ISMARA results: TCF12

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TCF12_ASCL2

Z-value: 0.72

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Transcription factors associated with TCF12_ASCL2

Gene Symbol	Gene ID	Gene Info
TCF12 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000140262.13	transcription factor 12
ASCL2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000183734.4	achaete-scute family bHLH transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ASCL2	hg19_v2_chr11_-_2292182_2292212	0.63	1.8e-04	Click!
TCF12	hg19_v2_chr15_+_57511609_57511664	0.56	1.2e-03	Click!

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_16085314 Show fit	3.62	ENST00000510224.1	PROM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	prominin 1
chr22_-_50970506 Show fit	2.70	ENST00000428989.2 ENST00000403326.1	ODF3B Ensembl NCBI GeneCards UniProt NextProt Show fit	outer dense fiber of sperm tails 3B
chr4_-_16085340 Show fit	2.61	ENST00000508167.1	PROM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	prominin 1
chr6_-_24911195 Show fit	2.55	ENST00000259698.4	FAM65B Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 65, member B
chr10_-_102089729 Show fit	2.39	ENST00000465680.2	PKD2L1 Ensembl NCBI GeneCards UniProt NextProt Show fit	polycystic kidney disease 2-like 1
chr17_-_39296739 Show fit	2.28	ENST00000345847.4	KRTAP4-6 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin associated protein 4-6
chr1_-_75139397 Show fit	2.13	ENST00000326665.5	C1orf173 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 173
chr1_+_18807424 Show fit	2.09	ENST00000400664.1	KLHDC7A Ensembl NCBI GeneCards UniProt NextProt Show fit	kelch domain containing 7A
chr16_+_67465016 Show fit	1.92	ENST00000326152.5	HSD11B2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hydroxysteroid (11-beta) dehydrogenase 2
chr7_-_73184588 Show fit	1.91	ENST00000395145.2	CLDN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	claudin 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	6.2	GO:2000768	glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.0	3.5	GO:0001895	retina homeostasis(GO:0001895)
0.1	2.9	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.6	2.5	GO:0097089	methyl-branched fatty acid metabolic process(GO:0097089)
0.0	2.4	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.3	2.3	GO:0050915	sensory perception of sour taste(GO:0050915)
0.0	2.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1	1.8	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	1.8	GO:0090383	phagosome acidification(GO:0090383)
0.3	1.7	GO:0015670	carbon dioxide transport(GO:0015670)

Showing 1 to 10 of 525 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	6.2	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	4.2	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1	3.3	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	3.3	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1	2.7	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	2.4	GO:0001650	fibrillar center(GO:0001650)
0.1	2.3	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	2.3	GO:0009925	basal plasma membrane(GO:0009925)
0.0	2.3	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	2.2	GO:0034704	calcium channel complex(GO:0034704)

Showing 1 to 10 of 159 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.4	GO:0042805	actinin binding(GO:0042805)
0.0	3.5	GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.2	2.7	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	2.4	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.2	2.2	GO:0032395	MHC class II receptor activity(GO:0032395)
0.6	1.7	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0	1.7	GO:0070888	E-box binding(GO:0070888)
0.0	1.7	GO:0003777	microtubule motor activity(GO:0003777)
0.1	1.6	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	1.6	GO:0045505	dynein intermediate chain binding(GO:0045505)

Showing 1 to 10 of 291 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	2.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	1.8	PID BMP PATHWAY	BMP receptor signaling
0.0	1.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.1	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	1.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.9	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	0.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	0.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	0.4	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Showing 1 to 10 of 20 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.3	2.8	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	2.2	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	2.1	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	1.7	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	1.7	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.1	1.6	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	1.6	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.1	1.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.2	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels

Showing 1 to 10 of 55 entries

Results for TCF12_ASCL2

Z-value: 0.72

Motif logo

Transcription factors associated with TCF12_ASCL2

Activity-expression correlation:

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: