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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for TCF21
Z-value: 1.48
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Transcription factors associated with TCF21
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF21 | hg19_v2_chr6_+_134210243_134210276 | 0.09 | 6.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF21
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 12.8 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 3.3 | 9.8 | GO:0046680 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775) |
| 1.7 | 8.7 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 1.4 | 8.6 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 2.1 | 6.4 | GO:0048627 | myoblast development(GO:0048627) |
| 1.0 | 6.2 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.4 | 6.1 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 1.8 | 5.5 | GO:0060279 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 1.7 | 5.1 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
| 0.1 | 4.9 | GO:0007019 | microtubule depolymerization(GO:0007019) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 16.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 11.6 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 2.0 | 9.8 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.1 | 8.6 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 8.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 8.1 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 8.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 7.2 | GO:0005811 | lipid particle(GO:0005811) |
| 1.8 | 5.5 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 5.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 1.4 | 9.8 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 1.4 | 8.6 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.0 | 8.0 | GO:0005198 | structural molecule activity(GO:0005198) |
| 1.9 | 7.8 | GO:0030395 | lactose binding(GO:0030395) |
| 1.3 | 6.7 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.2 | 5.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 1.8 | 5.5 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.7 | 5.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 4.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 9.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.6 | 8.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 5.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.2 | 4.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 3.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 3.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.8 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 2.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 18.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.3 | 17.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 10.4 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.2 | 7.4 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.5 | 6.8 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 5.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.2 | 4.7 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 4.6 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.0 | 4.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 4.2 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |