egg coat formation(GO:0035803)
0.4 1.3 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.4 2.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.3 1.3 GO:0046110 xanthine metabolic process(GO:0046110)
0.3 1.2 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.3 0.8 GO:0048627 myoblast development(GO:0048627)
0.3 1.0 GO:0035627 ceramide transport(GO:0035627)
0.2 1.1 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.2 0.8 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.2 0.9 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 0.8 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.2 0.8 GO:0086053 AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.2 0.6 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.1 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.1 0.6 GO:0007418 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.6 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.3 GO:0045210 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
0.1 0.4 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.5 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.4 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.1 0.6 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.4 GO:0021633 optic nerve structural organization(GO:0021633)
0.1 1.2 GO:0021603 cranial nerve formation(GO:0021603)
0.1 0.3 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.4 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.5 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.1 0.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 0.8 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.3 GO:0098758 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.1 0.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.5 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.1 0.3 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.1 0.5 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.1 0.4 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.1 1.3 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.3 GO:0032824 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.1 0.4 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1 0.7 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 2.3 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.5 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 1.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.5 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.1 0.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.8 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.2 GO:1902024 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.3 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.1 0.3 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.7 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.2 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.5 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 0.2 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.1 0.8 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.2 GO:0046398 UDP-glucuronate metabolic process(GO:0046398)
0.1 0.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 0.3 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.3 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 0.4 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.2 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.3 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 0.2 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.1 0.5 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.6 GO:0030091 protein repair(GO:0030091)
0.1 0.2 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1 0.3 GO:0061107 seminal vesicle development(GO:0061107)
0.1 0.2 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.2 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724)
0.1 0.4 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.3 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.5 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 1.2 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.5 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.2 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.4 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.1 GO:0050894 determination of affect(GO:0050894)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:1990502 dense core granule maturation(GO:1990502)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.2 GO:0097476 spinal cord motor neuron migration(GO:0097476)
0.0 0.5 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.5 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.1 GO:0019364 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.0 0.2 GO:0033504 floor plate development(GO:0033504)
0.0 0.3 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.2 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) positive regulation of t-circle formation(GO:1904431)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.0 0.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.2 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.1 GO:0043132 coenzyme A transport(GO:0015880) FAD transport(GO:0015883) coenzyme A transmembrane transport(GO:0035349) FAD transmembrane transport(GO:0035350) NAD transport(GO:0043132) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.0 0.2 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.1 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.0 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.2 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.6 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.2 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.3 GO:0070141 response to UV-A(GO:0070141)
0.0 0.3 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.2 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.3 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.1 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.5 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.1 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.0 0.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:0001944 blood vessel development(GO:0001568) vasculature development(GO:0001944)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0 0.1 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
0.0 0.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.1 GO:0097460 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.7 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.1 GO:0035962 response to interleukin-13(GO:0035962)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.3 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 2.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.4 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.5 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.5 GO:0016180 snRNA processing(GO:0016180)
0.0 0.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.6 GO:0097503 sialylation(GO:0097503)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.3 GO:0046606 negative regulation of centrosome cycle(GO:0046606)
0.0 0.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.7 GO:0032094 response to food(GO:0032094)
0.0 0.1 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
0.0 0.1 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.3 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.2 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.5 GO:0001825 blastocyst formation(GO:0001825)
0.0 0.1 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.2 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.1 GO:0006954 inflammatory response(GO:0006954)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.2 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 0.2 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.3 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.2 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.1 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.0 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.0 0.0 GO:0039019 pronephric nephron development(GO:0039019)
0.0 0.1 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.7 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.3 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.0 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 0.8 GO:0000811 GINS complex(GO:0000811)
0.2 0.7 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.2 1.0 GO:0031262 Ndc80 complex(GO:0031262)
0.1 1.0 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 2.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.4 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.1 1.3 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.8 GO:0036021 endolysosome lumen(GO:0036021)
0.1 1.2 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.3 GO:0036028 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 0.8 GO:0000796 condensin complex(GO:0000796)
0.1 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 1.2 GO:0090543 Flemming body(GO:0090543)
0.1 6.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 0.6 GO:0042382 paraspeckles(GO:0042382)
0.1 0.6 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.1 0.4 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 0.6 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.0 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 1.0 GO:0005922 connexon complex(GO:0005922)
0.0 0.2 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.5 GO:0030914 STAGA complex(GO:0030914)
0.0 0.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.5 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0032432 stress fiber(GO:0001725) actin filament bundle(GO:0032432) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0000801 central element(GO:0000801)
0.0 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0030686 90S preribosome(GO:0030686)
0.0 0.1 GO:0043219 lateral loop(GO:0043219)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.7 GO:0044815 DNA packaging complex(GO:0044815)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:1903439 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.3 2.9 GO:0032190 acrosin binding(GO:0032190)
0.3 1.0 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.2 1.7 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 0.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 0.9 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 0.8 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.2 0.8 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 1.3 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.1 1.4 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.3 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.3 GO:0019959 interleukin-8 binding(GO:0019959)
0.1 0.3 GO:0008518 reduced folate carrier activity(GO:0008518)
0.1 0.6 GO:0070728 leucine binding(GO:0070728)
0.1 0.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.4 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.7 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.3 GO:0008184 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.5 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.1 0.5 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.1 0.2 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 0.4 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1 0.2 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.1 2.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.3 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.4 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 0.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.1 0.3 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.1 0.2 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.5 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.4 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.0 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0031877 somatostatin receptor binding(GO:0031877)
0.0 0.8 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.2 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.3 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.7 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.1 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.0 0.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0080122 coenzyme A transmembrane transporter activity(GO:0015228) FAD transmembrane transporter activity(GO:0015230) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.7 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0003863 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.0 0.3 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.7 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.5 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.1 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.0 0.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 4.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.0 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 1.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 1.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.8 ST STAT3 PATHWAY STAT3 Pathway
0.0 2.4 PID AURORA A PATHWAY Aurora A signaling
0.0 1.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.6 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 5.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.5 PID MYC PATHWAY C-MYC pathway
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 0.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.0 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.5 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 1.3 REACTOME KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 1.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.2 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.6 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.0 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.7 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 2.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.8 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 2.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.4 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle