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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TBX5

Z-value: 0.82

Motif logo

Transcription factors associated with TBX5

Gene Symbol Gene ID Gene Info
ENSG00000089225.15 T-box transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX5hg19_v2_chr12_-_114841703_1148417260.337.7e-02Click!

Activity profile of TBX5 motif

Sorted Z-values of TBX5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_31488433 1.97 ENST00000455608.1
smoothelin
chr4_-_175443788 1.72 ENST00000541923.1
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr4_-_175443484 1.61 ENST00000514584.1
ENST00000542498.1
ENST00000296521.7
ENST00000422112.2
ENST00000504433.1
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr14_+_75746781 1.47 ENST00000555347.1
FBJ murine osteosarcoma viral oncogene homolog
chr11_-_2170786 1.47 ENST00000300632.5
insulin-like growth factor 2 (somatomedin A)
chr21_+_30502806 1.43 ENST00000399928.1
ENST00000399926.1
MAP3K7 C-terminal like
chr1_+_15736359 1.36 ENST00000375980.4
EF-hand domain family, member D2
chr7_+_40174565 1.33 ENST00000309930.5
ENST00000401647.2
ENST00000335693.4
ENST00000413931.1
ENST00000416370.1
ENST00000540834.1
succinylCoA:glutarate-CoA transferase
chr9_+_125137565 1.26 ENST00000373698.5
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr13_-_60738003 1.25 ENST00000400330.1
ENST00000400324.4
diaphanous-related formin 3
chr17_+_74372662 1.24 ENST00000591651.1
ENST00000545180.1
sphingosine kinase 1
chr20_+_306177 1.23 ENST00000544632.1
SRY (sex determining region Y)-box 12
chr11_-_58345569 1.21 ENST00000528954.1
ENST00000528489.1
leupaxin
chr1_+_8378140 1.19 ENST00000377479.2
solute carrier family 45, member 1
chr16_-_2205352 1.18 ENST00000563192.1
RP11-304L19.5
chr13_+_78109884 1.16 ENST00000377246.3
ENST00000349847.3
sciellin
chr4_-_175443943 1.15 ENST00000296522.6
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr8_-_144655141 1.09 ENST00000398882.3
maestro heat-like repeat family member 6
chr13_+_78109804 1.09 ENST00000535157.1
sciellin
chr19_-_46526304 1.08 ENST00000008938.4
peptidoglycan recognition protein 1
chr8_+_87111059 1.04 ENST00000285393.3
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr18_+_33877654 1.04 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
formin homology 2 domain containing 3
chr17_-_8059638 1.03 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
period circadian clock 1
chr2_-_216003127 1.02 ENST00000412081.1
ENST00000272895.7
ATP-binding cassette, sub-family A (ABC1), member 12
chr14_+_24540046 0.96 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
copine VI (neuronal)
chr13_-_60737898 0.96 ENST00000377908.2
ENST00000400319.1
ENST00000400320.1
ENST00000267215.4
diaphanous-related formin 3
chr7_-_27135591 0.96 ENST00000343060.4
ENST00000355633.5
homeobox A1
chr7_+_143013198 0.95 ENST00000343257.2
chloride channel, voltage-sensitive 1
chr12_+_107712173 0.94 ENST00000280758.5
ENST00000420571.2
BTB (POZ) domain containing 11
chr1_-_153521714 0.89 ENST00000368713.3
S100 calcium binding protein A3
chr19_+_16308711 0.87 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
adaptor-related protein complex 1, mu 1 subunit
chr15_+_85427879 0.87 ENST00000338602.2
ENST00000537216.1
ENST00000538177.1
ENST00000537624.1
solute carrier family 28 (concentrative nucleoside transporter), member 1
chrX_-_106959631 0.83 ENST00000486554.1
ENST00000372390.4
TSC22 domain family, member 3
chr9_+_125133315 0.80 ENST00000223423.4
ENST00000362012.2
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_48594248 0.79 ENST00000545984.1
ENST00000232375.3
ENST00000416568.1
ENST00000383734.2
ENST00000541519.1
ENST00000412035.1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr11_+_35198118 0.77 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44 molecule (Indian blood group)
chr19_+_10397648 0.77 ENST00000340992.4
ENST00000393717.2
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr6_+_34204642 0.76 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr14_+_75745477 0.75 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FBJ murine osteosarcoma viral oncogene homolog
chr20_+_306221 0.74 ENST00000342665.2
SRY (sex determining region Y)-box 12
chr22_-_20231207 0.73 ENST00000425986.1
reticulon 4 receptor
chr5_+_54320078 0.73 ENST00000231009.2
granzyme K (granzyme 3; tryptase II)
chr14_+_21467414 0.72 ENST00000554422.1
ENST00000298681.4
solute carrier family 39 (zinc transporter), member 2
chrX_+_70503037 0.71 ENST00000535149.1
non-POU domain containing, octamer-binding
chr19_+_16308659 0.71 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
adaptor-related protein complex 1, mu 1 subunit
chr1_+_207038699 0.69 ENST00000367098.1
interleukin 20
chr4_-_73434498 0.69 ENST00000286657.4
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr11_-_72385437 0.67 ENST00000418754.2
ENST00000542969.2
ENST00000334456.5
phosphodiesterase 2A, cGMP-stimulated
chr4_+_102268904 0.66 ENST00000527564.1
ENST00000529296.1
Uncharacterized protein
chr12_+_57853918 0.66 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI family zinc finger 1
chr5_-_54281407 0.65 ENST00000381403.4
endothelial cell-specific molecule 1
chr2_+_174219548 0.65 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
cell division cycle associated 7
chr19_+_41856816 0.65 ENST00000539627.1
transmembrane protein 91
chr7_+_76139833 0.64 ENST00000257632.5
uroplakin 3B
chr17_+_34538310 0.63 ENST00000444414.1
ENST00000378350.4
ENST00000389068.5
ENST00000588929.1
ENST00000589079.1
ENST00000589336.1
ENST00000400702.4
ENST00000591167.1
ENST00000586598.1
ENST00000591637.1
ENST00000378352.4
ENST00000358756.5
chemokine (C-C motif) ligand 4-like 1
chr17_-_39203519 0.63 ENST00000542137.1
ENST00000391419.3
keratin associated protein 2-1
chr17_+_37894179 0.63 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
growth factor receptor-bound protein 7
chr7_+_155090271 0.63 ENST00000476756.1
insulin induced gene 1
chr6_-_11382478 0.63 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
neural precursor cell expressed, developmentally down-regulated 9
chr19_+_10397621 0.62 ENST00000380770.3
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr7_+_139529040 0.61 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
thromboxane A synthase 1 (platelet)
chr3_-_48632593 0.61 ENST00000454817.1
ENST00000328333.8
collagen, type VII, alpha 1
chr2_+_234601512 0.61 ENST00000305139.6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr3_+_167453493 0.60 ENST00000295777.5
ENST00000472747.2
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr17_+_43922241 0.60 ENST00000329196.5
signal peptide peptidase like 2C
chr19_-_42931567 0.59 ENST00000244289.4
lipase, hormone-sensitive
chrX_-_106960285 0.59 ENST00000503515.1
ENST00000372397.2
TSC22 domain family, member 3
chrX_-_109561294 0.59 ENST00000372059.2
ENST00000262844.5
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr19_+_54385439 0.59 ENST00000536044.1
ENST00000540413.1
ENST00000263431.3
ENST00000419486.1
protein kinase C, gamma
chr17_-_61973929 0.58 ENST00000329882.8
ENST00000453363.3
ENST00000316193.8
chorionic somatomammotropin hormone 1 (placental lactogen)
chr4_-_186456652 0.58 ENST00000284767.5
ENST00000284770.5
PDZ and LIM domain 3
chr20_-_32891151 0.58 ENST00000217426.2
adenosylhomocysteinase
chr4_-_186456766 0.58 ENST00000284771.6
PDZ and LIM domain 3
chr5_-_176836577 0.58 ENST00000253496.3
coagulation factor XII (Hageman factor)
chr2_-_89521942 0.57 ENST00000482769.1
immunoglobulin kappa variable 2-28
chr1_+_150954493 0.57 ENST00000368947.4
annexin A9
chr6_-_41168920 0.57 ENST00000483722.1
triggering receptor expressed on myeloid cells-like 2
chr16_+_55600580 0.57 ENST00000457326.2
calpain, small subunit 2
chr7_+_139528952 0.57 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
thromboxane A synthase 1 (platelet)
chr2_+_234668894 0.56 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr2_+_68961934 0.56 ENST00000409202.3
Rho GTPase activating protein 25
chr19_-_16045220 0.55 ENST00000326742.8
cytochrome P450, family 4, subfamily F, polypeptide 11
chr15_-_71055769 0.55 ENST00000539319.1
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr7_+_80231466 0.55 ENST00000309881.7
ENST00000534394.1
CD36 molecule (thrombospondin receptor)
chr5_-_127418573 0.54 ENST00000508353.1
ENST00000508878.1
ENST00000501652.1
ENST00000514409.1
CTC-228N24.3
chr2_+_89998789 0.54 ENST00000453166.2
immunoglobulin kappa variable 2D-28
chr2_+_201676908 0.54 ENST00000409226.1
ENST00000452790.2
basic leucine zipper and W2 domains 1
chr1_+_207039154 0.54 ENST00000367096.3
ENST00000391930.2
interleukin 20
chrX_-_148713365 0.53 ENST00000511776.1
ENST00000507237.1
transmembrane protein 185A
chr15_+_89182178 0.53 ENST00000559876.1
interferon stimulated exonuclease gene 20kDa
chr10_+_94352956 0.53 ENST00000260731.3
kinesin family member 11
chr7_-_76255444 0.52 ENST00000454397.1
POM121 and ZP3 fusion
chr2_+_68961905 0.52 ENST00000295381.3
Rho GTPase activating protein 25
chrX_-_153775426 0.52 ENST00000393562.2
glucose-6-phosphate dehydrogenase
chr13_+_30510003 0.51 ENST00000400540.1
long intergenic non-protein coding RNA 544
chr3_+_135741576 0.51 ENST00000334546.2
protein phosphatase 2, regulatory subunit B'', alpha
chr19_-_41934635 0.50 ENST00000321702.2
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr17_-_39324424 0.50 ENST00000391356.2
keratin associated protein 4-3
chr19_-_10420459 0.49 ENST00000403352.1
ENST00000403903.3
zinc finger, GATA-like protein 1
chr3_-_197024394 0.47 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
discs, large homolog 1 (Drosophila)
chr7_+_143318020 0.47 ENST00000444908.2
ENST00000518791.1
ENST00000411497.2
family with sequence similarity 115, member C
chr8_+_32405728 0.47 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
neuregulin 1
chr7_+_76139741 0.46 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
uroplakin 3B
chr16_+_640201 0.46 ENST00000563109.1
RAB40C, member RAS oncogene family
chr8_+_32405785 0.46 ENST00000287842.3
neuregulin 1
chr11_-_88796803 0.46 ENST00000418177.2
ENST00000455756.2
glutamate receptor, metabotropic 5
chr10_+_135340859 0.45 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr1_-_12677714 0.45 ENST00000376223.2
dehydrogenase/reductase (SDR family) member 3
chr17_-_72358001 0.44 ENST00000375366.3
BTB (POZ) domain containing 17
chr19_+_17862274 0.44 ENST00000596536.1
ENST00000593870.1
ENST00000598086.1
ENST00000598932.1
ENST00000595023.1
ENST00000594068.1
ENST00000596507.1
ENST00000595033.1
ENST00000597718.1
FCH domain only 1
chr6_+_121756809 0.44 ENST00000282561.3
gap junction protein, alpha 1, 43kDa
chr13_-_99404875 0.43 ENST00000376503.5
solute carrier family 15 (oligopeptide transporter), member 1
chr7_+_2687173 0.43 ENST00000403167.1
tweety family member 3
chr11_-_85779971 0.43 ENST00000393346.3
phosphatidylinositol binding clathrin assembly protein
chr7_+_112063192 0.43 ENST00000005558.4
interferon-related developmental regulator 1
chr10_-_131762105 0.43 ENST00000368648.3
ENST00000355311.5
early B-cell factor 3
chr2_-_169769787 0.43 ENST00000451987.1
SPC25, NDC80 kinetochore complex component
chr14_-_37051798 0.42 ENST00000258829.5
NK2 homeobox 8
chr17_+_57970469 0.42 ENST00000443572.2
ENST00000406116.3
ENST00000225577.4
ENST00000393021.3
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr6_+_167536230 0.41 ENST00000341935.5
ENST00000349984.4
chemokine (C-C motif) receptor 6
chr2_+_228337079 0.41 ENST00000409315.1
ENST00000373671.3
ENST00000409171.1
ArfGAP with FG repeats 1
chr1_+_168250194 0.41 ENST00000367821.3
T-box 19
chr5_-_148758839 0.41 ENST00000261796.3
interleukin 17B
chr17_-_74533734 0.41 ENST00000589342.1
cytoglobin
chr13_-_79177673 0.41 ENST00000377208.5
POU class 4 homeobox 1
chr17_-_7297519 0.41 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3 readthrough (NMD candidate)
chr4_-_82136114 0.40 ENST00000395578.1
ENST00000418486.2
protein kinase, cGMP-dependent, type II
chr1_+_13910479 0.40 ENST00000509009.1
podoplanin
chr1_+_156254070 0.40 ENST00000405535.2
ENST00000456810.1
transmembrane protein 79
chr2_+_171673072 0.40 ENST00000358196.3
ENST00000375272.1
glutamate decarboxylase 1 (brain, 67kDa)
chr3_-_178984759 0.40 ENST00000349697.2
ENST00000497599.1
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr3_+_35722844 0.39 ENST00000436702.1
ENST00000438071.1
cAMP-regulated phosphoprotein, 21kDa
chr5_-_16738451 0.39 ENST00000274203.9
ENST00000515803.1
myosin X
chr11_-_2182388 0.38 ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
ENST00000397270.1
insulin
INS-IGF2 readthrough
chr12_-_102872317 0.38 ENST00000424202.2
insulin-like growth factor 1 (somatomedin C)
chr4_+_8582287 0.38 ENST00000382487.4
G protein-coupled receptor 78
chr2_+_171673417 0.38 ENST00000344257.5
glutamate decarboxylase 1 (brain, 67kDa)
chr7_-_105319536 0.38 ENST00000477775.1
ataxin 7-like 1
chrX_-_128788914 0.37 ENST00000429967.1
ENST00000307484.6
apelin
chr17_-_7297833 0.37 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3 readthrough (NMD candidate)
chr2_+_204193101 0.37 ENST00000430418.1
ENST00000424558.1
ENST00000261016.6
abl-interactor 2
chr2_+_201676256 0.37 ENST00000452206.1
ENST00000410110.2
ENST00000409600.1
basic leucine zipper and W2 domains 1
chr12_-_28124903 0.37 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
parathyroid hormone-like hormone
chr3_+_38035610 0.37 ENST00000465644.1
villin-like
chr14_+_24779376 0.37 ENST00000530080.1
leukotriene B4 receptor 2
chr22_+_38201114 0.37 ENST00000340857.2
H1 histone family, member 0
chr1_-_47655686 0.37 ENST00000294338.2
PDZK1 interacting protein 1
chr1_+_101702417 0.37 ENST00000305352.6
sphingosine-1-phosphate receptor 1
chr1_+_1981890 0.37 ENST00000378567.3
ENST00000468310.1
protein kinase C, zeta
chr16_-_29874211 0.36 ENST00000563415.1
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr15_+_41099254 0.36 ENST00000570108.1
ENST00000564258.1
ENST00000355341.4
ENST00000336455.5
zinc finger, FYVE domain containing 19
chr19_+_18723660 0.36 ENST00000262817.3
transmembrane protein 59-like
chr15_+_89181974 0.35 ENST00000306072.5
interferon stimulated exonuclease gene 20kDa
chr9_+_129376722 0.35 ENST00000526117.1
ENST00000373474.4
ENST00000355497.5
ENST00000425646.2
ENST00000561065.1
LIM homeobox transcription factor 1, beta
chr9_-_98784042 0.35 ENST00000412122.2
long intergenic non-protein coding RNA 92
chr5_-_54281491 0.35 ENST00000381405.4
endothelial cell-specific molecule 1
chr13_+_28195988 0.35 ENST00000399697.3
ENST00000399696.1
polymerase (RNA) I polypeptide D, 16kDa
chr1_+_202995611 0.35 ENST00000367240.2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr15_-_74043816 0.34 ENST00000379822.4
chromosome 15 open reading frame 59
chr11_+_46402297 0.34 ENST00000405308.2
midkine (neurite growth-promoting factor 2)
chr3_+_133292759 0.34 ENST00000431519.2
CDV3 homolog (mouse)
chr1_-_157670647 0.34 ENST00000368184.3
Fc receptor-like 3
chr12_-_49351228 0.34 ENST00000541959.1
ENST00000447318.2
ADP-ribosylation factor 3
chr17_-_33416231 0.34 ENST00000584655.1
ENST00000447669.2
ENST00000315249.7
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr11_+_119019722 0.33 ENST00000307417.3
ATP-binding cassette, sub-family G (WHITE), member 4
chr17_-_61996160 0.33 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
growth hormone 1
chr6_+_25652501 0.33 ENST00000334979.6
secretagogin, EF-hand calcium binding protein
chr2_-_72374948 0.33 ENST00000546307.1
ENST00000474509.1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr3_-_182703688 0.33 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCN1, defective in cullin neddylation 1, domain containing 1
chr12_-_91348949 0.33 ENST00000358859.2
coiled-coil glutamate-rich protein 1
chr12_+_81101277 0.33 ENST00000228641.3
myogenic factor 6 (herculin)
chr12_+_112563303 0.33 ENST00000412615.2
TRAF-type zinc finger domain containing 1
chr16_-_67190152 0.33 ENST00000486556.1
TNFRSF1A-associated via death domain
chr2_+_29336855 0.32 ENST00000404424.1
CAP-GLY domain containing linker protein family, member 4
chrX_+_69642881 0.32 ENST00000453994.2
ENST00000536730.1
ENST00000538649.1
ENST00000374382.3
glycerophosphodiester phosphodiesterase domain containing 2
chrX_-_148713440 0.32 ENST00000536359.1
ENST00000316916.8
transmembrane protein 185A
chr2_-_217724767 0.32 ENST00000236979.2
transition protein 1 (during histone to protamine replacement)
chr20_-_22565101 0.32 ENST00000419308.2
forkhead box A2
chr1_+_113009163 0.32 ENST00000256640.5
wingless-type MMTV integration site family, member 2B
chr1_+_156785425 0.32 ENST00000392302.2
neurotrophic tyrosine kinase, receptor, type 1
chr2_+_201994208 0.32 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr16_+_3162557 0.32 ENST00000382192.3
ENST00000219091.4
ENST00000444510.2
ENST00000414351.1
zinc finger protein 205
chr14_+_72399114 0.31 ENST00000553525.1
ENST00000555571.1
regulator of G-protein signaling 6
chr7_+_62809239 0.31 ENST00000456890.1
AC006455.1
chr19_-_4302375 0.31 ENST00000600114.1
ENST00000600349.1
ENST00000595645.1
ENST00000301272.2
transmembrane and immunoglobulin domain containing 2
chr11_+_122709200 0.30 ENST00000227348.4
cytotoxic and regulatory T cell molecule
chr7_-_142120321 0.30 ENST00000390377.1
T cell receptor beta variable 7-7
chr12_+_104324112 0.30 ENST00000299767.5
heat shock protein 90kDa beta (Grp94), member 1
chr12_+_112563335 0.30 ENST00000549358.1
ENST00000257604.5
ENST00000548092.1
ENST00000552896.1
TRAF-type zinc finger domain containing 1
chr3_-_120170052 0.30 ENST00000295633.3
follistatin-like 1
chr4_+_78079570 0.30 ENST00000509972.1
cyclin G2
chr17_-_40333099 0.30 ENST00000607371.1
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr2_-_219925189 0.30 ENST00000295731.6
indian hedgehog
chr3_+_14860469 0.30 ENST00000285046.5
FYVE, RhoGEF and PH domain containing 5
chr10_+_133918175 0.29 ENST00000298622.4
Janus kinase and microtubule interacting protein 3
chr8_+_99439214 0.29 ENST00000287042.4
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
chr12_+_50898881 0.29 ENST00000301180.5
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr22_+_46481861 0.29 ENST00000360737.3
hsa-mir-4763
chr6_-_26018007 0.29 ENST00000244573.3
histone cluster 1, H1a
chr3_-_49142504 0.29 ENST00000306125.6
ENST00000420147.2
glutaminyl-tRNA synthetase

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.5 GO:2001300 lipoxin metabolic process(GO:2001300)
0.4 1.2 GO:0046521 sphingoid catabolic process(GO:0046521)
0.4 1.1 GO:0032826 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.3 0.3 GO:2000196 positive regulation of female gonad development(GO:2000196)
0.3 2.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.3 1.0 GO:0035627 ceramide transport(GO:0035627)
0.2 0.7 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.2 1.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 0.6 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 0.8 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.2 0.6 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.2 0.6 GO:1900075 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.2 3.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 0.5 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 1.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 0.6 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.2 1.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 0.9 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.2 0.5 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 0.8 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 1.0 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1 0.6 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.1 0.4 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.1 0.4 GO:0042938 dipeptide transport(GO:0042938)
0.1 1.0 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.1 0.4 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.4 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.6 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.1 0.8 GO:0035803 egg coat formation(GO:0035803)
0.1 0.4 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.4 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 0.9 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.7 GO:0007418 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.4 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.1 0.4 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.5 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 0.7 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.6 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.6 GO:0032425 positive regulation of mismatch repair(GO:0032425)
0.1 0.5 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.1 0.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.6 GO:0070980 biphenyl catabolic process(GO:0070980)
0.1 0.3 GO:2001035 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 0.3 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 0.9 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 1.0 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 0.4 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 0.3 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.1 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.1 0.8 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.3 GO:0061386 closure of optic fissure(GO:0061386)
0.1 0.6 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 0.6 GO:2000332 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1 0.6 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 1.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.3 GO:0021553 olfactory nerve development(GO:0021553)
0.1 0.4 GO:0001834 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.6 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.5 GO:0010193 response to ozone(GO:0010193)
0.1 0.2 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.6 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.1 1.6 GO:0043485 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.1 0.3 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.3 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.1 0.4 GO:0042335 cuticle development(GO:0042335)
0.1 0.2 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.2 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.1 0.3 GO:0010728 regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.1 0.4 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.4 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.1 0.5 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.3 GO:0030421 defecation(GO:0030421)
0.1 1.2 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.1 0.4 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.1 0.3 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 0.5 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 0.3 GO:0060424 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.1 0.2 GO:0008050 female courtship behavior(GO:0008050)
0.1 0.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 0.2 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.1 0.2 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0019087 transformation of host cell by virus(GO:0019087)
0.0 0.2 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.2 GO:2001193 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.0 0.3 GO:0014826 cellular magnesium ion homeostasis(GO:0010961) vein smooth muscle contraction(GO:0014826)
0.0 0.5 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.7 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.1 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724)
0.0 0.2 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.6 GO:0042110 T cell activation(GO:0042110) T cell aggregation(GO:0070489) lymphocyte aggregation(GO:0071593)
0.0 0.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.0 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.8 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.2 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.3 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.0 0.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.2 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.4 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.3 GO:0071550 positive regulation of hair follicle development(GO:0051798) death-inducing signaling complex assembly(GO:0071550)
0.0 0.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.5 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 0.2 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.6 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.4 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.1 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0 0.3 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.1 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.4 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 1.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.5 GO:0007567 parturition(GO:0007567)
0.0 0.2 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.2 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.3 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.4 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.3 GO:0009595 detection of biotic stimulus(GO:0009595)
0.0 0.2 GO:0051775 response to redox state(GO:0051775)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.0 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 2.1 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 0.0 GO:0021586 pons maturation(GO:0021586)
0.0 0.3 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 0.1 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.0 GO:0007439 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.0 0.2 GO:0015732 prostaglandin transport(GO:0015732)
0.0 0.6 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.2 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.4 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.4 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.1 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.1 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.3 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.2 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.2 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.6 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 2.9 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 0.7 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.6 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.1 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.5 GO:0048599 oocyte development(GO:0048599)
0.0 0.1 GO:0051964 netrin-activated signaling pathway(GO:0038007) negative regulation of synapse assembly(GO:0051964)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0035976 AP1 complex(GO:0035976)
0.2 0.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 1.1 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.2 0.8 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.2 0.6 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 1.0 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.4 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.3 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.1 0.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.4 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.1 0.2 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 1.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.8 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.8 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.0 0.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.6 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)
0.0 2.3 GO:0001533 cornified envelope(GO:0001533)
0.0 0.9 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 2.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.9 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.4 GO:0030017 sarcomere(GO:0030017)
0.0 1.2 GO:0031904 endosome lumen(GO:0031904)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.7 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.2 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.4 GO:0005903 brush border(GO:0005903)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.7 GO:0097542 ciliary tip(GO:0097542)
0.0 1.0 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.5 2.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 1.2 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.4 1.2 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.4 1.1 GO:0008859 exoribonuclease II activity(GO:0008859)
0.3 1.4 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.3 1.0 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.3 1.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.2 0.7 GO:0038131 neuregulin receptor activity(GO:0038131)
0.2 0.9 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.2 1.2 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 0.6 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 0.5 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.2 1.4 GO:0043426 MRF binding(GO:0043426)
0.1 0.4 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 0.4 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.6 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.1 0.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 0.5 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.4 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.1 0.6 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.7 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 0.8 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.4 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.6 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.9 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.6 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.4 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.2 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 0.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.9 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.3 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.4 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.1 0.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.2 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.1 0.5 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 2.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.2 GO:0004913 interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.1 0.5 GO:0032190 acrosin binding(GO:0032190)
0.1 0.2 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.0 4.7 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.5 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.2 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.0 0.4 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 1.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 1.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 3.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.6 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.4 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.2 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.5 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.6 GO:0033130 acetylcholine receptor binding(GO:0033130) protein anchor(GO:0043495)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 0.4 GO:0070513 death domain binding(GO:0070513)
0.0 0.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 1.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.0 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.2 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.2 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0098960 postsynaptic neurotransmitter receptor activity(GO:0098960)
0.0 0.0 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0035326 enhancer binding(GO:0035326)
0.0 0.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 2.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 1.8 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 2.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 3.0 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.8 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.1 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.7 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.2 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.8 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.4 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.2 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.3 PID IFNG PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.8 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 1.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.9 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 1.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.9 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.8 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.1 REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels